Liquidity matters: Evidence from the Russian interbank market

We suggest an additional transmission channel of contagion on the interbank market - the liquidity channel. Examining the Russian banking sector, we and that the liquidity channel contributes significantly to understanding and predicting interbank market crises. Interbank market stability Granger causes the interbank market structure, while the opposite causality is rejected. This bolsters the view that the interbank market structure is endogenous. The results corroborate the thesis that prudential regulation at the individual bank level is insufficient to prevent systemic crises. We demonstrate that liquidity injections of a classical lender of last resort can effectively mitigate coordination failures on the interbank market both in theory and practice. Apparently, liquidity does matter.interbank market stability; contagion; liquidity channel; lender of last resort; Russia

Renormalization group analysis of generalized Coulomb systems in two dimensions

We present a renormalization group analysis of a two dimensional Coulomb gas with internal degrees of freedom. The specific model considered has a global O(3) internal symmetry. The behavior of this system in the low temperature region is found to differ appreciably from that of the XY model. © 1981

SISTEM INFORMASI PEGADAIAN DI FIJI FILE COM MENGGUNAKAN AJAX INFORMATION SYSTEMS IN PEGADAIAN FIJI FILE COM USING AJAX

Penggunaan teknologi computer dewasa ini berkembang sangat pesat dan menjadikan segala hal yang terlihat jauh menjadi begitu dekat, termasuk pada bidang pegadaian. Sistem informasi pegadaian di Fiji File Com ini merupakan sebuah aplikasi yang terdiri dari tiga pengguna yaitu nasabah, admin dan manager. Untuk membantu pembuatan sistem ini menggunakan pemrograman PHP dan ajax. Sedangkan pengembangan databasenya menggunakan Mysql. Perancangan sistem ini menggunakan beberapa diagram seperti: Relasi table, Flowchart, Diagram Konteks, Diagram 0. Dengan adanya sistem informasi pegadaian ini diharapkan mampu membantu administrator dalam melayani pelanggan atau nasabah dalam proses pegadaian barang. Kata kunci: Ajax, Pegadaian, Sistem Informasi

Trust in hybrid human‐automated decision‐support

Research has examined trust in humans and trust in automated decision support. Although reflecting a likely realization of decision support in high‐risk tasks such as personnel selection, trust in hybrid human‐automation teams has thus far received limited attention. In two experiments (N1 = 170, N2 = 154) we compare trust, trustworthiness, and trusting behavior for different types of decision‐support (automated, human, hybrid) across two assessment contexts (personnel selection, bonus payments). We additionally examined a possible trust violation by presenting one group of participants a preselection that included predominantly male candidates, thus reflecting possible unfair bias. Whereas fully‐automated decisions were trusted less, results suggest that trust in hybrid decision support was similar to trust in human‐only support. Trust violations were not perceived differently based on the type of support. We discuss theoretical (e.g., trust in hybrid support) and practical implications (e.g., keeping humans in the loop to prevent negative reactions)

Keanekaragaman Amphibi Di Areal Persawahan Kota Tondano Kabupaten Minahasa Provinsi Sulawesi Utara

Persawahan merupakan habitat yang baik bagi kehidupan amphibi. Amphibi memiliki fungsi ekologis sebagai penyeimbang ekosistem dan sebagai bioindikator lingkungan. Penilitian ini bertujuan untuk menganalisis keanekaragaman amphibi di areal persawahan Boleuvard Kota Tondano berdasarkan nilai indeks Shannon-Wiener. Penelitian ini menggunakan metode Line Transect yang dilaksanakan pada bulan Januari-Desember 2018. Nilai indeks keanekaragaman Shannon-Wiener pada transek satu H’ 0,782, transek dua H’1,208 dan transek tiga H’ 1,139. Berdasarkanhasilpenelitianterdapat lima  spesies yang ditemukanya itu Bufo melanostictus, Rana cancrifora, Rana chalconota, Fejevarya limnocharis, dan Hylarana nicobariensis. Berdasarkan kategori indeks Shannon-wiener keanekaragaman amphibi di areal persawahan Tondano termasuk dalam kategori sedangRice fields are good habitat for amphibian life. Amphibians have an ecological function as a counterweight to ecosystems and as an environmental bioindicator. This research tries to analyze the amphibians in the Boleuvard rice field area of Tondano City based on the Shannon-Wiener index value. This study uses the Path Transect method which was carried out in January - December 2018. The index value of the Shannon-Wiener contribution to habitatone H '0,782, habitat two H'1,208 and habitat three H' 1,139. Based on the results of the study found five species found, namely Bufo melanostictus, Rana cancrifora, Rana chalconota, Fejevarya limnocharis, and Hylarana nicobariensis. Based on the Shannon-wiener index category the various amphibians in the Tondano rice field area are included in the medium categor

