Modified biophysical profile in high-risk pregnancy and its correlation with perinatal outcome

Background: Aim of the present study was to evaluate the perinatal outcome in high-risk pregnancy with modified biophysical profile (MBPP). Methods: The study is observational study,65 high risk pregnant women fulfilling the inclusion criteria participated in the study. The study subjects were subjected to MBPP. Then perinatal outcomes were assessed in view of mode of delivery, maternal and neonatal morbidity and mortality. Results: Out of 65 cases, 78.5% had normal NST, 80% had normal AFI.3 neonates got admitted in NICU. 13 women underwent LSCS, 9 had instrumental delivery and rest delivered vaginally normal. Conclusions: The study showed that HRPs with MBPP abnormal or any of MBPP parameter abnormal have higher chances of perinatal morbidity and mortality

Neuroimaging in eclamptic patients and its clinical implications

Background: Aim of the study is to assess the utility of neuroimaging (CT/MRI) in eclamptic patients and correlating their clinical implications and to study the role of Injection Mannitol in case of Eclampsia who did not respond to injection magnesium sulphate alone. Methods: This prospective study was conducted in Pannadhay Mahila Chikitsalya Udaipur, RNT Medical College Udaipur, Rajasthan. 50 eclamptic patients fulfilling the inclusion and exclusion criteria were subjected to neuroimaging CT/MRI from August 2021 to August 2022. Injection Mannitol was added in eclamptic patients who did not respond to injection magnesium sulphate alone. Results: In this study neuroimaging were normal in 42% cases while 58% cases had pathological changes; PRES, haemorrhage, infarction, ischemia etc. Out of these PRES was seen in 48% cases. Mannitol was given in 14% patients and only one patient did not respond to mannitol. Conclusions: This study revealed that PRES was the main neurological component among patients. Neuroimaging helps in better management of eclampsia. Mannitol holds utility in managing the patients unresponsive to injection magnesium sulphate.

Effect of digitization of medical case files on doctor patient relationship in an Out Patient Department setting of Northern India: A comparative study

Background: Digitization of health records and health delivery processes in health care settings may have an impact on the Patient-Physician communication, wait times, that affect the overall patient satisfaction with the health care services. Aim & Objective: We ascertained the effect of digitization of medical case files on the doctor patient relationship (DPR) domain of patient satisfaction at an urban primary health center in India. Settings and Design: Comparative, cross-sectional study in primary health centres. Methods and Material: The patient satisfaction was compared between the patients attending the Public Health Dispensary (PHD) that uses digitized medical case file system and a Civil Dispensary (CD) which follows the conventional paper based medical records, using a Patient Satisfaction Questionnaire (PSQ). Statistical analysis used: Univariate analysis was done by chi-square test and adjusted analysis was done by multiple linear regression. Results: Patient satisfaction in DPR was found to be same between the digitized medical case files based and conventional OPD (p=0.453). Significantly higher overall patient satisfaction was reported in the conventional paper based OPD than the digitized OPD (p<0.001). Conclusions: Patient satisfaction towards the doctor-patient relationship (DPR) was same between paper based OPD and the digitized medical case files based OPD

Subtype-Specific and Co-Occurring Genetic Alterations in B-cell Non-Hodgkin Lymphoma

