Economy Law and Economic Analysis of Law and the Impact on Intellectual Property in the Common Law System

This article analyses the concept of economics applied to law in order to understand the school's analysis of legal phenomena by economic principles that emerged in 1960 in the United States of America, tracing the impacts on intellectual property law in the Common Law system. This study relies on the hypothetical-deductive method, with a focus on economic and legal literature, to conclude that intellectual property legislation is frequently modernized, especially at the time of major socio economic transformations such as an industrial revolution with the effect of boosting development and innovation, ensuring economic growth with the proper security and protection of industrial secrets and expertise

New Technologies and the Impact on Personality Rights in Brazil

As technology continues to evolve at an exponentially increasing pace, it transforms our lives and societies, thus shaping our perceptions of reality with high speed and impacting the relationship between the individual and the society, including businesses and, as a result, the legal system. The young area of law is trying to explore the effects of new technologies in our relationships with it, as well as identify the best use of new technologies to reduce the gap among new technology, new societal behaviors and various legal systems. The purpose of this paper is to examine the current uses of wearable technologies in Brazil and the legal issues emerging from the various uses of these technologies and their impact on personality rights. So, to what extent do the Brazilian users of emerging technologies appreciate the terms and conditions agreed by themselves and their impact on personality rights? The authors used empirical quantitative data from a cross-section of Brazilian users to explore the level of awareness in regards to the terms and conditions associated with the use of emerging technologies and the impact on their personality rights. The authors found that the large majority of these users of technology are unaware of the adverse impact of the agreed terms and conditions on their personality rights. Furthermore, they are also unaware of the basics of how the technology operates and therefore are unable to enforce their rights. The research is based on data collected by using only one survey with a sample of 500 students from three universities in three Brazilian States with an age range between 18 and 40 years old. This paper extends the previous research on the impact of emerging technologies on personality rights and demonstrates with empirical data that there is a serious risk of erosion of such rights. Furthermore, this research provides a unique insight into the users of emerging technologies in the emerging Brazilian market and the impact on the Brazilian legal system

INTELLECTUAL PROPERTY LAW IN THE FOURTH INDUSTRIAL REVOLUTION: TRADE SECRETS RISKS AND OPPORTUNITIES

ABSTRACTIntellectual Property (IP) is increasingly recognised as a paramount intangible asset influencing the value of companies, as well as their corporate strategies and management. This article focuses on the risks and opportunities associated with the implementation of new technologies on the protection of trade secrets. The study concludes that Intellectual Property Law and Contract Law solutions must be underpinned by the business strategy and the business model. In addition, changes to organisational structures are necessary to bring together functions that typically operate in silos in many manufacturing businesses, namely: Engineering, Information Technology, Commercial and Legal departments. The present study was guided by the inductive and hypothetical-deductive methods, using bibliographical research. KEYWORDS: Business Law; Intellectual Property; Industry 4.0; Risks and Opportunities. RESUMOA Propriedade Intelectual (PI) é cada vez mais reconhecida como um ativo intangível primordial que influencia o valor, as estratégias corporativas e a gestão da empresa. Este artigo enfoca os riscos e oportunidades associados à implementação de novas tecnologias na proteção de segredos comerciais. O estudo conclui que o Direto de Propriedade Intelectual e o Direito Contratual devem ser sustentados pela estratégia de negócios e pelo modelo de negócios. Além disso, mudanças nas estruturas organizacionais são necessárias para reunir funções que normalmente operam em silos em muitas empresas, por exemplo: engenharia, tecnologias da informação, departamentos comerciais e jurídicos. O presente estudo foi orientado pelos métodos indutivo e hipotético-dedutivo, utilizando pesquisa bibliográfica. PALAVRAS-CHAVE: Direito Empresarial; Propriedade Intelectual; Indústria 4.0; Riscos e Oportunidades

Editorial: Genotype-Phenotype Correlation in Parkinsonian Conditions

With the diffusion of cost-effective genetic analyses, an increase in the spectrum of reported genetic variants associated with sporadic Parkinson’s disease (sPD) (e.g., glucocerebrosidase— GBA) and monogenic parkinsonisms (dominant, recessive, and atypical forms) has been achieved. Each single variant may be associated to distinct prominent phenotypic characteristics helpful for diagnostic and prognostic purposes, thus ushering the era of precision medicine for movement disorders.Fil: Marsili, Luca. University of Cincinnati; Estados UnidosFil: Mata, Ignacio F.. Cleveland Clinic Foundation; Estados UnidosFil: Kauffman, Marcelo Andres. Universidad Austral. Facultad de Ciencias Biomédicas. Instituto de Investigaciones en Medicina Traslacional. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones en Medicina Traslacional; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Centro Universitario de Neurología "Dr. José María Ramos Mejía".; Argentin

Translation and validation of Hyperhidrosis Disease Severity Scale

Introduction: The evaluation of patients with hyperhidrosis (HH) can be accomplished, among other ways, through questionnaires and scales. The Hyperhidrosis Disease Severity Scale (HDSS) has been used as a simple and quick tool to perform this evaluation. Although HDSS has been well established in several languages, it has not been translated into Portuguese, restricting its specific use for Brazilian patients. The aim of this study was to translate HDSS into Portuguese and validate it in a sample of Brazilian subjects. Method: 290 Brazilian patients (69% women, with a mean age of 28.7±9.6 years and BMI 22.4±3.9 kg/m2) diagnosed with HH were evaluated using HDSS, Quality of Life Questionnaire (QLQ) and Sweating Evolution Questionnaire (SEQ) before and after a five-week oxybutynin treatment. Regarding validation, an association between HDSS results and two other questionnaires was performed. To analyze HDSS sensitivity, evaluation of effects pre- and post-treatment with oxybutynin was conducted. Furthermore, HDSS reproducibility was analyzed in a subsample in which the scale was applied again after 7 days of the first follow-up appointment. Results: There was statistical correlation between HDSS and QLQ and between HDSS and SEQ before treatment and after 5 weeks. Additionally, HDSS was reproducible and sensitive to clinical changes after the treatment period. Conclusion: The Portuguese version of HDSS has been validated and shown to be reproducible in a Brazilian sample. Therefore it can be used as a tool to improve medical assistance in patients with HH

How have advances in genetic technology modified movement disorder nosology?

