1,171 research outputs found
Fano Effect in a Few-Electron Quantum Dot
We have studied the Fano effect in a few-electron quantum dot side-coupled to
a quantum wire. The conductance of the wire, which shows an ordinal
staircase-like quantization without the dot, is modified through the
interference (the Fano effect) and the charging effects. These effects are
utilized to verify the exhaustion of electrons in the dot. The "addition energy
spectrum" of the dot shows a shell structure, indicating that the electron
confinement potential is fairly circular. A rapid sign inversion of the Fano
parameter on the first conductance plateau with the change of the wire gate
voltage has been observed, and explained by introducing a finite width of
dot-wire coupling.Comment: 11 pages, 7 figure
Heme Oxygenase-1 Expression Affects Murine Abdominal Aortic Aneurysm Progression.
Heme oxygenase-1 (HO-1), the rate-limiting enzyme in heme degradation, is a cytoprotective enzyme upregulated in the vasculature by increased flow and inflammatory stimuli. Human genetic data suggest that a diminished HO-1 expression may predispose one to abdominal aortic aneurysm (AAA) development. In addition, heme is known to strongly induce HO-1 expression. Utilizing the porcine pancreatic elastase (PPE) model of AAA induction in HO-1 heterozygous (HO-1+/-, HO-1 Het) mice, we found that a deficiency in HO-1 leads to augmented AAA development. Peritoneal macrophages from HO-1+/- mice showed increased gene expression of pro-inflammatory cytokines, including MCP-1, TNF-alpha, IL-1-beta, and IL-6, but decreased expression of anti-inflammatory cytokines IL-10 and TGF-beta. Furthermore, treatment with heme returned AAA progression in HO-1 Het mice to a wild-type profile. Using a second murine AAA model (Ang II-ApoE-/-), we showed that low doses of the HMG-CoA reductase inhibitor rosuvastatin can induce HO-1 expression in aortic tissue and suppress AAA progression in the absence of lipid lowering. Our results support those studies that suggest that pleiotropic statin effects might be beneficial in AAA, possibly through the upregulation of HO-1. Specific targeted therapies designed to induce HO-1 could become an adjunctive therapeutic strategy for the prevention of AAA disease
Low-temperature tapered-fiber probing of diamond NV ensembles coupled to GaP microcavities
In this work we present a platform for testing the device performance of a
cavity-emitter system, using an ensemble of emitters and a tapered optical
fiber. This method provides high-contrast spectra of the cavity modes,
selective detection of emitters coupled to the cavity, and an estimate of the
device performance in the single- emitter case. Using nitrogen-vacancy (NV)
centers in diamond and a GaP optical microcavity, we are able to tune the
cavity onto the NV resonance at 10 K, couple the cavity-coupled emission to a
tapered fiber, and measure the fiber-coupled NV spontaneous emission decay.
Theoretically we show that the fiber-coupled average Purcell factor is 2-3
times greater than that of free-space collection; although due to ensemble
averaging it is still a factor of 3 less than the Purcell factor of a single,
ideally placed center.Comment: 15 pages, 6 figure
Crossover from mesoscopic to universal phase for electron transmission in quantum dots
Measuring phase in coherent electron systems (mesoscopic systems) provides
ample information not easily revealed by conductance measurements. Phase
measurements in relatively large quantum dots (QDs) recently demonstrated a
universal like phase evolution independent of dot size, shape, and occupancy.
Explicitly, in Coulomb blockaded QDs the transmission phase increased
monotonically by pi throughout each conductance peak, thereafter, in the
conductance valleys the phase returned sharply to its base value. Expected
mesoscopic features in the phase, related to spin degeneracy or to exchange
effects, were never observed. Presently, there is no satisfactory full
explanation for the observed phase universality. Unfortunately, the phase in a
few-electron QDs, where it can be better understood was never measured. Here we
report on such measurements on a small QD that occupy only 1-20 electrons. Such
dot was embedded in one arm of a two path electron interferometer, with an
electron counter near the dot. Unlike the repetitive behavior found in larger
dots we found now mesoscopic features for dot occupation of less than some 10
electrons. An unexpected feature in this regime is a clear observation of the
occupation of two different orbital states by the first two electrons -
contrary to the recent publications. As the occupation increased the phase
evolved and turned universal like for some 14 electrons and higher. The present
measurements allowed us to determine level occupancy and parity. More
importantly, they suggest that QDs go through a phase transition, from
mesoscopic to universal like behavior, as the occupancy increases. These
measurements help in singling out potential few theoretical models among the
many proposed.Comment: 12 pages, 6 figure
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Effects of classification context on categorization in natural categories
