Innovative Production Technology of Drinks from Grape Cryopowders

A technology, based on the production of wine beverages from grape cryopowders in the mountain-valley zone of the Republic of Dagestan, is proposed. The data on the vacuum microwave drying of grape raw materials and subsequent grinding in a cryomill are presented. The modes of grape raw material preparation and its subsequent dehydration and cryo-grinding, which provide the possibility of successful use in the dried state in the production technology of wine drinks, are proposed. The principal feature is the use of whole grapes as a raw material, with rinds and seeds. The physical and chemical indicators, the content of phenolic substances and the organoleptic indicators of wine beverages made according to the traditional technology and the beverage made from grape cryopowders were studied. A comparative assessment of beverages was made. It is established that vacuum microwave drying conduces to better preservation of the properties of raw materials and finished products. The organoleptic assessment showed that the wine drinks developed according to the proposed technology had a more intense color and a more pronounced flavor of sweetness and sourness than traditional wine beverages. The advantage of this technology is the ability to transport grape cryopowders in unregulated temperature conditions to any point close to the consumer and carry out the production of wine beverages there

Determination of calcium and magnesium in the presence of drugs

Lack of calcium leads to clinical manifestations such as muscle tetany or weakness, heart rhythm disorders and seizures, osteoporosis, and osteopenia. Magnesium deficiency leads to severe disorders of the Central nervous system, cardiovascular diseases, respiratory disorders (such as chronic obstructive pulmonary disease), hemolytic anemia, type 2 diabetes, and is the cause of premenstrual syndrome - dysmenorrhea. The modern market of medicines offers a wide range of products to eliminate pain during the menstrual period in primary dysmenorrhea. That is why it is important to analyze the interaction between the components of drugs and calcium and magnesium ions. For the research were taken drugs used in gynecological practice, which belong to different clinical and pharmacological groups. Experimental data show that magnesium and calcium ions are able to enter into complexation reactions with active substances of drugs used in gynecological practice. The stability of the resulting complex compounds is comparable to the stability of these ions with Trilon BНедостаток кальция приводит к клиническим проявлениям, таким как мышечная тетания или слабость, нарушения сердечного ритма и судороги, остеопороз, остеопения. Дефицит магния влечет за собой тяжелые нарушения функций ЦНС, развиваются сердечно-сосудистые заболевания, дыхательные расстройства (такие как хроническая обструктивная болезнь легких), гемолитическая анемия, сахарный диабет второго типа и является причиной развития предменструального синдрома - дисменореи. Современный рынок лекарственных препаратов предлагает широкий ассортимент для устранения болевых ощущений во время периода менструации при первичной дисменорее. Именно поэтому актуальным является анализ взаимодействия между компонентами лекарственных препаратов и ионами кальция и магния. Для исследования были взяты лекарственные препараты, используемые в гинекологической практике, которые относятся к разным клинико- фармакологическим группам. Из полученных экспериментальных данных следует, что ионы магния и кальция способны вступать в реакции комплексообразования с активными действующими веществами лекарственных препаратов, используемых в гинекологической практике. Устойчивость образующихся комплексных соединений сопоставима с устойчивостью данных ионов с трилоном Б

Prevention of post-transfusion hepatitis c transmission through donor blood and its components

The aim of organizational aspects of preventing the transmission of hepatitis C virus with donor blood and its components.Materials and methods. An activity of the blood service establishments in Russia for the prevention of HCV infection through transfusion of blood and its components on the basis of the analysis of sectoral statistical surveys was studied.Results. The frequency of detection of antibodies to hepatitis C virus in blood donors and its components during 2009–2013 decreased by more than 1,5 times. The percentage of donors who have identified markers of hepatitis C virus was significantly different in different regions: from 0,51% to 1,36%. The activity of the blood service implemented method of plasma quarantine resulting annually rejected from 0,32% to 0,23% as a result of the identified markers of HCV. Pathogen inactivated plasma volume increased in 3 times, the platelet concentrate in 3,2 times.Conclusion. To ensure the safety of donated blood and its components in the blood service effectively the modern technology use for to prevention transmission of the HCV: quarantine of plasma, donor selection and development, inactivation of pathogens. The degree of implementation in practice of nonpaid voluntary blood transfusions significantly increased and is characterized by regional features in recent years

The influence of blood donation on the development of iron deficiency

The purpose of the study is to evaluate the effect of the number of blood donations on the development of iron deficiency.Цель исследования – оценить влияние числа донаций крови на развитие железодефицитного состояния

