Evaluation of efficacy and safety of lascufloxacin for nursing and healthcare associated pneumonia: single-arm, open-label clinical trial: A study protocol

Background: Lascufloxacin hydrochloride (LSFX) is a quinolone antibiotic that inhibits DNA gyrase and topoisomerase IV of bacteria, it is anticipated to minimize antibiotic resistance in bacteria. It exhibits antibacterial activity against a relatively wide range of bacterial species, including anaerobic bacteria, and its efficacy and safety against community-acquired pneumonia have been shown; however, its efficacy and safety against nursing and healthcare associated pneumonia (NHCAP) have not been verified.Methods/Design: Here, a single-arm, open-label, uncontrolled study was conducted in which LSFX was administered to patients with NHCAP at 24 facilities. The research subjects (77 cases) were orally administered 75 mg of LSFX once a day for 7 days. The primary endpoint was the clinical efficacy at the time of test of cure (TOC) (TOC; 5–10 days after the end of LSFX administration), while the secondary endpoints were the efficacy at the time of end of treatment, early clinical efficacy, microbiological efficacy at the time of TOC and end of treatment, and safety evaluation of LSFX.Discussion: NHCAP is a common pneumonia in clinical settings and a notable pneumonia whose mortality is high compared to community-acquired pneumonia. The present study showed the efficacy and safety of LSFX against NHCAP, which could lead to a larger number of therapeutic options for NHCAP

Real-time tracking reveals catalytic roles for the two DNA binding sites of Rad51

Rad51 drives DNA strand exchange, the central reaction in recombinational DNA repair. Two sites of Rad51 are responsible for DNA binding, but the function of these sites has proven elusive. Here, the authors employ real-time assays to reveal catalytic roles for the two DNA binding sites of Rad51

An Enforcement of 'Distinct Teaching Practice' at Hiroshima University (IV)

本稿の目的は, 本年度完成した「特色ある教育実習プログラム」の実施に関して, 事前指導と本実習の接続性に焦点を当て検証することである。検証の結果, 以下の点が明らかになった。①事前指導と本実習の接続性に関して, 概ね効果的であった。事前指導における学習指導案の作成方法, 教材研究の仕方, 児童・生徒理解が本実習に生かされている。本実習に向けての心構えや意識の向上, 必要な力量への気づき等が本実習へのスムーズな導入に繋がっている。②本実習を想定した創意工夫ある事前指導が各附属学校においてなされているが, 事前指導を通して明確化された課題に対して本実習までにどのような指導をするのか, その指導における大学と附属学校の役割と連携のあり方について検討を行う必要がある。③「接続性」に関する最大の課題は, 一連の各教育実習科目の位置づけ, 目的, 及び意義について, 教育実習生, 大学及び附属学校教職員が再度認識し直し共有化することにある