The Notes Information System Extention for Mobile Devices

Cílem této diplomové práce je návrh a implementace rozšíření firemního informačního systému do mobilních telefonů. Účelem je zjednodušit dostupnost informací mimo firmu a zvýšit efektivitu práce s informacemi. V první části jsou popsány metody a postupy, které byly použity jako teoretický základ této práce. Druhá část práce je věnovaná analýze současného stavu firmy. Tato část slouží jako podklad pro třetí část a tou je vlastní návrh nového řešení.The main aim of this diploma´s thesis is the devise and the implementation of the extension of information system for mobile phones. The target is to make it easy to get the needed information even when the user is not present in the company and make recieving and working with information effective. In the first part there are described methods and processes which form the theoretical part of this thesis. The second part is related to the analysis of the current state of this company. This part is the basis for the third part which is the real devise for a new solution.

Design of the Yourcut Mobile Application and its Deployment

Diplomová práce se zaměřuje na vytvoření aplikace Yourcut pro zefektivnění služeb oboru Holičství a kadeřnictví. Hlavním cílem této práce je tedy aplikaci vytvořit a nasadit do chytrého zrcadla, sestrojeného přímo k potřebám aplikace. Celou práci lze rozložit do tří částí. V první části se čitatel seznámí s veškerými technologickými předpoklady, které je potřeba znát k tomu, aby celou práci pochopil. Druhá část popisuje a analyzuje. Souhrnně seznamuje s problémy spojenými s vytvářením aplikace a všemi technickými a technologickými předpoklady, aby aplikace byla správně vytvořena. Poslední část popisující vytvoření aplikace, spolu se sestrojením chytrého zrcadla a jejich nasazení.The master's thesis focuses on the creation of the Yourcut application for streamlining the services of barbering. The main goal of this work is to create an application and deploy it in a smart mirror, built directly to the needs of the application. The whole work can be divided into three parts. In the first part, the reader gets acquainted with all the technological prerequisites that need to be known in order to understand the whole work. The second part describes and analyzes. It summarizes the problems associated with creating an application and all the technical and technological prerequisites for the application to be created correctly. In the last part there is a description of the application creating, along with the construction of a smart mirror and their deployment.

Modifying and Validating a Quality of Life Measure to Fit Your Patient Population

Introduction: A well-developed quality of life (QoL) instrument is valuable in identifying the burden of illness. We were interested in exploring whether existing QoL instruments were suitable for patients in our medical setting and, if not, whether this could be rectified by adapting an existing valid and reliable instrument to meet the specific needs of our patient population. For the purposes of this study, we chose to evaluate the quality of life of patients with breast cancer. Specifically, we were interested in two aspects of QoL in women with breast cancer. The first was whether existing instruments were pertinent to the women in our venue. The second research interest was dependent upon the first. If current instruments were found wanting, could this be rectified through the creation and validation of new domains of relevance to these patients? Method: First, five patients were interviewed to ascertain QoL issues pertinent to women in our medical setting. Second, to determine regional appropriateness of existing breast cancer QoL instruments, a search was conducted to identify and review existing breast cancer specific QoL instruments. Third, an addendum was created (to be used in conjunction with an existing instrument identified through the search) that contained three QoL domains not typically found: Financial, Spirituality and Satisfaction with Medical Care. The addendum was then tested along with an existing instrument (FACT-B). Results: Internal consistency for the new scales, Satisfaction with Medical Care, Spirituality, and Financial had alpha coefficients of 0.81, 0.80, and 0.63 respectively. The total score for FACT-B plus addendum was 0.69. Pearson’s correlation coefficients were 0.49 for Financial, 0.64 for Satisfaction with Medical Care, and 0.70 for Spirituality. Total test/retest was 0.71

Region-Specific Effects of Immunotherapy With Antibodies Targeting α-synuclein in a Transgenic Model of Synucleinopathy

