Loans and Legitimacy: The Evolution of Soviet-American Relations, 1919-1933

In 1919 the Soviet government directed Ludwig Martens to open a trade bureau in New York. Before his deportation two years later, Martens had established contact with nearly one thousand American firms and conducted trade in the face of a stiff Allied embargo. His work planted the seeds for growing commercial ties between the U.S. and the U.S.S.R. throughout the 1920s. Because the United States did not recognize the Soviet Union until 1933, historians have viewed the early Soviet–American relationship as an ideological stand-off. Katherine Siegel, drawing on public, private, and corporate documents as well as newly opened Soviet archives, paints a different picture. She finds that business ties flourished between 1923 and 1930, American sales to the Soviets grew twentyfold and American firms supplied Russians with more than a fourth of their imports. American businesses were only too eager to tap into huge Soviet markets. Under the Soviets\u27 New Economic Policy and first Five Year Plan, American firms invested in the U.S.S.R. and sold technical processes, provided consulting services, built factories, and trained Soviet engineers in the U.S. Most significantly, Siegel shows, this commercial relationship encouraged policy shifts at the highest levels of the U.S. government. Thus when Franklin D. Roosevelt opened diplomatic relations with Russia, he was building on ties that had been carefully constructed over the previous fifteen years. Siegel\u27s study makes an important contribution to a new understanding of early Soviet-American relations. Katherine A.S. Siegel is assistant professor of history at St. Joseph\u27s University, Philadelphia. Winner of the 1997 Phi Alpha Theta Award for a First Book An informative, scholarly study that is a delight to read. —American Historical Review Siegel is telling a great story, based on wonderful materials which she has unearthed from the Soviet archives. —Business History Review Siegel\u27s work is notable because she has conducted research in the official records of the former Soviet Union. The author demonstrates that the governments of Lenin and Stalin did not merely react to US initiatives but boldly sought American goods and money. . . —Choice As the first American effort to re-examine both sides of pre-recognition American-Soviet relations, Siegel\u27s work marks a significant historiographic milestone. —H-Net Reviews Siegel has enhanced our understanding of the relationship through the introduction of documents from the Soviet archives, by exploring in depth the first Soviet trade mission, and by demonstrating that there was a limited degree of flexibility in Republican policy in response to Moscow\u27s initiatives to promote trade and official acknowledgement. —Slavic Reviewhttps://uknowledge.uky.edu/upk_political_science_international_relations/1020/thumbnail.jp

Extensible Component Based Architecture for FLASH, A Massively Parallel, Multiphysics Simulation Code

FLASH is a publicly available high performance application code which has evolved into a modular, extensible software system from a collection of unconnected legacy codes. FLASH has been successful because its capabilities have been driven by the needs of scientific applications, without compromising maintainability, performance, and usability. In its newest incarnation, FLASH3 consists of inter-operable modules that can be combined to generate different applications. The FLASH architecture allows arbitrarily many alternative implementations of its components to co-exist and interchange with each other, resulting in greater flexibility. Further, a simple and elegant mechanism exists for customization of code functionality without the need to modify the core implementation of the source. A built-in unit test framework providing verifiability, combined with a rigorous software maintenance process, allow the code to operate simultaneously in the dual mode of production and development. In this paper we describe the FLASH3 architecture, with emphasis on solutions to the more challenging conflicts arising from solver complexity, portable performance requirements, and legacy codes. We also include results from user surveys conducted in 2005 and 2007, which highlight the success of the code.Comment: 33 pages, 7 figures; revised paper submitted to Parallel Computin

Integrated RNA and DNA sequencing reveals early drivers of metastatic breast cancer

