The Carriage House

Poem created for LCS 220 - Creativity and the Arts taught by Joan Zaretti. For the assignment, students chose a piece of campus artwork (either in the AIC or in the Unistructure) and wrote a poem describing the painting

New Discoveries on the Roles of “Other” HECT E3 Ubiquitin Ligases in Disease Development

HECT E3 ubiquitin ligases selectively recognize, bind, and ubiquitylate their substrate proteins to target them for 26S proteasomal degradation. There is increasing evidence that HECT E3 ubiquitin ligase dysfunction due to misfolding and/or the gene encoding the protein being mutated is responsible for the development of different diseases. Apart from the more prominent and well-characterized E6AP and members of the NEDD4 family, new studies have begun to reveal how other members of the HECT E3 ubiquitin ligase family function as well as their links to disease and developmental disorders. This chapter provides a comprehensive discussion on the more mysterious members of the HECT E3 ubiquitin ligase family and how they control intracellular processes. Specifically, AREL1, HACE1, HECTD1, HECTD4, G2E3, and TRIP12 will be examined as these enzymes have recently been identified as contributors to disease development

"I Just Signed Your Death Warrant": A Content Analysis of News Media Coverage of Violent Crimes Against Women in the #MeToo Era

Thesis advisor: Alyssa GoldmanThis study analyzes the narratives that emerged in the news media’s coverage of violent crimes against women during the #MeToo Movement. Additionally, it seeks to uncover if and how news media crime coverage differed based on the race of defendants. I conduct a content analysis of the news media coverage of the criminal cases State of Michigan v. Lawrence Gerard Nassar and Commonwealth of Pennsylvania v. William Henry Cosby, Jr. during the #MeToo Movement. I find that news media coverage of violent crimes against women typically exhibits an inverse relationship in which supportive portrayals of victims predict unsupportive portrayals of defendants, and vice versa. I also find some evidence to suggest that Black male defendants receive more lenient news media coverage than white male defendants. The results of this study demonstrate the power of social movements in influencing criminal justice outcomes and the news media’s role in shaping public opinion on criminal cases.Thesis (BA) — Boston College, 2021.Submitted to: Boston College. College of Arts and Sciences.Discipline: Departmental Honors.Discipline: Sociology

Maternity Care Transitions in Northern Rural Honduras: A Preliminary Ethnographic Inquiry

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/142501/1/j.1542-2011.2004.tb04452.x.pd

Ozempic (semaglutide) versus Nonpharmacologic Interventions For Weight Management in Overweight Individuals

Ozempic (semaglutide) is a medication prescribed for individuals managing Type 2 Diabetes Mellitus by mimicking the action of a hormone called GLP-1, helping to regulate glucose levels by stimulating insulin secretion and reducing glucagon secretion. Many patients with Type 2 Diabetes Mellitus rely on Ozempic (semaglutide) as a weight loss aid as opposed to implementing healthy lifestyle changes. This information proposes the question: in overweight individuals taking Ozempic (semaglutide), a medication prescribed for those with Type 2 Diabetes Mellitus, for the management of weight loss, does the use of Ozempic (semaglutide) compared to non-pharmacologic weight loss strategies exaggerate the occurrence of adverse effects? A literature search was conducted using CINAHL and PubMed employing the following search terms: ozempic, semaglutide, weight loss, non-pharmacologic weight loss, adverse effects, and obesity. A total of 12 articles met the inclusion criteria. The research shows that Ozempic (semaglutide) is an effective but short-term weight management aid, as most individuals regain the weight lost within one year. Though Ozempic (semaglutide) demonstrated the highest percent weight loss achieved of any anti-obesity medication (11.85%), it also results in augmented adverse effects. Commonly experienced adverse effects of Ozempic (semaglutide) include vomiting, diarrhea, hypoglycemia, cholelithiasis, tachycardia, thyroid carcinomas, reproductive complications, and stomach paralysis. Nonpharmacologic interventions like diet and exercise were found to be sustainable and have significantly fewer adverse effects, with exercise causing on average a 20% weight reduction. Based on these findings, evidence exists to support implementing nonpharmacologic strategies over Ozempic (semaglutide) for weight loss in overweight individuals

Reduced postpartum hemorrhage after implementation of active management of the third stage of labor in rural Honduras

