Thiruvalluvar’s Observation On Nature: A Study On The Classical Tamil Text Thirukkural

Thiruvalluvar was the foremost thinker of nature among the prominent classical Tamil poets. He not only wrote about morality but also about various themes and subjects. He lived with the nature which portrayed in his works. His famous work Thirukkural is applicable for all the time and people. Most of the researches in Tamil shows how he is associated with nature and the present paper is an attempt to show about his keen observation on the nature

Improved Performance by Combining Web Pre-Fetching Using Clustering with Web Caching Based on SVM Learning Method

Combining Web caching and Web pre-fetching results in improving the bandwidth utilization, reducing the load on the origin server and reducing the delay incurred in accessing information. Web pre-fetching is the process of fetching the Web objects from the origin server which has more likelihood of being used in future. The fetched contents are stored in the cache. Web caching is the process of storing the popular objects ”closer” to the user so that they can be retrieved faster. In the literature many interesting works have been carried out separately for Web caching and Web pre-fetching. In this work, clustering technique is used for pre-fetching and SVM-LRU technique forWeb caching and the performance is measured in terms of Hit Ratio (HR) and Byte Hit Ratio (BHR). With the help of real data, it is demonstrated that the above approach is superior to the method of combining clustering based prefetching technique with traditional LRU page replacement method for Web caching

Supply chain visibility for improving inbound logistics: a design science approach

Supply chain visibility (SCV) has been gaining recognition in recent years as a key factor for achieving analytical capabilities and improving supply chain performance. However, levels of SCV implementation lag behind current technological advances. This research was motivated by the lack of visibility in inbound logistics, which limits the possibility of managing deviation, in particular concerning changes in arrival time of incoming goods, in large industrial firms. We addressed this problem by adopting a design science approach. In particular, we followed context–intervention–mechanism–outcome (CIMO) logic to map and analyse material and information flows. The problems areas were successively translated via business and functional requirements into technological solutions. We evaluated alternative technologies using controlled experiments that mimicked real-life situations. This study provides guidance for manufacturing companies aiming to enhance deviation management and predictive capabilities by improving visibility in their inbound logistics and potentially extending visibility to other areas, such as internal and outbound fl

Atherogenic potential of microgravity hemodynamics in the carotid bifurcation: a numerical investigation

Long-duration spaceflight poses multiple hazards to human health, including physiological changes associated with microgravity. The hemodynamic adaptations occurring upon entry into weightlessness have been associated with retrograde stagnant flow conditions and thromboembolic events in the venous vasculature but the impact of microgravity on cerebral arterial hemodynamics and function remains poorly understood. The objective of this study was to quantify the effects of microgravity on hemodynamics and wall shear stress (WSS) characteristics in 16 carotid bifurcation geometries reconstructed from ultrasonography images using computational fluid dynamics modeling. Microgravity resulted in a significant 21% increase in flow stasis index, a 22–23% decrease in WSS magnitude and a 16–26% increase in relative residence time in all bifurcation branches, while preserving WSS unidirectionality. In two anatomies, however, microgravity not only promoted flow stasis but also subjected the convex region of the external carotid arterial wall to a moderate increase in WSS bidirectionality, which contrasted with the population average trend. This study suggests that long-term exposure to microgravity has the potential to subject the vasculature to atheroprone hemodynamics and this effect is modulated by subject-specific anatomical features. The exploration of the biological impact of those microgravity-induced WSS aberrations is needed to better define the risk posed by long spaceflights on cardiovascular health

Vertical distribution of traffic-generated PM2.5 and NO2 in a tropical urban environment

Ph.DDOCTOR OF PHILOSOPH

H2AFX (H2A histone family, member X)

Review on H2AFX (H2A histone family, member X), with data on DNA, on the protein encoded, and where the gene is implicated

Comparative catching efficiency of traditional prawn fishing gears in Pulicat lake of Tamil Nadu, India

303-310Prawn fishery in Pulicat Lake has a significant role in livelihood of the fishers, which is being harvested through different fishing gears. Here, we investigated the prawn-fishing gear and their catch composition. The information on various aspect about the gears was collected from the 48 respondents each month through pre-designed interview schedule by adopting random sampling. Results revealed that the quantity of prawn were higher in stake net (209.83 kg), followed by barriers (118.58 kg), drive-in-net (55.58 kg) tangle net (18.25 kg) and was statically significant at 5 %. It was estimated that more than half (52.16 %) of the total prawn catch in Pulicat Lake was obtained through stake net than the barriers (29.48 %), drive-in-net (13.82 %) and tangle net (4.54 %). The maximum quantity of prawn was obtained during the November and December in all the prawn-fishing gear (p < 0.05). This study concludes that non-selective fishing gears resulted in the abundant catch of juvenile fishes and crabs, need to be regulated mesh size, to support the conservation and sustainable harvest of the fishery resources in Pulicat Lake

