Backhaul-aware Robust 3D Drone Placement in 5G+ Wireless Networks

Using drones as flying base stations is a promising approach to enhance the network coverage and area capacity by moving supply towards demand when required. However deployment of such base stations can face some restrictions that need to be considered. One of the limitations in drone base stations (drone-BSs) deployment is the availability of reliable wireless backhaul link. This paper investigates how different types of wireless backhaul offering various data rates would affect the number of served users. Two approaches, namely, network-centric and user-centric, are introduced and the optimal 3D backhaul-aware placement of a drone-BS is found for each approach. To this end, the total number of served users and sum-rates are maximized in the network-centric and user-centric frameworks, respectively. Moreover, as it is preferred to decrease drone-BS movements to save more on battery and increase flight time and to reduce the channel variations, the robustness of the network is examined as how sensitive it is with respect to the users displacements.Comment: in Proc. IEEE ICC2017 Workshops, FlexNets201

THE EXPRESSION OF P53 AND MDM4 IN ORAL, LARYNGEAL AND CUTANEOUS SQUAMOUS CELL CARCINOMA; A COMPARATIVE STUDY

Background: P53 and MDM4 had been known to have dual mechanism depending on their localization. Nuclear p53 can bind to DNA and activate proapoptotic gene expression; cytoplasmic p53 can trigger transcription-independent apoptosis by directly interacting with Bcl-2 family members. Objectives: The aim of current study to evaluate and compare the expression of P53, MDM4 in oral , laryngeal and cutaneous SCC by microarray(TMA) and to investigate the correlation of expression of these markers with histopathological grading of tumor. Methods: One-hundred twenty paraffin embedded SCC sample of Iraqi patients collected during period 2009-2012, retrieved for TMA construction and the expression of P53 and MDM4 was examined by immunohistochemistry. Results: Data showed males with SCC were more than females ( 63.3%/76 , 36.7%/44). Most cancer types expressed both nuclear and cytoplasmic staining of P53 and MDM4 in different percentage, cutaneous Scc Nuclear/cytoplasm expression of P53 were ( 38.8%/94.6%), laryngeal (55%/90%), oral (36.8%/86.8%). Cutaneous SCC N/Cyt expression of MDM4 were (91.8%/72.9%), laryngeal (91.3%/76.3%), oral (97.5%/62.5%).There is no significant difference in expression of both protein markers and tumor types. Obvious significant correlation showed between tumor grading P53 nuclear expression. Conclusions: P53 and MDM4 were frequently overexpressed in SCC cases and there was a significant correlation between these markers. Nuclear p53 and cytoplasmic MDM4 overexpression can be considered as prognostic factor with tumour grading. High percentage MDM4 overexpression should be considered in their treatment

Methylprednisolone vs Dexamethasone in Management of COPD Exacerbation; a Randomized Clinical Trial

Introduction: Corticosteroids are routinely used in management of chronic obstructive pulmonary disease (COPD) exacerbation. The main purpose of present study was to compare the efficacy of methyl prednisolone (MP) and dexamethasone (DXM) for this purpose.Methods: Adult COPD patients entered the present clinical trial. All patients received standard treatment on admission and were then divided into 2 groups of intravenous MP and DXM. Patients were asked to rate their shortness of breath; sputum volume and viscosity; dyspnea; cough; and general wellbeing on a 0-5 scale. Baseline parameters such as O2 saturation, arterial blood gas parameters, and white blood cell (WBC) count were compared on admission and day 7 and 14 of therapy using SPSS 22.Results: 68 patients were randomly allocated to 2 groups of 34 (82.4% male). The baseline characteristics of the two groups were similar (p < 0.05). Comparison of treatment outcomes for the 7th day showed a significant difference between the 2 groups only regarding cough (p = 0.047), HCO3 (p < 0.001), and O2 saturation (p = 0.042). On day 14 the 2 groups were different only regarding cough (p = 0.048) and sputum viscosity (p = 0.011). There was a significant difference between the two groups regarding trend of changes in dyspnea (p = 0.02; DXM >> MP) and cough (p = 0.035; MP >> DXM). There were no significant differences between the two medications regarding side effects on 7th and 14th day after treatment.Conclusion: It seems that MP and DXM have similar efficacy and side effects in treatment of COPD exacerbation and selecting drug of choice would better be based on the most prominent symptoms of patients on admission

High expression of Talin-1 is associated with tumor progression and recurrence in melanoma skin cancer patients.