ObjectiveTo assess outcomes after auxiliary nurses were trained and given resources to use active management of the third stage of labor (AMTSL) for all women giving birth in a low‐resource, low‐risk, rural, public birth center setting in northern rural Honduras.MethodsAuxiliary nurses received training on estimation of blood loss before the preintervention phase of the study (July 2004 through April 2005) and AMTSL, including use of intramuscular oxytocin, and estimation of blood loss prior to the intervention phase (July 2007 through June 2008). Preintervention and intervention data on use of oxytocin, blood loss postpartum, hemorrhage rates, and management interventions were collected and compared.ResultsAfter nurses received training on AMTSL using intramuscular oxytocin, the use of intramuscular oxytocin during the third stage of labor increased from 63.8% to 96.5%. Postpartum hemorrhage rates decreased from 14.8% to 5.9% (P = 0.001). Use of intrapartum oxytocin, which can have adverse effects, also increased: from 6.1% to 22.7% (P < 0.001).ConclusionTraining auxiliary nurses to perform AMTSL using oxytocin in this birth center setting was effective in reducing the rate of postpartum hemorrhage; however, increased use of intrapartum oxytocin may be an unintended outcome of the increased accessibility of oxytocin.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/135583/1/ijgo217.pd

Peer Supporters’ Mental Health and Emotional Wellbeing needs:Key Factors and Opportunities for Co-Produced Training

Abstract Introduction Peer supporters are a valuable asset to mental health and support services, but their own mental health needs are often overlooked in research and practice. This study explored peer supporters' perceived challenges of maintaining their mental health and emotional wellbeing and co‐produced training needs. Methods A qualitative approach was used to explore factors affecting peer supporters' mental health and emotional wellbeing. Semi‐structured interviews and focus groups were conducted online with 11 peer supporters across North East England. Results A thematic analysis identified: ‘Lack of training and support’, ‘Role ambiguity’ and ‘Emotional labour’ as challenges experienced by peer supporters in relation to maintaining their mental health and emotional wellbeing. Peer supporters' own lived experiences had the potential to act as a barrier towards providing support to others. Conflict with peer ‘supportees’ sometimes negatively impacted on the peer supporter experience. Participant responses emphasised a need for person‐centred, co‐produced training. Conclusion This work highlights the need for targeted training for peer supporters, including both role‐specific education and strategies to support their mental health and emotional wellbeing. Patient or Public Contribution Participants were contacted and asked to provide feedback on finalised themes to ensure the analysis was congruent with their experiences, further enabling the future development of an emotional wellbeing training programme for peer supporters

Marine protected areas show low overlap with projected distributions of seabird populations in Britain and Ireland

EJC was funded by the Irish Petroleum Infrastructure Programme (PIP) IS013/08. WJG was funded by INSITE http://www.insitenorthsea.org/. AK was funded by the Irish Research CouncilGOIPD/2015/81. MJ was funded by the SFI Centre for Marine and Renewable Energy (12/RC/2302).Marine Protected Areas (MPAs) are an important tool for the conservation of seabirds. However, mapping seabird distributions using at-sea surveys or tracking data to inform the designation of MPAs is costly and time-consuming, particularly for far-ranging pelagic species. Here we explore the potential for using predictive distribution models to examine the effectiveness of current MPAs for the conservation of seabirds, using Britain and Ireland as a case study. A distance-weighted foraging radius approach was used to project distributions at sea for an entire seabird community during the breeding season, identifying hotspots of highest density and species richness. The percentage overlap between distributions at sea and MPAs was calculated at the level of individual species, family group, foraging range group (coastal or pelagic foragers), and conservation status. On average, 32.5% of coastal populations and 13.2% of pelagic populations overlapped with MPAs indicating that pelagic species, many of which are threatened, are likely to have significantly less coverage from protected areas. We suggest that a foraging radius approach provides a pragmatic and rapid method of assessing overlap with MPA networks for central place foragers. It can also act as an initial tool to identify important areas for potential designation. This would be particularly useful for regions throughout the world with limited data on seabird distributions at sea and limited resources to collect this data. Future assessment for marine conservation management should account for the disparity between coastal and pelagic foraging species to ensure that wider-ranging seabirds are afforded adequate levels of protection.PostprintPeer reviewe

Maximizing value of genetic sequence data requires an enabling environment and urgency

Severe price spikes of the major grain commodities and rapid expansion of cultivated area in the past two decades are symptoms of a severely stressed global food supply. Scientific discovery and improved agricultural productivity are needed and are enabled by unencumbered access to, and use of, genetic sequence data. In the same way the world witnessed rapid development of vaccines for COVID-19, genetic sequence data afford enormous opportunities to improve crop production. In addition to an enabling regulatory environment that allowed for the sharing of genetic sequence data, robust funding fostered the rapid development of coronavirus diagnostics and COVID-19 vaccines. A similar level of commitment, collaboration, and cooperation is needed for agriculture

Delivery of a clinical academic career programme: a collaborative approach

The clinical academic careers strategy in England is a new initiative in the National Health Service to develop a stronger clinical research ethos in nursing and Allied Health Professions and promote research and ensure collaboration between Higher Education Institutions and NHS. In response to the above strategic drive and the need to support new roles, the Mental Health, Health and Social Care (MH2aSC) research group at the University of Lincoln developed a bespoke programme to support clinicians seeking to build a clinical academic career. This paper presents data from the evaluation of the programme from the perspective of the first cohort of clinical academic scholars