Menarcheal age of blind girls: Menarcheal age in blind

Menarche is a developmental milestone. Age at which menarche is attained is highly variable and highly sensitive to a variety of internal and external forces like climatic conditions, physical and mental factors, nutrition and socio-economic status. Exposure to light and other visual cues may influence the pubertal changes. Menarcheal age (MA) of 110 blind girls was compared to that of 102 normal girls of same age group and of same area of residence. An advancement of 9 months in MA was seen in blind girls. Influence of light and other factors on menarche is discussed

Evaluation of an Ayurvedic polyherbal formulation (Sindhuvaradi agada) in Doxorubicin induced Cardiotoxicity- in wistar rats

Background: Presently cancer is second major cause of death in India. Doxorubicin, an anthracycline is frequently used to treat various human malignancies but at same time its use is warranted with irreversible cardiomyopathy. Ayurveda, ancient science of Medicine has advocated various herbal drugs for toxicological cases which include protection of Hrudaya (cardio-protective) and Sindhuvaradhi agada is one of them indicated for cobra envenomation. Objective: Study was aimed to evaluate Sindhuvaradi agada in Doxorubicin induced cardio-toxicity in Wistar rats. Methodology: Group I served as control. Cardio-toxicity was induced by Doxorubicin administration (15 mg/kg body weight for 2 weeks) in Group II. Group III was pretreated with aqueous solution of Sindhuvaradi agada (216 mg/kg body weight) for 2 weeks followed by Doxorubicin for next 2 weeks. In Group IV cardio-toxicity was produced by Doxorubicin administration for 2 weeks followed by administration of Sindhuvaradi agada in next 2 weeks. General mortality, histopathology of heart and biomarker enzymes (CPK-MB, SGOT, SGPT and Lipid Profile)was evaluated. Results: Pretreatment with Sindhuvaradi agada significantly (p<0.05) controlled myocardial damage as reflected in biomarker enzymes [CPK-MB (241.3 ± 5.25), SGOT (225.8 ± 6.63)] and also minimized the cardio myocyte damage when compared to Doxorubicin treated group [CPK-MB (258.8 ±18.33),SGOT(534 ± 102.8)]

Gold in the male reproductive tract of rat: A chronobiological study

In a 24 hour study, 10 adult male albino rats (total=60) were sacrificed at every four hour starting from 00:00 hours. Reproductive tissues and ndash; testis, epididymis (caput, corpus, cauda), vas deference, seminal vesicle, prostate (ventral, dorso ventral) and coagulating glands were dissected out and the level of gold was measured in each tissue by employing atomic absorption spectrophotometry. Level of gold differed showing peaks and nadirs at different timings, like dorso ventral prostate gland showed the highest amount (3.31 and micro;g per gram tissue) at 08:00 hrs and the lowest (0.03 and micro;g per gram) at 00:00 hrs. Fluctuation observed in the level of gold is discussed in terms of chronobiology. [J Med Allied Sci 2016; 6(2.000): 52-55

Evaluation of an Ayurvedic polyherbal formulation (Sindhuvaradi agada) in Doxorubicin induced Cardiotoxicity- in wistar rats

Background: Presently cancer is second major cause of death in India. Doxorubicin, an anthracycline is frequently used to treat various human malignancies but at same time its use is warranted with irreversible cardiomyopathy. Ayurveda, ancient science of Medicine has advocated various herbal drugs for toxicological cases which include protection of Hrudaya (cardio-protective) and Sindhuvaradhi agada is one of them indicated for cobra envenomation. Objective: Study was aimed to evaluate Sindhuvaradi agada in Doxorubicin induced cardio-toxicity in Wistar rats. Methodology: Group I served as control. Cardio-toxicity was induced by Doxorubicin administration (15 mg/kg body weight for 2 weeks) in Group II. Group III was pretreated with aqueous solution of Sindhuvaradi agada (216 mg/kg body weight) for 2 weeks followed by Doxorubicin for next 2 weeks. In Group IV cardio-toxicity was produced by Doxorubicin administration for 2 weeks followed by administration of Sindhuvaradi agada in next 2 weeks. General mortality, histopathology of heart and biomarker enzymes (CPK-MB, SGOT, SGPT and Lipid Profile)was evaluated. Results: Pretreatment with Sindhuvaradi agada significantly (p<0.05) controlled myocardial damage as reflected in biomarker enzymes [CPK-MB (241.3 ± 5.25), SGOT (225.8 ± 6.63)] and also minimized the cardio myocyte damage when compared to Doxorubicin treated group [CPK-MB (258.8 ±18.33),SGOT(534± 102.8)]