SiGe quantum dots for fast hole spin Rabi oscillations

We report on hole g-factor measurements in three terminal SiGe self-assembled quantum dot devices with a top gate electrode positioned very close to the nanostructure. Measurements of both the perpendicular as well as the parallel g-factor reveal significant changes for a small modulation of the top gate voltage. From the observed modulations we estimate that, for realistic experimental conditions, hole spins can be electrically manipulated with Rabi frequencies in the order of 100MHz. This work emphasises the potential of hole-based nano-devices for efficient spin manipulation by means of the g-tensor modulation technique

Dental Research Waste in Design, Analysis, and Reporting: A Scoping Review.

Research waste is highly prevalent across biomedical investigations. We aimed to assess the evidence on the extent of research waste in dental research. We performed a scoping review of empirical evaluations of dental studies assessing the prevalence and impact of limitations in design, conduct, analysis, and reporting of research. PubMed was searched using specific terms to retrieve studies dealing with design, conduct, analysis, and reporting of studies in dentistry, with no year or language restrictions. Of the 1,807 publications identified from the search and from manual searches, 71 were included in this review. The topic and article selection was based on the expert opinion of the authors. The existing evidence suggests that, although there are improvements over time, substantial deficiencies in all areas (design, conduct, analysis, reporting) were prevalent in dental research publications. Waste in research is a multifaceted problem without a simple solution. However, an appreciation of optimal research design and execution is a prerequisite and should be underpinned by policies that include appropriate training in research methods and properly aligned incentives

Information-centric networking for machine-to-machine data delivery: A case study in smart grid applications

Largely motivated by the proliferation of content-centric applications in the Internet, information-centric networking has attracted the attention of the research community. By tailoring network operations around named information objects instead of end hosts, ICN yields a series of desirable features such as the spatiotemporal decoupling of communicating entities and the support of in-network caching. In this article, we advocate the introduction of such ICN features in a new, rapidly transforming communication domain: the smart grid. With the rapid introduction of multiple new actors, such as distributed (renewable) energy resources and electric vehicles, smart grids present a new networking landscape where a diverse set of multi-party machine-to-machine applications are required to enhance the observability of the power grid, often in real time and on top of a diverse set of communication infrastructures. Presenting a generic architectural framework, we show how ICN can address the emerging smart grid communication challenges. Based on real power grid topologies from a power distribution network in the Netherlands, we further employ simulations to both demonstrate the feasibility of an ICN solution for the support of real-time smart grid applications and further quantify the performance benefits brought by ICN against the current host-centric paradigm. Specifically, we show how ICN can support real-time state estimation in the medium voltage power grid, where high volumes of synchrophasor measurement data from distributed vantage points must be delivered within a very stringent end-to-end delay constraint, while swiftly overcoming potential power grid component failures. © 1986-2012 IEEE

Stability and relapse after orthodontic treatment of deep bite cases—a long-term follow-up study

The purpose of this long-term follow-up study was twofold—firstly, to assess prevalence of relapse after treatment of deep bite malocclusion and secondly, to identify risk factors that predispose patients with deep bite malocclusion to relapse. Sixty-one former patients with overbite more than 50% incisor overlap before treatment were successfully recalled. Clinical data, morphometrical measurements on plaster casts before treatment, after treatment and at long-term follow-up, as well as cephalometric measurements before and after treatment were collected. The median follow-up period was 11.9 years. Patients were treated by various treatment modalities, and the majority of patients received at least a lower fixed retainer and an upper removable bite plate during retention. Relapse was defined as increase in incisor overlap from below 50% after treatment to equal or more than 50% incisor overlap at long-term follow-up. Ten per cent of the patients showed relapse to equal or larger than 50% incisor overlap, and their amount of overbite increase was low. Among all cases with deep bite at follow-up, gingival contact and palatal impingement were more prevalent in partially corrected noncompliant cases than in relapse cases. In this sample, prevalence and amount of relapse were too low to identify risk factors of relaps

Identification of Theophrastus’ pigments egyptios yanos and psimythion from archaeological excavations

