341 research outputs found
Vortex structure in spinor F=2 Bose-Einstein condensates
Extended Gross-Pitaevskii equations for the rotating F=2 condensate in a
harmonic trap are solved both numerically and variationally using trial
functions for each component of the wave function. Axially-symmetric vortex
solutions are analyzed and energies of polar and cyclic states are calculated.
The equilibrium transitions between different phases with changing of the
magnetization are studied. We show that at high magnetization the ground state
of the system is determined by interaction in "density" channel, and at low
magnetization spin interactions play a dominant role. Although there are five
hyperfine states, all the particles are always condensed in one, two or three
states. Two novel types of vortex structures are also discussed.Comment: 6 pages, 3 figure
Chromospheric Anemone Jets as Evidence of Ubiquitous Reconnection
The heating of the solar chromosphere and corona is a long-standing puzzle in
solar physics. Hinode observations show the ubiquitous presence of
chromospheric anemone jets outside sunspots in active regions. They are
typically 3 to 7 arc seconds = 2000 to 5000 kilometers long and 0.2 to 0.4 arc
second = 150 to 300 kilometers wide, and their velocity is 10 to 20 kilometers
per second. These small jets have an inverted Y-shape, similar to the shape of
x-ray anemone jets in the corona. These features imply that magnetic
reconnection similar to that in the corona is occurring at a much smaller
spatial scale throughout the chromosphere and suggest that the heating of the
solar chromosphere and corona may be related to small-scale ubiquitous
reconnection.Comment: 10 pages, 5 figure
The Second Transmembrane Domain of P2X7 Contributes to Dilated Pore Formation
Activation of the purinergic receptor P2X7 leads to the cellular permeability of low molecular weight cations. To determine which domains of P2X7 are necessary for this permeability, we exchanged either the C-terminus or portions of the second transmembrane domain (TM2) with those in P2X1 or P2X4. Replacement of the C-terminus of P2X7 with either P2X1 or P2X4 prevented surface expression of the chimeric receptor. Similarly, chimeric P2X7 containing TM2 from P2X1 or P2X4 had reduced surface expression and no permeability to cationic dyes. Exchanging the N-terminal 10 residues or C-terminal 14 residues of the P2X7 TM2 with the corresponding region of P2X1 TM2 partially restored surface expression and limited pore permeability. To further probe TM2 structure, we replaced single residues in P2X7 TM2 with those in P2X1 or P2X4. We identified multiple substitutions that drastically changed pore permeability without altering surface expression. Three substitutions (Q332P, Y336T, and Y343L) individually reduced pore formation as indicated by decreased dye uptake and also reduced membrane blebbing in response to ATP exposure. Three others substitutions, V335T, S342G, and S342A each enhanced dye uptake, membrane blebbing and cell death. Our results demonstrate a critical role for the TM2 domain of P2X7 in receptor function, and provide a structural basis for differences between purinergic receptors. © 2013 Sun et al
The male fetal biomarker INSL3 reveals substantial hormone exchange between fetuses in early pig gestation
The peptide hormone INSL3 is uniquely produced by the fetal testis to promote the transabdominal phase of testicular descent. Because it is fetal sex specific, and is present in only very low amounts in the maternal circulation, INSL3 acts as an ideal biomarker with which to monitor the movement of fetal hormones within the pregnant uterus of a polytocous species, the pig. INSL3 production by the fetal testis begins at around GD30. At GD45 of the ca.114 day gestation, a time at which testicular descent is promoted, INSL3 evidently moves from male to female allantoic compartments, presumably impacting also on the female fetal circulation. At later time-points (GD63, GD92) there is less inter-fetal transfer, although there still appears to be significant INSL3, presumably of male origin, in the plasma of female fetuses. This study thus provides evidence for substantial transfer of a peptide hormone between fetuses, and probably also across the placenta, emphasizing the vulnerability of the fetus to extrinsic hormonal influences within the uterus
Long-term (trophic) purinergic signalling: purinoceptors control cell proliferation, differentiation and death
The purinergic signalling system, which uses purines and pyrimidines as chemical transmitters, and purinoceptors as effectors, is deeply rooted in evolution and development and is a pivotal factor in cell communication. The ATP and its derivatives function as a 'danger signal' in the most primitive forms of life. Purinoceptors are extraordinarily widely distributed in all cell types and tissues and they are involved in the regulation of an even more extraordinary number of biological processes. In addition to fast purinergic signalling in neurotransmission, neuromodulation and secretion, there is long-term (trophic) purinergic signalling involving cell proliferation, differentiation, motility and death in the development and regeneration of most systems of the body. In this article, we focus on the latter in the immune/defence system, in stratified epithelia in visceral organs and skin, embryological development, bone formation and resorption, as well as in cancer. Cell Death and Disease (2010) 1, e9; doi:10.1038/cddis.2009.11; published online 14 January 201
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