The ORFEUS II Echelle Spectrum of HD 93521: A reference for interstellar molecular hydrogen

During the second flight of the ORFEUS-SPAS mission in November/December 1996, the Echelle spectrometer was used extensively by the Principal and Guest Investigator teams as one of the two focal plane instruments of the ORFEUS telescope. The spectrum of HD 93521 was obtained during this mission with a total integration time of 1740 s. This spectrum shows numerous sharp interstellar absorption lines. We identified 198 lines of molecular hydrogen including at least 7 lines with a high velocity component. Also most of the 67 identified interstellar metal lines are visible with a high velocity component. We present plots of the complete ORFEUS Echelle spectrum together with tables of all identified interstellar absorption lines including all 14 detectable HI lines. In addition several identified stellar lines, partially with narrow absorption components, and stellar wind lines are given in a separate table.Comment: 18 pages, 33 figure

Antidepressant activity of anti-cytokine treatment: a systematic review and meta-analysis of clinical trials of chronic inflammatory conditions.

Inflammatory cytokines are commonly elevated in acute depression and are associated with resistance to monoaminergic treatment. To examine the potential role of cytokines in the pathogenesis and treatment of depression, we carried out a systematic review and meta-analysis of antidepressant activity of anti-cytokine treatment using clinical trials of chronic inflammatory conditions where depressive symptoms were measured as a secondary outcome. Systematic search of the PubMed, EMBASE, PsycINFO and Cochrane databases, search of reference lists and conference abstracts, followed by study selection process yielded 20 clinical trials. Random effect meta-analysis of seven randomised controlled trials (RCTs) involving 2370 participants showed a significant antidepressant effect of anti-cytokine treatment compared with placebo (standardised mean difference (SMD)=0.40, 95% confidence interval (CI), 0.22-0.59). Anti-tumour necrosis factor drugs were most commonly studied (five RCTs); SMD=0.33 (95% CI; 0.06-0.60). Separate meta-analyses of two RCTs of adjunctive treatment with anti-cytokine therapy and eight non-randomised and/or non-placebo studies yielded similar small-to-medium effect estimates favouring anti-cytokine therapy; SMD=0.19 (95% CI, 0.00-0.37) and 0.51 (95% CI, 0.34-0.67), respectively. Adalimumab, etanercept, infliximab and tocilizumab all showed statistically significant improvements in depressive symptoms. Meta-regression exploring predictors of response found that the antidepressant effect was associated with baseline symptom severity (P=0.018) but not with improvement in primary physical illness, sex, age or study duration. The findings indicate a potentially causal role for cytokines in depression and that cytokine modulators may be novel drugs for depression in chronically inflamed subjects. The field now requires RCTs of cytokine modulators using depression as the primary outcome in subjects with high inflammation who are free of other physical illnesses.Molecular Psychiatry advance online publication, 18 October 2016; doi:10.1038/mp.2016.167

The ORFEUS II Echelle Spectrometer: Instrument description, performance and data reduction

During the second flight of the ORFEUS-SPAS mission in November/December 1996, the Echelle spectrometer was used extensively by the Principal and Guest Investigator teams as one of the two focal plane instruments of the ORFEUS telescope. We present the in-flight performance and the principles of the data reduction for this instrument. The wavelength range is 90 nm to 140 nm, the spectral resolution is significantly better than lambda/(Delta lambda) = 10000, where Delta lambda is measured as FWHM of the instrumental profile. The effective area peaks at 1.3 cm^2 near 110 nm. The background is dominated by straylight from the Echelle grating and is about 15% in an extracted spectrum for spectra with a rather flat continuum. The internal accuracy of the wavelength calibration is better than +/- 0.005 nm.Comment: 8 pages, 8 figure

HIRDES - The High-Resolution Double-Echelle Spectrograph for the World Space Observatory Ultraviolet (WSO/UV)

The World Space Observatory Ultraviolet (WSO/UV) is a multi-national project grown out of the needs of the astronomical community to have future access to the UV range. WSO/UV consists of a single UV telescope with a primary mirror of 1.7m diameter feeding the UV spectrometer and UV imagers. The spectrometer comprises three different spectrographs, two high-resolution echelle spectrographs (the High-Resolution Double-Echelle Spectrograph, HIRDES) and a low-dispersion long-slit instrument. Within HIRDES the 102-310nm spectral band is split to feed two echelle spectrographs covering the UV range 174-310nm and the vacuum-UV range 102-176nm with high spectral resolution (R>50,000). The technical concept is based on the heritage of two previous ORFEUS SPAS missions. The phase-B1 development activities are described in this paper considering performance aspects, design drivers, related trade-offs (mechanical concepts, material selection etc.) and a critical functional and environmental test verification approach. The current state of other WSO/UV scientific instruments (imagers) is also described.Comment: Accepted for publication in Advances in Space Researc

The WSO, a world-class observatory for the ultraviolet

The World Space Observatory is an unconventional space project proceeding via distributed studies. The present design, verified for feasibilty, consists of a 1.7-meter telescope operating at the second Largangian point of the Earth-Sun system. The focal plane instruments consist of three UV spectrometers covering the spectral band from Lyman alpha to the atmospheric cutoff with R~55,000 and offering long-slit capability over the same band with R~1,000. In addition, a number of UV and optical imagers view adjacent fields to that sampled by the spectrometers. Their performance compares well with that of HST/ACS and the spectral capabilities of WSO rival those of HST/COS

The formation of planetary disks and winds: an ultraviolet view

Planetary systems are angular momentum reservoirs generated during star formation. This accretion process produces very powerful engines able to drive the optical jets and the molecular outflows. A fraction of the engine energy is released into heating thus the temperature of the engine ranges from the 3000K of the inner disk material to the 10MK in the areas where magnetic reconnection occurs. There are important unsolved problems concerning the nature of the engine, its evolution and the impact of the engine in the chemical evolution of the inner disk. Of special relevance is the understanding of the shear layer between the stellar photosphere and the disk; this layer controls a significant fraction of the magnetic field building up and the subsequent dissipative processes ougth to be studied in the UV. This contribution focus on describing the connections between 1 Myr old suns and the Sun and the requirements for new UV instrumentation to address their evolution during this period. Two types of observations are shown to be needed: monitoring programmes and high resolution imaging down to, at least, milliarsecond scales.Comment: Accepted for publication in Astrophysics and Space Science 9 figure