Comparison of collagen biomatrix and omentum effectiveness on peripheral nerve regeneration

Despite the presence of various nerve coaptation materials and techniques, achievement of the functional nerve regeneration is still inadequate. This study was aimed to compare the effectiveness of conduit composed of collagen biomatrix and omentum graft on peripheral nerve regeneration. Thirty-five male Wistar rats were divided into four groups. In the control group, the right sciatic nerve was skeletonized from the sciatic notch till the point of bifurcation. In the primary epineural repair group, the nerve was transected 1 cm proximal to the bifurcation with a sharp pair of micro scissors and then repaired with four epineural sutures. In the collagen biomatrix group, the epineural repaired nerve was wrapped with collagen biomatrix. In the collagen group, the epineural repaired nerve was wrapped with the nonpediculated omentum. Assessment of the nerve regeneration was based on functional (Walking Track Analysis, Electrophysiological Measurements), histological, and morphometric criteria. Light and electron microscopic examinations showed that collagen-biomatrix-wrapped specimens have the best regeneration. The electrophysiological study confirmed the recovery of electrical activity in the regenerated axons

Sacral Spine Eosinophilic Granuloma in an Adult Patient: A Case Report of Unusual Age and Location

Eosinophilic granuloma one of a triad of diseases under Langerhans' cell histiocytosis as known as Histiocytosis X, is a rare disorder characterized with uncontrolled proliferation of histiocytes, mostly seen among children and adolescents instead of adults. Although the clinical picture is well defined, there are still unclear aspects on etiology, histology and prognosis. Here we are presenting our experiences on a case of eosinophilic granuloma interestingly in an adult patient. She was admitted with back and hip pain. After her diagnosis of sacral spine osteolytic tumor, the biopsy was performed in our clinic and her histopathology was resulted as eosinophilic granuloma. In this paper we are presenting the clinical and hystopathological features of esonophilic granuloma. We aimed to contribute an additional data to the literature on eosinophilic granuloma presented with an atypical localization and age. According to current literature, there are only few reports on both adults and sacrum affected with eosinophilic granuloma

Wewnątrzkomorowy dysembrioplastyczny guz neuroepitelialny – opis przypadku

Dysembryoplastic neuroepithelial tumour (DNT) is located in the cerebral cortex with very few exceptions. In this article, an extremely rare case of intraventricular DNT originating from the septum pellucidum is reported. A 25-year-old woman presented with 5-month history of headache. Cranial magnetic resonance imaging (MRI) scans revealed a mass in the right lateral and third ventricle which was hypointense on T1-weighted image, and hyperintense on T2-weighted images. No contrast enhancement was detected. The lesion was excised totally using a transcallosal-transventricular approach. Immunohistochemical examination revealed DNT. The patient was discharged without any neurological deficits. Intraventricular DNT presents with symptoms of increased intracranial pressure rather than seizures. Distinguishing DNT from other intraventricular tumours is essential as DNT is characterized by benign clinical course and does not require adjuvant therapy.Dysembrioplastyczne guzy neuroepitelialne (DNT) są umiejscowione, z nielicznymi wyjątkami, w korze mózgowej. W bieżącej pracy autorzy przedstawiają wyjątkowo rzadki przypadek chorej z DNT położonym wewnątrzkomorowo, wychodzącym z przegrody przezroczystej. Chora, 25 lat, zgłosiła się z powodu utrzymującego się od 5 miesięcy bólu głowy. W badaniu za pomocą rezonansu magnetycznego uwidoczniono guz położony w komorze bocznej prawej i w komorze trzeciej, hipointensywny w obrazach T1-zależnych, hiperintensywny w obrazach T2-zależnych i niewzmacniający się po podaniu środka kontrastowego. Guz wycięto w całości z dojścia przez ciało modzelowate i przez komorę. W badaniu immunohistochemicznym stwierdzono DNT. Chora została wypisana do domu bez ubytkowych objawów neurologicznych. Wewnątrzkomorowe DNT przejawiają się raczej wystąpieniem objawów wzmożonego ciśnienia śródczaszkowego niż napadów padaczkowych. Odróżnianie DNT od innych guzów wewnątrzkomorowych jest nieodzowne ze względu na fakt, że guz przebiega łagodnie i nie wymaga leczenia wspomagającego

