Managing strategies for organochlorine contaminated soils for a safe food production

Background: Organochlorine pesticides such as dieldrin, DDT and others are highly persistant pesticides, which were applied world wide against pests in horticulture, fruit and arable crops. Although they are forbidden since more than thirty years in the European Union (EU), the compounds remain still in soil. Several crops are known to accumulate these pesticides in eatable parts up to critical levels. For instance dieldrin is detected in high economic value crops such as cucumbers (Cucurbitaceae) and in tomatoes (Solanaceae). Besides plant type and climatic conditions, soil properties, e.g. pH and soil organic carbon content influence the pesticide uptake. In particular in labelled food and feed stuff production, such as organic farming according to EU Regulation (EEC) No. 2092/91, consumer expectations in safe, high quality food are extremely high. Since organic farming is prospering – more than 10% of vegetable production is certified organic in Switzerland – the organochlorine residues in organic food stuff have become a major issue for food control authorities. Enquires showed that imported food from EU countries was partly highly contaminated with organochlorine pesticides such as pumpkin seed and oil. Hence, the organochlorine problem in food stuff is expected to occur EU wide

Low-Level Lead Exposure and Intellectual Impairment in Children: Koller et al. Respond

Low-Level Lead Exposure and Intellectual Impairment in Children: Koller et al. Respon

A Comparison of Radio and X-Ray Morphologies of Four Clusters of Galaxies Containing Radio Halos

Clusters of galaxies may contain cluster-wide, centrally located, diffuse radio sources, called halos. They have been found to show morphologies similar to those of the X-ray emission. To quantify this qualitative statement we performed a point-to-point comparison of the radio and the X-ray emission for four clusters of galaxies containing radio halos: Coma, Abell 2255, Abell 2319, Abell 2744. Our study leads to a linear relation between the radio and the X-ray surface brightness in two clusters, namely Abell 2255 and Abell 2744. In Coma and A2319 the radio and the X-ray brightnesses seem to be related with a sub-linear power law. Implications of these findings within simple radio halo formation models are briefly discussed.Comment: 9 pages, 13 .ps figures, accepted by A&

Herausforderungen an der Schnittstelle Schule - Beruf: Beiträge zur Fachtagung "Wege ebnen an der Schnittstelle Schule - Beruf. Wie gelingt ein erfolgreicher Übergang?" vom 18. September 2013 in Wien

Aus dem Vorwort: "... Ziel dieser Veranstaltung, die am 18. September 2013 in der Zentrale der OeAD GmbH in Wien stattfand, war es, Stärken und Schwächen im Übergangsmanagement in Österreich auszuloten und bisherige gute Ansätze (Good Practices) in diesem Kontext aufzuzeigen. Die Veranstaltung gab zahlreichen PraktikerInnen, WissenschafterInnen und Verantwortlichen aus der bildungs- wie arbeitsmarktpolitischen Praxis die Möglichkeit, den Diskurs zu diesem Thema fortzuführen, neue Beiträge zu liefern und politischen Verbesserungsbedarf zu formulieren. Der vorliegend AMS report enthält die erweiterten Versionen ausgewählter Vorträge, die anlässlich dieser Tagung gehalten wurden. Die Veranstalter der Tagung, die OeAD GmbH - Nationalagentur Lebenslanges Lernen, die Abt. Arbeitsmarktforschung und Berufsinformation des AMS Österreich sowie das sozialwissenschaftliche Forschungsinstitut abif - Analyse, Beratung und interdisziplinäre Forschung bedanken sich bei allen TeilnehmerInnen dieser rege besuchten Veranstaltung und wünschen allen LeserInnen dieses AMS reports eine aufschlussreiche und interessante Lektüre. ...

A Balanced Risk–Benefit Analysis to Determine Human Risks Associated with Pyrrolizidine Alkaloids (PA)—The Case of Tea and Herbal Infusions

Humans are exposed to pyrrolizidine alkaloids (PA) through different sources, mainly from contaminated foodstuff. Teas and herbal infusions (T&HI) can be contaminated by PA producing weed. PA can possess toxic, mutagenic, genotoxic, and carcinogenic properties. Thus, possible health risks for the general population are under debate. There is a strong safety record for T&HI and additionally epidemiological evidence for the preventive effects of regular tea consumption on cardiovascular events and certain types of cancer. There is no epidemiological evidence, however, for human risks of regular low dose PA exposure. Recommended regulatory PA-threshold values are based on experimental data only, accepting big uncertainties. If a general risk exists through PA contaminated T&HI, it must be small compared to other frequently accepted risks of daily living and the proven health effects of T&HI. Decision making should be based on a balanced riskbenefit analysis. Based on analyses of the scientific data currently available, it is concluded that the benefits of drinking T&HI clearly outweigh the negligible health risk of possible PA contamination. At the same time, manufacturers must continue their efforts to secure good product quality and to be transparent on their measures of quality control and risk communication

A Balanced Risk-Benefit Analysis to Determine Human Risks Associated with Pyrrolizidine Alkaloids (PA)-The Case of Herbal Medicinal Products Containing St. John's Wort Extracts (SJW)

