Dueling Lyres: Competing Consolatory Practices in the Roman Empire

What does the Roman consolatory tradition reveal about the Romans’ expectations for proper behavior, especially in regards to gender? Can archeological evidence reveal the philosophical beliefs of individuals in Rome? This thesis addresses these questions in three parts. Part One offers an analysis of the consolatory letter tradition, represented by consolation letters found in Cicero’s Epistulae Ad Familiares, Seneca’s De Consolatione Ad Helviam, Ad Marciam, and Epistulae Morales, and Plutarch’s De Consolatione Ad Uxorem. In this section, I argue that consolation letters reinforced the gendered opposition of rational and irrational behavior in Roman society. This section also includes a discussion of the potential didactic purposes of female-addressed consolation letters. Part Two compares the consolation letters to the consolatory poems and laments of the Flavian poet Statius. I argue that Statius presents a competing philosophical framework of Roman behavior that valorizes the “feminine spheres” of mourning and lamentation. Additionally, Statius weakens the obligations of the individual to the political public of Rome in favor of a system that values pietas and community validation. In Part Three, I compare selected metrical epitaphs to Statius’ consolation poems in the Silvae. In doing this I attempt to relate the real-life practices of Romans with the philosophical frameworks presented in Parts One and Two in order to determine what contexts might lead individuals to prefer some funeral practices over others

Telehealth vs Face to Face Pediatric Screenings: A Pilot Study

The global pandemic heightened the importance of occupational therapy (OT) education programs to prepare students for telehealth practice. The objective was to examine the following research questions: 1. Does self-assessment of pediatric competency skills improve following participation in pediatric screenings? 2. Is there a difference in self-assessment of pediatric competency skills between those students who perform pediatric screenings via telehealth versus face-to-face? 3. What is the lived experience for students who perform telehealth and face-to-face pediatric screenings? A mixed method- quasi-experimental design and phenomenological tradition were employed. The study utilized online surveys, focus groups, telehealth screenings with an urban preschool, and face-to-face screenings at a Christian suburban preschool in the Midwest. Participants included forty-nine first year, Master of OT students at a private university. Students performed screenings using the ASQ-3 via telehealth or face-to-face formats. Outcomes measures included: Self-Assessment of Competency- Pediatric Screening (SAC-PS) survey, Pediatric Screening Experience Survey, and Focus Group Semi-Structured Interview Questions. No statistically significant differences were found on SAC-PS scores between formats, F (11, 49) = .661, p = .76, Ꞃ2 = .17. Post-screening scores were statistically significantly higher (M =48.95, SD = 4.02) than pre-screening (M =43.58, SD =4.69) for all students, F (11,49) = 36, p2= .58. Improvements from pre-to post-pediatric screenings were found for ten of eleven questions at the

Non-Universal Stellar Initial Mass Functions: Large Uncertainties in Star Formation Rates at z≈2−4z\approx 2-4 and Other Astrophysical Probes

We explore the assumption, widely used in many astrophysical calculations, that the stellar initial mass function (IMF) is universal across all galaxies. By considering both a canonical Salpeter-like IMF and a non-universal IMF, we are able to compare the effect of different IMFs on multiple observables and derived quantities in astrophysics. Specifically, we consider a non-universal IMF which varies as a function of the local star formation rate, and explore the effects on the star formation rate density (SFRD), the extragalactic background light, the supernova (both core-collapse and thermonuclear) rates, and the diffuse supernova neutrino background. Our most interesting result is that our adopted varying IMF leads to much greater uncertainty on the SFRD at $z \approx 2-4$ than is usually assumed. Indeed, we find a SFRD (inferred using observed galaxy luminosity distributions) that is a factor of $\gtrsim 3$ lower than canonical results obtained using a universal Salpeter-like IMF. Secondly, the non-universal IMF we explore implies a reduction in the supernova core-collapse rate of a factor of $\sim2$, compared against a universal IMF. The other potential tracers are only slightly affected by changes to the properties of the IMF. We find that currently available data do not provide a clear preference for universal or non-universal IMF. However, improvements to measurements of the star formation rate and core-collapse supernova rate at redshifts $z \gtrsim 2$ may offer the best prospects for discernment.Comment: 15 pages, 11 figures, 1 appendi

Critical Foundations for Civic Engagement: Reimagining Civic Learning for a University Honors Program

Scholars are calling attention to shortcomings of service-learning, including the development of civic skills and adoption of a social change framework. Informed by this literature, this article uses a mixed-methods case study to detail the development, and initial outcomes, of a civic engagement course intended to lay a critical foundation for future service. This study documents the process of reimagining the class, formerly organized as a service project, and course evaluations and reflections are used to assess outcomes. Initial assessment signals impact in challenging previous assumptions about service, understanding the multifaceted nature of civic engagement, and motivating future responsible engagement

