875 research outputs found
Deterministic models of quantum fields
Deterministic dynamical models are discussed which can be described in
quantum mechanical terms. -- In particular, a local quantum field theory is
presented which is a supersymmetric classical model. The Hilbert space approach
of Koopman and von Neumann is used to study the classical evolution of an
ensemble of such systems. Its Liouville operator is decomposed into two
contributions, with positive and negative spectrum, respectively. The unstable
negative part is eliminated by a constraint on physical states, which is
invariant under the Hamiltonian flow. Thus, choosing suitable variables, the
classical Liouville equation becomes a functional Schroedinger equation of a
genuine quantum field theory. -- We briefly mention an U(1) gauge theory with
``varying alpha'' or dilaton coupling where a corresponding quantized theory
emerges in the phase space approach. It is energy-parity symmetric and,
therefore, a prototype of a model in which the cosmological constant is
protected by a symmetry.Comment: 6 pages; synopsis of hep-th/0510267, hep-th/0503069, hep-th/0411176 .
Talk at Constrained Dynamics and Quantum Gravity - QG05, Cala Gonone
(Sardinia, Italy), September 12-16, 2005. To appear in the proceeding
Desensitizing Inflation from the Planck Scale
A new mechanism to control Planck-scale corrections to the inflationary eta
parameter is proposed. A common approach to the eta problem is to impose a
shift symmetry on the inflaton field. However, this symmetry has to remain
unbroken by Planck-scale effects, which is a rather strong requirement on
possible ultraviolet completions of the theory. In this paper, we show that the
breaking of the shift symmetry by Planck-scale corrections can be
systematically suppressed if the inflaton field interacts with a conformal
sector. The inflaton then receives an anomalous dimension in the conformal
field theory, which leads to sequestering of all dangerous high-energy
corrections. We analyze a number of models where the mechanism can be seen in
action. In our most detailed example we compute the exact anomalous dimensions
via a-maximization and show that the eta problem can be solved using only
weakly-coupled physics.Comment: 34 pages, 3 figures
On two-dimensional surface attractors and repellers on 3-manifolds
We show that if is an -diffeomorphism with a surface
two-dimensional attractor or repeller and is a
supporting surface for , then and
there is such that: 1) is a union
of disjoint tame surfaces such that every is
homeomorphic to the 2-torus . 2) the restriction of to
is conjugate to Anosov automorphism of
Treatment of poorly differentiated neuroendocrine tumours with etoposide and cisplatin
The purpose of this study was to evaluate by a retrospective analysis of 53 patients the efficacy of chemotherapy combining etoposide and cisplatin in the treatment of neuroendocrine tumours. The regimen was a combination of etoposide 100 mg m–2 day–1 for 3 days and cisplatin 100 mg m–2 on day 1, given by 2-h intravenous infusion, administered every 21 days. Twelve patients had a well-differentiated and 41 a poorly differentiated neuroendocrine tumour. Toxicity of treatment was assessed in 50 patients and efficacy in 52 patients. Among the 11 patients with a well-differentiated tumour evaluable for tumoural response, only one (9.4%) had a partial response for 8.5 months. Forty-one patients with a poorly differentiated tumour showed an objective response rate of 41.5% (four complete and 13 partial responses); the median duration of response was 9.2 months, the median overall survival 15 months and the median progression-free survival 8.9 months. Haematological grade 3–4 toxicity was observed in 60% of the cases with one treatment-related death, digestive grade 3–4 toxicity in 40% and grade 3 alopecia was constant. No severe renal, hearing and neurological toxicities were observed (grade 1 in 6%, 14%, 72% respectively and no grade >1). We confirm that poorly differentiated neuroendocrine tumours are chemosensitive to the etoposide plus cisplatin combination. However, the prognosis remains poor with a 2-year survival lower than 20% confirming that new therapeutic strategies have to be developed. © 1999 Cancer Research Campaig
Quantum chromodynamics with advanced computing
We survey results in lattice quantum chromodynamics from groups in the USQCD
Collaboration. The main focus is on physics, but many aspects of the discussion
are aimed at an audience of computational physicists.Comment: 17 pp. Featured presentation at Scientific Discovery with Advanced
Computing, July 13-17, Seattl
PCR Improves Diagnostic Yield from Lung Aspiration in Malawian Children with Radiologically Confirmed Pneumonia
Accurate data on childhood pneumonia aetiology are essential especially from regions where mortality is high, in order to inform case-management guidelines and the potential of prevention strategies such as bacterial conjugate vaccines. Yield from blood culture is low, but lung aspirate culture provides a higher diagnostic yield. We aimed to determine if diagnostic yield could be increased further by polymerase chain reaction (PCR) detection of bacteria (Streptococcus pneumoniae and Haemophilus influenzae b) and viruses in lung aspirate fluid.A total of 95 children with radiological focal, lobar or segmental consolidation had lung aspirate performed and sent for bacterial culture and for PCR for detection of bacteria, viruses and Pneumocystis jirovecii. In children with a pneumococcal aetiology, pneumococcal bacterial loads were calculated in blood and lung aspirate fluid.Blood culture identified a bacterial pathogen in only 8 patients (8%). With the addition of PCR on lung aspirate samples, causative pathogens (bacterial, viral, pneumocystis) were identified singly or as co-infections in 59 children (62%). The commonest bacterial organism was S.pneumoniae (41%), followed by H. influenzae b (6%), and the commonest virus identified was adenovirus (16%), followed by human bocavirus (HBoV) (4%), either as single or co-infection.In a select group of African children, lung aspirate PCR significantly improves diagnostic yield. Our study confirms a major role of S.pneumoniae and viruses in the aetiology of childhood pneumonia in Africa
The deuteron: structure and form factors
A brief review of the history of the discovery of the deuteron in provided.
