The Carriage House

Poem created for LCS 220 - Creativity and the Arts taught by Joan Zaretti. For the assignment, students chose a piece of campus artwork (either in the AIC or in the Unistructure) and wrote a poem describing the painting

New Discoveries on the Roles of “Other” HECT E3 Ubiquitin Ligases in Disease Development

HECT E3 ubiquitin ligases selectively recognize, bind, and ubiquitylate their substrate proteins to target them for 26S proteasomal degradation. There is increasing evidence that HECT E3 ubiquitin ligase dysfunction due to misfolding and/or the gene encoding the protein being mutated is responsible for the development of different diseases. Apart from the more prominent and well-characterized E6AP and members of the NEDD4 family, new studies have begun to reveal how other members of the HECT E3 ubiquitin ligase family function as well as their links to disease and developmental disorders. This chapter provides a comprehensive discussion on the more mysterious members of the HECT E3 ubiquitin ligase family and how they control intracellular processes. Specifically, AREL1, HACE1, HECTD1, HECTD4, G2E3, and TRIP12 will be examined as these enzymes have recently been identified as contributors to disease development

Maternity Care Transitions in Northern Rural Honduras: A Preliminary Ethnographic Inquiry

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/142501/1/j.1542-2011.2004.tb04452.x.pd

Peer Supporters’ Mental Health and Emotional Wellbeing needs:Key Factors and Opportunities for Co-Produced Training

Abstract Introduction Peer supporters are a valuable asset to mental health and support services, but their own mental health needs are often overlooked in research and practice. This study explored peer supporters' perceived challenges of maintaining their mental health and emotional wellbeing and co‐produced training needs. Methods A qualitative approach was used to explore factors affecting peer supporters' mental health and emotional wellbeing. Semi‐structured interviews and focus groups were conducted online with 11 peer supporters across North East England. Results A thematic analysis identified: ‘Lack of training and support’, ‘Role ambiguity’ and ‘Emotional labour’ as challenges experienced by peer supporters in relation to maintaining their mental health and emotional wellbeing. Peer supporters' own lived experiences had the potential to act as a barrier towards providing support to others. Conflict with peer ‘supportees’ sometimes negatively impacted on the peer supporter experience. Participant responses emphasised a need for person‐centred, co‐produced training. Conclusion This work highlights the need for targeted training for peer supporters, including both role‐specific education and strategies to support their mental health and emotional wellbeing. Patient or Public Contribution Participants were contacted and asked to provide feedback on finalised themes to ensure the analysis was congruent with their experiences, further enabling the future development of an emotional wellbeing training programme for peer supporters

Marine protected areas show low overlap with projected distributions of seabird populations in Britain and Ireland

EJC was funded by the Irish Petroleum Infrastructure Programme (PIP) IS013/08. WJG was funded by INSITE http://www.insitenorthsea.org/. AK was funded by the Irish Research CouncilGOIPD/2015/81. MJ was funded by the SFI Centre for Marine and Renewable Energy (12/RC/2302).Marine Protected Areas (MPAs) are an important tool for the conservation of seabirds. However, mapping seabird distributions using at-sea surveys or tracking data to inform the designation of MPAs is costly and time-consuming, particularly for far-ranging pelagic species. Here we explore the potential for using predictive distribution models to examine the effectiveness of current MPAs for the conservation of seabirds, using Britain and Ireland as a case study. A distance-weighted foraging radius approach was used to project distributions at sea for an entire seabird community during the breeding season, identifying hotspots of highest density and species richness. The percentage overlap between distributions at sea and MPAs was calculated at the level of individual species, family group, foraging range group (coastal or pelagic foragers), and conservation status. On average, 32.5% of coastal populations and 13.2% of pelagic populations overlapped with MPAs indicating that pelagic species, many of which are threatened, are likely to have significantly less coverage from protected areas. We suggest that a foraging radius approach provides a pragmatic and rapid method of assessing overlap with MPA networks for central place foragers. It can also act as an initial tool to identify important areas for potential designation. This would be particularly useful for regions throughout the world with limited data on seabird distributions at sea and limited resources to collect this data. Future assessment for marine conservation management should account for the disparity between coastal and pelagic foraging species to ensure that wider-ranging seabirds are afforded adequate levels of protection.PostprintPeer reviewe

Maximizing value of genetic sequence data requires an enabling environment and urgency

