De San in zuidelijk Afrika : over solastalgie, ‘rewilding’ en een oproep tot ‘nieuwe zuinigheid’

Het is tijd om na te denken over hoe het na de coronapandemie anders kan. In dit essay doen wij dat door terug te grijpen op elementen uit de levenswijze van een groep jagers en verzamelaars in zuidelijk Afrika, de San, en hoe die gedurende duizenden jaren in staat is geweest op een zuinige wijze te leven in en met de natuur

Sensitivity to situated positionings: Generating insight into organizational change

Within ethnographic forms of organisational research, sensitivity to context is generally acknowledged as a critical ingredient for analysing processes and practices. When conducting such research, however, researchers typically privilege one particular research context for generating knowledge: although some ethnographic scholars underscore the importance of adopting a diversity of both insider and outsider roles, ethnographic research is usually equated with gaining a deep familiarity with the field of study through immersion. First, we argue that, although immersion elicits valuable knowledge ‘from within’, its prioritisation inevitably blinds the researcher’s eye to equally interesting insights stemming from alternative – and often unintended – positionings. Testifying to the significance of researchers’ relational reflexivity for data interpretation, we show how a variety of researcher’ positionings vis-à-vis the researched generated a variety of insights. Critical sensitivity to fieldworker identities in an ethnographic study of planned organisational change within a police organisation allowed us, second, to criticise the change management literature for routinely building on a fixed dichotomy between ‘change agents’ and ‘change recipients’ and to empirically demonstrate a wider variety of police officers’ positionings in relation to change initiatives (i.e. countering, complying with and co-opting) and its initiators (i.e. engaging in other-depreciating, self-questioning or self-affirming identity work)

Clinical presentation and long-term follow-up of dopamine beta hydroxylase deficiency

Dopamine beta hydroxylase (DBH) deficiency is an extremely rare autosomal recessive disorder with severe orthostatic hypotension, that can be treated with L-threo-3,4-dihydroxyphenylserine (L-DOPS). We aimed to summarize clinical, biochemical, and genetic data of all world-wide reported patients with DBH-deficiency, and to present detailed new data on long-term follow-up of a relatively large Dutch cohort. We retrospectively describe 10 patients from a Dutch cohort and 15 additional patients from the literature. We identified 25 patients (15 females) from 20 families. Ten patients were diagnosed in the Netherlands. Duration of follow-up of Dutch patients ranged from 1 to 21 years (median 13 years). All patients had severe orthostatic hypotension. Severely decreased or absent (nor)epinephrine, and increased dopamine plasma concentrations were found in 24/25 patients. Impaired kidney function and anemia were present in all Dutch patients, hypomagnesaemia in 5 out of 10. Clinically, all patients responded very well to L-DOPS, with marked reduction of orthostatic complaints. However, orthostatic hypotension remained present, and kidney function, anemia, and hypomagnesaemia only partially improved. Plasma norepinephrine increased and became detectable, while epinephrine remained undetectable in most patients. We confirm the core clinical characteristics of DBH-deficiency and the pathognomonic profile of catecholamines in body fluids. Impaired renal function, anemia, and hypomagnesaemia can be part of the clinical presentation. The subjective response to L-DOPS treatment is excellent and sustained, although the neurotransmitter profile in plasma does not normalize completely. Furthermore, orthostatic hypotension as well as renal function, anemia, and hypomagnesaemia improve only partially