3,458 research outputs found
Attenuation of ischemic liver injury by prostaglandin E<inf>1</inf> analogue, misoprostol, and prostaglandin I<inf>2</inf> analogue, OP-41483
Background: Prostaglandin has been reported to have protective effects against liver injury. Use of this agent in clinical settings, however, is limited because of drugrelated side effects. This study investigated whether misoprostol, prostaglandin E1 analogue, and OP-41483, prostaglandin I2 analogue, which have fewer adverse effects with a longer half-life, attenuate ischemic liver damage. Study Design: Thirty beagle dogs underwent 2 hours of hepatic vascular exclusion using venovenous bypass. Misoprostol was administered intravenously for 30 minutes before ischemia and for 3 hours after reperfusion. OP-41483 was administered intraportally for 30 minutes before ischemia (2 μg/kg/min) and for 3 hours after reperfusion (0.5 μg/kg/min). Animals were divided into five groups: untreated control group (n = 10); high-dose misoprostol (total 100 μg/kg) group (MP-H, n = 5); middle-dose misoprostol (50 μg/kg) group (MP-M, n = 5); low-dose misoprostol (25 μg/kg) group (MP-L, n = 5); and OP-41483 group (OP, n = 5). Animal survival, hepatic tissue blood flow (HTBF), liver function, and histology were analyzed. Results: Two-week animal survival rates were 30% in control, 60% in MP-H, 100% in MP-M, 80% in MP-L, and 100% in OP. The treatments with prostaglandin analogues improved HTBF, and attenuated liver enzyme release, adenine nucleotrides degradation, and histologic abnormalities. In contrast to the MP-H animals that exhibited unstable cardiovascular systems, the MP- M, MP-L, and OP animals experienced only transient hypotension. Conclusions: These results indicate that misoprostol and OP-41483 prevent ischemic liver damage, although careful dose adjustment of misoprostol is required to obtain the best protection with minimal side effects
Quantum Monte Carlo Study on Magnetization Processes
A quantum Monte Carlo method combining update of the loop algorithm with the
global flip of the world line is proposed as an efficient method to study the
magnetization process in an external field, which has been difficult because of
inefficiency of the update of the total magnetization. The method is
demonstrated in the one dimensional antiferromagnetic Heisenberg model and the
trimer model. We attempted various other Monte Carlo algorithms to study
systems in the external field and compared their efficiency.Comment: 5 pages, 9 figures; added references for section 1, corrected typo
Global classical solutions for partially dissipative hyperbolic system of balance laws
This work is concerned with (-component) hyperbolic system of balance laws
in arbitrary space dimensions. Under entropy dissipative assumption and the
Shizuta-Kawashima algebraic condition, a general theory on the well-posedness
of classical solutions in the framework of Chemin-Lerner's spaces with critical
regularity is established. To do this, we first explore the functional space
theory and develop an elementary fact that indicates the relation between
homogeneous and inhomogeneous Chemin-Lerner's spaces. Then this fact allows to
prove the local well-posedness for general data and global well-posedness for
small data by using the Fourier frequency-localization argument. Finally, we
apply the new existence theory to a specific fluid model-the compressible Euler
equations with damping, and obtain the corresponding results in critical
spaces.Comment: 39 page
Quantum simulations of the superfluid-insulator transition for two-dimensional, disordered, hard-core bosons
We introduce two novel quantum Monte Carlo methods and employ them to study
the superfluid-insulator transition in a two-dimensional system of hard-core
bosons. One of the methods is appropriate for zero temperature and is based
upon Green's function Monte Carlo; the other is a finite-temperature world-line
cluster algorithm. In each case we find that the dynamical exponent is
consistent with the theoretical prediction of by Fisher and co-workers.Comment: Revtex, 10 pages, 3 figures (postscript files attached at end,
separated by %%%%%% Fig # %%%%%, where # is 1-3). LA-UR-94-270
<Abstract of annual report>Characterization of Die Wall Pressure to Predict Capping of Flat-or Convex-Faced Drug Tablets of Various Sizes.
Dimer-Quadrupolar Quantum Phase Transition in the Quasi-One-Dimensional Heisenberg Model with Biquadratic Interaction
The quasi-one-dimensional S=1 Heisenberg antiferromagnet with a biquadratic
term is investigated at zero temperature by quantum Monte Carlo simulation. As
the magnitude of the inter-chain coupling is increased, the system undergoes a
phase transition from a spontaneously dimerized phase to a N\'eel ordered or
spin nematic phase. The numerical results suggest the possibility of an
unconventional second-order transition in which the symmetry group
characterizing one phase is not a subgroup of the other.Comment: 4 pages, 4 figure
Statistics of lowest excitations in two dimensional Gaussian spin glasses
A detailed investigation of lowest excitations in two-dimensional Gaussian
spin glasses is presented. We show the existence of a new zero-temperature
exponent lambda describing the relative number of finite-volume excitations
with respect to large-scale ones. This exponent yields the standard thermal
exponent of droplet theory theta through the relation, theta=d(lambda-1). Our
work provides a new way to measure the thermal exponent theta without any
assumption about the procedure to generate typical low-lying excitations. We
find clear evidence that theta < theta_{DW} where theta_{DW} is the thermal
exponent obtained in domain-wall theory showing that MacMillan excitations are
not typical.Comment: 4 pages, 3 figures, (v2) revised version, (v3) corrected typo
Energetics and geometry of excitations in random systems
Methods for studying droplets in models with quenched disorder are critically
examined. Low energy excitations in two dimensional models are investigated by
finding minimal energy interior excitations and by computing the effect of bulk
perturbations. The numerical data support the assumptions of compact droplets
and a single exponent for droplet energy scaling. Analytic calculations show
how strong corrections to power laws can result when samples and droplets are
averaged over. Such corrections can explain apparent discrepancies in several
previous numerical results for spin glasses.Comment: 4 pages, eps files include
- …