77 research outputs found
Multidirectional Synthesis of Substituted Indazoles via Iridium-Catalyzed C–H Borylation
Directed Ortho Borylation of Phenol Derivatives Catalyzed by a Silica-Supported Iridium Complex
Supplementary Material for: Contemplation of the effect of nivolumab plus cabosantinib therapy on cerebral hemorrhage in patients with brain metastasis of renal cell carcinoma: A case report
Although the response to combination therapy has been reported in patients with brain metastases from advanced renal cancer, treatment-related cerebral hemorrhage has not been adequately studied. The CheckMate 9ER clinical trial of nivolumab and cabozantinib excluded patients with brain metastases. Therefore, the associated treatment outcomes in these patients with brain metastases are unclear. Herein, we report a case of bleeding from brain metastases in a patient with advanced renal cancer after gamma knife combination therapy with nivolumab and cabozantinib. Fortunately, the cerebral hemorrhage of the patient was alleviated by conservative treatment. Despite treatment interruption, the metastatic lesions reduced in size, and treatment was gradually resumed. In this case study, we report the risk of cerebral hemorrhage in combination therapy for brain metastasis cases, how to manage hemorrhage cases, and their prognosis
Iridium-catalyzed C–H borylation of quinolines and unsymmetrical 1,2-disubstituted benzenes: insights into steric and electronic effects on selectivity
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