Equivariant geometric K-homology for compact Lie group actions

Let G be a compact Lie-group, X a compact G-CW-complex. We define equivariant geometric K-homology groups K^G_*(X), using an obvious equivariant version of the (M,E,f)-picture of Baum-Douglas for K-homology. We define explicit natural transformations to and from equivariant K-homology defined via KK-theory (the "official" equivariant K-homology groups) and show that these are isomorphism.Comment: 25 pages. v2: some mistakes corrected, more detail added, Michael Walter as author added. To appear in Abhandlungen aus dem Mathematischen Seminar der Universit\"at Hambur

Operator *-correspondences in analysis and geometry

An operator *-algebra is a non-selfadjoint operator algebra with completely isometric involution. We show that any operator *-algebra admits a faithful representation on a Hilbert space in such a way that the involution coincides with the operator adjoint up to conjugation by a symmetry. We introduce operator *-correspondences as a general class of inner product modules over operator *-algebras and prove a similar representation theorem for them. From this we derive the existence of linking operator *-algebras for operator *-correspondences. We illustrate the relevance of this class of inner product modules by providing numerous examples arising from noncommutative geometry.Comment: 31 pages. This work originated from the MFO workshop "Operator spaces and noncommutative geometry in interaction

Adenoviral vectors for highly selective gene expression in central serotonergic neurons reveal quantal characteristics of serotonin release in the rat brain

<p>Abstract</p> <p>Background</p> <p>5-hydroxytryptamine (5 HT, serotonin) is one of the key neuromodulators in mammalian brain, but many fundamental properties of serotonergic neurones and 5 HT release remain unknown. The objective of this study was to generate an adenoviral vector system for selective targeting of serotonergic neurones and apply it to study quantal characteristics of 5 HT release in the rat brain.</p> <p>Results</p> <p>We have generated adenoviral vectors which incorporate a 3.6 kb fragment of the rat tryptophan hydroxylase-2 (TPH-2) gene which selectively (97% co-localisation with TPH-2) target raphe serotonergic neurones. In order to enhance the level of expression a two-step transcriptional amplification strategy was employed. This allowed direct visualization of serotonergic neurones by EGFP fluorescence. Using these vectors we have performed initial characterization of EGFP-expressing serotonergic neurones in rat organotypic brain slice cultures. Fluorescent serotonergic neurones were identified and studied using patch clamp and confocal Ca²⁺imaging and had features consistent with those previously reported using post-hoc identification approaches. Fine processes of serotonergic neurones could also be visualized in un-fixed tissue and morphometric analysis suggested two putative types of axonal varicosities. We used micro-amperometry to analyse the quantal characteristics of 5 HT release and found that central 5 HT exocytosis occurs predominantly in quanta of ~28000 molecules from varicosities and ~34000 molecules from cell bodies. In addition, in somata, we observed a minority of large release events discharging on average ~800000 molecules.</p> <p>Conclusion</p> <p>For the first time quantal release of 5 HT from somato-dendritic compartments and axonal varicosities in mammalian brain has been demonstrated directly and characterised. Release from somato-dendritic and axonal compartments might have different physiological functions. Novel vectors generated in this study open a host of new experimental opportunities and will greatly facilitate further studies of the central serotonergic system.</p

The Baum-Connes Conjecture via Localisation of Categories

We redefine the Baum-Connes assembly map using simplicial approximation in the equivariant Kasparov category. This new interpretation is ideal for studying functorial properties and gives analogues of the assembly maps for all equivariant homology theories, not just for the K-theory of the crossed product. We extend many of the known techniques for proving the Baum-Connes conjecture to this more general setting

Uniformization and an Index Theorem for Elliptic Operators Associated with Diffeomorphisms of a Manifold

We consider the index problem for a wide class of nonlocal elliptic operators on a smooth closed manifold, namely differential operators with shifts induced by the action of an isometric diffeomorphism. The key to the solution is the method of uniformization: We assign to the nonlocal problem a pseudodifferential operator with the same index, acting in sections of an infinite-dimensional vector bundle on a compact manifold. We then determine the index in terms of topological invariants of the symbol, using the Atiyah-Singer index theorem.Comment: 16 pages, no figure

Homology and K--Theory Methods for Classes of Branes Wrapping Nontrivial Cycles

We apply some methods of homology and K-theory to special classes of branes wrapping homologically nontrivial cycles. We treat the classification of four-geometries in terms of compact stabilizers (by analogy with Thurston's classification of three-geometries) and derive the K-amenability of Lie groups associated with locally symmetric spaces listed in this case. More complicated examples of T-duality and topology change from fluxes are also considered. We analyse D-branes and fluxes in type II string theory on ${\mathbb C}P^3\times \Sigma_g \times {\mathbb T}^2$ with torsion $H-$flux and demonstrate in details the conjectured T-duality to ${\mathbb R}P^7\times X^3$ with no flux. In the simple case of $X^3 = {\mathbb T}^3$, T-dualizing the circles reduces to duality between ${\mathbb C}P^3\times {\mathbb T}^2 \times {\mathbb T}^2$ with $H-$flux and ${\mathbb R}P^7\times {\mathbb T}^3$ with no flux.Comment: 27 pages, tex file, no figure

Fluxes, Brane Charges and Chern Morphisms of Hyperbolic Geometry

The purpose of this paper is to provide the reader with a collection of results which can be found in the mathematical literature and to apply them to hyperbolic spaces that may have a role in physical theories. Specifically we apply K-theory methods for the calculation of brane charges and RR-fields on hyperbolic spaces (and orbifolds thereof). It is known that by tensoring K-groups with the rationals, K-theory can be mapped to rational cohomology by means of the Chern character isomorphisms. The Chern character allows one to relate the analytic Dirac index with a topological index, which can be expressed in terms of cohomological characteristic classes. We obtain explicit formulas for Chern character, spectral invariants, and the index of a twisted Dirac operator associated with real hyperbolic spaces. Some notes for a bivariant version of topological K-theory (KK-theory) with its connection to the index of the twisted Dirac operator and twisted cohomology of hyperbolic spaces are given. Finally we concentrate on lower K-groups useful for description of torsion charges.Comment: 26 pages, no figures, LATEX. To appear in the Classical and Quantum Gravit

Some Remarks on Group Bundles and C*-dynamical systems

We introduce the notion of fibred action of a group bundle on a C(X)-algebra. By using such a notion, a characterization in terms of induced C*-bundles is given for C*-dynamical systems such that the relative commutant of the fixed-point algebra is minimal (i.e., it is generated by the centre of the given C*-algebra and the centre of the fixed-point algebra). A class of examples in the setting of the Cuntz algebra is given, and connections with superselection structures with nontrivial centre are discussed.Comment: 22 pages; to appear on Comm. Math. Phy