55 research outputs found
Forebrain-independent generation of hyperthermic convulsions in infant rats
Febrile seizures are the most common type of convulsive events in children. It is generally assumed that the generalization of these seizures is a result of brainstem invasion by the initial limbic seizure activity. Using precollicular transection in 13-day-old rats to isolate the forebrain from the brainstem, we demonstrate that the forebrain is not required for generation of tonic-clonic convulsions induced by hyperthermia or kainate. Compared with sham-operated littermate controls, latency to onset of convulsions in both models was significantly shorter in pups that had undergone precollicular transection, indicating suppression of the brainstem seizure network by the forebrain in the intact animal. We have shown previously that febrile seizures are precipitated by hyperthermia-induced respiratory alkalosis. Here, we show that triggering of hyperthermia-induced hyperventilation and consequent convulsions in transected animals are blocked by diazepam. The present data suggest that the role of endogenous brainstem activity in triggering tonic-clonic seizures should be re-evaluated in standard experimental models of limbic seizures. Our work sheds new light on the mechanisms that generate febrile seizures in children and, therefore, on how they might be treated.Peer reviewe
Nature of Spin Excitations in Two-dimensional Mott Insulators: Undoped Cuprates and Other Materials
We investigate the excitation spectrum of a two-dimensional resonating
valence bond (RVB) state. Treating the -flux phase with antiferromagnetic
correlations as a variational ground state, we recover the long wavelength
magnon as an "RVB exciton". However, we find that this excitation does NOT
exhaust the entire spectral weight and the high energy spectrum is dominated by
fermionic excitations. The latter can be observed directly by inelastic neutron
scattering and we predict their characteristic energy scales along different
high symmetry directions in the magnetic Brillouin zone. We also interpret
experimental results on two magnon Raman scattering and mid-infrared absorption
within this scenario.Comment: Minor corrections in the text and references to match the form as
appeared in Phys. Rev. Lett. 86, 1626 (2001
Alleviating Environmental Health Disparities Through Community Science and Data Integration
Environmental contamination is a fundamental determinant of health and well-being, and when the environment is compromised, vulnerabilities are generated. The complex challenges associated with environmental health and food security are influenced by current and emerging political, social, economic, and environmental contexts. To solve these “wicked” dilemmas, disparate public health surveillance efforts are conducted by local, state, and federal agencies. More recently, citizen/community science (CS) monitoring efforts are providing site-specific data. One of the biggest challenges in using these government datasets, let alone incorporating CS data, for a holistic assessment of environmental exposure is data management and interoperability. To facilitate a more holistic perspective and approach to solution generation, we have developed a method to provide a common data model that will allow environmental health researchers working at different scales and research domains to exchange data and ask new questions. We anticipate that this method will help to address environmental health disparities, which are unjust and avoidable, while ensuring CS datasets are ethically integrated to achieve environmental justice. Specifically, we used a transdisciplinary research framework to develop a methodology to integrate CS data with existing governmental environmental monitoring and social attribute data (vulnerability and resilience variables) that span across 10 different federal and state agencies. A key challenge in integrating such different datasets is the lack of widely adopted ontologies for vulnerability and resiliency factors. In addition to following the best practice of submitting new term requests to existing ontologies to fill gaps, we have also created an application ontology, the Superfund Research Project Data Interface Ontology (SRPDIO)
Epithelial endoplasmic reticulum stress orchestrates a protective IgA response.
