507 research outputs found
On the occurrence of Bursatella leachii de Blainville, 1817 in Izmir Bay, Turkey
One of the well- established alien species in the eastern Mediterranean basin is Bursatella leachii, also known as a lessepsian immigrant. The present paper provides a contribution to Bursatella leachii’sdistribution in the Bay of Izmir, Turkish Aegean Sea
Використання волоконно-оптичних інтелектуальних структур діагностування технічного стану зовнішніх обводів літака
Article is devoted to the possibilities of usage of the fiber-optic intelligence structure for the diagnosis of the technical conditions of the outside of the airplane. Рассмотрена возможность использования волоконно-оптических интеллектуальных структур для диагностирования технического состояния внешних обводов самолета. Розглянуто можливість використання волоконно-оптичних інтелектуальних структур для діагностування технічного стану зовнішніх обводів літака
Human C4orf14 interacts with the mitochondrial nucleoid and is involved in the biogenesis of the small mitochondrial ribosomal subunit.
The bacterial homologue of C4orf14, YqeH, has been linked to assembly of the small ribosomal subunit. Here, recombinant C4orf14 isolated from human cells, co-purified with the small, 28S subunit of the mitochondrial ribosome and the endogenous protein co-fractionated with the 28S subunit in sucrose gradients. Gene silencing of C4orf14 specifically affected components of the small subunit, leading to decreased protein synthesis in the organelle. The GTPase of C4orf14 was critical to its interaction with the 28S subunit, as was GTP. Therefore, we propose that C4orf14, with bound GTP, binds to components of the 28S subunit facilitating its assembly, and GTP hydrolysis acts as the release mechanism. C4orf14 was also found to be associated with human mitochondrial nucleoids, and C4orf14 gene silencing caused mitochondrial DNA depletion. In vitro C4orf14 is capable of binding to DNA. The association of C4orf14 with mitochondrial translation factors and the mitochondrial nucleoid suggests that the 28S subunit is assembled at the mitochondrial nucleoid, enabling the direct transfer of messenger RNA from the nucleoid to the ribosome in the organelle.Medical Research Council (MRC); Biotechnology and Biological Sciences Research Council (BBSRC); European Union; Academy of Finland (to H.M.C.). Funding for open access charge: MRC
Thermal stress induces glycolytic beige fat formation via a myogenic state.
Environmental cues profoundly affect cellular plasticity in multicellular organisms. For instance, exercise promotes a glycolytic-to-oxidative fibre-type switch in skeletal muscle, and cold acclimation induces beige adipocyte biogenesis in adipose tissue. However, the molecular mechanisms by which physiological or pathological cues evoke developmental plasticity remain incompletely understood. Here we report a type of beige adipocyte that has a critical role in chronic cold adaptation in the absence of β-adrenergic receptor signalling. This beige fat is distinct from conventional beige fat with respect to developmental origin and regulation, and displays enhanced glucose oxidation. We therefore refer to it as glycolytic beige fat. Mechanistically, we identify GA-binding protein α as a regulator of glycolytic beige adipocyte differentiation through a myogenic intermediate. Our study reveals a non-canonical adaptive mechanism by which thermal stress induces progenitor cell plasticity and recruits a distinct form of thermogenic cell that is required for energy homeostasis and survival
Small-Size Resonant Photoacoustic Cell of Inclined Geometry for Gas Detection
A photoacoustic cell intended for laser detection of trace gases is
represented. The cell is adapted so as to enhance the gas-detection performance
and, simultaneously, to reduce the cell size. The cell design provides an
efficient cancellation of the window background (a parasite response due to
absorption of laser beam in the cell windows) and acoustic isolation from the
environment for an acoustic resonance of the cell. The useful photoacoustic
response from a detected gas, window background and noise are analyzed in
demonstration experiments as functions of the modulation frequency for a
prototype cell with the internal volume ~ 0.5 cm^3. The minimal detectable
absorption for the prototype is estimated to be ~ 1.2 10^{-8} cm^{-1} W
Hz^{-1/2}.Comment: 11 pages, 5 figure
Controlled Diffraction Liquid-Crystal Structures with a Photoalignment Polymer
The characteristics of electric-field-controlled diffraction elements based on a nematic liquid crystal
and a new photoalignment polymer have been studied. The photocross-linking of this polymer allows periodic
oriented structures and liquid crystal phase gratings with a 30% diffraction efficiency in the first order to
be formed
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