Angiotensin Converting Enzyme- Inhibitors Associated Cough: A Prospective Evaluation in Hypertensives

Background/Objective: To determine the prevalence of ACE-Is induced cough among Nigerian hypertensives and evaluate any association with patients' age or sex. Methods: A prospective case-control study.One hundred and sixty-eight hypertensive patients on angiotensin converting enzyme-inhibitors (ACE-Is; captopril and lisinopril) were matched in age and sex with controls that were on anti-hypertensives that excluded ACE-Is (nifedipine, aldomet and moduretic). Both groups of patients were followed up on either drug as a monotherapy over an average of 9 months. Results: The prevalence of ACE-Is induced cough was 20.2%, while that of the alternative group was 0.6%. There was a significant statistical difference between ACE-Is and the alternatives medications-induced cough: OR=42.37(95%CI; 6.11-843.32), P< 0.0001.There was however, no significant statistical difference between captopril and lisinopril-induced cough, OR=1.30 (95%CI;0. 6-2.81), P value=0.587 and no significant age or sex differences were observed in the occurrence of cough; OR=0.97 (95%CI; 0.52-1.81), P value= 0.95 and OR=0.79(95%CI; 0.27-2.28), P value=0.808 respectively. Conclusion: Cough complicating ACE-Is therapy is not uncommon; however, it has no link with the patients' age or sex.Fond/Objectif : Pour d\ue9terminer la pr\ue9dominance de la toux induite de ACE-Is parmi des hypertensifs nig\ue9rians et \ue9valuer n'importe quelle association avec l'\ue2ge ou le sexe des malades. La m\ue9thode : une \ue9tude \ue9ventuelle de cas commande.cent et soixante-huit de malades hypertensifssur inhibiteurs de l'enzyme de conversion de l'angiotensine(ACE-Is : captopril et lisinopril) ont \ue9t\ue9 \ue9gal\ue9 en l'\ue2ge et en sexe avec les contr\uf4les qui \ue9taient sur anti-hypertensifs excluant l'ACE-Is (nif\ue9dipine, aldomet et modulatoire). Les deux groupes de malades ont \ue9t\ue9 observ\ue9s sur la drogue comme une monoth\ue9rapie par-dessus une moyenne de 9 mois. R\ue9sultats : la pr\ue9dominance de la toux induite d'ACE-Is \ue9tait 20,2 %, pendant que celle du groupe alternatif \ue9tait 0,6 %. Il y avait une diff\ue9rence statistique significative entre l'ACE-Is et la toux induite m\ue9dications alternatives : OR=42.37 (95%CI; 6.11-843.32), P <0.0001. Il y avait pourtant, aucune diff\ue9rence statistique significative entre captopril et latoux induite lisinopril, OR=1.30 (95%CI; 0. 6-2.81), P valeur=0,587 et aucun \ue2ge significatif ou diff\ue9rences sexuelles n'a \ue9t\ue9 observ\ue9 dans l'occurrence de toux; OR=0.97 (95%CI; 0.52-1.81), P valeur = 0.95 et OR=0.79 (95%CI; 0.27-2.28), P valeur=0.808 respectivement. La conclusion : la Toux compliquant de la th\ue9rapie d'ACE-Is n'est pas rare ; cependant, il n'a pas de lien avec l'\ue2ge ou le sexe des malades

Antihypertensive Therapy Among Hypertensive Patients as Seen in the Middle Belt of Nigeria

Background: In spite of increased awareness on hypertension among Nigerians, control of blood pressure among hypertensive patients is still unacceptably poor. This study was therefore designed to assess the compliance rate to antihypertensive therapy among Nigerians and factors influencing it. Method: Two hundred and twenty four consecutive hypertensive patients were prospectively studied using a pre-tested questionnaire. Results: A total of 100 males (44.6%) and 124 females participated in the study. The age ranged between 35-82 years. Calcium channel blockers were the most frequently prescribed medication (39.3%) followed by diuretics (14.3%). Combination therapy was seen in 35.7% of the patients. B-blockers were the rarest drug as a single agent (1.8%). Using multivariate analysis, access to the hospital was the only independent predictor of Systolic Blood Pressure level. 39.3% of the respondents volunteered history of having stopped their drugs at one time or the other over a one year period for different reasons with high cost and scarcity of drugs being the most prevalent. 85.7% of the patients spent between two hundred and two thousand Naira monthly on drug procurement. Conclusion: Calcium channel blockers are rapidly gaining ground as first line antihypertensive agents in tertiary hospitals in Nigeria. This study has underscored the need to bring health care centres closer to the people in a bid to improve the control of blood pressure