Prenatal cannabinoid exposure and early language development

IntroductionThe effect of prenatal cannabis exposure (PCE) on childhood neurodevelopment remains poorly understood. There is a paucity of studies describing the neurodevelopment impact of PCE in infancy. The Mullen Scale of Early Learning (MSEL) is a cognitive screening tool that can be used from birth to 68 months and includes language and motor domains. Here we aim to explore the association between PCE during pregnancy and neurodevelopmental outcomes at 12 months of age.MethodsParticipants were pregnant persons/infant pairs enrolled in The Safe Passage Study, a large prospective cohort study. Inclusion criteria included data available on PCE with associated MSEL scores at 12 months of age. Exposed participants were defined as early exposure (1st trimester only) or late exposure (2nd or 3rd trimester) and were randomly matched with unexposed participants. Multiple linear regression models were performed to test associations between prenatal cannabis exposure and the five Mullen subscales: gross motor, fine motor, expressive language, receptive language, and visual reception.ResultsSixty-nine exposed and 138 randomly matched unexposed infants were included in the analyses. Mothers of children with PCE were younger with the mean age 23.7 years for early exposure (n = 51) and 22.8 years for late exposure (n = 18). Maternal characteristics with prenatal cannabis use include a high-school education, American Indian or Alaska Native descent, lower socioeconomic status and co-use of tobacco. There were no gestational age or sex difference among the groups. Expressive (95% CI: 2.54–12.76; p = 0.0036,) and receptive language scores (95% CI: 0.39–8.72; p = 0.0322) were significantly increased between late-exposed infants compared to unexposed infants following adjustment for covariates. Gross motor scores (95% CI: 1.75–13; p = 0.0105) were also significantly increased for early-exposed infants with no difference in visual reception scores.ConclusionPreclinical studies have shown abnormal brain connectivity in offspring exposed to cannabis affecting emotional regulation, hyperactivity, and language development. Results from this study link PCE to altered early language development within the first year of life. Exposed infants demonstrated increased expressive and receptive language scores at 12 months of age, which can translate to better performance in school. However, further research is needed to determine the implications of these results later in childhood

Multiomic profiling of breast cancer cells uncovers stress MAPK-associated sensitivity to AKT degradation

More than 50% of human tumors display hyperactivation of the serine/threonine kinase AKT. Despite evidence of clinical efficacy, the therapeutic window of the current generation of AKT inhibitors could be improved. Here, we report the development of a second-generation AKT degrader, INY-05-040, which outperformed catalytic AKT inhibition with respect to cellular suppression of AKT-dependent phenotypes in breast cancer cell lines. A growth inhibition screen with 288 cancer cell lines confirmed that INY-05-040 had a substantially higher potency than our first-generation AKT degrader (INY-03-041), with both compounds outperforming catalytic AKT inhibition by GDC-0068. Using multiomic profiling and causal network integration in breast cancer cells, we demonstrated that the enhanced efficacy of INY-05-040 was associated with sustained suppression of AKT signaling, which was followed by induction of the stress mitogen-activated protein kinase (MAPK) c-Jun N-terminal kinase (JNK). Further integration of growth inhibition assays with publicly available transcriptomic, proteomic, and reverse phase protein array (RPPA) measurements established low basal JNK signaling as a biomarker for breast cancer sensitivity to AKT degradation. Together, our study presents a framework for mapping the network-wide signaling effects of therapeutically relevant compounds and identifies INY-05-040 as a potent pharmacological suppressor of AKT signaling

Multiomic profiling of breast cancer cells uncovers stress MAPK-associated sensitivity to AKT degradation

More than 50% of human tumors display hyperactivation of the serine/threonine kinase AKT. Despite evidence of clinical efficacy, the therapeutic window of the current generation of AKT inhibitors could be improved. Here, we report the development of a second-generation AKT degrader, INY-05-040, which outperformed catalytic AKT inhibition with respect to cellular suppression of AKT-dependent phenotypes in breast cancer cell lines. A growth inhibition screen with 288 cancer cell lines confirmed that INY-05-040 had a substantially higher potency than our first-generation AKT degrader (INY-03-041), with both compounds outperforming catalytic AKT inhibition by GDC-0068. Using multiomic profiling and causal network integration in breast cancer cells, we demonstrated that the enhanced efficacy of INY-05-040 was associated with sustained suppression of AKT signaling, which was followed by induction of the stress mitogen-activated protein kinase (MAPK) c-Jun N-terminal kinase (JNK). Further integration of growth inhibition assays with publicly available transcriptomic, proteomic, and reverse phase protein array (RPPA) measurements established low basal JNK signaling as a biomarker for breast cancer sensitivity to AKT degradation. Together, our study presents a framework for mapping the network-wide signaling effects of therapeutically relevant compounds and identifies INY-05-040 as a potent pharmacological suppressor of AKT signaling