Objectives: Pyrrolizidine alkaloids (PA) exist ubiquitously in our environment. More than 6000 plants, about 3% of the world's flowering plants, are known to synthesize PA. As a consequence, many herbal ingredients, including St. John's wort (SJW), are contaminated with PA that can possess acute and subchronic toxic effects as well as mutagenic and genotoxic properties. Therefore, the possible benefits of SJW as an herbal remedy against depression need to be weighed against the possible risks of unwanted PA intake. Methods: We searched the literature regarding the current knowledge on PA and evaluated the evidence on the antidepressant effects of quantified SJW extract based on a Cochrane Review and the current practice guidelines on depression. Risks are depicted in form of a risk ladder and benefits in form of an icon array. Results: Evidence from clinical studies indicates that quantified SJW extract is an effective treatment option for mild to moderate depression with fewer side effects than conventional antidepressants. Health statistics from different countries do not quantify cases of death caused by PA intake. However, deaths due to suicide, often triggered by depression, are common (11 in 1000 in Germany in 2015) and rank between fatalities due to liver diseases (16 in 1000) and household accidents (10 in 1000). Conclusions: Quantified SJW extract is a safe and effective treatment option, and its potential of treating depression outweighs the (hypothetical) risk of unwanted PA intake

Recent Developments in Low-Level Lead Exposure and Intellectual Impairment in Children

In the last decade children’s blood lead levels have fallen significantly in a number of countries, and current mean levels in developed countries are in the region of 3 μg/dL. Despite this reduction, childhood lead poisoning continues to be a major public health problem for certain at-risk groups of children, and concerns remain over the effects of lead on intellectual development in infants and children. The evidence for lowered cognitive ability in children exposed to lead has come largely from prospective epidemiologic studies. The current World Health Organization/Centers for Disease Control and Prevention blood level of concern reflects this and stands at 10 μg/dL. However, a recent study on a cohort of children whose lifetime peak blood levels were consistently < 10 μg/dL has extended the association of blood lead and intellectual impairment to lower levels of lead exposure and suggests there is no safety margin at existing exposures. Because of the importance of this finding, we reviewed this study in detail along with other recent developments in the field of low-level lead exposure and children’s cognitive development. We conclude that these findings are important scientifically, and efforts should continue to reduce childhood exposure. However, from a public health perspective, exposure to lead should be seen within the many other risk factors impacting on normal childhood development, in particular the influence of the learning environment itself. Current lead exposure accounts for a very small amount of variance in cognitive ability (1–4%), whereas social and parenting factors account for 40% or more

Role of psychiatric hospitals during a pandemic: introducing the Munich Psychiatric COVID-19 Pandemic Contingency Plan

BACKGROUND Psychiatry is facing major challenges during the current coronavirus disease 2019 (COVID)-19 pandemic. These challenges involve its actual and perceived role within the medical system, in particular how psychiatric hospitals can maintain their core mission of attending to people with mental illness while at the same time providing relief to overstretched general medicine services. Although psychiatric disorders comprise the leading cause of the global burden of disease, mental healthcare has been deemphasised in the wake of the onslaught of the pandemic: to make room for emergency care, psychiatric wards have been downsized, clinics closed, psychiatric support systems discontinued and so on. To deal with this pressing issue, we developed a pandemic contingency plan with the aim to contain, decelerate and, preferably, avoid transmission of COVID-19 and to enable and maintain medical healthcare for patients with mental disorders. AIMS To describe our plan as an example of how a psychiatric hospital can share in providing acute care in a healthcare system facing an acute and highly infectious pandemic like COVID-19 and at the same time provide support for people with mental illness, with or without a COVID-19 infection. METHOD This was a descriptive study. RESULTS The plan was based on the German national pandemic strategy and several legal recommendations and was implemented step by step on the basis of the local COVID-19 situation. In addition, mid- and long-term plans were developed for coping with the aftermath of the pandemic. CONCLUSIONS The plan enabled the University Hospital to maintain medical healthcare for patients with mental disorders. It has offered the necessary flexibility to adapt its implementation to the first and second waves of the COVID-19 pandemic in Germany. The plan is designed to serve as an easily adaptable blueprint for psychiatric hospitals around the world

Essential role of CCL21 in establishment of central self-tolerance in T cells.

The chemokine receptor CCR7 directs T cell relocation into and within lymphoid organs, including the migration of developing thymocytes into the thymic medulla. However, how three functional CCR7 ligands in mouse, CCL19, CCL21Ser, and CCL21Leu, divide their roles in immune organs is unclear. By producing mice specifically deficient in CCL21Ser, we show that CCL21Ser is essential for the accumulation of positively selected thymocytes in the thymic medulla. CCL21Ser-deficient mice were impaired in the medullary deletion of self-reactive thymocytes and developed autoimmune dacryoadenitis. T cell accumulation in the lymph nodes was also defective. These results indicate a nonredundant role of CCL21Ser in the establishment of self-tolerance in T cells in the thymic medulla, and reveal a functional inequality among CCR7 ligands in vivo