The Effect of Quetiapine on Treatment of Experimental Acute Spinal Cord Injury

AIM: It is well known that treatment modalities against secondary damage due to spinal cord injury (SCI) are very important. This phase has been researched in many experimental studies. Apoptosis is one of the major mechanisms of secondary damage on spinal cord. The present study was undertaken to determine if quetiapine, a 5-HT2 receptor blocker atypical antipsychotic agent can rescue neuronal cells from apoptosis in a SCI model. MATERIAL and METHODS: Thirty-two female Wistar rats were separated to 4 equal groups. Total laminectomy was performed at T5-7 level and spinal cord injury was produced by using the clip compression technique. Each rat from groups ``1 day{''} (D-I) and ``7 days{''} (D-II) was daily injected intraperitoneally with Quetiapine (10 mg/kg/day). No treatment was administered to the control groups ``1 day{''} (K-I) and ``7 days{''} (K-II). At the end of follow-up periods, all animals were sacrificed and spinal cords were removed. Apoptotic cells were evaluated by using immunohistochemical technique (TUNEL) in injured spinal cord specimens. RESULTS: There was a statistically significant difference while counting ApopTag positive cells, both at 1 day groups of K-I and D-I (p=0.00000008) and at 7 day groups of K-II and D-II (p=0.000005). Unlike the 1-day period, a statistically significant difference was found between grey and white matter ApopTag positive cells at the 7th day (p=0.0001). CONCLUSION: Quetiapine has a protective effect on secondary damage caused by SCI, while also can be used in post-traumatic stress disorder, depression and agitation as a versatile agent

Spine Tango in Turkish: Development of a Local Registry System

AIM: Successfully established registry systems, rather than personal efforts to collect data, are required to record, analyze, compare and secure patient related data. Unfortunately, our country does not have such patient registry systems for spinal pathologies and surgeries at this time. In order to fill this gap in patient management in Turkey, the authors adopted already established Spine Tango registry system in a unique way answering the requirements of our health system. This article aims to present the adaptation process of Spine Tango forms for use in Turkish and describe the first implementation with 50 patients treated for spinal pathologies in a tertiary referral center. MATERIAL and METHODS: In 2011, an effort was initiated by the first author to translate the original Spine Tango forms into Turkish. Funding for this project was provided by authors themselves. With the assistance of a Spine Tango team, the translation process was completed. The Turkish forms were then used in an academic institution with a high spinal workload. A local solution was developed by the authors using commercially available software and mobile instruments. This system was tested with 50 spine patients from June 2012 to January 2013. RESULTS: The analysis of the data gathered using the new Turkey Spine Tango registry system was successful. CONCLUSION: In an environment of exponentially increasing medical data, successfully established registry systems have the potential to facilitate patient management. The authors recommend the use of Turkish Spine Tango forms for clinics performing spinal interventions

Primary Intracerebral Alveolar Soft Part Sarcoma in an 11-Year-Old Girl: Case Report and Review of the Literature.

Alveolar soft part sarcoma (ASPS), a rarely observed tumor, is a soft tissue sarcoma with an unidentified cell origin. It constitutes 0.5-1.0% of all soft tissue sarcomas. It may appear in various parts of the body, but mostly observed in the trunk and the extremities. It has a high metastasis potential. To the best of our knowledge, only three cases of primary intracranial ASPS without a demonstrable lesion elsewhere is encountered. An 11-year-old girl was operated because of fronto-parietal mass lesion by craniotomy. Pathological examination revealed ASPS and no primary focus was detected. In spite of radiotherapy and chemotherapy as an adjuvant therapy, after 45 months she had a second operation for recurrence of the tumor. Since it is possible to observe metastases in late phases, up to 30 years, the patients must be followed up for a long period. Although radiotherapy and chemotherapy followed by surgery is the most accepted treatment strategy, the prognosis is still poor

Retrospective Analysis of 449 Intracranial Meningioma Patients Operated Between 2007 and 2013 at a Single Institute

AIM: Meningioma literature has many large surgical case series, which have been references of text books and neurosurgical practice. Many of those series were published when stereotactic radiosurgery (SRS) was not so common or these series were in terms of World Health Organization (WHO) 2000 classification. In this study, we aimed to make an update to the current literature using WHO 2007 classification system. MATERIAL and METHODS: Four hundred eighty-eight intracranial meningioma patients underwent open surgery in 2007-2013 and 449 of them were included in this study. All pathological specimens were re-evaluated in terms of WHO 2007 classification. All demographical and follow-up records and imaging archives were investigated by using our center's central automation system and National Central Population Management System. If records were not available or not adequate, investigators made phone calls to patients. Pediatric patients were excluded. RESULTS: Three hundred twenty-six female (76.2\%) and 123 male (27.4\%) patients were analyzed. Their ages ranged from 18 to 84 years (mean=51.6 +/- 11.9 years). The most common subtype of meningioma was meningothelial meningioma (51.7\%), followed by atypical meningioma (20.3\%). WHO Grade I meningiomas had statistically random localization distribution, but WHO Grade II meningiomas were more common in the convexity, parasagittal and middle fossa. Younger age was found to be significantly related with tumor recurrence or progression. Seventy-three (16.2\%) patients underwent SRS and 64 (14.2\%) patients underwent adjuvant radiotherapy (ART) after surgery. Convexity localization was found to be associated with recurrence, mortality and higher WHO 2007 grade. CONCLUSION: Convexity meningiomas are associated with recurrence, mortality and higher WHO 2007 grade. Convexity meningiomas should be totally resected in order to achieve maximum benefit from surgery