Clinical, radiologic, pathologic, and molecular characteristics of long-term survivors of diffuse intrinsic pontine glioma (DIPG): a collaborative report from the International and European Society for Pediatric Oncology DIPG registries

Purpose Diffuse intrinsic pontine glioma (DIPG) is a brainstem malignancy with a median survival of < 1 year. The International and European Society for Pediatric Oncology DIPG Registries collaborated to compare clinical, radiologic, and histomolecular characteristics between short-term survivors (STSs) and long-term survivors (LTSs). Materials and Methods Data abstracted from registry databases included patients from North America, Australia, Germany, Austria, Switzerland, the Netherlands, Italy, France, the United Kingdom, and Croatia. Results Among 1,130 pediatric and young adults with radiographically confirmed DIPG, 122 (11%) were excluded. Of the 1,008 remaining patients, 101 (10%) were LTSs (survival ≥ 2 years). Median survival time was 11 months (interquartile range, 7.5 to 16 months), and 1-, 2-, 3-, 4-, and 5-year survival rates were 42.3% (95% CI, 38.1% to 44.1%), 9.6% (95% CI, 7.8% to 11.3%), 4.3% (95% CI, 3.2% to 5.8%), 3.2% (95% CI, 2.4% to 4.6%), and 2.2% (95% CI, 1.4% to 3.4%), respectively. LTSs, compared with STSs, more commonly presented at age < 3 or > 10 years (11% v 3% and 33% v 23%, respectively; P < .001) and with longer symptom duration ( P < .001). STSs, compared with LTSs, more commonly presented with cranial nerve palsy (83% v 73%, respectively; P = .008), ring enhancement (38% v 23%, respectively; P = .007), necrosis (42% v 26%, respectively; P = .009), and extrapontine extension (92% v 86%, respectively; P = .04). LTSs more commonly received systemic therapy at diagnosis (88% v 75% for STSs; P = .005). Biopsies and autopsies were performed in 299 patients (30%) and 77 patients (10%), respectively; 181 tumors (48%) were molecularly characterized. LTSs were more likely to harbor a HIST1H3B mutation (odds ratio, 1.28; 95% CI, 1.1 to 1.5; P = .002). Conclusion We report clinical, radiologic, and molecular factors that correlate with survival in children and young adults with DIPG, which are important for risk stratification in future clinical trials

Average Heart Rate and Energy Expenditure Validity of Garmin Vivoactive 3 and Fenix 6 Wrist Watches During Light Circuit Resistance Training

Our laboratory recently found wrist-worn wearable technology devices to be valid for measuring average heart rate (HR), but not valid for estimated energy expenditure (EE) compared to criterion devices, during steady state aerobic training (walking, running, biking). However, the validity of wrist-worn devices for HR and EE measures during resistance training is largely unknown. PURPOSE: The purpose of this study was to determine if two wrist-worn devices, Garmin Vivoactive 3 and Garmin Fenix 6 Pro, record valid measures of average HR and EE while performing circuit resistance training. METHODS: Twenty participants (n=10 female, n=10 male; age: 23.2 ± 7.7 years) completed this study. The Garmin Vivoactive 3 and Garmin Fenix 6 Pro were tested along with the Polar H10 chest strap and Cosmed K5 portable metabolic unit as the criterions for average HR and EE, respectively. Participants completed 4 circuits of 4 exercises (front squat, reverse lunge, push-ups, and shoulder press) using dumbbells at a light intensity with 1 set of 10 repetitions per exercise and 30 seconds rest between exercises and 1-1.5 min. rest between circuits. Mean absolute percent error (MAPE, ≤10%) and Lin’s Concordance (ρ≥0.7) were used to validate the device’s average HR (in bpm) and estimated EE (in kcals) compared to criterion reference devices. Dependent T-tests determined differences (p≤0.05). RESULTS: Average HR for Garmin Vivoactive 3 and Fenix 6 Pro were significantly different (p\u3c0.01) than the Polar H10 (115.0±23.9 and 124.5±15.4 vs 128.9±19.0 bpm, respectively), and were not considered valid (MAPE: 44.8% and 25.1%; Lin’s Concordance: 0.50 and 0.63, respectively). Estimated EE for Garmin Vivoactive 3 and Fenix 6 Pro were significantly different (p\u3c0.0001) than the Cosmed K5 (31.7±12.3 and 39.7±13.1 vs 20.3±5.5 kcals, respectively), and were not considered valid (MAPE: 309.7% and 322.1%; Lin’s Concordance: 0.04 and 0.15, respectively). CONCLUSION: Anyone involved in any resistance training aspect should be aware of the limitations of these wrist-worn devices in measuring average HR or EE