Breast cancer metastasis remains a clinical challenge, even within a single patient across multiple sites of the disease. Genome-wide comparisons of both the DNA and gene expression of primary tumors and metastases in multiple patients could help elucidate the underlying mechanisms that cause breast cancer metastasis. To address this issue, we performed DNA exome and RNA sequencing of matched primary tumors and multiple metastases from 16 patients, totaling 83 distinct specimens. We identified tumor-specific drivers by integrating known protein-protein network information with RNA expression and somatic DNA alterations and found that genetic drivers were predominantly established in the primary tumor and maintained through metastatic spreading. In addition, our analyses revealed that most genetic drivers were DNA copy number changes, the TP53 mutation was a recurrent founding mutation regardless of subtype, and that multiclonal seeding of metastases was frequent and occurred in multiple subtypes. Genetic drivers unique to metastasis were identified as somatic mutations in the estrogen and androgen receptor genes. These results highlight the complexity of metastatic spreading, be it monoclonal or multiclonal, and suggest that most metastatic drivers are established in the primary tumor, despite the substantial heterogeneity seen in the metastases

'They never pass me the ball’: exposing ableism through the leisure experiences of disabled children, young people and their families.

In this paper, we explore the participation of disabled children, young people and their families in leisure activities. Drawing on the accounts of disabled children, young people and their parents and carers, we reflect on the leisure spaces that they access and record some of their experiences within them. Using the concept of ‘ableism’ (Campbell 2009) we interrogate the data gathered as part a two-year project funded by the Economic and Social Research Council (RES – 062-23-1138) (http//www.rihsc.mmu.ac.uk/postblairproject/):‘Does every child matter, Post-Blair: the interconnections of disabled childhoods'. By doing so we identify some of the inherent and embedded discriminations in favour of those children and young people who are perceived to be ‘able’ that simultaneously work to exclude the young 'kinds of people' (Hacking 2007), categorised as 'disabled', and their families from leisure facilities and opportunities. We suggest that currently, disabled families and children occupy a mix of ‘mainstream', ‘segregated’ and ‘separate’ leisure spaces. We discuss the impact of occupying these spaces and ask: What do the experiences of accessing leisure by disabled children, young people and their families reveal about the processes and practices of ableism? To what extent are children and families required to 'pass'as'normal enough' to gain access to leisure spaces? To what extent are ‘segregated’ leisure opportunities regulated and produced by a kind of ‘diagnostic apartheid’ (Campbell 2008a: 155)? What is the role and value of 'separate' leisure activities? </p

Management of infantile hemangiomas during the COVID pandemic

This article is made available for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.The COVID‐19 pandemic has caused significant shifts in patient care including a steep decline in ambulatory visits and a marked increase in the use of telemedicine. Infantile hemangiomas (IH) can require urgent evaluation and risk stratification to determine which infants need treatment and which can be managed with continued observation. For those requiring treatment, prompt initiation decreases morbidity and improves long‐term outcomes. The Hemangioma Investigator Group has created consensus recommendations for management of IH via telemedicine. FDA/EMA‐approved monitoring guidelines, clinical practice guidelines, and relevant, up‐to‐date publications regarding initiation and monitoring of beta‐blocker therapy were used to inform the recommendations. Clinical decision‐making guidelines about when telehealth is an appropriate alternative to in‐office visits, including medication initiation, dosage changes, and ongoing evaluation, are included. The importance of communication with caregivers in the context of telemedicine is discussed, and online resources for both hemangioma education and propranolol therapy are provided

The Long March: A Sample Preparation Technique that Enhances Contig Length and Coverage by High-Throughput Short-Read Sequencing

High-throughput short-read technologies have revolutionized DNA sequencing by drastically reducing the cost per base of sequencing information. Despite producing gigabases of sequence per run, these technologies still present obstacles in resequencing and de novo assembly applications due to biased or insufficient target sequence coverage. We present here a simple sample preparation method termed the “long march” that increases both contig lengths and target sequence coverage using high-throughput short-read technologies. By incorporating a Type IIS restriction enzyme recognition motif into the sequencing primer adapter, successive rounds of restriction enzyme cleavage and adapter ligation produce a set of nested sub-libraries from the initial amplicon library. Sequence reads from these sub-libraries are offset from each other with enough overlap to aid assembly and contig extension. We demonstrate the utility of the long march in resequencing of the Plasmodium falciparum transcriptome, where the number of genomic bases covered was increased by 39%, as well as in metagenomic analysis of a serum sample from a patient with hepatitis B virus (HBV)-related acute liver failure, where the number of HBV bases covered was increased by 42%. We also offer a theoretical optimization of the long march for de novo sequence assembly