Application of homogenization theory to the study of trabecular bone mechanics

It is generally accepted that the strength and stiffness of trabecular bone is strongly affected by trabecular microstructure. It has also been hypothesized that stress induced adaptation of trabecular bone is affected by trabecular tissue level stress and/or strain. At this time, however, there is no generally accepted (or easily accomplished) technique for predicting the effect of microstructure on trabecular bone apparent stiffness and strength or estimating tissue level stress or strain. In this paper, a recently developed mechanics theory specifically designed to analyze microstructured materials, called the homogenization theory, is presented and applied to analyze trabecular bone mechanics. Using the homogenization theory it is possible to perform microstructural and continuum analyses separately and then combine them in a systematic manner. Stiffness predictions from two different microstructural models of trabecular bone show reasonable agreement with experimental results, depending on metaphyseal region, (R2>0.5 for proximal humerus specimens, R2 <0.5 for distal femur and proximal tibia specimens). Estimates of both microstructural strain energy density (SED) and apparent SED show that there are large differences (up to 30 times) between apparent SED (as calculated by standard continuum finite element analyses) and the maximum microstructural or tissue SED. Furthermore, a strut and spherical void microstructure gave very different estimates of maximum tissue SED for the same bone volume fraction (BV/TV). The estimates from the spherical void microstructure are between 2 and 20 times greater than the strut microstructure at 10-20% BV/TV.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/29647/1/0000736.pd

A comparison of homogenization and standard mechanics analyses for periodic porous composites

Composite material elastic behavior has been studied using many approaches, all of which are based on the concept of a Representative Volume Element (RVE). Most methods accurately estimate effective elastic properties when the ratio of the RVE size to the global structural dimensions, denoted here as ν, goes to zero. However, many composites are locally periodic with finite ν. The purpose of this paper was to compare homogenization and standard mechanics RVE based analyses for periodic porous composites with finite ν. Both methods were implemented using a displacement based finite element formulation. For one-dimensional analyses of composite bars the two methods were equivalent. Howver, for two- and three-dimensional analyses the methods were quite different due to the fact that the local RVE stress and strain state was not determined uniquely by the applied boundary conditions. For two-dimensional analyses of porous periodic composites the effective material properties predicted by standard mechanics approaches using multiple cell RVEs converged to the homogenization predictions using one cell. In addition, homogenization estimates of local strain energy density were within 30% of direct analyses while standard mechanics approaches generally differed from direct analyses by more than 70%. These results suggest that homogenization theory is preferable over standard mechanics of materials approaches for periodic composites even when the material is only locally periodic and ν is finite.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/47812/1/466_2004_Article_BF00369853.pd

Kinetic Study for the Evaluation of Palladium-On-Charcoal Catalyst Cctivity in the Decarbonylation of Aldehydes

Aldehydes when treated with palladium-on-charcoal catalyst at about 160 -170 degrees c undergo catalytic decarbonylation, that is, lose elements of carbon monoxide. The reaction had not been investigated in great detail. A few recent studies, however, have proved catalytic decarbonylation to be one of the most interesting chemical reactions and offer many a challenging problem worthy of further investigation. The author attempted to study the kinetics of decarbonylation. A representative aldehyde, namely, cinnamaldehyde was catalytically decarbonylated to elucidate the kinetic order of the reaction. An attempt was also made to evaluate the best catalyst for decarbonylation by establishing a relationship between palladium content of the catalyst and reaction velocity