Immunoglobulin A (IgA) is the major secretory immunoglobulin isotype found at mucosal surfaces, where it regulates microbial commensalism and excludes luminal factors from contacting intestinal epithelial cells (IECs). IgA is induced by both T cell-dependent and -independent (TI) pathways. However, little is known about TI regulation. We report that IEC endoplasmic reticulum (ER) stress induces a polyreactive IgA response, which is protective against enteric inflammation. IEC ER stress causes TI and microbiota-independent expansion and activation of peritoneal B1b cells, which culminates in increased lamina propria and luminal IgA. Increased numbers of IgA-producing plasma cells were observed in healthy humans with defective autophagy, who are known to exhibit IEC ER stress. Upon ER stress, IECs communicate signals to the peritoneum that induce a barrier-protective TI IgA response.Wellcome Trust Senior Investigator Award 106260/Z/14/Z
HORIZON2020/European Research Council Consolidator Grant 64888
Effect of aliskiren on post-discharge outcomes among diabetic and non-diabetic patients hospitalized for heart failure: insights from the ASTRONAUT trial
Aims The objective of the Aliskiren Trial on Acute Heart Failure Outcomes (ASTRONAUT) was to determine whether aliskiren, a direct renin inhibitor, would improve post-discharge outcomes in patients with hospitalization for heart failure (HHF) with reduced ejection fraction. Pre-specified subgroup analyses suggested potential heterogeneity in post-discharge outcomes with aliskiren in patients with and without baseline diabetes mellitus (DM). Methods and results ASTRONAUT included 953 patients without DM (aliskiren 489; placebo 464) and 662 patients with DM (aliskiren 319; placebo 343) (as reported by study investigators). Study endpoints included the first occurrence of cardiovascular death or HHF within 6 and 12 months, all-cause death within 6 and 12 months, and change from baseline in N-terminal pro-B-type natriuretic peptide (NT-proBNP) at 1, 6, and 12 months. Data regarding risk of hyperkalaemia, renal impairment, and hypotension, and changes in additional serum biomarkers were collected. The effect of aliskiren on cardiovascular death or HHF within 6 months (primary endpoint) did not significantly differ by baseline DM status (P = 0.08 for interaction), but reached statistical significance at 12 months (non-DM: HR: 0.80, 95% CI: 0.64-0.99; DM: HR: 1.16, 95% CI: 0.91-1.47; P = 0.03 for interaction). Risk of 12-month all-cause death with aliskiren significantly differed by the presence of baseline DM (non-DM: HR: 0.69, 95% CI: 0.50-0.94; DM: HR: 1.64, 95% CI: 1.15-2.33; P < 0.01 for interaction). Among non-diabetics, aliskiren significantly reduced NT-proBNP through 6 months and plasma troponin I and aldosterone through 12 months, as compared to placebo. Among diabetic patients, aliskiren reduced plasma troponin I and aldosterone relative to placebo through 1 month only. There was a trend towards differing risk of post-baseline potassium ≥6 mmol/L with aliskiren by underlying DM status (non-DM: HR: 1.17, 95% CI: 0.71-1.93; DM: HR: 2.39, 95% CI: 1.30-4.42; P = 0.07 for interaction). Conclusion This pre-specified subgroup analysis from the ASTRONAUT trial generates the hypothesis that the addition of aliskiren to standard HHF therapy in non-diabetic patients is generally well-tolerated and improves post-discharge outcomes and biomarker profiles. In contrast, diabetic patients receiving aliskiren appear to have worse post-discharge outcomes. Future prospective investigations are needed to confirm potential benefits of renin inhibition in a large cohort of HHF patients without D
The Changing Landscape for Stroke\ua0Prevention in AF: Findings From the GLORIA-AF Registry Phase 2
Background GLORIA-AF (Global Registry on Long-Term Oral Antithrombotic Treatment in Patients with Atrial Fibrillation) is a prospective, global registry program describing antithrombotic treatment patterns in patients with newly diagnosed nonvalvular atrial fibrillation at risk of stroke. Phase 2 began when dabigatran, the first non\u2013vitamin K antagonist oral anticoagulant (NOAC), became available. Objectives This study sought to describe phase 2 baseline data and compare these with the pre-NOAC era collected during phase 1. Methods During phase 2, 15,641 consenting patients were enrolled (November 2011 to December 2014); 15,092 were eligible. This pre-specified cross-sectional analysis describes eligible patients\u2019 baseline characteristics. Atrial fibrillation disease characteristics, medical outcomes, and concomitant diseases and medications were collected. Data were analyzed using descriptive statistics. Results Of the total patients, 45.5% were female; median age was 71 (interquartile range: 64, 78) years. Patients were from Europe (47.1%), North America (22.5%), Asia (20.3%), Latin America (6.0%), and the Middle East/Africa (4.0%). Most had high stroke risk (CHA2DS2-VASc [Congestive heart failure, Hypertension, Age 6575 years, Diabetes mellitus, previous Stroke, Vascular disease, Age 65 to 74 years, Sex category] score 652; 86.1%); 13.9% had moderate risk (CHA2DS2-VASc = 1). Overall, 79.9% received oral anticoagulants, of whom 47.6% received NOAC and 32.3% vitamin K antagonists (VKA); 12.1% received antiplatelet agents; 7.8% received no antithrombotic treatment. For comparison, the proportion of phase 1 patients (of N = 1,063 all eligible) prescribed VKA was 32.8%, acetylsalicylic acid 41.7%, and no therapy 20.2%. In Europe in phase 2, treatment with NOAC was more common than VKA (52.3% and 37.8%, respectively); 6.0% of patients received antiplatelet treatment; and 3.8% received no antithrombotic treatment. In North America, 52.1%, 26.2%, and 14.0% of patients received NOAC, VKA, and antiplatelet drugs, respectively; 7.5% received no antithrombotic treatment. NOAC use was less common in Asia (27.7%), where 27.5% of patients received VKA, 25.0% antiplatelet drugs, and 19.8% no antithrombotic treatment. Conclusions The baseline data from GLORIA-AF phase 2 demonstrate that in newly diagnosed nonvalvular atrial fibrillation patients, NOAC have been highly adopted into practice, becoming more frequently prescribed than VKA in Europe and North America. Worldwide, however, a large proportion of patients remain undertreated, particularly in Asia and North America. (Global Registry on Long-Term Oral Antithrombotic Treatment in Patients With Atrial Fibrillation [GLORIA-AF]; NCT01468701
Recommended from our members
Ontology-Enriched Cyberinfrastructure in Support of FAIR Marine Metagenomics: What More Can We Learn from Our Data?
Ever-increasing quantities of sequencing data have enabled novel insights into the structure, dynamics, and function of microbial communities in the oceans; however, data management efforts are outpaced by the volumes of new data generated. Life-science ontologies representing information about genes, species taxonomy, and environmental parameters hold the promise of improving the digital data ecosystem by making these high-value datasets Findable, Accessible, Reusable, and Interoperable (FAIR). However, efforts using these ontologies to harmonize, integrate, and analyze marine metagenomic data have been limited thus far. In this dissertation, we present three studies demonstrating the relevance of using life-science ontologies to get more out of existing metagenomic datasets by using ontologies to harmonize, integrate, and analyze state-of-the-art marine metagenomic data.In the first study, we present Planet Microbe a cyberinfrastructure system for marine microbiome and physiochemical datasets. This novel web-based platform re-integrates multi- component marine microbiome datasets published in various data repositories into a single harmonized and manually curated resource. Planet Microbe enables the discovery of sequencing data and its accompanying environmental and physiochemical context based on terminology from life- science ontologies. Additionally, Planet Microbe addresses the challenges of creating a cyberinfrastructure platform enabling the open sharing and discovery of historical and ongoing oceanographic marine metagenomic sequencing efforts.
The second study created a technical specification by which Planet Microbe's multifaceted marine metagenomic data could be encapsulated within a machine-readable framework to comprehensively represent the physicochemical data accompanying sequencing data using life- science ontologies. The new technical specification leverages Frictionless Data Packages and ontologies from the Open Biological and Biomedical Ontology Foundry. In the study, we used the new specification to harmonize the Planet Microbe datasets. We demonstrated its capability to produce results that can be used in the meta-analysis, which recapitulates known marine ecological relationships and distributions.
In the third study, we integrated the ontology-harmonized environmental and physicochemical data from the Planet Microbe web portal along with functional and taxonomic results computed from those datasets into a novel semantic web microservice. This web service enables the use of terminology from ontologies to discover and analyze subsets of data relevant to specific biological questions, which can be posed to the system as natural language questions. In the paper, we evaluate the system and use it to ask and answer various new questions about the community structure and function of microbes from multiple marine and aquatic environments.