The patterns of classification of borderline instances of eight common taxonomic categories were examined under three different instructional conditions to test two predictions: first, that lack of a specified context contributes to vagueness in categorization, and second, that altering the purpose of classification can lead to greater or lesser dependence on similarity in classification. The instructional conditions contrasted purely pragmatic with more technical/quasi-legal contexts as purposes for classification, and these were compared with a no-context control. The measures of category vagueness were between-subjects disagreement and within-subjects consistency, and the measures of similarity based categorization were category breadth and the correlation of instance categorization probability with mean rated typicality, independently measured in a neutral context. Contrary to predictions, none of the measures of vagueness, reliability, category breadth, or correlation with typicality were generally affected by the instructional setting as a function of pragmatic versus technical purposes. Only one subcondition, in which a situational context was implied in addition to a purposive context, produced a significant change in categorization. Further experiments demonstrated that the effect of context was not increased when participants talked their way through the task, and that a technical context did not elicit more all-or-none categorization than did a pragmatic context. These findings place an important boundary condition on the effects of instructional context on conceptual categorization
The hippocampi of children with chromosome 22q11.2 deletion syndrome have localized anterior alterations that predict severity of anxiety
BACKGROUND: Individuals with 22q11.2 deletion syndrome (22q11.2DS) have an elevated risk for schizophrenia, which increases with history of childhood anxiety. Altered hippocampal morphology is a common neuroanatomical feature of 22q11.2DS and idiopathic schizophrenia. Relating hippocampal structure in children with 22q11.2DS to anxiety and impaired cognitive ability could lead to hippocampus-based characterization of psychosis-proneness in this at-risk population. METHODS: We measured hippocampal volume using a semiautomated approach on MRIs collected from typically developing children and children with 22q11.2DS. We then analyzed hippocampal morphology with Localized Components Analysis. We tested the modulating roles of diagnostic group, hippocampal volume, sex and age on local hippocampal shape components. Lastly, volume and shape components were tested as covariates of IQ and anxiety. RESULTS: We included 48 typically developing children and 69 children with 22q11.2DS in our study. Hippocampal volume was reduced bilaterally in children with 22q11.2DS, and these children showed greater variation in the shape of the anterior hippocampus than typically developing children. Children with 22q11.2DS had greater inward deformation of the anterior hippocampus than typically developing children. Greater inward deformation of the anterior hippocampus was associated with greater severity of anxiety, specifically fear of physical injury, within the 22q11.2DS group. LIMITATIONS: Shape alterations are not specific to hippocampal subfields. CONCLUSION: Alterations in the structure of the anterior hippocampus likely affect function and may impact limbic circuitry. We suggest these alterations potentially contribute to anxiety symptoms in individuals with 22q11.2DS through modulatory pathways. Altered hippocampal morphology may be uniquely linked to anxiety risk factors for schizophrenia, which could be a powerful neuroanatomical marker of schizophrenia risk and hence protection
Fabrication of Triangular Nanobeam Waveguide Networks in Bulk diamond Using Single-Crystal Silicon Hard Masks
A scalable approach for integrated photonic networks in single-crystal
diamond using triangular etching of bulk samples is presented. We describe
designs of high quality factor (Q=2.51x10^6) photonic crystal cavities with low
mode volume (Vm=1.062x({\lambda}/n)^3), which are connected via waveguides
supported by suspension structures with predicted transmission loss of only
0.05 dB. We demonstrate the fabrication of these structures using transferred
single-crystal silicon hard masks and angular dry etching, yielding photonic
crystal cavities in the visible spectrum with measured quality factors in
excess of Q=3x103.Comment: This article will be published in Applied Physics Letter
Sources of Nonnative Centrarchids in the Upper Colorado River Revealed by Stable Isotope and Microchemical Analyses of Otoliths
Nonnative fishes represent a significant impediment to the recovery of imperiled fishes, including those endemic to the Colorado River in the southwestern United States. Efforts to control nonindigenous fish abundance in the upper Colorado River basin have been unsuccessful owing in part to lack of knowledge regarding nonnative fish recruitment sources. We determined the source habitat (floodplain pond versus riverine habitats) for nonnative centrarchid fishes (largemouth bass Micropterus salmoides, green sunfish Lepomis cyanellus, bluegill L. macrochirus, and black crappie Pomoxis nigromaculatus) in the upper Colorado River using stable hydrogen isotopic composition (δD) and strontium:calcium (Sr:Ca) ratios in fish otoliths as natural markers of environmental history. Stable hydrogen isotope analysis revealed that 59% of centrarchids exhibited the otolith core signatures expected for riverine-origin fish, while 22% had emigrated from floodplain ponds and 19% were of uncertain origin. Strontium:calcium ratio data were consistent with the δD assays and indicated that relatively few fish immigrated to the river from high-salinity habitats. Black crappie was the only species that originated primarily from floodplain ponds. Efforts to control the abundance of most of the fishes included in this study should be concentrated in riverine habitats given the hydrologic conditions (below-average river discharge) present during our study. However, the proportion of pond-origin fish increased with fish age, which, coupled with historical river discharge data, suggested that floodplain pond contributions to riverine nonnative fish populations fluctuate with the interannual variations in flow regime and river–pond connectivity. Our results are the first to demonstrate the utility of δD as a natural marker of fish environmental history that will probably provide valuable insights into the management of fish in other environments
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