A human ALDH1A2 gene variant is associated with increased newborn kidney size and serum retinoic acid

Nephron number varies widely between 0.3 and 1.3 million per kidney in humans. During fetal life, the rate of nephrogenesis is influenced by local retinoic acid (RA) level such that even moderate maternal vitamin A deficiency limits the final nephron number in rodents. Inactivation of genes in the RA pathway causes renal agenesis in mice; however, the impact of retinoids on human kidney development is unknown. To resolve this, we tested for associations between variants of genes involved in RA metabolism (ALDH1A2, CYP26A1, and CYP26B1) and kidney size among normal newborns. Homozygosity for a common (1 in 5) variant, rs7169289(G), within an Sp1 transcription factor motif of the ALDH1A2 gene, showed a significant 22% increase in newborn kidney volume when adjusted for body surface area. Infants bearing this allele had higher umbilical cord blood RA levels compared to those with homozygous wild-type ALDH1A2 rs7169289(A) alleles. Furthermore, the effect of the rs7169289(G) variant was evident in subgroups with or without a previously reported hypomorphic RET 1476(A) proto-oncogene allele that is critical in determining final nephron number. As maternal vitamin A deficiency is widespread in developing countries and may compromise availability of retinol for fetal RA synthesis, our study suggests that the ALDH1A2 rs7169289(G) variant might be protective for such individuals

Human Parechovirus Infections in Canada

These infections are associated with a variety of clinical syndromes, in part related to specific serotype

Genetic Analysis of 10 Unrelated Korean Families with p22-phox-deficient Chronic Granulomatous Disease: An Unusually Identical Mutation of the CYBA Gene on Jeju Island, Korea

Chronic granulomatous disease (CGD) is a rare hereditary disorder characterized by recurrent life-threatening bacterial and fungal infections. The underlying defect in CGD is an inability of phagocytes to produce reactive oxygen species as a result of defects in NADPH oxidase. Considering that CGD generally affects about 3-4 in 1,000,000 individuals, it is surprising that the prevalence of CGD on Jeju Island is 20.7 in 1,000,000 individuals. We performed genetic analysis on 12 patients from 10 unrelated families and found that all patients had an identical homozygous single-base substitution of C to T in exon 1 (c.7C>T) of the CYBA gene, which was expected to result in a nonsense mutation (p.Q3X). Because Jeju Island has long been a geologically isolated region, the high prevalence of CGD on Jeju Island is presumably associated with an identical mutation inherited from a common ancestor or proband

Evaluation of High Resolution Melting analysis as an alternate tool to screen for risk alleles associated with small kidneys in Indian newborns

<p>Abstract</p> <p>Background</p> <p>Single nucleotide polymorphisms (SNPs) are the most common forms of sequence variations in the human genome. They contribute to the human phenotypic spectrum and are associated with variations in response to pathogens, drugs and vaccines. Recently, SNPs in three human genes involved in kidney development (<it>RET</it>, <it>PAX2 </it>and <it>ALDH1A2</it>) have been reported to be associated with variation in renal size and function. These known SNPs could potentially be used in the clinic as markers for identifying babies who may have smaller kidneys and permit close follow up for early detection of hypertension and acquired renal dysfunction. The aim of this study was to evaluate the use of High Resolution Melting technique (HRM) as a tool for detecting the known SNPs in these three genes in comparison to sequencing which is the gold standard.</p> <p>Methods</p> <p>High resolution melting analysis was performed on 75 DNA samples that were previously sequenced for the known polymorphisms in <it>RET </it>(rs1800860), <it>PAX2 </it>(rs11190688) and <it>ALDH1A2 </it>(rs7169289) genes. The SNPs were G > A transitions in <it>RET </it>and <it>PAX2 </it>and A > G in <it>ALDH1A2 </it>gene. A blinded assessment was performed on these samples for evaluation of the HRM technique as compared to sequencing.</p> <p>Results</p> <p>Each variant had a unique melt curve profile that was reproducible. The shift in melting temperature (Tm) allowed visual discrimination between the homozygous alleles (major and minor) in all three genes. The shape of the melting curve as compared to the major allele homozygous curve allowed the identification of the heterozygotes in each of the three SNPs. For validation, HRM was performed on 25 samples for each of the three SNPs. The results were compared with the sequencing results and 100% correct identification of the samples was obtained for <it>RET</it>, <it>PAX2</it>, and <it>ALDA1H2 </it>gene.</p> <p>Conclusion</p> <p>High Resolution Melting analysis is a simple, rapid and cost effective technique that could be used in a large population to identify babies with the risk alleles. These high risk children could be followed up for early detection of hypertension and acquired renal dysfunction.</p