Design and baseline characteristics of the finerenone in reducing cardiovascular mortality and morbidity in diabetic kidney disease trial

Background: Among people with diabetes, those with kidney disease have exceptionally high rates of cardiovascular (CV) morbidity and mortality and progression of their underlying kidney disease. Finerenone is a novel, nonsteroidal, selective mineralocorticoid receptor antagonist that has shown to reduce albuminuria in type 2 diabetes (T2D) patients with chronic kidney disease (CKD) while revealing only a low risk of hyperkalemia. However, the effect of finerenone on CV and renal outcomes has not yet been investigated in long-term trials. Patients and Methods: The Finerenone in Reducing CV Mortality and Morbidity in Diabetic Kidney Disease (FIGARO-DKD) trial aims to assess the efficacy and safety of finerenone compared to placebo at reducing clinically important CV and renal outcomes in T2D patients with CKD. FIGARO-DKD is a randomized, double-blind, placebo-controlled, parallel-group, event-driven trial running in 47 countries with an expected duration of approximately 6 years. FIGARO-DKD randomized 7,437 patients with an estimated glomerular filtration rate >= 25 mL/min/1.73 m(2) and albuminuria (urinary albumin-to-creatinine ratio >= 30 to <= 5,000 mg/g). The study has at least 90% power to detect a 20% reduction in the risk of the primary outcome (overall two-sided significance level alpha = 0.05), the composite of time to first occurrence of CV death, nonfatal myocardial infarction, nonfatal stroke, or hospitalization for heart failure. Conclusions: FIGARO-DKD will determine whether an optimally treated cohort of T2D patients with CKD at high risk of CV and renal events will experience cardiorenal benefits with the addition of finerenone to their treatment regimen. Trial Registration: EudraCT number: 2015-000950-39; ClinicalTrials.gov identifier: NCT02545049

Culturological approach as a conceptual basis for renewing modern higher pedagogical education

The article substantiates the prospects and productivity of the culturological approach, in the context of which culture is considered to be a source of content of higher pedagogical education and as a method of its research and design. Theoretical deduction of the concept of “culture” allows us to focus on the definitions that expand understanding of the essence of culture. The relationship between education and culture, a person and culture is revealed. The application of culturological approach in modern pedagogy is asserted, which provides a view of pedagogical phenomena and processes as cultural phenomena, requires certain ways of their cultural description, interpretation and construction, and focuses on a broad approach to culture and education in the context of general philosophical understanding. Probable changes in the content of pedagogical education in the context of the culturological approach, which cause adjustment of educational technologies, are outlined. At the normative level, it is manifested in the requirements to the content-related component as “containing culture” and “creating culture”, of the procedural side, which differs in the integrity, integrative unity of all the components; management of educational and pedagogical activities on the principles of dialogue and mutual respect; educational space as a culturally appropriate, multicultural environment; learning technologies as human-dimensional, innovative, value-oriented

Culturological approach as a conceptual basis for renewing modern higher pedagogical education

The article substantiates the prospects and productivity of the culturological approach, in the context of which culture is considered to be a source of content of higher pedagogical education and as a method of its research and design. Theoretical deduction of the concept of “culture” allows us to focus on the definitions that expand understanding of the essence of culture. The relationship between education and culture, a person and culture is revealed. The application of culturological approach in modern pedagogy is asserted, which provides a view of pedagogical phenomena and processes as cultural phenomena, requires certain ways of their cultural description, interpretation and construction, and focuses on a broad approach to culture and education in the context of general philosophical understanding. Probable changes in the content of pedagogical education in the context of the culturological approach, which cause adjustment of educational technologies, are outlined. At the normative level, it is manifested in the requirements to the content-related component as “containing culture” and “creating culture”, of the procedural side, which differs in the integrity, integrative unity of all the components; management of educational and pedagogical activities on the principles of dialogue and mutual respect; educational space as a culturally appropriate, multicultural environment; learning technologies as human-dimensional, innovative, value-oriente

From the experience of organizing artistic and productive activities of older preschool children by means of distance education in the conditions of quarantine measures for the spread of COVID-19

The relevance of the article relates to the need for continuing preschool education under quarantine conditions to prevent the spread of COVID-19 by means of distance technologies and preparation of children for STEAM education. Artistic and productive activities are considered to be the resource of STEAM education. The aim of the article is to substantiate educational opportunities of distance education programs for undertaking artistic and productive activities of older preschool children on quarantine. Research methods: theoretical analysis, surveys, generalization of experience, analysis of children’s products, parental feedback. The scientific basis of the study is a set of approaches of different levels. Scientific novelty of the research is two-fold. The possibility of organizing artistic and productive activities of older preschool children by means of remote technologies in terms of preparing parents to interact with educators and organizational, technical, informational assistance to children. The features of the organization of such education in Ukraine under conditions of introducing quarantine measures are revealed. Practical significance is viewed through development and approbation of the content of classes on artistic and productive activities, integrated with the fundamentals of mathematics. There have been developed the questionnaires on digital competence for educators and digital literacy for parents