Celiac Disease and Migraine Headaches: Current Knowledge and Future Directions

Background: Migraine headaches and celiac disease are widespread problems affecting millions of patients worldwide.  Celiac disease is an autoimmune disease in which the consumption of gluten leads to the development of an abnormal immune response in the intestines and the atrophy of intestinal villi. The most characteristic clinical symptoms of celiac disease are gastrointestinal symptoms. Nevertheless, manifestations of the nervous system, including migraines, are also sometimes noted. A gluten-free diet is the only effective therapeutic approach for patients with celiac disease. It reduces symptoms and halts the progression of the disease. Neurological symptoms, including migraines, are frequent extraintestinal manifestations. In this study we aim to elaborate on current knowledge concerning both coexisting of migraines and celiac disease as well as effect of gluten free diet on headaches in patients with celiac disease, gluten intolerance and healthy individuals   Results: Headaches, especially migraines, are more common in patients suffering from celiac disease. Numerous studies indicate that a gluten-free diet may help in the treatment of headaches and is also an effective way to stop the progression of celiac disease. Conclusion: Migraine headaches are quite common in patients with celiac disease, and a gluten-free diet may help alleviate them. The findings suggest the need for increased awareness of the co-occurrence of these two conditions. A gluten-free diet is the only effective treatment for celiac disease and can stop progression of the disease. Further research is needed to determine the potential benefits of such a diet in patients with gluten intolerance or healthy individuals

Laboratory tests in geriatric patients - an overview of the latest reports

Laboratory tests are extremely important in patient’s monitoring and/or diagnosing. We described those that are particularly significant for elderly patients, namely: peripheral blood morphology, arterial blood gasometry, cancer markers. The aim of this article is to summarize current knowledge about laboratory tests important in geriatrics, as well as draw attention to the diverse use of laboratory tests in clinical practise

Comprehensive Insights into Neuropsychiatric Systemic Lupus Erythematosus

Introduction: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease, often affecting women of childbearing age, with periods of exacerbations and remissions. SLE can impact multiple organs, causing a range of clinical symptoms. Neuropsychiatric systemic lupus erythematosus (NPSLE) includes symptoms like headaches, seizures, anxiety disorders, cognitive dysfunctions, psychosis, and neuropathies. Its diagnosis is challenging, and treatment is complex. Purpose: This study aims to explain the pathophysiology of NPSLE, describe diagnostic methods, and summarize current treatment methods based on recent research. Methods: Databases such as PubMed, Medline, and ResearchGate were used. State of current knowledge: Early and accurate diagnosis of SLE is crucial for optimal patient management. The 2019 EULAR/ACR classification criteria have improved diagnostic precision with a weighted scoring system for diverse disease manifestations. Therapy of neuropsychiatric lupus focuses on symptom control and causal treatment, considering anti-inflammatory action or counteracting ischemic incidents. It involves immunosuppressive agents and antiplatelet or anticoagulant substances. Non-pharmacological interventions and lifestyle modifications are also important. The dynamic criteria reflect ongoing advancements in understanding SLE, emphasizing continuous research and collaboration. Conclusions: The diagnosis of NPSLE requires excluding other causes of neuropsychiatric symptoms, such as infections, endocrine disorders, or drug reactions. Diagnostic methods vary based on symptoms, including lumbar puncture, CSF analysis, EEG, cognitive function assessment, and MRI. The treatment of NPSLE focuses on symptom control and causal treatment, with therapy individualized based on symptom severity and patient burden

The effect of multiple nutritional factors on hypothyroidism - a systemic review

Objective: The study aims to investigate the impact of various supplements, namely selenium, vitamin D, zinc, magnesium, vitamin A, iodine, L-carnitine, and proteolytic enzymes, on the management of hypothyroidism, with a particular focus on Hashimoto’s thyroiditis. Materials and Methods: The PubMed database was searched using the keywords „Hashimoto,” „hypothyroidism,” „sport,” „physical activity,” and „diet.” Results: Several studies show that supplements can help manage hypothyroidism. Vitamin D lowers TSH levels, with varying effects on thyroid hormones. Selenium reduces TPOAb, TGAb, and TSH levels, and boosts antioxidant activity, indicating potential immune benefits. Zinc is crucial for thyroid hormone synthesis, with supplementation improving fT3 levels. Magnesium and vitamin A together enhance thyroid function and reduce inflammation. Adequate iodine intake supports thyroid function, while both deficiency and excess can cause thyroid issues. L-carnitine reduces fatigue by enhancing energy metabolism, and proteolytic enzymes have anti-inflammatory effects, aiding autoimmune thyroid disease management. Conclusions: The study highlights the potential benefits of supplementing mentioned nutrients in managing hypothyroidism by improving thyroid function, reducing inflammation, and better overall health in hypothyroid patients. Further large-scale, long-term studies are required to confirm these findings and determine optimal dosages and combinations for better effectiveness

The protection of plant biodiversity in Lodz Province

The aim of the work was to review the information concerning the biological diversity of flora in the Lodz Province. The appearance of danger in ecosystems homeostasis were described. Part of the work focus on the various forms of the biodiversity plants protection in the Province well as advantages of the biological sustainability of biocenosis.W pracy zostały zebrane i uporządkowane informacje dotyczące biologicznej różnorodności świata roślinnego na terenie województwa łódzkiego. Część pracy poświęcono na omówienie zagrożeń równowagi ekosystemów występujących na terenie regionu. Szczegółowo przedstawione zostały formy ochrony bioróżnorodności roślin województwa jak również korzyści płynące z utrzymania równowagi biologicznej biocenoz