Synucleinopathies represent a group of neurodegenerative disorders which are characterized by intracellular accumulation of aggregated α-synuclein. α-synuclein misfolding and oligomer formation is considered a major pathogenic trigger in these disorders. Therefore, targeting α-synuclein species represents an important candidate therapeutic approach. Our aim was to analyze the biological effects of passive immunization targeting α-synuclein and to identify the possible underlying mechanisms in a transgenic mouse model of oligodendroglial α-synucleinopathy. We used PLP-α-synuclein mice overexpressing human α-synuclein in oligodendrocytes. The animals received either antibodies that recognize α-synuclein or vehicle. Passive immunization mitigated α-synuclein pathology and resulted in reduction of total α-synuclein in the hippocampus, reduction of intracellular accumulation of aggregated α-synuclein, particularly significant in the spinal cord. Lowering of the extracellular oligomeric α-synuclein was associated with reduction of the density of activated iba1-positive microglia profiles. However, a shift toward phagocytic microglia was seen after passive immunization of PLP-α-synuclein mice. Lowering of intracellular α-synuclein was mediated by autophagy degradation triggered after passive immunization in PLP-α-synuclein mice. In summary, the study provides evidence for the biological efficacy of immunotherapy in a transgenic mouse model of oligodendroglial synucleinopathy. The different availability of the therapeutic antibodies and the variable load of α-synuclein pathology in selected brain regions resulted in differential effects of the immunotherapy that allowed us to propose a model of the underlying mechanisms of antibody-aided α-synuclein clearance

Composition statique et automatique des ressources dans les environnements Web: une application pour la gestion de l'énergie des bâtiments