The current status of both experiment and theory for the elastic electron
scattering is then presented.Comment: 80 pages, 33 figures, submited to Advances in Nuclear Physic
Second-line chemotherapy for patients with advanced gastric cancer: who may benefit?
No established second-line chemotherapy is available for patients with advanced gastric cancer failing to respond or progressing to first-line chemotherapy. However, 20–40% of these patients commonly receive second-line chemotherapy. We evaluated the influence of clinico-pathologic factors on the survival of 175 advanced gastric cancer patients, who received second-line chemotherapy at three oncology departments. Univariate and multivariate analyses found five factors which were independently associated with poor overall survival: performance status 2 (hazard ratio (HR), 1.79; 95% CI, 1.16–2.77; P=0.008), haemoglobin ⩽11.5 g l−1 (HR, 1.48; 95% CI, 1.06–2.05; P=0.019), CEA level >50 ng ml−1 (HR, 1.86; 95% CI, 1.21–2.88; P=0.004), the presence of greater than or equal to three metastatic sites of disease (HR, 1.72; 95% CI, 1.16–2.53; P=0.006), and time-to-progression under first-line chemotherapy ⩽6 months (HR, 1.97; 95% CI, 1.39–2.80; P<0.0001). A prognostic index was constructed dividing patients into low- (no risk factor), intermediate- (one to two risk factors), or high- (three to five risk factors) risk groups, and median survival times for each group were 12.7 months, 7.1 months, and 3.3 months, respectively (P<0.001). In the absence of data deriving from randomised trials, this analysis suggests that some easily available clinical factors may help to select patients with advanced gastric cancer who could derive more benefit from second-line chemotherapy
The NANOGrav Nine-year Data Set: Excess Noise in Millisecond Pulsar Arrival Times
Gravitational wave (GW) astronomy using a pulsar timing array requires high-quality millisecond pulsars (MSPs), correctable interstellar propagation delays, and high-precision measurements of pulse times of arrival. Here we identify noise in timing residuals that exceeds that predicted for arrival time estimation for MSPs observed by the North American Nanohertz Observatory for Gravitational Waves. We characterize the excess noise using variance and structure function analyses. We find that 26 out of 37 pulsars show inconsistencies with a white-noise-only model based on the short timescale analysis of each pulsar, and we demonstrate that the excess noise has a red power spectrum for 15 pulsars. We also decompose the excess noise into chromatic (radio-frequency-dependent) and achromatic components. Associating the achromatic red-noise component with spin noise and including additional power-spectrum-based estimates from the literature, we estimate a scaling law in terms of spin parameters (frequency and frequency derivative) and data-span length and compare it to the scaling law of Shannon & Cordes. We briefly discuss our results in terms of detection of GWs at nanohertz frequencies
Broadband Spectral Modeling of the Extreme Gigahertz-Peaked Spectrum Radio Source PKS B0008-421
J. R. Callingham, et al., “Broadband Spectral Modeling of the Extreme Gigahertz-Peaked Spectrum Radio Source PKS B0008-421”, Astrophysical Journal, Vol. 809(2), August 2015. © 2015. The American Astronomical Society. All rights reserved.We present broadband observations and spectral modeling of PKS B0008-421, and identify it as an extreme gigahertz-peaked spectrum (GPS) source. PKS B0008-421 is characterized by the steepest known spectral slope below the turnover, close to the theoretical limit of synchrotron self-absorption, and the smallest known spectral width of any GPS source. Spectral coverage of the source spans from 0.118 to 22 GHz, which includes data from the Murchison Widefield Array and the wide bandpass receivers on the Australia Telescope Compact Array. We have implemented a Bayesian inference model fitting routine to fit the data with various absorption models. We find that without the inclusion of a high-frequency exponential break the absorption models can not accurately fit the data, with significant deviations above and below the peak in the radio spectrum. The addition of a high-frequency break provides acceptable spectral fits for the inhomogeneous free-free absorption and double-component synchrotron self-absorption models, with the inhomogeneous free-free absorption model statistically favored. The requirement of a high-frequency spectral break implies that the source has ceased injecting fresh particles. Additional support for the inhomogeneous free-free absorption model as being responsible for the turnover in the spectrum is given by the consistency between the physical parameters derived from the model fit and the implications of the exponential spectral break, such as the necessity of the source being surrounded by a dense ambient medium to maintain the peak frequency near the gigahertz region. The discovery of PKS B0008-421 suggests that the next generation of low radio frequency surveys could reveal a large population of GPS sources that have ceased activity, and that a portion of the ultra-steep spectrum source population could be composed of these GPS sources in a relic phase.Peer reviewedFinal Published versio
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