The First Synthesis of an Optically Active Molecular Bevel Gear with Only Two Cogs on Each Wheel (SYNTHETIC ORGANIC CHEMISTRY-Fine Organic Synthesis)

Both enantiomers of the molecular bevel gear 1 having only two cogs on each wheel consisting of 8,8'-disubstituted 1,1'-binaphthyl ether were synthesized for the first time

人の皮膚の力学刺激応答と力学物性に関する臨床および単一細胞レベルの研究

13301甲第5706号博士（融合科学）金沢大学博士論文要旨Abstract 掲載予定あ

人の皮膚の力学刺激応答と力学物性に関する臨床および単一細胞レベルの研究

13301甲第5706号博士（融合科学）金沢大学博士論文本文Full 掲載予定あ

Large Polarization Degree of Comet 2P/Encke Continuum Based on Spectropolarimetric Signals During Its 2017 Apparition

Spectropolarimetry is a powerful technique for investigating the physical properties of gas and solid materials in cometary comae without mutual contamination, but there have been few spectropolarimetric studies to extract each component. We attempt to derive the continuum polarization degree of comet 2P/Encke, free from influence of molecular emissions. The target is unique in that it has an orbit dynamically decoupled from Jupiter like main-belt asteroids, while ejecting gas and dust like ordinary comets. We observed the comet using the Higashi-Hiroshima Optical and Near-Infrared Camera attached to the Cassegrain focus of the 150-cm Kanata telescope on UT 2017 February 21 when the comet was at the solar phase angle of 75.7 deg. We find that the continuum polarization degree with respect to the scattering plane is 33.8+/-2.7 % at the effective wavelength of 0.815 um, which is significantly higher than those of cometary dust in a high-Pmax group at similar phase angles. Assuming that an ensemble polarimetric response of 2P/Encke's dust as a function of phase angle is morphologically similar with those of other comets, its maximum polarization degree is estimated to > 40 % at the phase angle of ~100 deg. In addition, we obtain the polarization degrees of the C2 swan bands (0.51-0.56 um), the NH2 alpha bands (0.62-0.69 um) and the CN-red system (0.78-0.94 um) in a range of 3-19 %, which depend on the molecular species and rotational quantum numbers of each branch. The polarization vector aligns nearly perpendicularly to the scattering plane with the average of 0.4 deg over a wavelength range of 0.50-0.97 um. From the observational evidence, we conjecture that the large polarization degree of 2P/Encke would be attributable to a dominance of large dust particles around the nucleus, which have remained after frequent perihelion passages near the Sun.Comment: 9 pages, 4 figures, accepted for publication in Astronomy & Astrophysic

Evidence on percutaneous radiofrequency and microwave ablation for liver metastases over the last decade

Purpose　This review aimed to summarize the treatment outcomes of percutaneous radiofrequency ablation (RFA) and microwave ablation (MWA) for metastatic liver tumors based on the findings of published studies over the last decade. Materials and methods　Literature describing the survival outcomes of ablation therapy for liver metastases was explored using the PubMed database on April 26, 2022, and articles published in 2012 or later were selected. The included studies met the following criteria: (i) English literature, (ii) original clinical studies, and (iii) literature describing overall survival (OS) of thermal ablation for metastatic liver tumors. All case reports and cohort studies with fewer than 20 patients and those that evaluated ablation for palliative purposes were excluded. Results　RFA was the most commonly used method for ablation, while MWA was used in several recent studies. RFA and MWA for liver metastases from various primary tumors have been reported; however, majority of the studies focused on colorectal cancer. The local control rate by RFA and MWA varied widely among the studies, ranging approximately 50–90%. Five-year survival rates of 20–60% have been reported following ablation for colorectal liver metastases by a number of studies, and several reports of 10-year survival rates were also noted. Conclusion　Comparative studies of local therapies for colorectal liver metastases demonstrated that RFA provides comparable survival outcomes to surgical metastasectomy and stereotactic body radiation therapy

Leptospirosis in Squirrels Imported from United States to Japan

We diagnosed leptospirosis in 2 patients exposed to southern flying squirrels imported from the United States to Japan. Patients worked with exotic animals in their company. Leptospira isolates from 1 patient and 5 of 10 squirrels at the company were genetically and serologically identical and were identified as Leptospira kirschneri

Prospective evaluation of core number of biopsy for renal tumor: are multiple cores preferable?

Purpose This single-center, single-arm, prospective, open-label study was conducted to evaluate the optimal number of cores (single or multiple) in renal tumor biopsy. Materials and methods Forty-four biopsies of 44 tumors (mean diameter, 2.7 ± 1.0 cm; range, 1.6–5.0 cm) were included. Biopsy was performed under ultrasound or computed tomography fluoroscopy guidance using an 18-gauge cutting needle and the co-axial method. Two or more specimens were obtained, which were divided into first and subsequent specimens. “First specimen” and “all specimens” were histologically evaluated (i.e., appropriateness of specimen, histological diagnosis, subtype, and Fuhrman grade of renal cell carcinoma [RCC]) blindly and independently by two board-certified pathologists. Results Multiple specimens were successfully and safely obtained in all the biopsies. All tumors were histologically diagnosed; 40 malignancies included 39 RCCs and 1 solitary fibrous tumor, and 4 benign lesions included 2 angiomyolipomas, 1 oncocytoma, and 1 capillary hemangioma. In all RCCs, the subtype could be determined (32 clear cell RCCs, 4 chromophobe RCCs, and 3 papillary RCCs), and the Furman grade was determined in 38 RCCs. When only the first specimen was evaluated, 22.7% of the specimens were inappropriate for diagnosis, and 34 (77.3%) were histologically diagnosed. The diagnostic yield was significantly lower than that of all specimens (P = 0.0044). Univariate analysis revealed that smaller lesions were a significant predictor of diagnostic failure (P = 0.020). Conclusion Biopsy with multiple cores significantly improved diagnostic yield. Thus, operators should obtain multiple cores during renal tumor biopsy

Balenine, Imidazole Dipeptide Promotes Skeletal Muscle Regeneration by Regulating Phagocytosis Properties of Immune Cells

Balenine is one of the endogenous imidazole dipeptides derived from marine products. It is composed of beta-alanine and 3-methyl-L-histidine, which exist mainly in the muscles of marine organisms. The physiological functions of dietary balenine are not well-known. In this study, we investigated whether the supplementation of dietary balenine was associated with muscle function in a cardiotoxin-indued muscle degeneration/regeneration model. Through morphological observation, we found that the supplementation of balenine-enriched extract promoted the regeneration stage. In addition, the expression of regeneration-related myogenic marker genes, such as paired box protein 7, MyoD1, myogenin, and Myh3, in a group of mice fed a balenine-enriched extract diet was higher than that in a group fed a normal diet. Moreover, the supplementation of balenine-enriched extract promoted the expression of anti-inflammatory cytokines as well as pro-inflammatory cytokines at the degeneration stage. Interestingly, phagocytic activity in the balenine group was significantly higherthan that in the control group in vitro. These results suggest that balenine may promote the progress of muscle regeneration by increasing the phagocytic activity of macrophages