575 research outputs found
Shaping the future for primary care education and training project. Best practise in education and training strategies for integrated health and social care: a benchmarking tool
This tool has been designed to encourage the systematic evaluation of current services offered in your organisation in relation to education and training. The aim of the
benchmarking process is to enable your organisation to judge its ability in six domains: team working, communication, role awareness, personal and professional development, practice development and leadership and team working. Associated with each domain are a set of key questions you should ask about your services in relation to evidencebased ‘best practice’. ‘Best’ practice has been identified and summarised through a systematic review of the literature and through consultation with services users and professionals
Shaping the future for primary care education and training project. Best practise in education and training strategies for integrated health and social care: development of a benchmarking tool
Collaboration and partnership working between Higher Education and the NHS is an essential requirement for
effective delivery of care (Universities UK 2003). The North West Universities Association (NWUA) and the North
West Development Agency (NWDA) are two organisations at the forefront of creating such alliances. The
research project, Shaping the Future for Primary Care Education and Training Project is a collaborative
partnership between both these organisations and seven North West Higher Education Institutions. In addition,
the project brings together for the first time all the key partners in the health, social care and education sectors
who are involved in supporting the delivery of integrated health and social care in the North West Region
New frontiers in QLR: definition, design and display
Research that is attentive to temporal processes and durational phenomena is an important tradition within the social sciences internationally with distinct disciplinary trajectories. Qualitative longitudinal research emerged as a distinct methodological paradigm around the turn of the millennium, named within the UK through journal special issues, literature reviews and funding commitments. In 2012-3 the ESRC National Centre for Research Methods funded a network for methodological innovation to map ’New frontiers of QLR’, bringing together a group of scholars who have been actively involved in establishing QLR as a methodological field. The network provided an opportunity to consolidate the learning that has developed in QLR over a sustained period of investment and to engage critically with what QLR might mean in new times. This paper documents the series of discussions staged by the network involving the definition of QLR, the kinds of relationships and practices it involves and the consequences of these in a changing landscape for social research. The series was deliberately interdisciplinary ensuring that we engaged with the temporal perspectives and norms of different academic and practice traditions and this has both enriched and complicated the picture that has emerged from our deliberations. In this paper we argue that QLR is a methodological paradigm that by definition moves with the times, and is an ongoing site of innovation and experiment. Key issues identified for future development in QLR include: intervening in debates of ‘big data’ with visions of deep data that involve following and connecting cases over time; the potential of longitudinal approaches to reframe the ‘sample’ exploring new ways of connecting the particular and the general; new thinking about research ethics that move us beyond anonymity to better explore the meanings of confidentiality and the co-production of research knowledge; and finally the promotion of a QLR sensibility that involves a heightened awareness of the here and now in the making of knowledge, yet which also connects research biographically over a career, enriched by a reflexive understanding of time as a resource in the making of meaning
Learning Style Diversity in Post –Secondary Distance Education
During the fall semester of 2005, 153 university graduate students’ preferred learning styles were measured with the Kolb Learning Style Inventory, online version 3.1. The primary findings of the study indicated all of the learning styles and processes described by Kolb were represented in the distance learning population and suggested distance and residential learners uniquely engage the learning process. Biblical references were discussed with respect to the uniqueness displayed by study participants
DNA methylation and socioeconomic status in a Mexican-American birth cohort.
Background: Maternal social environmental stressors during pregnancy are associated with adverse birth and child developmental outcomes, and epigenetics has been proposed as a possible mechanism for such relationships. Methods: In a Mexican-American birth cohort of 241 maternal-infant pairs, cord blood samples were measured for repeat element DNA methylation (LINE-1 and Alu). Linear mixed effects regression was used to model associations between indicators of the social environment (low household income and education, neighborhood-level characteristics) and repeat element methylation. Results from a dietary questionnaire were also used to assess the interaction between maternal diet quality and the social environment on markers of repeat element DNA methylation. Results: After adjusting for confounders, living in the most impoverished neighborhoods was associated with higher cord blood LINE-1 methylation (β = 0.78, 95%CI 0.06, 1.50, p = 0.03). No other neighborhood-, household-, or individual-level socioeconomic indicators were significantly associated with repeat element methylation. We observed a statistical trend showing that positive association between neighborhood poverty and LINE-1 methylation was strongest in cord blood of infants whose mothers reported better diet quality during pregnancy (pinteraction = 0.12). Conclusion: Our findings indicate a small yet unexpected positive association between neighborhood-level poverty during pregnancy and methylation of repetitive element DNA in infant cord blood and that this association is possibly modified by diet quality during pregnancy. However, our null findings for other adverse SES indicators do not provide strong evidence for an adverse association between early-life socioeconomic environment and repeat element DNA methylation in infants
Associations of PON1 and genetic ancestry with obesity in early childhood.