Together these studies provide a series of complementary resources for using ontologies and related informatics technologies to bring together marine metagenomic and contextual data, harmonize them via comprehensively machine-readable ontology annotations, and analyze them with the rich knowledge-based represented within the state-of-the-art life-science ontologies such as the Gene Ontology. This work represents a future direction in marine metagenomic research where data made FAIR using the Planet Microbe cyberinfrastructure system can be discovered and re-used to answer different questions than originally intended
EnvironmentOntology/envo: Polar express
About this release
This release features a large collection of classes representing polar and cryosphere-related environments and environmental processes, primarily prepared by @kaiiam. These semantics are in aid of efforts such as the Alfred Wegener Institute's Frontiers in Arctic Marine Monitoring programme. Knowledge was harvested from numerous resources - such as the review by Boetius et al. (2015, Nat Rev Microbiol 13: 677–690) - which are cross referenced in each class. Efforts to align with existing resources have been initiated, e.g.: https://github.com/ESIPFed/sweet/issues/7
Past and ongoing work related to this project is organised in project cryophile. This work has also motivated the general development of the environmental process hierarchy.
A number of other requests, such as that for fissures (see #466) are also bundled in this release.
As usual, the hyperlinks to the terms will be live once OntoBee runs its import cycle over the weekend; however, the PURLs are valid immediately.
To better axiomatise the new classes and enhance existing ones, we have also imported numerous classes from other OBO projects, detailed below.
New Terms
aeolian transport of snow
aeolian transport process
atmosphere and water column exposed melt pond
atmosphere-exposed melt pond
blue ice
brine channel formation process
brine channel
brine rejection from seawater
calving of ice from an iceberg
channel
cirque glacier
cold season
compaction process
continental subsurface zone
cryoconite hole
cryoconite
cryoform
depositional process
englacial stream
erosionally enriched glacial ice
erosionally enriched ice
explosion process
first year ice formation process
first year ice
fissure water
frazil ice formation
frazil ice
gas emission process
geographic basin
glacial erosion process
glacial ice calving process
glacial ice gain
glacial ice loss
glacial ice
glacial sintering
glacial transport process
grease ice layer
hydrocarbon gas emission process
ice ablation zone
ice floe
ice formation process
ice gain
iceberg calving process
ice-encased melt pond
intraglacial lake
marine sediment
material accumulation process
material decumulation process
material transformation process
material transport process
melt pond
methane gas emission process
methane-laden permafrost
methane-releasing thermokarst lake
methane-sourced permafrost crater
multiyear ice formation process
multiyear ice
new ice formation process
new ice
nilas formation process
nilas
nivation
pancake ice
perennial snow patch
permafrost methane explosion
permafrost thawing process
planetary subsurface zone
powdery snow avalanche
powdery snow
sea ice floe
sea ice formation process
sea ice formation process
season generating process
season
seasonal melting process
seasonal snow patch
second year ice formation
second year ice
sedimentation in a water body
shallow marine sediment
shuga formation process
shuga
slab avalanche
slab snow
slush formation process
slush ice layer
slush ice
snow drift formation
snow drift
snow mass
snow patch
snowpack
solid-phase sintering
soot
subglacial lake
supraglacial lake
thaw hole
thermokarst depression
thermokarst lake
thermokarst
warm season
water column exposed melt pond
wet snow avalanche
young ice formation process
young ice
New imported classes
PURL
label
http://purl.obolibrary.org/obo/IAO_0000104
plan specification
http://purl.obolibrary.org/obo/IAO_0000109
measurement datum
http://purl.obolibrary.org/obo/IAO_0000100
data set
http://purl.obolibrary.org/obo/IAO_0000584
time sampled measurement data set
http://purl.obolibrary.org/obo/IAO_0000582
time stamped measurement datum
http://purl.obolibrary.org/obo/IAO_0000032