The role of genetics and its technological development have been fundamental in advancing the field of movement disorders, opening the door to precision medicine. Starting from the revolutionary discovery of the locus of the Huntington’s disease gene, we review the milestones of genetic discoveries in movement disorders and their impact on clinical practice and research efforts. Before the 1980s, early techniques did not allow the identification of genetic alteration in complex diseases. Further advances increasingly defined a large number of pathogenic genetic alterations. Moreover, these techniques allowed epigenomic, transcriptomic and microbiome analyses. In the 2020s, these new technologies are poised to displace phenotype-based classifications towards a nosology based on genetic/biological data. Advances in genetic technologies are engineering a reversal of the phenotype-to-genotype order of nosology development, replacing convergent clinicopathological disease models with the genotypic divergence required for future precision medicine applications.Fil: Sturchio, A.. University of Cincinnati; Estados UnidosFil: Marsili, L.. University of Cincinnati; Estados UnidosFil: Mahajan, A.. University of Cincinnati; Estados UnidosFil: Grimberg, M.B.. University of Cincinnati; Estados UnidosFil: Kauffman, Marcelo Andres. Universidad Austral. Facultad de Ciencias Biomédicas. Instituto de Investigaciones en Medicina Traslacional. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones en Medicina Traslacional; ArgentinaFil: Espay, A.J.. University of Cincinnati; Estados Unido

Holmes Tremor‐Like Phenotype in DYT1 Dystonia

Holmes tremor is characterized by a combination of a flexion‐extension resting postural and action tremor, most often due to mesencephalic lesions affecting the nigrostriatal and cerebello‐thalamo‐cortical pathways. On the other hand, dystonic tremor represents a jerky postural and action tremor, which if severe enough may include a resting component and may arise from cerebellar and nigrostriatal dysfunction. Here, we present a patient with a four‐decade history of progressive tremor, initially interpreted as Holmes tremor with a dystonic (pseudospastic) gait, in whom whole exome sequencing (WES) demonstrated a pathogenic TOR1A deletion. This case highlights two important clinical points, (1) the need for proper semiologic interpretation: direct DYT1 testing could have been entertained if tremor was properly categorized as dystonic rather than cerebellar at the outset; and (2) the phenotypic variability of DYT1 dystonia, with tremor as a presenting and disabling feature separate from the body part affected by dystonia (“tremor associated with dystonia”).Fil: Rodríguez Quiroga, Sergio Alejandro. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Ramos Mejía"; ArgentinaFil: González Morón, Dolores. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Ramos Mejía"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Espay, Alberto J. University of Cincinnati; Estados UnidosFil: Kauffman, Marcelo Andres. Universidad Austral. Facultad de Ciencias Biomédicas. Instituto de Investigaciones en Medicina Traslacional. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones en Medicina Traslacional; Argentin

GenIO: A phenotype-genotype analysis web server for clinical genomics of rare diseases

Background: GenIO is a novel web-server, designed to assist clinical genomics researchers and medical doctors in the diagnostic process of rare genetic diseases. The tool identifies the most probable variants causing a rare disease, using the genomic and clinical information provided by a medical practitioner. Variants identified in a whole-genome, whole-exome or target sequencing studies are annotated, classified and filtered by clinical significance. Candidate genes associated with the patient's symptoms, suspected disease and complementary findings are identified to obtain a small manageable number of the most probable recessive and dominant candidate gene variants associated with the rare disease case. Additionally, following the American College of Medical Genetics and Genomics and the Association of Molecular Pathology (ACMG-AMP) guidelines and recommendations, all potentially pathogenic variants that might be contributing to disease and secondary findings are identified. Results: A retrospective study was performed on 40 patients with a diagnostic rate of 40%. All the known genes that were previously considered as disease causing were correctly identified in the final inherit model output lists. In previously undiagnosed cases, we had no additional yield. Conclusion: This unique, intuitive and user-friendly tool to assists medical doctors in the clinical genomics diagnostic process is openly available at https://bioinformatics.ibioba-mpsp-conicet.gov.ar/GenIO/.Fil: Koile, Daniel Isaac. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigación en Biomedicina de Buenos Aires - Instituto Partner de la Sociedad Max Planck; ArgentinaFil: Córdoba, Marta. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Ramos Mejía"; Argentina. Universidad Austral. Facultad de Ciencias Biomédicas. Instituto de Investigaciones en Medicina Traslacional. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones en Medicina Traslacional; ArgentinaFil: de Sousa Serro, Maximiliano Guillermo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigación en Biomedicina de Buenos Aires - Instituto Partner de la Sociedad Max Planck; ArgentinaFil: Kauffman, Marcelo Andres. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Ramos Mejía"; Argentina. Universidad Austral. Facultad de Ciencias Biomédicas. Instituto de Investigaciones en Medicina Traslacional. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones en Medicina Traslacional; ArgentinaFil: Yankilevich, Patricio. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigación en Biomedicina de Buenos Aires - Instituto Partner de la Sociedad Max Planck; Argentin