21 research outputs found
Association between IgM Anti-Herpes Simplex Virus and Plasma Amyloid-Beta Levels
OBJECTIVE: Herpes simplex virus (HSV) reactivation has been identified as a possible risk factor for Alzheimer's disease (AD) and plasma amyloid-beta (Aβ) levels might be considered as possible biomarkers of the risk of AD. The aim of our study was to investigate the association between anti-HSV antibodies and plasma Aβ levels. METHODS: The study sample consisted of 1222 subjects (73.9 y in mean) from the Three-City cohort. IgM and IgG anti-HSV antibodies were quantified using an ELISA kit, and plasma levels of Aβ(1-40) and Aβ(1-42) were measured using an xMAP-based assay technology. Cross-sectional analyses of the associations between anti-HSV antibodies and plasma Aβ levels were performed by multi-linear regression. RESULTS: After adjustment for study center, age, sex, education, and apolipoprotein E-e4 polymorphism, plasma Aβ(1-42) and Aβ(1-40) levels were specifically inversely associated with anti-HSV IgM levels (β = -20.7, P=0.001 and β = -92.4, P=0.007, respectively). In a sub-sample with information on CLU- and CR1-linked SNPs genotyping (n=754), additional adjustment for CR1 or CLU markers did not modify these associations (adjustment for CR1 rs6656401, β = -25.6, P=0.002 for Aβ(1-42) and β = -132.7, P=0.002 for Aβ(1-40;) adjustment for CLU rs2279590, β = -25.6, P=0.002 for Aβ(1-42) and β = -134.8, P=0.002 for Aβ(1-40)). No association between the plasma Aβ(1-42)-to-Aβ(1-40) ratio and anti-HSV IgM or IgG were evidenced. CONCLUSION: High anti-HSV IgM levels, markers of HSV reactivation, are associated with lower plasma Aβ(1-40) and Aβ(1-42) levels, which suggest a possible involvement of the virus in the alterations of the APP processing and potentially in the pathogenesis of AD in human
Returning Genetic Research Results: Considerations for Existing No-Return and Future Biobanks
For Whose Protection? Reproductive Hazards and Exclusionary Policies in the United States and Britain. By Sally J. Kenney. Ann Arbor: University of Michigan Press, 1993. 375p. 18.95 paper.
Human Reproduction, Emerging Technologies, and Conflicting Rights. Robert H. Blank and Janna C. Merrick Washington, DC:Congressional Quarterly Press,1995, 269 pp. US$21.95 cloth. ISBN 0-87187-938-7. Congressional Quarterly Press, 1414 22nd St. NW, Washington, DC 20037, USA.
From Chance to Choice: Genetics and Justice - Allen Buchanan, Dan W. Brock, Norman Daniels, and Daniel Wikler New York, NY: Cambridge University Press, 2000, 412 pp. US $29.95 cloth. ISBN 0521660017. Cambridge University Press, 40 W. 20th St., New York, NY 10011-4211, USA.
IRB practices and policies regarding the secondary research use of biospecimens Ethics in Biomedical Research
10.1186/s12910-015-0020-1BMC Medical Ethics16