12 research outputs found
Fermionic zeromodes in heterotic fivebrane backgrounds
We investigate the explicit form of the fermionic zeromodes in heterotic
fivebrane backgrounds. By explicitly solving the fermionic field equations in
fivebrane backgrounds, two normalizable and physical fermionic zeromodes are
obtained. Each of these zeromodes has a non-vanishing gravitino component. We
suggest a possible scenario of the gravitino pair condensation.Comment: 9 page
A Report on Hydrographic Activities Following the Great East Japan Earthquake
The Great East Japan Earthquake (Mw9.0) on 11 March 2011 accompanied with a huge tsunami of more than 10 meters in height devastated many cities and ports along the Pacific coast of northeastern Japan, and claimed nearly 20,000 lives with many of them still missing. This report reviews actions taken by the Japan Hydrographic and Oceanographic Department (JHOD) after this unprecedented disaster. Immediately after the earthquake, the JHOD carried out hydrographic surveys for the urgent need to help clear the passage in ports due to sunken debris swept away by the tsunami. These surveys have enabled the vessels with relief supplies on board for the affected areas to enter the ports. The JHOD revisited the affected ports for the next stage of hydrographic surveys. These surveys will contribute to revised nautical charts based on new data collected after the earthquake, and includes the ongoing restoration and reconstruction work of quays and port facilities. This stage includes the re-determination of the datum level of the affected ports, which is necessary because of large subsidence being reported in the areas. All of these efforts by the JHOD clearly demonstrate the significance of the hydrographic activities in case of the post-quake emergency situation, not only for the safety of navigation but also for economic recovery
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Overexpressing IRS1 in Endothelial Cells Enhances Angioblast Differentiation and Wound Healing in Diabetes and Insulin Resistance
The effect of enhancing insulinâs actions in endothelial cells (ECs) to improve angiogenesis and wound healing was studied in obesity and diabetes. Insulin receptor substrate 1 (IRS1) was overexpressed in ECs using the VE-cadherin promoter to create ECIRS1 TG mice, which elevated pAkt activation and expressions of vascular endothelial growth factor (VEGF), Flk1, and VE-cadherin in ECs and granulation tissues (GTs) of full-thickness wounds. Open wound and epithelialization rates and angiogenesis significantly improved in normal mice and high fat (HF) dietâinduced diabetic mice with hyperinsulinemia in ECIRS1 TG versus wild type (WT), but not in insulin-deficient diabetic mice. Increased angioblasts and EC numbers in GT of ECIRS1 mice were due to proliferation in situ rather than uptake. GT in HF-fed diabetic mice exhibited parallel decreases in insulin and VEGF-induced pAkt and EC numbers by >50% without changes in angioblasts versus WT mice, which were improved in ECIRS1 TG mice on normal chow or HF diet. Thus, HF-induced diabetes impaired angiogenesis by inhibiting insulin signaling in GT to decrease the differentiation of angioblasts to EC, which was normalized by enhancing insulinâs action targeted to EC, a potential target to improve wound healing in diabetes and obesity
Bone morphogenetic protein-2 down-regulates miR-206 expression by blocking its maturation process
MicroRNAs (miRNAs) are small non-coding RNAs that are emerging as important post-transcriptional gene regulators. miR-206 is unique in that it is expressed only in skeletal muscle, including the myoblastic C2C12 cell line. In C2C12 cells, miR-206 expression was reduced dramatically after bone morphogenetic protein (BMP)-2 treatment. The down-regulation of miR-206 expression was also observed after co-transfection with constitutively-active Smad1 and Smad4, which are the intracellular signaling molecules of the BMP pathway. BMP-2 also reduced miR-206 expression in the presence of Îą-amanitin in a similar manner to that in the absence of Îą-amanitin. Moreover, the expression of pri-miR-206 was increased upon BMP-2 treatment for 6 hours compared to that in the absence of BMP-2. These results suggested that BMP-2 down-regulates miR-206 expression at the post-transcriptional level, by inhibiting the processing of pri-miR-206 into mature miR-206, and that BMP-2 could regulate miRNA biogenesis by a novel mechanism
Insulin decreases atherosclerosis by inducing endothelin receptor B expression
Endothelial cell (EC) insulin resistance and dysfunction, caused by diabetes, accelerates atherosclerosis. It is unknown whether specifically enhancing EC-targeted insulin action can decrease atherosclerosis in diabetes. Accordingly, overexpressing insulin receptor substrate-1 (IRS1) in the endothelia of Apoe-/- mice (Irs1/Apoe-/-) increased insulin signaling and function in the aorta. Atherosclerosis was significantly reduced in Irs1/ApoE-/- mice on diet-induced hyperinsulinemia and hyperglycemia. The mechanism of insulin's enhanced antiatherogenic actions in EC was related to remarkable induction of NO action, which increases endothelin receptor B (EDNRB) expression and intracellular [Ca2+]. Using the mice with knockin mutation of eNOS, which had Ser1176 mutated to alanine (AKI), deleting the only known mechanism for insulin to activate eNOS/NO pathway, we observed that IRS1 overexpression in the endothelia of Aki/ApoE-/- mice significantly decreased atherosclerosis. Interestingly, endothelial EDNRB expression was selectively reduced in intima of arteries from diabetic patients and rodents. However, endothelial EDNRB expression was upregulated by insulin via P13K/Akt pathway. Finally EDNRB deletion in EC of Ldlr-/- and Irs1/Ldlr-/- mice decreased NO production and accelerated atherosclerosis, compared with Ldlr-/- mice. Accelerated atherosclerosis in diabetes may be reduced by improving insulin signaling selectively via IRS1/Akt in the EC by inducing EDNRB expression and NO production