scalar measurement datum
http://purl.obolibrary.org/obo/IAO_0000136
is about
http://purl.obolibrary.org/obo/IAO_0000221
is quality measurement of
http://purl.obolibrary.org/obo/RO_0002404
causally downstream of
http://purl.obolibrary.org/obo/RO_0002411
causally upstream of
http://purl.obolibrary.org/obo/CHEBI_63248
oxidant
http://purl.obolibrary.org/obo/PATO_0000318
blue
http://purl.obolibrary.org/obo/PATO_0001855
horizontal
http://purl.obolibrary.org/obo/PATO_0000411
circular
http://purl.obolibrary.org/obo/PATO_0000964
transparent
http://purl.obolibrary.org/obo/PATO_0001354
translucent
http://purl.obolibrary.org/obo/PATO_0000963
opaque
http://purl.obolibrary.org/obo/PATO_0001171
elastic
http://purl.obolibrary.org/obo/PATO_0001172
inelastic
http://purl.obolibrary.org/obo/PATO_0000689
continuous (of a process)
http://purl.obolibrary.org/obo/PATO_0005011
continuous (of a material entity)
http://purl.obolibrary.org/obo/PATO_0001688
increased elevation
http://purl.obolibrary.org/obo/PATO_0001689
decreased elevation
http://purl.obolibrary.org/obo/PATO_0000591
increased thickness
http://purl.obolibrary.org/obo/PATO_0000592
decreased thickness
http://purl.obolibrary.org/obo/PATO_0001781
irregular thickness
Commit log
commit cb7178e00f41b15b9038b0d8a55ae2118d497426
Author: pbuttigieg
Date: Sat Apr 15 11:06:00 2017 +0200
closes #466, added IAO imports
commit 886dfbc7e062caafcb4637225752b1992d398b6b
Merge: b445dd5 3dbcd1e
Author: Pier Luigi Buttigieg
Date: Fri Apr 14 11:03:51 2017 +0200
Merge pull request #487 from kaiiam/master
This merge adds a healthy dose of classes and relations for project cryophile - covering environments and their processes in polar systems
commit 3dbcd1e0e189162f2fe8be62021c8fa147ac6260
Merge: fe2966e b445dd5
Author: Kai
Date: Thu Apr 13 11:28:07 2017 +0200
Merge remote-tracking branch 'upstream/master'
Merged IAO imports and makefile changes from Pier.
commit b445dd57954a1d55741ee813181ff25bb12a146d
Author: pbuttigieg
Date: Wed Apr 12 18:55:24 2017 +0200
added IAO import and edited Makefile accordingly
commit fe2966e834151540bf9270a023b6047baf616ccb
Author: Kai
Date: Tue Apr 11 17:23:52 2017 +0200
Added in_subset envoPolar for polar related classes, removed cirque basin as duplicate concept predating it cirque existed, and move the valley hierarchy under geographic depression. #487
commit 3e8f57bb30d6db8c4de4e7d4a468099096b33624
Author: Kai
Date: Tue Apr 11 11:58:40 2017 +0200
Fixed bug in cryoconite hole axiomatization, changed causally downstream of some aeolian transport process to formed as result of some aeolian transport process.
commit dc8b426a52546b4fc9be70381be87d4733516880
Merge: 1d9e254 bbba184
Author: Kai
Date: Tue Apr 11 11:32:47 2017 +0200
Merge remote-tracking branch 'upstream/master'
Imported causal relations from RO.
commit 1d9e25490eb8aa7eb91f17154389001b9bcdd2e0
Author: Kai
Date: Tue Apr 11 11:31:35 2017 +0200
Began adding Pier's orcid to the project cryophile classes created. Addressed the melt pond #489, and thaw hole hierarchies, creating the upper level class channel and moving tunnel under it. Also made issue requesting for a class such as PATO:microbial community #499.
commit bbba1845e1fdde1486b03bc11f29def6c2ca3a87
Merge: 5359e45 73dccf6
Author: pbuttigieg
Date: Mon Apr 10 20:58:20 2017 +0200
Merge branch 'master' of https://github.com/EnvironmentOntology/envo
syncing web-edited files with local push on imports
commit 5359e45770941b41d65fc6e1e1d4e97ba856b7c5
Author: pbuttigieg
Date: Mon Apr 10 20:57:59 2017 +0200
added causal relations to RO import
commit 1cdcf0fa99aaed10dfb9bca034cd913843966a7b
Author: Kai
Date: Mon Apr 10 12:28:11 2017 +0200
Added final classes for project cryophile pull request 3 snowpack, perennial snow patch, move the precipitation process hierarchy to be subclass of material transport process, see https://github.com/EnvironmentOntology/envo/pull/487#issuecomment-292571243
commit d81e45445e12742d6e245c75bfa86ef792013e9b
Author: Kai
Date: Sun Apr 9 01:21:30 2017 +0200
Added and modified more polar related terms, season generating process associated terms as well as snow melt and snow drift associated terms see latter half of https://github.com/EnvironmentOntology/envo/pull/487#issuecomment-292571243 starting with season generating process and ending with snow patch.