Obesity in children has become an epidemic in the U.S. and is particularly prominent in minority populations such as Mexican-Americans. In addition to physical activity and diet, genetics also plays a role in obesity etiology. A few studies in adults and adolescents suggest a link between obesity and paraoxonase 1 (PON1), a multifunctional enzyme that can metabolize organophosphate pesticides and also has antioxidant properties. We determined PON1192 genotype and arylesterase levels (ARYase, measure of PON1 enzyme quantity), to characterize the relationship between PON1 and obesity in young Mexican-American children (n = 373) living in an agricultural community in California. Since PON1 polymorphisms and obesity both vary between ethnic groups, we estimated proportional genetic ancestry using 106 ancestral informative markers (AIMs). Among children, PON1192 allele frequencies were 0.5 for both alleles, and the prevalence of obesity was high (15% and 33% at ages two and five, respectively). The average proportion of European, African, and Native American ancestry was 0.40, 0.09, and 0.51, yet there was wide inter-individual variation. We found a significantly higher odds of obesity (9.3 and 2.5- fold) in PON1192QQ children compared to PON1192RR children at ages two and five, respectively. Similar relationships were seen with BMI Z-scores at age two and waist circumference at age five. After adjusting for genetic ancestry in models of PON1 and BMI Z-score, effect estimates for PON1192 genotype changed 15% and 9% among two and five year old children, respectively, providing evidence of genetic confounding by population stratification. However even after adjustment for genetic ancestry, the trend of increased BMI Z-scores with increased number of PON1192 Q alleles remained. Our findings suggest that PON1 may play a role in obesity independent of genetic ancestry and that studies of PON1 and health outcomes, especially in admixed populations, should account for differences due to population stratification
C3D – an imaging radiation damage experiment on UKUBE-1
The Open University, in collaboration with e2v technologies Ltd and XCAM Ltd, have been selected to fly an experimental payload on board the UK Space Agency's UKube-1 pilot Cubesat programme. Cubesat payloads offer a unique opportunity to rapidly build and fly space hardware for minimal cost, providing easy access to the space environment. The proposed payload incorporated new imaging technology using a CMOS image sensor into a combined Earth Observation (EO) technology demonstrator and in-orbit radiation damage characterisation instrument, to help raise the TRL of the sensor technology. Based around the e2v 1.3 MPixel 0.18 micron process “eye-on-Si” CMOS devices, the instrument consists of 3 distinct image sensors; one devoted to radiation damage monitoring (RDM), as well as a narrow field imager (NFI) and a wide field imager (WFI). The narrow and wide field imagers are expected to achieve resolutions of 25 m and 350 m respectively from a 650 km orbit, providing sufficient swathe widths of 30 and 450 km respectively. The radiation damage experiment has been designed to verify and reinforce ground based testing that has been conducted on the e2v eye-on-Si family of devices and includes a TEC for temperature control as well as RADFETs for in-orbit dosimetry. Of particular interest are Single Event Effects (SEEs); Single Event Upset (SEU) and Single Event Latchup (SEL) effects etc. and the experiment contains operating modes to evaluate these during SAA passage. The novel instrument design allows for a wide range of capabilities the within highly constrained mass (170g), power (1W) and space budgets providing a model for future use on similarly constrained missions, such as planetary rovers. Scheduled for launch in June 2014, this project should not only provide valuable data helping to raise the TRL of the technology to prove flight heritage for future missions, but also provide outreach opportunities demonstrating the capabilities of such payloads
Sex differences in DNA methylation assessed by 450 K BeadChip in newborns.
BackgroundDNA methylation is an important epigenetic mark that can potentially link early life exposures to adverse health outcomes later in life. Host factors like sex and age strongly influence biological variation of DNA methylation, but characterization of these relationships is still limited, particularly in young children.MethodsIn a sample of 111 Mexican-American subjects (58 girls , 53 boys), we interrogated DNA methylation differences by sex at birth using the 450 K BeadChip in umbilical cord blood specimens, adjusting for cell composition.ResultsWe observed that ~3% of CpG sites were differentially methylated between girls and boys at birth (FDR P < 0.05). Of those CpGs, 3031 were located on autosomes, and 82.8% of those were hypermethylated in girls compared to boys. Beyond individual CpGs, we found 3604 sex-associated differentially methylated regions (DMRs) where the majority (75.8%) had higher methylation in girls. Using pathway analysis, we found that sex-associated autosomal CpGs were significantly enriched for gene ontology terms related to nervous system development and behavior. Among hits in our study, 35.9% had been previously reported as sex-associated CpG sites in other published human studies. Further, for replicated hits, the direction of the association with methylation was highly concordant (98.5-100%) with previous studies.ConclusionsTo our knowledge, this is the first reported epigenome-wide analysis by sex at birth that examined DMRs and adjusted for confounding by cell composition. We confirmed previously reported trends that methylation profiles are sex-specific even in autosomal genes, and also identified novel sex-associated CpGs in our methylome-wide analysis immediately after birth, a critical yet relatively unstudied developmental window
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Pregnancy lipidomic profiles and DNA methylation in newborns from the CHAMACOS cohort.
Lipids play a role in many biological functions and the newly emerging field of lipidomics aims to characterize the varying classes of lipid molecules present in biological specimens. Animal models have shown associations between maternal dietary supplementation with fatty acids during pregnancy and epigenetic changes in their offspring, demonstrating a mechanism through which prenatal environment can affect outcomes in children; however, data on maternal lipid metabolite levels during pregnancy and newborn DNA methylation in humans are sparse. In this study, we assessed the relationship of maternal lipid metabolites measured in the blood from pregnant women with newborn DNA methylation profiles in the Center for the Health Assessment of Mothers and Children of Salinas cohort. Targeted metabolomics was performed by selected reaction monitoring liquid chromatography and triple quadrupole mass spectrometry to measure 92 metabolites in plasma samples of pregnant women at ∼26 weeks gestation. DNA methylation was assessed using the Infinium HumanMethylation 450K BeadChip adjusting for cord blood cell composition. We uncovered numerous false discovery rate significant associations between maternal metabolite levels, particularly phospholipid and lysolipid metabolites, and newborn methylation. The majority of the observed relationships were negative, suggesting that higher lipid metabolites during pregnancy are associated with lower methylation levels at genes related to fetal development. These results further elucidate the complex relationship between early life exposures, maternal lipid metabolites, and infant epigenetic status
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