Complementary Information for Reducing Parameter Uncertainty in Distributed Rainfall-Runoff Modeling

Source: ICHE Conference Archive - https://mdi-de.baw.de/icheArchiv

In vivo microdialysis reveals age-dependent decrease of brain interstitial fluid tau levels in P301S human tau transgenic mice

Although tau is a cytoplasmic protein, it is also found in brain extracellular fluids, e.g., CSF. Recent findings suggest that aggregated tau can be transferred between cells and extracellular tau aggregates might mediate spread of tau pathology. Despite these data, details of whether tau is normally released into the brain interstitial fluid (ISF), its concentration in ISF in relation to CSF, and whether ISF tau is influenced by its aggregation are unknown. To address these issues, we developed a microdialysis technique to analyze monomeric ISF tau levels within the hippocampus of awake, freely moving mice. We detected tau in ISF of wild-type mice, suggesting that tau is released in the absence of neurodegeneration. ISF tau was significantly higher than CSF tau and their concentrations were not significantly correlated. Using P301S human tau transgenic mice (P301S tg mice), we found that ISF tau is fivefold higher than endogenous murine tau, consistent with its elevated levels of expression. However, following the onset of tau aggregation, monomeric ISF tau decreased markedly. Biochemical analysis demonstrated that soluble tau in brain homogenates decreased along with the deposition of insoluble tau. Tau fibrils injected into the hippocampus decreased ISF tau, suggesting that extracellular tau is in equilibrium with extracellular or intracellular tau aggregates. This technique should facilitate further studies of tau secretion, spread of tau pathology, the effects of different disease states on ISF tau, and the efficacy of experimental treatments

A Cooperative Game Using the P300 EEG-Based Brain-Computer Interface

In this paper, we present a cooperative game, Brainio Bros 300, using a brain-computer interface (BCI). The game is cooperatively controlled by two people using P300-generating color discrimination. The two users advance through the game together, one as the “player” and the other as the “supporter” providing assistance. We assumed that players would be able-bodied, while supporters would include people with severe disabilities. Through experiments using human subjects, we evaluated the subjects’ impressions of the game and its usefulness. The results of the impression evaluation showed that the subjects generally had good impressions, and there were many opinions that such cooperative games are interesting. We also discuss the possibilities of using the P300 BCI

One-loop anomalous couplings and matching conditions in the nonlinear realization of the SU(2) Higgs Model

We study the renormalization of the nonlinear realization of the SU(2) Higgs model in the modified minimal subtraction renormalization scheme. We propose that the effective field method with truncated operator series is trustworthy even when the Higgs boson is relatively light. Using the technique of background field method in the coordinate space, we derive the matching conditions at tree and one loop order, both in the regions where the Higgs boson is heavy and where it is light. We obtain the complete one-loop anomalous couplings up to ${\Large O} (p^4)$ in the SU(2) Higgs model. We observe that the contribution of the gauge bosons and the Goldstone bosons to the anomalous couplings at the one-loop level is significant. By establishing the correspondence between our coordinate space calculation and the momentum space calculation that exists in the literature, we find agreement in all the matching conditions in the heavy Higgs boson limit.Comment: 40 pages, 1 Postscript figure, 12 eps figures, uses subeqn.st

Observability of the Lightest MSSM Higgs Boson with Explicit CP Violation via Gluon Fusion at the LHC

We investigate the observability of the lightest Higgs boson in the gluon-fusion channel at the CERN Large Hadron Collider (LHC) in the minimal supersymmetric Standard Model with explicit CP-violating mixing among three neutral Higgs bosons. The lightest Higgs boson with its mass less than 130 GeV can be detected at the LHC via its gluon-fusion production followed by the decay into two photons. The explicit CP violation can suppress both the production cross section and the two-photon decay branching fraction so significantly that the signal cross section may be more than ten times smaller than the SM signal. This reduction factor can be as small as 1/40 if the lightest Higgs boson mass is 115 GeV and its production cross section at LEP2 is more than 90 % that of the SM case.Comment: 12 pages, 4 eps figures, a reference with two papers adde

Properties of 125 GeV Higgs boson in non-decoupling MSSM scenarios

Tantalizing hints of the Higgs boson of mass around 125 GeV have been reported at the LHC. We explore the MSSM parameter space in which the 125 GeV state is identified as the heavier of the CP even Higgs bosons, and study two scenarios where the two photon production rate can be significantly larger than the standard model (SM). In one scenario, $\Gamma(H\to \gamma\gamma)$ is enhanced by a light stau contribution, while the $WW^{\ast}$ ($ZZ^{\ast}$) rate stays around the SM rate. In the other scenario, $\Gamma(H\to b\bar{b})$ is suppressed and not only the $\gamma\gamma$ but also the $WW^{\ast}$ ($ZZ^{\ast}$) rates should be enhanced. The $\tau\bar{\tau}$ rate can be significantly larger or smaller than the SM rate in both scenarios. Other common features of the scenarios include top quark decays into charged Higgs boson, single and pair production of all Higgs bosons in $e^+e^-$ collisions at $\sqrt{s}\lesssim 300$ GeV.Comment: 20 pages, 5 figures, accepted version for publication in JHE