Angiotensin converting enzyme-inhibitors associated cough: a prospective evalution in hypertensives

Background/Objective: To determine the prevalence of ACE-Is induced cough among Nigerian hypertensives and evaluate any association with patients' age or sex. Methods: A prospective case-control study.One hundred and sixty-eight hypertensive patients on angiotensin converting enzyme-inhibitors (ACE-Is; captopril and lisinopril) were matched in age and sex with controls that were on anti-hypertensives that excluded ACE-Is (nifedipine, aldomet and moduretic). Both groups of patients were followed up on either drug as a monotherapy over an average of 9 months. Results: The prevalence of ACE-Is induced cough was 20.2%, while that of the alternative group was 0.6%. There was a significant statistical difference between ACE-Is and the alternatives medications-induced cough: OR=42.37(95%CI; 6.11-843.32), P< 0.0001.There was however, no significant statistical difference between captopril and lisinopril-induced cough, OR=1.30 (95%CI;0. 6-2.81), P value=0.587 and no significant age or sex differences were observed in the occurrence of cough; OR=0.97 (95%CI; 0.52-1.81), P value= 0.95 and OR=0.79(95%CI; 0.27-2.28), P value=0.808 respectively. Conclusion: Cough complicating ACE-Is therapy is not uncommon; however, it has no link with the patients' age or sex

ANTIHYPERTENSIVE THERAPY AMONG HYPERTENSIVE PATIENTS AS SEEN IN THE MIDDLE BELT OF NIGERIA

Background: In spite of increased awareness on hypertension among Nigerians, control of blood pressure among hypertensive patients is still unacceptably poor. This study was therefore designed to assess the compliance rate to antihypertensive therapy among Nigerians and factors influencing it. Method: Two hundred and twenty four consecutive hypertensive patients were prospectively studied using a pre-tested questionnaire. Results: A total of 100 males (44.6%) and 124 females participated in the study. The age ranged between 35-82 years. Calcium channel blockers were the most frequently prescribed medication (39.3%) followed by diuretics (14.3%). Combination therapy was seen in 35.7% of the patients. B-blockers were the rarest drug as a single agent (1.8%). Using multivariate analysis, access to the hospital was the only independent predictor of Systolic Blood Pressure level. 39.3% of the respondents volunteered history of having stopped their drugs at one time or the other over a one year period for different reasons with high cost and scarcity of drugs being the most prevalent. 85.7% of the patients spent between two hundred and two thousand Naira monthly on drug procurement. Conclusion: Calcium channel blockers are rapidly gaining ground as first line antihypertensive agents in tertiary hospitals in Nigeria. This study has underscored the need to bring health care centres closer to the people in a bid to improve the control of blood pressure

Mahzenü'l-ulûm, kısm-ı evvel: ulum ve fünuna dair mebahisi havidir

Maarif Nezâret-İ Celilesi’nin Ruhsatiyle Tab Ve Temsil Olunmuşdur. Eserin Baş Tarafındaki İlave Sayfalarda "Takriz"Ler Vardır. Basım Tarihi İç Kapakta 1308 Olarak Ketebe Kaydında İse 12 Rebiülevvel 1309 Olarak Verilmiştir. Eserde "Marmara Üniversitesi Fen-Edebiyat Fakültesi Kütüphanesi" Mührü Vardır. Ayrıca "Mekteb-İ Tefeyyüz" Mükafat Kitabı Etiketi Vardır. Eserin 2. Sayfasında Matbaa (Şirket-İ Mürettibiye Kütübhane Ve Matbaası) Amblemi Vardır. Mekteb-İ Tefeyyüz Mükafat Kitabıdır

Comparison of QRS duration in African blacks and European caucasians

This study aimed to compare the QRS duration in a large population of healthy individuals living in Nigeria with a Caucasian population living in Scotland. The Nigerian population consisted of 782 males and 479 females with an age range of 20-87 years. The Caucasian population consisted of 859 males and 637 females with an age range from 18-82 years. For the Nigerian population, the overall QRS duration for males was 87.9 ± 9.4ms and for females, it was 83.4 ± 7.6ms. For the Caucasian population, the overall QRS duration in males was 93.7 + 9.8ms and in females was 86.1 + 7.7ms. In both populations, the mean QRS duration was higher in males than in females. There was a significantly longer QRS duration in Caucasian males and females compared to their Nigerian counterparts. However, the upper limits of normal QRS duration differed little between the two races

Dissociating perception and action in a metacontrast paradigm

SIGLEAvailable from British Library Document Supply Centre-DSC:DXM021656 / BLDSC - British Library Document Supply CentreGBUnited Kingdo