Following 4th c. B.C. Theophrastus treatise On Stones, regarding preparation of pigments, blue and white ones coming from fresh archaeological excavations in Attica, Greece, a blue made by Kremer factory and a white reproduced following ancient recipe were all submitted to analytical measurements. New results derived from the application of Infrared Photoacoustic Spectroscopy (IRPAS), Scanning Electron X Ray Microprobe Analyser (SEM-EDS), X-Ray Diffraction (XRD) and Raman spectroscopy identified their mineralogical content. The Theophrastus’ “psimythion” and “kyanos egyptios” are attributed to the lead white (cerussite and hydrocerussite) and the Egyptian blue (cuprorivaite) respectively.Suivant le traité « Des Pierres » de Théophraste, ive siècle BC, à propos de la préparation des pigments, un pigment blanc et un bleu provenant de fouilles archéologiques récentes en Attique, un bleu fabriqué par le laboratoire Kremer et un blanc reproduit selon une ancienne recette ont été soumis à des analyses physiques. La spectroscopie photoacoustique infrarouge (IRPAS), l’analyse par microscopie électronique à balayage et spectroscopie à dispersion d’énergie (SEM-EDS) et la spectroscopie Raman ont permis d’identifier leur composition minéralogique. Les Théophraste psimythion et kyanos egyptios sont respectivement attribués au blanc de plomb (cérusite et hydrocérusite) et au bleu égyptien (cuprorivaite)

Prognostic value of preoperative dynamic contrast-enhanced MRI perfusion parameters for high-grade glioma patients

INTRODUCTION: The prognostic value of the dynamic contrast-enhanced (DCE) MRI perfusion and its histogram analysis-derived metrics is not well established for high-grade glioma (HGG) patients. The aim of this prospective study was to investigate DCE perfusion transfer coefficient (Ktrans), vascular plasma volume fraction (vp), extracellular volume fraction (ve), reverse transfer constant (kep), and initial area under gadolinium concentration time curve (IAUGC) as predictors of progression-free (PFS) and overall survival (OS) in HGG patients. METHODS: Sixty-nine patients with suspected anaplastic astrocytoma or glioblastoma underwent preoperative DCE-MRI scans. DCE perfusion whole tumor region histogram parameters, clinical details, and PFS and OS data were obtained. Univariate, multivariate, and Kaplan–Meier survival analyses were conducted. Receiver operating characteristic (ROC) curve analysis was employed to identify perfusion parameters with the best differentiation performance. RESULTS: On univariate analysis, ve and skewness of vp had significant negative impacts, while kep had significant positive impact on OS (P < 0.05). ve was also a negative predictor of PFS (P < 0.05). Patients with lower ve and IAUGC had longer median PFS and OS on Kaplan–Meier analysis (P < 0.05). Ktrans and ve could also differentiate grade III from IV gliomas (area under the curve 0.819 and 0.791, respectively). CONCLUSIONS: High ve is a consistent predictor of worse PFS and OS in HGG glioma patients. vp skewness and kep are also predictive for OS. Ktrans and ve demonstrated the best diagnostic performance for differentiating grade III from IV gliomas

Creatine kinase BB isoenzyme levels in tumour cytosols and survival of breast cancer patients.

Creatinine kinase BB (CK-BB) is elevated in many tumours including those of the breast. We have recently described a new, highly sensitive and specific method for measuring CK-BB, based on monoclonal antibodies and time-resolved fluorometry. Using this method, we quantitated CK-BB in 172 breast tumour cytosols and examined the associations between CK-BB and other clinicopathological variables and patient survival. High CK-BB levels were seen more frequently in tumours from patients who were younger (age < 50 years), patients who qualified for chemotherapy and patients with oestrogen receptor-positive tumours. No association was seen between CK-BB and tumour stage, grade, size, histological type or the progesterone receptor. In univariate analysis, the risk of relapse or death was higher in the group with tumours containing high CK-BB levels but the difference did not reach statistical significance. In multivariate analysis, the risk of death was statistically significantly higher in the high-CK-BB group. Analysis of subsets of patients revealed that patients with oestrogen receptor-negative cancer have higher risk of death if their tumours contain high levels of CK-BB. Our data suggest that, in general, CK-BB is associated with more aggressive tumours but its value as a prognostic indicator is limited. CK-BB content of breast tumours may be more useful as an aid in selecting therapy directed at inhibiting this enzyme activity and thus depriving tumour cells of their energy source