A calibration method for broad-bandwidth cavity enhanced absorption spectroscopy performed with supercontinuum radiation

An efficient calibration method has been developed for broad-bandwidth cavity enhanced absorption spectroscopy. The calibration is performed using phase shift cavity ring-down spectroscopy, which is conveniently implemented through use of an acousto-optic tunable filter (AOTF). The AOTF permits a narrowband portion of the SC spectrum to be scanned over the full high-reflectivity bandwidth of the cavity mirrors. After calibration the AOTF is switched off and broad-bandwidth CEAS can be performed with the same light source without any loss of alignment to the set-up. We demonstrate the merits of the method by probing transitions of oxygen molecules O-2 and collisional pairs of oxygen molecules (O-2)(2) in the visible spectral range

Impact of Curcuma longa extract on the expression level of brain transporters in in vivo model

Introduction: Blood brain barrier and multidrug resistance phenomenon are subjects of many investigations. Mainly, because of their functions in protecting the central nervous system (CNS) by blocking the delivery of toxic substances to the brain. This special function has some disadvantages, like drug delivery to the brain in neurodegenerative diseases. Objective: The aim of this study was to examine how natural and synthetic substances affect the expression levels of genes (Mdr1a, Mdr1b, Mrp1, Mrp2, Oatp1a4, Oatp1a5 and Oatp1c1) that encode transporters in the blood-brain barrier. Methods: cDNA was synthesized from total RNA isolated from rat hippocampus. The expression level of genes was determined using real-time PCR (RT-PCR) method. Results: Our findings showed that verapamil, as a synthetic substance, caused the greatest reduction of mRNA level of genes studied. The standardized extract of Curcuma longa reduced the expression level for Mrp1 and Mrp2, whereas the increase of mRNA level was observed for Mdr1b, Oatp1a5 and Oatp1c1. Conclusions: These results suggests that herbal extracts may play an important role in overcoming the blood brain barrier during pharmacotherap

Discovering features in gravitational-wave data through detector characterization, citizen science and machine learning

The observation of gravitational waves is hindered by the presence of transient noise (glitches). We study data from the third observing run of the Advanced LIGO detectors, and identify new glitch classes: Fast Scattering/Crown and Low-frequency Blips. Using training sets assembled by monitoring of the state of the detector, and by citizen-science volunteers, we update the Gravity Spy machine-learning algorithm for glitch classification. We find that Fast Scattering/Crown, linked to ground motion at the detector sites, is especially prevalent, and identify two subclasses linked to different types of ground motion. Reclassification of data based on the updated model finds that 27% of all transient noise at LIGO Livingston belongs to the Fast Scattering class, while 8% belongs to the Low-frequency Blip class, making them the most frequent and fourth most frequent sources of transient noise at that site. Our results demonstrate both how glitch classification can reveal potential improvements to gravitational-wave detectors, and how, given an appropriate framework, citizen-science volunteers may make discoveries in large data sets

Propriedades químicas de um Neossolo Quartzarênico sob diferentes sistemas de manejo no Cerrado mato-grossense Soil chemical properties in a Typic Quartzipisamment under different management systems in Brazilian savanna in Mato Grosso State, Brazil

O objetivo deste trabalho foi avaliar o efeito de diferentes usos da terra e sistemas de manejo do solo, nas características químicas de um Neossolo Quartzarênico, no Cerrado de Mato Grosso. Os tratamentos estudados foram: cerrado nativo; uma pastagem de baixa produtividade com 22 anos de implantação; plantio convencional com 1 e 4 anos de uso e diferentes sucessões de culturas; e plantio direto com 5 anos de implantação. Foram determinados os teores de carbono e nitrogênio, pH, acidez potencial, capacidade de troca de cátions (CTC), fósforo disponível, bases trocáveis e saturação por bases do solo. Os valores mais baixos de pH, fósforo disponível, potássio, cálcio e magnésio foram observados nas áreas sob cerrado e pastagem, e a menor concentração de carbono no solo sob pastagem refletiu menor CTC do solo. A aplicação do calcário nos tratamentos com plantio convencional e direto favorece o aumento das concentrações de cálcio e magnésio no solo. Nesses sistemas, a saturação por bases (V%) do solo é mais elevada nas áreas com maior tempo de implantação (4 e 5 anos). Embora o Neossolo Quartzarênico possua limitações para o cultivo, em razão de sua baixa fertilidade natural, se adequadamente manejado, este solo apresenta potencial para o cultivo agrícola.<br>The objective of this work was to evaluate the effect of different land uses and soil management systems, on chemical characteristics of a Typic Quartzipisamment in the savanna (Cerrado) of Mato Grosso State, Brazil. The treatments studied were: native cerrado; pasture with low productivity for 22 years; conventional tillage with one and four years and different crop successions; and no-tillage for five years. Soil carbon and nitrogen, pH, potential acidity, cation exchange capacity (CEC), available phosphorus, exchangeable bases and base saturation were determined. The cerrado and pasture treatments had the lowest pH, available phosphorus, calcium and magnesium values; and the low soil carbon level under pasture system led to lower soil potential CEC. Liming in conventional tillage and no-tillage promotes an increase in soil calcium and magnesium content. In these systems, the soil base saturation (V%) is higher in the areas with a greater time of implantation (4 and 5 years). Although Neossolo Quartzipisamment has limitations for cultivation purposes, due to low inherent fertility, this soil type may have agricultural potential if managed properly