B-cell non-Hodgkin lymphoma (B-NHL) encompasses multiple clinically and phenotypically distinct subtypes of malignancy with unique molecular etiologies. Common subtypes of B-NHL, such as diffuse large B-cell lymphoma, have been comprehensively interrogated at the genomic level, but rarer subtypes, such as mantle cell lymphoma, remain less extensively characterized. Furthermore, multiple B-NHL subtypes have thus far not been comprehensively compared using the same methodology to identify conserved or subtype-specific patterns of genomic alterations. Here, we employed a large targeted hybrid-capture sequencing approach encompassing 380 genes to interrogate the genomic landscapes of 685 B-NHL tumors at high depth, including diffuse large B-cell lymphoma, mantle cell lymphoma, follicular lymphoma, and Burkitt lymphoma. We identified conserved hallmarks of B-NHL that were deregulated in the majority of tumors from each subtype, including frequent genetic deregulation of the ubiquitin proteasome system. In addition, we identified subtype-specific patterns of genetic alterations, including clusters of co-occurring mutations and DNA copy number alterations. The cumulative burden of mutations within a single cluster were more discriminatory of B-NHL subtypes than individual mutations, implicating likely patterns of genetic cooperation that contribute to disease etiology. We therefore provide the first cross-sectional analysis of mutations and DNA copy number alterations across major B-NHL subtypes and a framework of co-occurring genetic alterations that deregulate genetic hallmarks and likely cooperate in lymphomagenesis

Clinicopathological study of Odontogenic Cysts -a retrospective study.

Introduction: Odontogenic cysts are characterized by a pathological cavity either completely or partially covered with epithelial tissue. These cysts are one of the most common osseous -destructive lesions affecting the jaws. The aim of the present study was to determine the relative prevalence of odontogenic cysts and to identify the clinicopathological characteristics. Methodology: A retrospective observational study was conducted on 1011 histopathological reports from January 2008 to December 2012. Patients with radicular cysts, dentigerous cysts, odontogenic keratocysts, lateral periodontal cysts and glandular odontogenic cysts were further analyzed. The following variables were recorded: age, gender, clinical characteristics of the lesions such as size, location and association with impacted teeth and a descriptive analysis of the study variables was carried out. Results: Among 1011 biopsy reports analyzed, 131 cases of odontogenic cysts (13%) were diagnosed. The age of patients ranged from 10 to 85 years. The gender distribution showed a male predilection (n=81; 62%), compared to females (n=50; 38%). The lesion size ranged from 3-130 mm; with a mean size of 18 mm. The mandible (n=74; 56%) was more commonly involved than the maxilla (n=57; 44%). The majority of cysts were detected in the posterior mandible followed by the anterior maxilla. Impacted teeth most commonly associated with odontogenic cysts was lower third molar, followed by upper canine. Conclusion: Radicular cysts, dentigerous cysts and odontogenic keratocysts were the most common cystic lesions, accounting for 88.9% of all odontogenic cysts, with radicular cysts being most common

Fracture resistance of endodontically treated permanent anterior teeth restored with three different esthetic post systems: An in vitro study

Background: Esthetic coronal reconstruction of fractured anterior teeth is often performed using intra radicular posts. Most of the commonly used commercially esthetic post systems do not exhibit similar physical properties as dentin resulting in failures. Aim: To evaluate and compare the fracture resistance and mode of failure of simulated traumatized permanent central incisors restored with three different post systems including biologic dentin posts. Materials and Methods: A total of 40 recently extracted human maxillary central incisors with similar dimensions were decoronated 2 mm above the cemento-enamel junction and endodontically treated. Ten specimens were randomly selected as the Group I - Control group (core built teeth without intraradicular posts). The remaining 30 teeth were equally divided and restored with zirconia (Group II, n = 10), fiber re-inforced composite (FRC) (Group III, n = 10) and biologic dentin posts (Group IV, n = 10) using resin bonded cement and their cores built-up. These samples were embedded in acrylic resin and then secured in a Universal Testing Machine and subjected to fracture resistance testing. The location of failure in the specimens was evaluated using a stereomicroscope. Results: Intergroup comparison revealed that the control group and zirconia post group (522 ± 110 N) demonstrated the least fracture resistance, while dentin post group (721 ± 127 N) the highest. There was no statistically significant difference between fiber post and dentin post groups. Fractures that were repairable were observed in fiber post and dentin post groups, whereas mostly unrestorable, catastrophic fractures were observed in the zirconia post group. Conclusion: Teeth restored with the biologic dentin post system demonstrated the highest fracture resistance and repairable fractures, closely followed by FRC post system. The least fracture resistance and most catastrophic fractures were demonstrated by the zirconia post system