Severe price spikes of the major grain commodities and rapid expansion of cultivated area in the past two decades are symptoms of a severely stressed global food supply. Scientific discovery and improved agricultural productivity are needed and are enabled by unencumbered access to, and use of, genetic sequence data. In the same way the world witnessed rapid development of vaccines for COVID-19, genetic sequence data afford enormous opportunities to improve crop production. In addition to an enabling regulatory environment that allowed for the sharing of genetic sequence data, robust funding fostered the rapid development of coronavirus diagnostics and COVID-19 vaccines. A similar level of commitment, collaboration, and cooperation is needed for agriculture

Delivery of a clinical academic career programme: a collaborative approach

The clinical academic careers strategy in England is a new initiative in the National Health Service to develop a stronger clinical research ethos in nursing and Allied Health Professions and promote research and ensure collaboration between Higher Education Institutions and NHS. In response to the above strategic drive and the need to support new roles, the Mental Health, Health and Social Care (MH2aSC) research group at the University of Lincoln developed a bespoke programme to support clinicians seeking to build a clinical academic career. This paper presents data from the evaluation of the programme from the perspective of the first cohort of clinical academic scholars

RE-AIM Evaluation of One You Lincolnshire Integrated Lifestyle Service: Interim Report

Introduction: Many unhealthy behaviours such as tobacco smoking, poor diet, harmful alcohol use, and physical inactivity tend to group. In England, around a quarter of people are engaged in three or more unhealthy behaviours, contributing to a higher risk of ill health. Interventions, known as integrated lifestyle services (ILS), encourage sustained health changes and reduced costs. There is limited evidence on the effectiveness of ILSs in rural settings and factors that impact implementation. One You Lincolnshire is a non-NHS provider working with GP practices, community care services and local charities to offer online, digital lifestyle support for individuals with long-term health conditions. Methods: This study aimed to identify the impact of addressing unhealthy behaviours for an individual through One You Lincolnshire (OYL), establish how OYL has been implemented, and highlight any potential risks and challenges that may impact the intervention in the future. This presentation will give an overview of the key findings from phase 1 of the evaluation, which used a mixed-method approach and was co-produced with a multi-stakeholder group. The study had a total of 53 participants, including Service Users (n = 24), Health Professionals (n= 9), One You Lincolnshire staff (n=17) and Stakeholders (n=3). Key Findings: Thematic analysis was used to identify key themes in service delivery and implementation. From the interviews and focus groups, the key findings were as follows:  - Online delivery model offered much greater accessibility for a wide range of clients in rural areas.​  -Once referred, an integrated service model decreased barriers for stigmatised health needs such as smoking cessation or alcohol reduction.​ -A legacy of decommissioning services led to apprehension for some health professionals to adopt the model. The results from phase 1 highlight that digital service delivery during the covid pandemic may increase accessibility for individuals with long-term health conditions. Also, participating in multiple pathways suggest an increase in sustained long-term changes.  Conclusion: Integrated lifestyle services could be an effective model to tackle co-morbidities with opportunities to work with community partners to develop robust care pathways. However, there are still challenges in adopting the model by GP practices and the need to further explore the service's health outcomes and cost-effectiveness. Implications: These findings will be used to make real-time changes to One You Lincolnshire service delivery and contribute to a broader body of research on the implementation of ILS in rural settings. One limitation of the study was the dropout of some participants between survey and interview, resulting in fewer service users' perspectives than desired. However, phase 2 will focus on a more extensive dataset to triangulate the findings

Rethinking International Investment Governance: Principles for the 21st Century

Rethinking International Investment Governance: Principles for the 21st Century – written over the course of a week by a distinguished group of experts in international economic governance using the Booksprint process – aims to serve as a practical resource for those interested in the elements of an international investment system that promotes sustainable development and achieves legitimacy by providing benefits to all stakeholders. The objective of Rethinking International Investment Governance is to change the terms of the debate so that societal values and goals are at the center of discussions about each reform proposal and process. This book rethinks international investment law as a key system in global economic governance that should incorporate principles of transparency, participation, reciprocity, accountability, and subsidiarity. It critically evaluates the current system of investment governance in light of those principles and goals. And finally, it proposes possible reforms – including multilateral ones – that would realign the governance of international investment with 21st century goals including reduction of poverty and inequality, and protection of human dignity, the environment and the planet.https://scholarship.law.columbia.edu/sustainable_investment_books/1000/thumbnail.jp