Highly asymmetric probability distribution from a finite-width upward step during inflation

We study a single-field inflation model in which the inflaton potential has an upward step between two slow-roll regimes by taking into account the finite width of the step. We calculate the probability distribution function (PDF) of the curvature perturbation $P[{\cal{R}}]$ using the $\delta N$ formalism. The PDF has an exponential-tail only for positive ${\cal{R}}$ whose slope depends on the step width. We find that the tail may have a significant impact on the estimation of the primordial black hole abundance. We also show that the PDF $P[{\cal{R}}]$ becomes highly asymmetric on a particular scale exiting the horizon before the step, at which the curvature power spectrum has a dip. This asymmetric PDF may leave an interesting signature in the large scale structure such as voids.Comment: 19 pages, 7 figure

Preliminary study of discrimination of human vocal commands in walrus (Odobenus rosmarus divergens)

Walruses seem to use various acoustic signals in social context. So, the auditory faculty is seems to be important for walruses. Can walruses understand another animals' vocal information using auditory sense? This study tested whether a male walrus could discriminate human vocal words and perform different actions corresponding to each one under various conditions. The subject, a male walrus (Odobenus rosmarus) named Pou, was set on the ground, and the experimenter spoke one of the ten words to the subject under the following conditions; (1) The experimenter stood close to the subject and spoke each vocal stimulus wearing a black cloak and goggles so that the experimenter's eye and body movements would not influence the subject's behavior, (2) A wooden board was placed between the experimenter and the subject so that the subject could not see the experimenter, (3) A wooden board was placed between the experimenter and the subject so that the subject could not to see the experimenter, and the experimenter uttered each vocal stimulus through an audio speaker. Under each condition, when the subject performed the correct action corresponding to the vocal stimulus, he was rewarded with a piece of fish. As a result, the subject responded correctly to almost all the human vocal stimuli in every condition, including when the speaker was not visible. This means that he was indeed responding to the vocal words and not the experimenter's cues. This study demonstrated that walruses can hear and identify human vocal words using their auditory sense and can form correspondence between vocal words and their meanings

Comparison of lung cancer cell lines representing four histopathological subtypes with gene expression profiling using quantitative real-time PCR

<p>Abstract</p> <p>Background</p> <p>Lung cancers are the most common type of human malignancy and are intractable. Lung cancers are generally classified into four histopathological subtypes: adenocarcinoma (AD), squamous cell carcinoma (SQ), large cell carcinoma (LC), and small cell carcinoma (SC). Molecular biological characterization of these subtypes has been performed mainly using DNA microarrays. In this study, we compared the gene expression profiles of these four subtypes using twelve human lung cancer cell lines and the more reliable quantitative real-time PCR (qPCR).</p> <p>Results</p> <p>We selected 100 genes from public DNA microarray data and examined them by DNA microarray analysis in eight test cell lines (A549, ABC-1, EBC-1, LK-2, LU65, LU99, STC 1, RERF-LC-MA) and a normal control lung cell line (MRC-9). From this, we extracted 19 candidate genes. We quantified the expression of the 19 genes and a housekeeping gene, <it>GAPDH</it>, with qPCR, using the same eight cell lines plus four additional validation lung cancer cell lines (RERF-LC-MS, LC-1/sq, 86-2, and MS-1-L). Finally, we characterized the four subtypes of lung cancer cell lines using principal component analysis (PCA) of gene expression profiling for 12 of the 19 genes (<it>AMY2A</it>, <it>CDH1</it>, <it>FOXG1</it>, <it>IGSF3</it>, <it>ISL1</it>, <it>MALL</it>, <it>PLAU</it>, <it>RAB25</it>, <it>S100P</it>, <it>SLCO4A1</it>, <it>STMN1</it>, and <it>TGM2</it>). The combined PCA and gene pathway analyses suggested that these genes were related to cell adhesion, growth, and invasion. <it>S100P </it>in AD cells and <it>CDH1 </it>in AD and SQ cells were identified as candidate markers of these lung cancer subtypes based on their upregulation and the results of PCA analysis. Immunohistochemistry for S100P and RAB25 was closely correlated to gene expression.</p> <p>Conclusions</p> <p>These results show that the four subtypes, represented by 12 lung cancer cell lines, were well characterized using qPCR and PCA for the 12 genes examined. Certain genes, in particular <it>S100P </it>and <it>CDH1</it>, may be especially important for distinguishing the different subtypes. Our results confirm that qPCR and PCA analysis provide a useful tool for characterizing cancer cell subtypes, and we discuss the possible clinical applications of this approach.</p

