Parameter selection for model updating with global sensitivity analysis

National Science Foundation of China (NSFC) under Grant No. 11372084 Sem PDF conforme despacho.The problem of selecting parameters for stochastic model updating is one that has been studied for decades, yet no method exists that guarantees the ‘correct’ choice. In this paper, a method is formulated based on global sensitivity analysis using a new evaluation function and a composite sensitivity index that discriminates explicitly between sets of parameters with correctly-modelled and erroneous statistics. The method is applied successfully to simulated data for a pin-jointed truss structure model in two studies, for the cases of independent and correlated parameters respectively. Finally, experimental validation of the method is carried out on a frame structure with uncertainty in the position of two masses. The statistics of mass positions are confirmed by the proposed method to be correctly modelled using a Kriging surrogate.authorsversionpublishe

Neural responses to intention and benefit appraisal are critical in distinguishing gratitude and joy

This work was supported by the National Natural Science Foundation of China (No. 31170973 and No. 31471001) and by the Leverhulme Trust (RPG-2019-010). We would like to thank Dongyan Wu for her technical support.Peer reviewedPublisher PD

Acidic Polysaccharide from Angelica sinensis

Anemia of chronic disease (ACD) is the second most prevalent anemia and frequently occurs in patients with acute or chronic immune activation. In the current study, we evaluated the therapeutic efficacy of Angelica sinensis polysaccharide (ASP) against ACD in rats and the potential mechanisms involved. The results showed that ASP inhibited inflammatory hepcidin in both HepG2 cells and ACD rats by blocking the IL-6/STAT3 and BMP/SMAD pathways. In ACD rats, the administration of ASP increased ferroportin expression, mobilized iron from the liver and spleen, increased serum iron levels, caused an elevation of serum EPO, and effectively relieved the anemia. Furthermore, ASP inhibited NF-κB p65 activation via the IκB kinases- (IKKs-) IκBα pathway, thereby reducing the secretion of interleukin-6 (IL-6) and TNF-α, which is known to inhibit erythropoiesis. Our findings indicate that ASP is a potential treatment option for patients suffering from ACD

Do Chinese Traditional and Modern Cultures Affect Young Adults’ Moral Priorities?

Dramatic cultural change has occurred in Mainland China over the past four decades, yet little is known about how this cultural shift impacts Chinese peoples’ moral values. The present research aims to fill this gap by examining whether Chinese traditional and modern cultures influence young adults’ moral judgments. Study 1 investigated the relation between psychological traditionality/modernity and moral concerns. Results indicated that participants who strongly endorsed Chinese traditional culture prioritize relationship concern rather than justice concern. Study 2 used the cultural priming method and tested the effects of traditional and modern icons on moral concerns. Results suggested that participants who were primed with traditional or modern or neutral icons did not give priority to relationship or justice concern. Together, our findings provide initial empirical evidence on whether Chinese traditional and modern cultures shift the moral mindsets of bicultural young Chinese among alternative (and even competing) moral codes

Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches

Extracellular vesicles (EVs), through their complex cargo, can reflect the state of their cell of origin and change the functions and phenotypes of other cells. These features indicate strong biomarker and therapeutic potential and have generated broad interest, as evidenced by the steady year-on-year increase in the numbers of scientific publications about EVs. Important advances have been made in EV metrology and in understanding and applying EV biology. However, hurdles remain to realising the potential of EVs in domains ranging from basic biology to clinical applications due to challenges in EV nomenclature, separation from non-vesicular extracellular particles, characterisation and functional studies. To address the challenges and opportunities in this rapidly evolving field, the International Society for Extracellular Vesicles (ISEV) updates its 'Minimal Information for Studies of Extracellular Vesicles', which was first published in 2014 and then in 2018 as MISEV2014 and MISEV2018, respectively. The goal of the current document, MISEV2023, is to provide researchers with an updated snapshot of available approaches and their advantages and limitations for production, separation and characterisation of EVs from multiple sources, including cell culture, body fluids and solid tissues. In addition to presenting the latest state of the art in basic principles of EV research, this document also covers advanced techniques and approaches that are currently expanding the boundaries of the field. MISEV2023 also includes new sections on EV release and uptake and a brief discussion of in vivo approaches to study EVs. Compiling feedback from ISEV expert task forces and more than 1000 researchers, this document conveys the current state of EV research to facilitate robust scientific discoveries and move the field forward even more rapidly