ПРОФИЛАКТИКА ПОСТТРАНСФУЗИОННОГО ВИРУСНОГО ГЕПАТИТА С ПРИ ПЕРЕЛИВАНИИ ДОНОРСКОЙ КРОВИ И ЕЕ КОМПОНЕНТОВ

The aim of organizational aspects of preventing the transmission of hepatitis C virus with donor blood and its components.Materials and methods. An activity of the blood service establishments in Russia for the prevention of HCV infection through transfusion of blood and its components on the basis of the analysis of sectoral statistical surveys was studied.Results. The frequency of detection of antibodies to hepatitis C virus in blood donors and its components during 2009–2013 decreased by more than 1,5 times. The percentage of donors who have identified markers of hepatitis C virus was significantly different in different regions: from 0,51% to 1,36%. The activity of the blood service implemented method of plasma quarantine resulting annually rejected from 0,32% to 0,23% as a result of the identified markers of HCV. Pathogen inactivated plasma volume increased in 3 times, the platelet concentrate in 3,2 times.Conclusion. To ensure the safety of donated blood and its components in the blood service effectively the modern technology use for to prevention transmission of the HCV: quarantine of plasma, donor selection and development, inactivation of pathogens. The degree of implementation in practice of nonpaid voluntary blood transfusions significantly increased and is characterized by regional features in recent years .Цель. Исследование организационных аспектов профилактики передачи вирусного гепатита С с донорской кровью и ее компонентами.Материалы и методы. Проведено изучение деятельности учреждений службы крови России по предупреждению инфицирования ВГС при переливании донорской крови и ее компонентов на основе анализа отраслевых статистических наблюдений.Результаты. Частота выявления антител к вирусному гепатиту С у доноров крови и ее компонентов в течение 2009–2013 гг. снизилась более чем в 1,5 раз. Процентное число доноров, у которых выявлены маркеры вируса гепатита С, существенно отличалось в различных регионах: от 0,51% до 1,36%. В деятельность службы крови внедрен метод карантинизации плазмы, в результате чего ежегодно бракуется от 0,32% до 0,23% вследствие выявленных маркеров ВГС. Объем патогенинактивированной плазмы увеличился в 3 раза, тромбоцитного концентрата – в 3,2 раза.Заключение. Для обеспечения безопасности донорской крови и ее компонентов в службе крови эффективно применяются современные технологии профилактики передачи ВГС: карантинизация плазмы, отбор доноров и развитие безвозмездного добровольного донорства, инактивация патогенов. Cтепень их внедрения в трансфузиологическую практику в последние годы существенно повышается и характеризуется региональными особенностями

Роль нутриентов и пробиотических препаратов в терапии депрессии

Currently, a growing amount of data is emerging on the role of various environmental factors (nutrients, gut microbiota, etc.) on formation of depression. The impact on these factors can be effective not only in treatment of major depressive disorder, but also in its early prevention. Therefore, a more detailed study of environmental factors in depression can lead both to a better understanding of the etiology and pathogenesis of the disorder and to optimization of approaches to its treatment. The aim of the review was to assess the potential role of a number of environmental factors associated with nutritional aspects and characteristics of individual microflora, as well as to review the prospects of a strategy for affecting these factors in treatment and prevention of depression. В настоящее время появляется все больше сведений о роли различных экологических факторов (особенностей питания, бактериальной флоры человека и проч.) в формировании депрессии. Воздействие на указанные факторы может быть эффективно не только в лечении депрессивного расстройства, но и его ранней профилактике. Таким образом, более подробное изучение роли экологических факторов в формировании депрессии может способствовать как лучшему пониманию этиопатогенеза данного заболевания, так и оптимизации подходов по борьбе с ним.Цель обзора: оценить потенциальную роль в формировании депрессии ряда экологических факторов, связанных с нутритивными аспектами и особенностями микрофлоры индивида, а также перспективность стратегии воздействия на данные факторы в лечении и профилактике депрессивного расстройства.

Neuronal Chemokines: Versatile Messengers In Central Nervous System Cell Interaction

Whereas chemokines are well known for their ability to induce cell migration, only recently it became evident that chemokines also control a variety of other cell functions and are versatile messengers in the interaction between a diversity of cell types. In the central nervous system (CNS), chemokines are generally found under both physiological and pathological conditions. Whereas many reports describe chemokine expression in astrocytes and microglia and their role in the migration of leukocytes into the CNS, only few studies describe chemokine expression in neurons. Nevertheless, the expression of neuronal chemokines and the corresponding chemokine receptors in CNS cells under physiological and pathological conditions indicates that neuronal chemokines contribute to CNS cell interaction. In this study, we review recent studies describing neuronal chemokine expression and discuss potential roles of neuronal chemokines in neuron–astrocyte, neuron–microglia, and neuron–neuron interaction

Higres - Visualization System for Clustered Graphs and Graph Algorithms

We present the Higres system - a visualization tool, an editor for clustered graphs and a platform for execution and animation of graph algorithms. Higres can handle any attributed graphs and perform animated semantic processing of them. The semantics of a graph can be defined by the user in the graph editor. The user can also create new external modules to process graphs with defined semantics. In addition we provide a possibility to extend system with new graph drawing algorithms by using special type of external modules for this purpose. We provide an easy to use C++ library for implementation of both types of extensions