Diagnostic ability of contrast-enhanced computed tomography formetastatic cervical nodes in head and neck squamous cell carcinomas : significance of additional coronal reconstruction images

Purpose: To evaluate the significance of additional coronal reconstruction images in the diagnostic ability of contrastenhanced computed tomography (CECT) for metastatic cervical nodes in patients with head and neck squamous cell carcinomas (HNSCC). Material and methods: We retrospectively assessed 97 metastatic and 141 reactive histologically proven cervical nodes of 38 patients with HNSCC, who underwent CECT before neck dissection. Observer #1, an expert radiologist in head and neck imaging, and observer #2, a general radiologist, reviewed all CECT images. The observers first assessed the presence of nodal metastasis using axial CECT alone (A-CECT). Three days later, they reassessed its presence using combined axial and coronal CECT (A&C-CECT). Results: The sensitivity of A-CECT vs. A&C-CECT was 73.2% vs. 75.3% for observer #1 (p = 0.73) and 69.1% vs. 69.1% for observer #2 (p = 1.00), respectively. The specificity of A-CECT versus A&C-CECT was 92.2% vs. 97.2% for observer #1 (p < 0.05) and 92.9% vs. 95.7% for observer #2 (p = 0.22), respectively. The accuracy of A-CECT versus A&C-CECT was 84.5% vs. 88.2% for observer #1 (p < 0.05) and 83.2% vs. 85.3% for observer #2 (p = 0.30), respectively. The area under the curve (AUC) of A-CECT vs. A&C-CECT was 0.86 vs. 0.91 for observer #1 (p < 0.05) and 0.85 vs. 0.85 for observer #2 (p = 0.80), respectively. Conclusions: The specificity, accuracy, and AUC increased with the use of coronal images during the assessment by the expert radiologist. The appropriate use of coronal images allowed proper configuration recognition and improved diagnostic ability

Stargazer: Long-Term and Multiregional Measurement of Timing/ Geolocation-Based Cloaking

Malicious hosts have come to play a significant and varied role in today's cyber attacks. Some of these hosts are equipped with a technique called cloaking, which discriminates between access from potential victims and others and then returns malicious content only to potential victims. This is a serious threat because it can evade detection by security vendors and researchers and cause serious damage. As such, cloaking is being extensively investigated, especially for phishing sites. We are currently engaged in a long-term cloaking study of a broader range of threats. In the present study, we implemented Stargazer, which actively monitors malicious hosts and detects geographic and temporal cloaking, and collected 30,359,410 observations between November 2019 and February 2022 for 18,397 targets from 13 sites where our sensors are installed. Our analysis confirmed that cloaking techniques are widely abused, i.e., not only in the context of specific threats such as phishing. This includes geographic and time-based cloaking, which is difficult to detect with single-site or one-shot observations. Furthermore, we found that malicious hosts that perform cloaking include those that survive for relatively long periods of time, and those whose contents are not present in VirusTotal. This suggests that it is not easy to observe and analyze the cloaking malicious hosts with existing technologies. The results of this study have deepened our understanding of various types of cloaking, including geographic and temporal ones, and will help in the development of future cloaking detection methods

Bond strength of artificial teeth to thermoplastic denture base resin for injection molding.