Computational study of the motor neuron protein KIF5A to identify nsSNPs, bioactive compounds, and its key regulators

Introduction: Kinesin family member 5A (KIF5A) is a motor neuron protein expressed in neurons and involved in anterograde transportation of organelles, proteins, and RNA. Variations in the KIF5A gene that interfere with axonal transport have emerged as a distinguishing feature in several neurodegenerative disorders, including hereditary spastic paraplegia (HSP10), Charcot-Marie-Tooth disease type 2 (CMT2), and Amyotrophic Lateral Sclerosis (ALS).Methods: In this study, we implemented a computational structural and systems biology approach to uncover the role of KIF5A in ALS. Using the computational structural biology method, we explored the role of non-synonymous Single Nucleotide Polymorphism (nsSNPs) in KIF5A. Further, to identify the potential inhibitory molecule against the highly destabilizing structure variant, we docked 24 plant-derived phytochemicals involved in ALS.Results: We found KIF5AS291F variant showed the most structure destabilizing behavior and the phytocompound “epigallocatechin gallate” showed the highest binding affinity (−9.0 Kcal/mol) as compared to wild KIF5A (−8.4 Kcal/mol). Further, with the systems biology approach, we constructed the KIF5A protein-protein interaction (PPI) network to identify the associated Kinesin Families (KIFs) proteins, modules, and their function. We also constructed a transcriptional and post-transcriptional regulatory network of KIF5A. With the network topological parameters of PPIN (Degree, Bottleneck, Closeness, and MNC) using CytoHubba and computational knock-out experiment using Network Analyzer, we found KIF1A, 5B, and 5C were the significant proteins. The functional modules were highly enriched with microtubule motor activity, chemical synaptic transmission in neurons, GTP binding, and GABA receptor activity. In regulatory network analysis, we found KIF5A post-transcriptionally down-regulated by miR-107 which is further transcriptionally up-regulated by four TFs (HIF1A, PPARA, SREBF1, and TP53) and down-regulated by three TFs (ZEB1, ZEB2, and LIN28A).Discussion: We concluded our study by finding a crucial variant of KIF5A and its potential therapeutic target (epigallocatechin gallate) and KIF5A associated significant genes with important regulators which could decrypt the novel therapeutics in ALS and other neurodegenerative diseases

Comparative genomic analysis reveals habitat-specific genes and regulatory hubs within the genus Novosphingobium

© The Author(s), 2017. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in mSystems 2 (2017): e00020-17, doi:10.1128/mSystems.00020-17.Species belonging to the genus Novosphingobium are found in many different habitats and have been identified as metabolically versatile. Through comparative genomic analysis, we identified habitat-specific genes and regulatory hubs that could determine habitat selection for Novosphingobium spp. Genomes from 27 Novosphingobium strains isolated from diverse habitats such as rhizosphere soil, plant surfaces, heavily contaminated soils, and marine and freshwater environments were analyzed. Genome size and coding potential were widely variable, differing significantly between habitats. Phylogenetic relationships between strains were less likely to describe functional genotype similarity than the habitat from which they were isolated. In this study, strains (19 out of 27) with a recorded habitat of isolation, and at least 3 representative strains per habitat, comprised four ecological groups—rhizosphere, contaminated soil, marine, and freshwater. Sulfur acquisition and metabolism were the only core genomic traits to differ significantly in proportion between these ecological groups; for example, alkane sulfonate (ssuABCD) assimilation was found exclusively in all of the rhizospheric isolates. When we examined osmolytic regulation in Novosphingobium spp. through ectoine biosynthesis, which was assumed to be marine habitat specific, we found that it was also present in isolates from contaminated soil, suggesting its relevance beyond the marine system. Novosphingobium strains were also found to harbor a wide variety of mono- and dioxygenases, responsible for the metabolism of several aromatic compounds, suggesting their potential to act as degraders of a variety of xenobiotic compounds. Protein-protein interaction analysis revealed β-barrel outer membrane proteins as habitat-specific hubs in each of the four habitats—freshwater (Saro_1868), marine water (PP1Y_AT17644), rhizosphere (PMI02_00367), and soil (V474_17210). These outer membrane proteins could play a key role in habitat demarcation and extend our understanding of the metabolic versatility of the Novosphingobium species.This work was supported by grants from the Department of Biotechnology (DBT), R.K., S.H., K.P., A.B., and U.S. gratefully acknowledge the National Bureau of Agriculturally Important Microorganisms (NBAIM), Science and Engineering Research Board (SERB), N-PDF (PDF/2015/000062), (PDF/2015, 000319), University Grant Commission (UGC) for the Dr. D. S. Kothari Postdoctoral Fellowship and UGC for providing fellowships, respectively