Wind Parks in Poland—New Challenges and Perspectives

The wind farm market in Poland evolved very dynamically in the years 2000–2015. Unfortunately, the high public resistance caused the government in 2016 to freeze the development of this industry by introducing a restrictive act, which practically stopped the wind farm industry overnight. The climate aspects, such as reduction of the carbon footprint, which have been considered and widely discussed for several years at the European Union forums, were a chance to change this situation. The new regulations gave hope that the wind energy industry in Poland would soon be unblocked, unfortunately the commitment to coal was still an effective barrier, which is clearly visible in the presented study. The Russian aggression against Ukraine, which resulted in a blockade of hydrocarbon imports, has completely changed the center of gravity of the Polish energy and heating economy. The article focuses on the accelerated changes in the renewable energy sources (RESs) and the related legislation, especially emphasizing the prospect of building offshore wind farms. The huge European energy crisis means that new solutions, both legislative and technological, which will allow to quickly switch to green energy, must appear in Poland immediately. The direct conversion of green energy from RES farms into thermal energy in the planned investment in heat energy plants is discussed. This article also presents a broad view of new opportunities as well as the challenges and prospects that have recently arisen in the wind energy industry in Poland

Planning sales income on the example of companies with publishing industry

<p>This report presents an analysis of the financial situation of the company, sales forecast and prognostic balance for next year.</p

Ablacja w leczeniu migotania przedsionków. Jak prowadzić pacjenta w praktyce lekarza rodzinnego ręka w rękę z elektrofizjologiem?

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Od przybytku głowa jednak boli, czyli opowieść o dodatkowych szlakach przedsionkowo-komorowych

In the article we present the issue of pre-excitation syndromes. We present their classification and the translation of anatomy to the electrocardiographic records from a historical perspective. We describe the pathomechanism of the initiation and persistence of pathognomonic for patients with an accessory pathway atrioventricular tachycardias: orthodromic and antidromic. We present indications and methods of treatment with particular attention on invasive treatment (ablation). This is bec ause the majority of patients have indications for invasive treatment (all patients with an accessory pathway potentially increasing the risk of sudden cardiac death and symptomatic patients). The subject is illustrated by a case report of a 41-year-old patient who underwent electrophysiological study and ablation of an accessory atrioventricular pathway with a short effective refractory period, performed using the CARTO electroanatomical system (without fluoroscopy).    W artykule przybliżono zagadnienie zespołów preekscytacji. Ich klasyfikację i połączenie podłoża anatomicznego z zapisami elektrokardiograficznymi przedstawiono w ujęciu historycznym. Opisano patomechanizm powstawania i utrzymywania się patognomonicznych dla pacjentów z dodatkowym szlakiem częstoskurczów przedsionkowo-komorowych: ortodromowego i antydromowego. Przedstawiono wskazania i metody leczenia ze szczególnym uwzględnieniem leczenia inwazyjnego za pomocą ablacji. Wynika to stąd, że większość pacjentów ma wskazania do leczenia zabiegowego (wszyscy pacjenci z dodatkowym szlakiem potencjalnie zwiększającym ryzyko zatrzymania krążenia i pacjenci objawowi). Całość zilustrowano opisem przypadku 41-letniego pacjenta, u którego wykonano badanie elektrofizjologiczne i ablację dodatkowego szlaku przedsionkowo-komorowego o krótkim okresie refrakcji, przy użyciu systemu elektroanatomicznego CARTO

Fractionated Seminal Plasma of Boar Ejaculates Analyzed by LC–MS/MS: Its Effects on Post-Thaw Semen Quality

This study aimed to characterize the protein composition of fractionated seminal plasma (SP) by liquid chromatography mass spectrometry (LC–MS/MS) analysis and investigate its effects on survival of frozen-thaw (FT) boar spermatozoa following storage. Seminal plasma (SP) was fractionated by gel filtration chromatography to give two fractions, SP1 with more than 40 kDa (&gt;40 kDa) and SP2 with less than 40 kDa (&lt;40 kDa). SP1 and SP2 were subjected to LC–MS/MS and bioinformatics analysis. Following cryopreservation, FT boar semen (n = 7) was thawed in Beltsville Thawing Solution (BTS), BTS + SP1 or BTS + SP2, stored at different periods and subjected to post-thaw (PT) quality assessment. A total of 52 and 22 abundant proteins were detected in SP1 and SP2, respectively. FN1, ANGPTL1, and KIF15 proteins were more abundance in SP1, whereas a high abundance of spermadhesins (PSP-I and PSP-II) was detected in SP2. Proteins of the fractionated SP were involved in various biological processes, such as cell motility and signal transduction. The dominant pathway of SP1 proteins was the apelin signaling pathway (GNA13, MEF2D, SPHK2, and MEF2C), whereas a pathway related to lysosome (CTSH, CTSB, and NPC2) was mainly represented by SP2 proteins. In most of the boars, significantly higher motility characteristics, membrane integrity, and viability were observed in FT spermatozoa exposed to SP1 or SP2 compared with BTS. The results of our study confirm that a combination of several proteins from the fractionated SP exerted beneficial effects on the sperm membrane, resulting in improved quality characteristics following PT storage