Nowadays, a plethora of Web-based environments (Web applications, Web platforms, etc.), publish their functions as RESTful services, i.e., self-contained and self-describing resources that follow the REpresentational State Transfer (REST) architectural style principles. As the Web has become a major medium of communication, integrating objects (e.g., smart devices) into the Web and taking advantage of its open popular standards has created an emerging trend: the Web of Things (WoT). In the WoT, objects expose their functions also as resources respecting the REST principles. Each resource provides well defined functions that meet specific users’ requests. However, there are cases in which a single resource is not sufficient to answer users’ requests, and often, combining two or more resources forming a resource composition, achieves the desired output. Nevertheless, several challenges are to be addressed when composing resources.In this thesis, we address three challenges. The first one consists on verifying the behavior of static resource compositions built manually by the user, as several design errors may occur (e.g., end-loops preventing other resources to run, and datatype mismatch between the Inputs/Outputs of the linked resources). For the other two challenges, the targeted Web environments are hybrid providing: (i) dynamic resources (connected to/removed from the environment at different instances), and (ii) static resources (established to be always available). The challenges focus respectively on the automatic resource discovery, while considering resource location (whenever exposed by objects), and the automatic selection of the appropriate resources to form suitable compositions satisfying users’ requests. To cope with these challenges, we first propose a formal model based on Colored Petri Nets (CPN) that maps resources behavior with their composition to CPN. This allows to use CPN behavioral properties to verify the correctness of static compositions behavior. Then, we propose a formal graph representation linking static resource to dynamic ones, allowing adapted graph algorithms to explore the semantically annotated descriptions of the traversed graph resources, in order to identify automatically the required resources. The resource discovery process uses an original defined indexing schema that allows identifying the resources based on their location (if exposed by objects), and enhancing resource search in large Web environments connecting many resources. As for automatic resource selection, we present a Selection Strategy Adaptor that selects the suitable resources to form several compositions with different implementation alternatives, taking into account Quality of Resource (QoR), Inputs/Outputs matching of related resources, as well as resource availability. Our proposal is generic as it can be applicable in Web environments belonging to different application domains. However, in this thesis, it has been illustrated inthe smart buildings domain, more particularly, in projects for managing buildings’ energy behavior.Aujourd’hui, de nombreux environnements basés sur le Web, tels que les applications Web et les plateformes Web, fournissent leurs fonctions en tant que services RESTful, qui sont des ressources autonomes et auto-descriptives qui suivent le style architectural du REST (REpresentational State Transfer). Comme le Web est devenu un moyen de communication principal, intégrer des objets dans le Web (tels que les appareils intelligents) et exploiter ses technologies populaires, ont abouti au développement d’un nouveau concept : le Web des objets (ou Web of Things (WoT) en Anglais). Dans le WoT, les objets exposent leurs fonctions en tant que ressources respectant également les principes de REST. Chaque ressource fournit des fonctions qui répondent à des demandes spécifiques des utilisateurs. Mais, parfois, une seule ressource ne suffit pas pour répondre à certaines demandes et, souvent, la combinaison de plusieurs ressources, formant une composition de ressources, permet d’obtenir le résultat souhaité. Néanmoins, il existe plusieurs défis à relever lors de la composition de ressources.Dans cette thèse, nous faisons face à trois défis. Le premier consiste à vérifier le bon comportement des compositions statiques, où les ressources sont sélectionnées et liées manuellement par l’utilisateur, vu que plusieurs erreurs de conception peuvent survenir, telles que des boucles produites empêchant d’autres ressources de s’exécuter et la non correspondance entre les type de données des entrées/sorties des ressources liées. Les deux autres défis sont liés aux environnements Web hybrides fournissant des ressources : (i) dynamiques (connectées/déconnectées de l’environnement à différents instants) et (ii) statiques (établies pour être toujours disponibles). Dans ce cas, les défis portent respectivement sur la découverte automatique des ressources, en tenant compte de la position des ressources (exposées par des objets), et sur la sélection automatique des ressources appropriées pour former des compositions répondant aux demandes de l’utilisateur.Pour faire face à ces différents défis, nous proposons tout d’abord un modèle formel basé sur les réseaux de Petri colorés (Colored Petri Nets (CPN) en Anglais) qui exprime le comportement des ressources et leur composition en CPN. Cela permet d’utiliser les propriétés de CPN pour vérifier le bon comportement des compositions statiques. Ensuite nous proposons une représentation graphique formelle liant les ressources statiques à celles dynamiques, permettant à des algorithmes de graphe, adaptés à explorer les descriptions sémantiques des ressources parcourues, de découvrir automatiquement les ressources requises. Le processus de la découverte utilise un schéma d’indexation défini pour identifier les ressources en fonction de leur position (si elles sont exposées par des objets) et améliorer la recherche dans des environnements Web connectant de nombreuses ressources. En ce qui concerne la sélection automatique des ressources, on présente un adaptateur de stratégie de sélection qui permet de sélectionner les ressources les plus appropriées parmi celles qui sont candidates, pour former plusieurs compositions ayant différentes alternatives d’implémentation, tenant compte de la qualité des ressources, du matching entre les entrées/sorties des ressources liées, ainsi que de leurs disponibilités.Nos contributions proposées sont génériques qui peuvent être appliquées dans des environnements Web appartenant à différents domaines d’applications métiers. Cependant, dans cette thèse, nos solutions sont illustrées dans le domaine des bâtiments intelligents, en s’appuyant sur des projets de gestion du comportement énergétique des bâtiments

