Magnetogravitational instability of anisotropic plasma with Hall effect

Magnetogravitational instability of anisotropic plasma with Hall effec

Optimizing weight control in diabetes: antidiabetic drug selection

S Kalra1, B Kalra1, AG Unnikrishnan2, N Agrawal3, S Kumar41Bharti Hospital, Karnal; 2Amrita Institute of Medical Science, Kochi; 3Medical College, Gwalior; 4Excel Life Sciences, Noida, IndiaDate of preparation: 18th August 2010Conflict of interest: SK has received speaker fees from Novo Nordisk, sanofi-aventis, MSD, Eli Lilly, BMS, and AstraZeneca.Clinical question: Which antidiabetic drugs provide optimal weight control in patients with type 2 diabetes?Results: Metformin reduces weight gain, and may cause weight loss, when given alone or in combination with other drugs. Pioglitazone and rosiglitazone use is associated with weight gain. Use of the glucagon-like peptide-1 (GLP-1) analogs, liraglutide and exenatide, is associated with weight loss. Dipeptidyl peptidase-4 (DPP-4) inhibitors are considered weight-neutral. Results with insulin therapy are conflicting. Insulin detemir provides weight control along with glycemic control.Implementation: • Weight gain is considered an inevitable part of good glycemic control using conventional modalities of treatment such as sulfonylureas.• Use of metformin, weight-sparing insulin analogs such as insulin detemir, and liraglutide, should be encouraged as monotherapy, or in combination with other drugs.Keywords: weight control, diabete

‘So people know I'm a Sikh’: Narratives of Sikh masculinities in contemporary Britain

This article examines British-born Sikh men's identification to Sikhism. In particular, it focuses on the appropriation and use of Sikh symbols amongst men who define themselves as Sikh. This article suggests that whilst there are multiple ways of ‘being’ a Sikh man in contemporary post-colonial Britain, and marking belonging to the Sikh faith, there is also a collectively understood idea of what an ‘ideal’ Sikh man should be. Drawing upon Connell and Messerschmidt's discussion of locally specific hegemonic masculinities (2005. “Hegemonic Masculinity: Rethinking the Concept.” Gender and Society 19 (6): 829–859), it is suggested that an ideal Sikh masculine identity is partly informed by a Khalsa discourse, which informs a particular performance of Sikh male identity, whilst also encouraging the surveillance of young men's activities both by themselves and by others. These Sikh masculinities are complex and multiple, rotating to reaffirm, challenge and redefine contextualised notions of hegemonic masculinity within the Sikh diaspora in post-colonial Britain. Such localised Sikh masculinities may both assert male privilege and reap patriarchal dividends (Connell, W. 1995. Masculinities. Cambridge: Polity Press), resulting in particular British Sikh hegemonic masculinities which seek to shape the performance of masculinity, yet in another context these very same performances of masculinity may also signify a more marginalised masculinity vis-à-vis other dominant hegemonic forms

Can Differentiable Decision Trees Learn Interpretable Reward Functions?

There is an increasing interest in learning reward functions that model human intent and human preferences. However, many frameworks use blackbox learning methods that, while expressive, are difficult to interpret. We propose and evaluate a novel approach for learning expressive and interpretable reward functions from preferences using Differentiable Decision Trees (DDTs) for both low- and high-dimensional state inputs. We explore and discuss the viability of learning interpretable reward functions using DDTs by evaluating our algorithm on Cartpole, Visual Gridworld environments, and Atari games. We provide evidence that that the tree structure of our learned reward function is useful in determining the extent to which a reward function is aligned with human preferences. We visualize the learned reward DDTs and find that they are capable of learning interpretable reward functions but that the discrete nature of the trees hurts the performance of reinforcement learning at test time. However, we also show evidence that using soft outputs (averaged over all leaf nodes) results in competitive performance when compared with larger capacity deep neural network reward functions

AmniSure: A Point of Care Diagnostic for Preterm, Term Prelabor Rupture of Membranes

Background: Accurate, early diagnosis, prompt appropriate intervention is essential in the management of rupture of membranes (ROM), especially preterm. Aim: The aim was to determine efficacy of AmniSure rapid immunoassay placental alpha‑microglobulin‑1 test for accurate diagnosis of true ROM in women with watery discharge after 28 weeks gestation, compare with conventional methods. Subjects and Methods: Study was carried out in women presenting with ROM to labor the room of referral rural medical institute in Central India after ethical approval. Prospective study was performed in women presenting with symptoms/signs of ROM after 28 weeks of gestation. Sterile speculum examination was performed to observe pooling of liquor. Nitrazine, ferning tests were done to diagnose ROM. Vaginal examination was performed to determine cervical dilatation, effacement, station of presenting part in term cases. If all or 2 of 3 tests (pooling, ferning, and nitrazine) were positive, provisional diagnosis of ROM was made. Confirmation of ROM was done at birth. However, if 2 of 3 tests were negative, sterile speculum examination was repeated after 30 min of the first test. Test performance was calculated by comparing AmniSure results against final diagnosis at birth. Of 200 patients between 28 and 42 weeks gestation recruited for study, 31.5% (63/200) were preterm, 68.5% (137/200) term. Statistical analysis of data collected in the electronic database using SPSS version (Amnisure International LLC, 30 JFK Street, 4th Floor, Cambridge, MA 02138, USA). Results: AmniSure rapid immunoassay, rapid method for diagnosis of ROM, has 100% specificity, 99.44% sensitivity (one false negative due to meconium and immediate cesarean section). Conclusion: In comparison to nitrazine, pooling, ferning, AmniSure has almost 100% sensitivity, specificity.Keywords: AmniSure, diagnosis, meconium, preterm, term rupture of membrane

Mechanoluminescnce and photoluminescence in gamma irradiated NaCl:Eu

Rare earth (RE) ions posses unique optical behavior when doped into phosphors. Eu2+ activated phosphors find use in many applications. Eu2+ emission arises from the lowest band of 4f6 5d configuration to 8S7/2  state of 4f7. NaCl having different concentrations of Eu were prepared by melt technique. The crystals of small sizes were cleaved from the grown crystal block and crushed to obtain powder or microcrystalline form of NaCl. Annealed samples were exposed to gamma rays at dose level 0.930kGy. Mechanoluminescnce (ML) was excited impulsively by dropping a load of mass 0.4 kg with the impact velocity of   0.6 ms-1 on to it. An intense ML peak was observed in its ML glow curve. ML intensity increases with increasing concentration of dopant. ML emission spectrum shows a single peak at 482 nm. Photoluminescence (PL) of the sample has also been recorded and a single peak at 427 nm was observed. Shift in ML and PL emission spectrum was observed

Complementary effects of CRM and social media on customer co-creation and sales performance in B2B firms: The role of salesperson self-determination needs

Highlights Social media, CRM technology & social CRM enrich the knowledge of salespeople. Social media, CRM technology & social CRM support value co-creation efforts. Knowledge mediates the effects of social media, CRM technology, and social CRM. Job autonomy & sales quota ease moderate the effect of knowledge on value co-creation. Value co-creation increases sales performance. Abstract This study examines the effects of salespeople\u27s social media and customer relationship management (CRM) technology use on value co-creation through knowledge and the downstream impact on sales performance. Based on task-technology fit and self-determination theories, the findings reveal that social media, CRM technology, and their interaction support salespeople in their value co-creation efforts through the mediating role of knowledge enriched by these tools. The results indicate a significant moderating effect of salesperson job autonomy and sales quota ease in enhancing the relationship between knowledge and value co-creation. The study concludes by discussing important implications that stem from our analyses