BACKGROUND: Talin-1 as a component of multi-protein adhesion complexes plays a role in tumor formation and migration in various malignancies. This study investigated Talin-1 in protein levels as a potential prognosis biomarker in skin tumors. METHODS: Talin-1 was evaluated in 106 skin cancer (33 melanomas and 73 non-melanomas skin cancer (NMSC)) and 11 normal skin formalin-fixed paraffin-embedded (FFPE) tissue samples using immunohistochemical technique on tissue microarrays (TMAs). The association between the expression of Talin-1 and clinicopathological parameters, as well as survival outcomes, were assessed. RESULTS: Our findings from data minings through bioinformatics tools indicated dysregulation of Talin-1 in mRNA levels for skin cancer samples. In addition, there was a statistically significant difference in Talin-1 expression in terms of intensity of staining, percentage of positive tumor cells, and H-score in melanoma tissues compared to NMSC (P = 0.001, P \u3c 0.001, and P \u3c 0.001, respectively). Moreover, high cytoplasmic expression of Talin-1 was found to be associated with significantly advanced stages (P = 0.024), lymphovascular invasion (P = 0.023), and recurrence (P = 0.006) in melanoma cancer tissues. Our results on NMSC showed a statistically significant association between high intensity of staining and the poor differentiation (P = 0.044). No significant associations were observed between Talin-1 expression levels and survival outcomes of melanoma and NMSC patients. CONCLUSION: Our observations showed that higher expression of Talin1 in protein level may be significantly associated with more aggressive tumor behavior and advanced disease in patients with skin cancer. However, further studies are required to find the mechanism of action of Talin-1 in skin cancers

The Association Between Higher Expression of Talin-1 and the Reduced Survival Rate in Ovarian Serous Carcinoma Patients

Background & Objective: Talin-1 is a constituent of the multiprotein adhesion complexes that play main role in the formation of tumors and migration in different types of malignancies. The present study aimed to assess expression and prognostic significance of the talin-1 protein in ovarian serous carcinoma (OSC) patients. Methods: The expression of talin-1 in mRNA and its protein levels were investigated for ovarian cancer (OC) by using bioinformatics tools, including Gene Expression Profiling Interactive Analysis 2 (GEPIA2), Gene Expression Database of Normal and Tumor Tissue 2 (GENT2), and The University of ALabama at Birmingham CANcer data analysis Portal (UALCAN) databases. Thereafter, immunohistochemical (IHC) staining was used to study the expression patterns of the talin-1 protein using 46 paraffin-embedded OSC tissue specimens, 25 benign tumors, and 20 normal tissues, which were assembled in tissue microarrays (TMAs). We also assessed the potential association between the expression of the talin-1 protein, various clinicopathological parameters, and survival outcomes. Results: Our IHC examination for talin-1 was significantly overexpressed in OSC tissues compared to benign tumors and normal tissues. The Kaplan-Meier survival analysis has also indicated statistically significant differences in terms of diseasespecific survival (DSS) and progression-free survival (PFS) between the patients with high and low expression levels of talin-1, respectively. Conclusion: The talin-1 protein was overexpressed in OSC tissues, and a high expression level of talin-1 was found to be significantly associated with tumor aggressiveness and poorer DSS or PFS. Therefore, talin-1 may serve as a molecular marker of cancer progression and a novel prognostic biomarker in these patients

Synthesis and characterization of Zeolite/Fe3O4 nanocomposite by green quick precipitation method.

A green quick precipitation method was successfully used for synthesis of magnetic iron oxide nanoparticles (Fe3O4-NPs) on the surface of sodium/potassium type zeolite. Ferric chloride, ferrous chloride and sodium hydroxide aqueous solutions were used in the synthesis and coating of the Fe3O4-NPs on the surface of the zeolite to produce the zeolite/magnetic iron oxide nanocomposite (zeolite/Fe3O4 –NCs). The reaction was performed in aqueous suspension phase under the ambient condition as green chemistry method. Characterization with Fourier transforms infrared spectroscopy (FT‒IR), powder X-ray diffraction (PXRD), scanning electron microscopy (SEM), energy dispersive X-ray fluorescence (EDXF) and transmission electron microscopy (TEM) confirmed the formation of Fe3O4-NPs with mean particle sizes of 3.55±1.02 nm on the surface of the zeolite