The Kindergarten in Brno-Tuřany

Cílem diplomové práce je návrh novostavby mateřské školy v Brně - Tuřanech. V budově jsou dvě učebny a jedna dílna pro kreativní tvorbu dětí. Jedná se o jednopodlažní budovu. Budova má dva typy střech: plochou zelenou střechu a jednoplášťovou šikmou střechu pokrytou plechem. Obvodové stěny jsou navrženy z keramických tvárnic opatřené tepelně izolačním systémem EITCS. Kolem budovy je oplocení, parkovací plocha a zpevněné plochy, které vedou k mateřské škole. Za mateřskou školou je navržené dětské hřiště. Vytápění zajišťují tepelná čerpadla země-voda a fotovoltaické panely. Třídy jsou vytápěny podlahovým topením. V budově je klimatizace. Stavba využívá dešťovou vodu ke splachování toalet a zavlažování trávníku. Třetí část diplomové práce obsahuje řešení vnitřního akustického prostředí. Akustické řešení je založeno na optimálním době dozvuku a návrhu pohltivých materiálů, absorpčních předmětů a vnitřních obkladů.The aim of the diploma thesis is the design of a new kindergarten building in Brno - Tuřany. The building has two classrooms and one workshop for the creation of ceramic products. It is a one-storey building. The building has two types of roofs: a flat green roof and a mono pitched roof covered by metal. The external walls is designed by ceramic blocks with external thermal insulation composite system (ETICS). Around the building is fencing, parking area and paved areas which lead to the kindergarten. Behind the building is a playground. Heating is provided by ground-water heat pumps and photovoltaic panels. The classrooms are heated by floor heating. The building has air conditioning. The building uses rainwater to flush the toilets and lawn irrigation. The third part of diploma thesis includes solutions of interior acoustic environment. Classrooms is subordinate to norm and standards as an interior sound reverberation or sound reflectance. Acoustic solution is based on optimal design of absorptive materials and interior facing.

LA PARTICIPATION DE L'AUDIT COMPTABLE AU SOUTIEN DU CONTRÔLE FISCAL. Etude de cas : la direction des impôts de la wilaya d'oum el bouaghi

The thesis is to address the participation of the financial audit support tax audit, in reference to the Algerian tax system, and barriers to in the latter, and most important is the tax fraud that destroyed the national economy in general and the interests of public treasures in particular, financial resources that help the state economic development strategies are put into channels undetermined. This in order to establish and practical issues of the thesis, which leads us to control mechanisms that protect tax and penalized one stroke tax fraud, therefore we created a system to fight against tax evasion which is to audit the account of taxpayers companies and establishments primarily economic, in the end this mechanism helps us to recover state assets and protect the national economy

Apartment Building in Zámrsk

Stavba se nachází na severním okraji obce zámrsk. novostavba bytového domu zahrnuje 6 bytových jednotek, 4 vnitřní parkovací stání + 6 venkovních stání z toho jedno je vyhrazeno pro osoby s omezenou schopností pohybu. navrhovaný objekt také řeší kromě kompletní vybavenosti bytových jednotek, technické zázemí, úložný prostor a sklepní kóje pro každou bytovou jednotku. Vzhledem k velikosti obce je rozsah navrhované stavby adekvátním dílem pro navýšení bytových kapacit v klidném a příjemném místě. Vertikálně funguje obytný soubor jako trojpodlažní, podsklepená stavba. Střecha je řešena jako plochá vegetační s extenzivním vegetací. Objekt má maximální velikost 25,82 x 13,8 x 7,10 mThe building is located on the northern edge of the village of zámrsk. The new building of the apartment building includes 6 residential units, 4 indoor parking spaces + 6 outdoor parking spaces, one of which is reserved for persons with reduced mobility. The proposed building also solves in addition to complete equipment of residential units, technical facilities, storage space and cellars for each apartment unit. due to the size of the municipality, the scope of the proposed construction is an adequate part for increasing the residential capacity in a quiet and pleasant place. Vertically, the residential set functions as a three-storey, sub-collapsed building. The roof is designed as a flat vegetation with extensive vegetation. The building has a maximum size of 25.82 x 13.8 x 7.10 m

Interaktivní model areálu Městského úřadu Břeclav

This thesis is in a first way focused on interactive model of Břeclav Municipal Office, which makes the orientation inside the building easier for users to find the services they look for. The work is primarily focused on modeling in certain program environments and then on its real functioning and deployment