Bioactive compounds recovery optimization from vine pruning residues using conventional heating and microwave-assisted extraction methods

Polyphenol compounds from vine pruning residue (VPR) were extracted by conventional heating and microwave-assisted treatments. For each treatment, total phenolic compounds and their antioxidant activity were optimized by experimental design. Maximal extraction of polyphenolic compounds (2.17g/100g VPR) was obtained at 80°C, 120min and 45% of ethanol by conventional heating, and 2.37g/100g of VPR were extracted by microwave-assisted process at 120°C, 5min and 60% of ethanol. Ellagic acid and apigenin were the predominant polyphenolic compounds in the extracts, achieving concentration of 68.65 and 208.23mg/100g VPR, respectively for conventional heating and 185.15 and 118.84mg/100g of VPR for microwave-assisted treatment. The results showed reduction of extraction time and energy consumption for microwave-assisted treatment leading to cost-effective technology for the extraction of polyphenol compounds. Furthermore, the results hereby compiled allow for the tailor-made extraction of specific high-value compounds from a renewable biomass as vine pruning residue.Portuguese Foundation for Science and Technology (FCT) under the scope of the strategic funding of UID/BIO/04469/2019 unitBioTecNorte operation(NORTE-01-0145-FEDER-000004) funded by the European Regional Development Fund under the scope of Norte2020 - Programa Operacional Regional do NorteInternational Cooperation Program CNPq/CSFinfo:eu-repo/semantics/publishedVersio

Exercise intensity and its effects on thyroid hormones

Key words: exercise; thyroid hormone; thyroxin

CARMIL2 Deficiency Presenting as Very Early Onset Inflammatory Bowel Disease

Background: Children with very early onset inflammatory bowel diseases (VEO-IBD) often have a refractory and severe disease course. A significant number of described VEO-IBD-causing monogenic disorders can be attributed to defects in immune-related genes. The diagnosis of the underlying primary immunodeficiency (PID) often has critical implications for the treatment of patients with IBD-like phenotypes

Stilbenoid-Enriched Grape Cane Extracts for the Biocontrol of Grapevine Diseases

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