This research was conducted to investigate the bond strength between artificial teeth and a thermoplastic denture base resin for injection molding with different surface preparations for use in flexible resin removable partial dentures. Composite resin denture teeth and acrylic denture resin teeth were bonded to three types of thermoplastic denture base resins for injection molding (polyamide, polyester, and polycarbonate) and a conventional heat-polymerized polymethyl methacrylate (PMMA) resin (control). The ridge lap surfaces of the artificial teeth were classified into four groups based on the type of ridge lap surface treatment applied (n=10): no treatment, ethyl acetate, small T-shaped tunnel, and large T-shaped tunnel. The specimens were tested for bond strength. The results showed that the ethyl acetate treatment was ineffective for enhancing the bond strength (p>0.05) between the artificial teeth and thermoplastic denture base resin for injection molding, whereas the T-shaped tunnel was quite effective in this regard (p<0.05).福岡歯科大学2020年

Effect of Reinforcement on the Flexural Properties of Injection-Molded Thermoplastic Denture Base Resins.

To evaluate the effect of reinforcement on the flexural properties of injection-molded thermoplastic denture base resins.Three injection-molded thermoplastic denture base resins (polyamide, polyester, polycarbonate) were selected for this study, and a conventional heat-polymerized denture base resin (PMMA) was used as a control. Continuous unidirectional glass fiber-reinforced composite (FRC) and metal wire were used for reinforcement. Reinforced bar-shaped specimens (65 mm long, 10 mm wide, 3.3 mm high) were fabricated (n = 10). The flexural strength at the proportional limit (FS-PL) and the elastic modulus were measured using a three-point bending test.All the denture base material specimens reinforced with FRC possessed a significantly higher FS-PL compared to those without reinforcement. The FS-PL of the polycarbonate specimens reinforced with metal wire was significantly higher than that without reinforcement, and there was no significant difference in the FS-PL between the polycarbonate specimens reinforced with FRC and those with metal wire. The order of the elastic modulus according to the denture base material, arranged in terms of statistical significance, was as follows: PMMA (3.46 ± 0.53 GPa) > polycarbonate (2.69 ± 0.48 GPa) > polyester (2.00 ± 0.39 GPa) > polyamide (1.14 ± 0.35 GPa). The order of the elastic modulus according to the reinforcement, arranged in terms of statistical significance, was as follows: metal wire (2.74 ± 0.96 GPa) > FRC (2.40 ± 0.89 GPa) > no reinforcement (1.82 ± 0.83 GPa).Continuous unidirectional glass fiber-reinforced composite (FRC) reinforcement had a satisfactory reinforcing effect for the injection-molded thermoplastic denture base resins.福岡歯科大学2017年

Effect of three metal priming agents on the bond strength of adhesive resin cement to Ag-Zn-Sn-In alloy and component metals.

The aim of this study was to investigate the effect of three metal priming agents on the bond strength of adhesive resin cement to Silver-Zinc-Tin-Indium (Ag-Zn-Sn-In) alloy and pure Ag, Zn, Sn, and In. The specimens were air-abraded with alumina and then primed with one of three metal priming agents: V-Primer, Estenia Opaque Primer, or Alloy Primer. The metal disks were bonded with adhesive resin cement (Super-Bond Bulk-mix technique). Shear bond strengths (n=10/group) were determined before and after 50,000 thermocycles for Ag-Zn-Sn-In alloy as well as after 5,000 thermocycles for pure Ag, Zn, Sn and In. For Ag-Zn-Sn-In alloy, the post-thermocycling bond strength of the Alloy Primer group was significantly higher than that of the other primers. It can be concluded that Alloy Primer containing both the vinyl-thione monomer (VBATDT) and hydrophobic phosphate monomer (MDP) is effective for bonding Ag-Zn-Sn-In alloy and pure Ag, Zn and Sn.福岡歯科大学2017年