Who am I? Mothers’ shifting identities, loss and sensemaking after workplace exit

© 2015, © The Author(s) 2015. We analyse mothers’ retrospective accounts of their transition from professional worker to stay-at-home mother using a framework that integrates sensemaking and border theory. The data come from in-depth interviews with former professional and managerial women in London. Continuing struggles to reconcile professional and maternal identities before and after workplace exit illustrate how identity change is integral to workplace exit. The concept of ‘choice’, which takes place at one point in time, obfuscates this drawn-out process. Mothers pay a high cost in lost professional identities, especially in the initial stages after workplace exit. They cope with this loss and the disjuncture of leaving employment by moving back and forth across the border between home and work – a classic action of sensemaking. Subsequent communal sensemaking and community action bolster mothers’ fragile status at home, eventually leading to reconciliation of their loss and finally enabling them to view their exit ‘choice’ as right

Money and relationships online: communication and norm formation in women’s discussions of couple resource allocation

© London School of Economics and Political Science 2018 Research on intra-household resource allocation practices has largely ignored the role of communication within but especially beyond the household. This article shows that discussions engaged in outside of the household shed light on intra-household deliberation and also contribute to an understanding of how norms are formed and used in discussions and negotiations. Using data from the website Mumsnet, and grounding our analysis in a framework that combines the literature on gender norms in allocation practices with insights from the study of online communication, we contribute to the sociological literature on household distribution in three ways: first, we show that women use discussion sites like Mumsnet to clarify and sometimes contest social norms regarding money and relationships; second, we show that users conceive the ability to communicate with partners as a source of ‘relationship power’ and use online discussion with other women to develop that skill; third, we argue that sites like Mumsnet provide fresh insights into household resource allocation processes. The article concludes with a broader discussion of the role of communication in household distribution and the value of online data for understanding such processes

Exome sequencing identifies nonsegregating nonsense ATM and PALB2 variants in familial pancreatic cancer.

We sequenced 11 germline exomes from five families with familial pancreatic cancer (FPC). One proband had a germline nonsense variant in ATM with somatic loss of the variant allele. Another proband had a nonsense variant in PALB2 with somatic loss of the variant allele. Both variants were absent in a relative with FPC. These findings question the causal mechanisms of ATM and PALB2 in these families and highlight challenges in identifying the causes of familial cancer syndromes using exome sequencing

How Women Have Fared with the Rise of the People's Republic of China in Global Supply Chain Trade

Global supply chain (GSC) trade has been a driving force underlying economic transformation, urbanization, and social change in the People’s Republic of China (PRC). Female migrants account for a large share of the labor force in the country’s GSC production base. Using province-level panel data, this study employs regression analysis to examine how the country’s rapid integration into the supply chain has affected women’s welfare outcomes captured by occupational status. The analysis shows mixed results. On the one hand, global integration through trade expansion improved the concentration of men and women equally in professional and skilled occupations and in management positions. On the other hand, female employment in manufacturing for GSC trade increased faster than male employment. This trend decreased in turn the male–female sex ratio among those aged 0–4 years. This finding is consistent with other studies on the PRC that confirm the beneficial effect of a relative rise in women’s income in reducing the sex imbalance. Gender-specific policies should support female migrants in moving up the job ladder in GSC trade through higher education and skills training for professional and leadership positions. This should be complemented with incentives for the private sector—the biggest source of employment in the PRC—to promote gender equality by harnessing the advancement in technology and opportunities offered by the rapid growth of GSC trade

Remarks on flavor-neutrino propagators and oscillation formulae

We examine the general structure of the formulae of neutrino oscillations proposed by Blasone and Vitiello(BV). Reconstructing their formulae with the retarded propagators of the flavor neutrino fields for the case of many flavors, we can get easily the formulae which satisfy the suitable boundary conditions and are independent of arbitrary mass parameters $\{\mu_{\rho}\}$, as is obtained by BV for the case of two flavors. In this two flavor case, our formulae reduce to those obtained by BV under $T$-invariance condition. Furthermore, the reconstructed probabilities are shown to coincide with those derived with recourse to the mass Hilbert space ${\cal H}_{m}$ which is unitarily inequivalent to the flavor Hilbert space ${\cal H}_{f}$. Such a situation is not found in the corresponding construction a la BV. Then the new factors in the BV's formulae, which modify the usual oscill ation formulae, are not the trace of the flavor Hilbert space construction, but come from Bogolyubov transformation among the operators of spin-1/2 ne utrino with different masses.Comment: revtex, 16 page

OC 8510 BIOTRANSFORMATION OF PRAZIQUANTEL FOR THE PHARMACOKINETIC OPTIMISATION OF PRAZIQUANTEL USE IN MASS DRUG ADMINISTRATION AND DEVELOPMENT OF NEW PAEDIATRIC FORMULATIONS

