A case of gangliocytic paraganglioma in the ampulla of Vater

<p>Abstract</p> <p>Background</p> <p>Duodenal gangliocytic paraganglioma is an extremely rare tumor and few cases have been reported to date.</p> <p>Case presentation</p> <p>The authors report a case of gangliocytic paraganglioma verified by post-op pathology after pancreaticoduodenectomy for a tumor in the ampulla of Vater. The 56-year-old male patient concerned visited our emergency room with melena that started one week prior to hospitalization. The patient was diagnosed to have a tumor in the ampulla of Vater with bleeding on its surface. However post-op, he was diagnosed as having gangliocytic paraganglioma by immunohistochemistry.</p> <p>Conclusion</p> <p>This tumor has precise clinical implications, and if continuous follow up is conducted after careful diagnosis and surgical treatment, invasive major operations, such as, radical pancreaticoduodenectomy can be avoided.</p

Development of Genetic Markers for Triploid Verification of the Pacific Oyster,

The triploid Pacific oyster, which is produced by mating tetraploid and diploid oysters, is favored by the aquaculture industry because of its better flavor and firmer texture, particularly during the summer. However, tetraploid oyster production is not feasible in all oysters; the development of tetraploid oysters is ongoing in some oyster species. Thus, a method for ploidy verification is necessary for this endeavor, in addition to ploidy verification in aquaculture farms and in the natural environment. In this study, a method for ploidy verification of triploid and diploid oysters was developed using multiplex polymerase chain reaction (PCR) panels containing primers for molecular microsatellite markers. Two microsatellite multiplex PCR panels consisting of three markers each were developed using previously developed microsatellite markers that were optimized for performance. Both panels were able to verify the ploidy levels of 30 triploid oysters with 100% accuracy, illustrating the utility of microsatellite markers as a tool for verifying the ploidy of individual oysters

Investigating the Relationship between Serum Interleukin-17 Levels and Systemic Immune-Mediated Disease in Patients with Dry Eye Syndrome

Purpose: To investigate the association between dry eye syndrome (DE) and serum levels of interleukin (IL)-17 in patients with systemic immune-mediated diseases. Methods: IL-17 and IL-23 levels were measured in the sera of patients whose tear production was &lt;5 mm on the Schirmer test. Subjects included patients with chronic graft-versus-host disease (GVHD), rheumatoid arthritis (RA), Sjogren’s syndrome (SS), systemic lupus erythematosus (SLE), and no systemic disease. Corneal/conjunctival fluorescein staining was scored and the correlation between the score and the IL-17 level was evaluated. Results: A strong correlation existed between IL-17 level and the type of systemic disease. IL-17 was significantly elevated in patients with chronic GVHD compared to those with RA and SS. IL-17 was not detectable in patients with SLE or in those without systemic disease. IL-23 was not detected in any of the subjects. IL-17 was significantly increased in patients with high fluorescein staining scores. Conclusions: Our data suggest that IL-17 is involved in the pathogenesis of DE in patients with systemic immune-mediated diseases. Key Words: Chronic graft-versus-host disease, Dry eye syndromes, Interleukin-17, Rheumatoid arthritis, Sjogren’s syndrom

서 론 췌장 신경내분비 종양은 최근 발생 및 진단 빈도가 높아진 것으로 보고되고 있으나[1,2] 전체 유병률이 10만명 당 1명 이하의 드문 질 환으로 임상양상 및 생존과 관련된 예후 인자는 정확히 알려져 있지 않다[3,4]. 지금까지의 국내외 보고들은 대부분 그 증례가 부족하여 일반화된 결론을 내리기에는 어려움이 있었다[5-7]. 췌장 신경내분비 종양은 임상양상에 따라 기능성과 비기능성 신 경내분비 종양으로 분류할 수 있는데, 현미경적으로는 감별이 어

Purpose: Pancreatic neuroendocrine tumors (PNETs) are rare neoplasms with reported incidence of &lt; 1 per 100,000 persons per year. PNETs are classified as functional or nonfunctional depending on their production of specific pancreatic endocrine hormones. This study presents the clinicopathologic characteristics and outcomes of PNETs experienced in a single institution

Primary Cardiac Lymphoma Presenting With Atrioventricular Block

Primary cardiac lymphomas (PCL) are extremely rare. Clinical manifestations may be variable and are attributed to location. Here, we report on a case of PCL presenting with atrioventricular (AV) block. A 55 year-old male had experienced chest discomfort with unexplained dyspnea and night sweating. His initial electrocardiogram (ECG) revealed a first degree AV block. Along with worsening chest discomfort and dyspnea, his ECG changed to show second degree AV block (Mobitz type I). Computed tomography (CT) scan showed a cardiac mass (about 7 cm) and biopsy was performed. Pathologic finding confirmed diffuse large B-cell lymphoma. The patient was treated with multi-drug combination chemotherapy (R-CHOP: Rituximab, cyclophoshamide, anthracycline, vincristine, and prednisone). After treatment, ECG changed to show normal sinus rhythm with complete remission on follow-up CT scan