2,616 research outputs found
Measurements of neutron capture in U²³⁸ in lattices of uranium rods in heavy water
"NYO-9659."Also issued as a Ph. D. thesis in the Dept. of Nuclear Engineering, 1962Includes bibliographical references (pages 119-145)Contract AT(30-1)-234
Robotic Antimicrobial Susceptibility Platform (RASP): A next-generation approach to One Health surveillance of antimicrobial resistance
Background
Surveillance of antimicrobial resistance (AMR) is critical to reducing its wide-reaching impact. Its reliance on sample size invites solutions to longstanding constraints regarding scalability. A robotic platform (RASP) was developed for high-throughput AMR surveillance in accordance with internationally recognized standards (CLSI and ISO 20776-1:2019) and validated through a series of experiments.
Methods
Experiment A compared RASP’s ability to achieve consistent MICs with that of a human technician across eight replicates for four Escherichia coli isolates. Experiment B assessed RASP’s agreement with human-performed MICs across 91 E. coli isolates with a diverse range of AMR profiles. Additionally, to demonstrate its real-world applicability, the RASP workflow was then applied to five faecal samples where a minimum of 47 E. coli per animal (239 total) were evaluated using an AMR indexing framework.
Results
For each drug–rater–isolate combination in Experiment A, there was a clear consensus of the MIC and deviation from the consensus remained within one doubling dilution (the exception being gentamicin at two dilutions). Experiment B revealed a concordance correlation coefficient of 0.9670 (95% CI: 0.9670–0.9670) between the robot- and human-performed MICs. RASP’s application to the five faecal samples highlighted the intra-animal diversity of gut commensal E. coli, identifying between five and nine unique isolate AMR phenotypes per sample.
Conclusions
While adhering to internationally accepted guidelines, RASP was superior in throughput, cost and data resolution when compared with an experienced human technician. Integration of robotics platforms in the microbiology laboratory is a necessary advancement for future One Health AMR endeavours
Simple SUSY Breaking Mechanism by Coexisting Walls
A SUSY breaking mechanism with no messenger fields is proposed. We assume
that our world is on a domain wall and SUSY is broken only by the coexistence
of another wall with some distance from our wall. We find an model
in four dimensions which admits an exact solution of a stable non-BPS
configuration of two walls and studied its properties explicitly. We work out
how various soft SUSY breaking terms can arise in our framework.
Phenomenological implications are briefly discussed. We also find that
effective SUSY breaking scale becomes exponentially small as the distance
between two walls grows.Comment: 43 pages, latex, 7 figure
Well‐being, Reasonableness, and the Natural Environment
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/88110/1/j.1758-0854.2011.01055.x.pd
Aid conditionalities, international Good Manufacturing Practice standards and local production rights: a case study of local production in Nepal
© 2015 Brhlikova et al. This is an Open Access article distributed under the terms of the Creative Commons Attribution License
(http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium,
provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://
creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.This work was supported by the Economic and Social Research Council and
the Department for International Development [RES-167-25-0110] through
the collaborative research project
Tracing Pharmaceuticals in South Asia
(2006
–
2009). In addition to the authors of this paper, the project team
included: Soumita Basu, Gitanjali Priti Bhatia, Erin Court, Abhijit Das, Stefan
Ecks, Patricia Jeffery, Roger Jeffery, Rachel Manners, and Liz Richardson.
Martin Chautari (Kathmandu) and the Centre for Health and Social Justice
(New Delhi) provided resources drawn upon in writing this paper but are
not responsible for the views expressed, nor are ESRC or DFID.
Ethical review was provided by the School of Social and Political Science at
the University of Edinburgh, and ethical approval in Nepal for the study
granted by the Nepal Health Research Council (NHRC)
Polymorphisms in Toll-like receptor 4 ( TLR4 ) are associated with protection against leprosy
Accumulating evidence suggests that polymorphisms in Toll-like receptors (TLRs) influence the pathogenesis of mycobacterial infections, including leprosy, a disease whose manifestations depend on host immune responses. Polymorphisms in TLR2 are associated with an increased risk of reversal reaction, but not susceptibility to leprosy itself. We examined whether polymorphisms in TLR4 are associated with susceptibility to leprosy in a cohort of 441 Ethiopian leprosy patients and 197 healthy controls. We found that two single nucleotide polymorphisms (SNPs) in TLR4 (896G>A [D299G] and 1196C>T [T399I]) were associated with a protective effect against the disease. The 896GG, GA and AA genotypes were found in 91.7, 7.8 and 0.5% of leprosy cases versus 79.9, 19.1 and 1.0% of controls, respectively (odds ratio [OR] = 0.34, 95% confidence interval [CI] 0.20-0.57, P < 0.001, additive model). Similarly, the 1196CC, CT and TT genotypes were found in 98.1, 1.9 and 0% of leprosy cases versus 91.8, 7.7 and 0.5% of controls, respectively (OR = 0.16, 95% CI 0.06--.40, P < 0.001, dominant model). We found that Mycobacterium leprae stimulation of monocytes partially inhibited their subsequent response to lipopolysaccharide (LPS) stimulation. Our data suggest that TLR4 polymorphisms are associated with susceptibility to leprosy and that this effect may be mediated at the cellular level by the modulation of TLR4 signalling by M. lepra
Domain Wall Junction in N=2 Supersymmetric QED in four dimensions
An exact solution of domain wall junction is obtained in N=2 supersymmetric
(SUSY) QED with three massive hypermultiplets. The junction preserves two out
of eight SUSY. Both a (magnetic) Fayet-Iliopoulos (FI) term and complex masses
for hypermultiplets are needed to obtain the junction solution. There are zero
modes corresponding to spontaneously broken translation, SUSY, and U(1). All
broken and unbroken SUSY charges are explicitly worked out in the Wess-Zumino
gauge in N=1 superfields as well as in components. The relation to models in
five dimensions is also clarified.Comment: 27 pages, 6 figures, comments on zero modes added, a few references
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