BackgroundPraziquantel (PZQ) is the only drug available for the treatment of all forms of schistosomiasis. New paediatric formulations for the active enantiomer R-PZQ and the racemate PZQ are currently under development. There is however limited drug metabolism and pharmacokinetic data on PZQ available to support these initiatives. Detailed knowledge of PZQ metabolism will enable the use of PBPK modelling to determine appropriate doses for the new formulations in paediatric patients and to predict risks for drug-drug interactions in mass drug administration.MethodsBiotransformation studies on PZQ were conducted in human liver microsomes and recombinant Cytochrome P450s (CYPs). Structure elucidation was inferred from mass spectra. Enzyme kinetic studies to determine the Michaelis-Menten kinetics, Km and Vmax, of the formation of the main metabolites and analysis of clinical samples were determined by LC-MS/MS.ResultsCYP reaction phenotyping studies with HLM and r-CYPs indicate major involvement of CYP1A2, 2 C19, 2D6 and 3A4/5 in the metabolism of R- and S-PZQ. Biotransformation studies showed that PZQ is metabolised to cis-4-OH-PZQ mainly by CYP1A2 and CYP2C19. CYP3A4/5 metabolises PZQ to a mono-hydroxyl metabolite (X-OH-PZQ) whilst CYP2D6 metabolises PZQ to minor novel mono-hydroxyl metabolite (Y-OH-PZQ) both pending structural elucidation by nuclear magnetic resonance. R-PZQ was more rapidly cleared than S–PZQ with variable interindividual AUC and Cmax.Discussion and conclusionThe differential role of CYP1A2 and CYP2C19 and of CYP3A4 and CYP3A5 in the formation the 4-OH-PZQ and the novel X-OH-PZQ respectively are intriguing findings as this has not been reported before in humans. In vitro, cis and not trans 4-OH-PZQ formation has been observed contrary in vivo reports in humans which indicate trans 4-OH-PZQ as the main metabolite. The data will enable us to understand the rapid clearance of PZQ and predict potential drug-drug-gene interactions which mayexplain the inter-individual variability of PZQ pharmacokinetics

School closures and educational attainment in Ethiopia: Can extra classes help children to catch up?

Data availability statement: The data that support the findings of this study are available in Young Lives at https://beta. ukdataservice.ac.uk/datacatalogue/studies/study?id=7823&type=Data%20catalogue.ORCID: Fiona Carmichael https://orcid.org/0000-0002-7932-2410; Christian K. Darko https://orcid.org/0000-0002-1665-2594; Shireen Kanji https://orcid.org/0000-0003-3512-2596; Nicholas Vasilakos https://orcid.org/0000-0003-3279-2885.Copyright © 2022 The Authors. School closures impact children's attainment adversely, but understanding the effects of closures on children's attainment in lower-income countries is still limited. Addressing this deficit, this study examines how past school closures have impacted children's educational attainment in Ethiopia. The study uses individual student-level data from the Young Lives School Survey and standardised test scores in mathematics and language recorded at the start and end of the school year to model children's attainment. Multiple regression with propensity score matching is used to analyse how attainment over the school year is impacted by school closures for a matched sub-sample of 4842 students. The effectiveness of additional classes to make up for lost learning is also evaluated. Past school closures have had a detrimental effect on attainment in mathematics, but not literacy. Extra classes, specifically those that families do not pay for, have helped children in the past to recuperate lost learning and could serve this function post-Covid-19. Inequalities in learning outcomes, measured by Gini coefficients in educational attainment, are widened by school closures. Applying these results to the extensive school closures under Covid-19 furthers our understanding of the likely effects on academic attainment and can inform policy to mitigate the impact.https://beta. ukdataservice.ac.uk/datacatalogue/studies/study?id=7823&type=Data%20catalogu

Psychobiobehavioral model for preterm birth in pregnant women in low- and middle-income countries

Preterm birth (PTB) is a final common outcome resulting from many interrelated etiological pathways; of particular interest is antenatal psychosocial distress (i.e., stress, anxiety, and depression). In LMI countries, both exposure to severe life stressors and rate of PTB are on average greater when compared with high-income countries. In LMI countries women are exposed to some of the most extreme psychosocial stress worldwide (e.g., absolute poverty, limited social resources). High prevalence of antenatal stress and depression have been observed in some studies from LMI countries. We propose a psychosocial, biological, and behavioral model for investigating the complex multisystem interactions in stress responses leading to PTB and explain the basis of this approach. We discuss ethical considerations for a psychosocial, biological, and behavioral screening tool to predict PTB from a LMI country perspective

Learning-by-doing as an approach to teaching social entrepreneurship

Many studies have explored the use of learning-by-doing in higher education, but few have applied this to social entrepreneurship contexts and applications: this paper addresses this gap in the literature. Our programme involved students working with different stakeholders in an interactive learning environment to generate real revenue for social enterprises. Our results show that learning-by-doing enables students to develop their entrepreneurial skills and enhance their knowledge of social businesses. The findings also show that students became more effective at working in teams and in formulating and applying appropriate business strategies for the social enterprises. Overall, the learning-by-doing approach discussed in this paper is capable of developing the entrepreneurial skills of students, but there are challenges that need to be addressed if such an approach is to be effective