commit c85ef18e5a2160d4748cd1d7eb7a4abb7d5b03a7
Author: Kai
Date: Fri Apr 7 19:20:53 2017 +0200
Modified and added classes polar and gas emission processes see https://github.com/EnvironmentOntology/envo/pull/487#issuecomment-292526931
commit fcbd366cd52e212a3fe95739e3769da585bb1f75
Merge: cf41b5a 73dccf6
Author: Kai
Date: Fri Apr 7 10:42:17 2017 +0200
Merge remote-tracking branch 'upstream/master'
commit cf41b5a0d1c6de78207d3b1721b557cdc975f6fe
Author: Kai
Date: Fri Apr 7 10:40:41 2017 +0200
Added ice formation process and ice type related classes see https://github.com/EnvironmentOntology/envo/pull/487#discussion_r110089957
commit 73dccf6dba1d8e48291f5e192359dd6e0ac25b58
Author: Pier Luigi Buttigieg
Date: Thu Apr 6 18:17:01 2017 +0200
Resort and give ranges to new patterns in #492
commit 31ca0c713ec8f2dc2df70ce563a2141e5c4eb08d
Author: pbuttigieg
Date: Thu Apr 6 18:01:43 2017 +0200
added oxidant for #487
commit 9cdfcb158d1fb30fd5b22a9e69d365482819404c
Merge: 43557c3 9fa5ec8
Author: Kai
Date: Thu Apr 6 14:48:40 2017 +0200
Merge remote-tracking branch 'upstream/master'
importing pato terms from upstream
commit 9fa5ec862da9bc672ba62faa418a060d8357fa50
Author: pbuttigieg
Date: Thu Apr 6 14:45:24 2017 +0200
imported PATO classes for #486 #487 #488
commit 43557c3a736eda95f7d8481e4689adb39bbfc091
Author: Kai
Date: Thu Apr 6 10:43:37 2017 +0200
Added ice formation and ice flow related classes see https://github.com/EnvironmentOntology/envo/pull/487#discussion_r110089957
commit 47b20923876a11779c42d32f64f8f74135f5a379
Author: Kai
Date: Thu Apr 6 08:45:18 2017 +0200
Added and updated meltpond related classes see https://github.com/EnvironmentOntology/envo/pull/487#discussion_r109682927 discussion which was somehow clipped of from #487
commit e3e88c1d9c8b3833f697fa28882fcfcd91bb0429
Author: Kai
Date: Thu Apr 6 08:13:04 2017 +0200
minor edits for #487
commit b0c253e40b37a5c203a8505b7663b01ab638ddc1
Author: Kai
Date: Wed Apr 5 13:28:47 2017 +0200
modified sediment and arctic related classes as doccumented in #483 and #487
commit f144d1c1393ae3c8cdb2983a0a994bd02371ed06
Author: Kai
Date: Fri Mar 31 19:29:51 2017 +0200
added more arctic classes see discussion in #483
commit b94e86b413f6e11d662356102d433aa8f15fb8a5
Merge: b280935 43150a7
Author: Pier Luigi Buttigieg
Date: Thu Mar 30 18:33:42 2017 +0200
Merge pull request #481 from kaiiam/master
This PR has been reviewed and is ready for merging. There will still be edits that will follow, but in a new PR from @kaiiam.
commit 43150a7cd193fabc464e3ec86b5053946acf5c73
Author: Kai
Date: Thu Mar 30 18:14:08 2017 +0200
final edits for #481
commit 17f65c62aad086330feeb5305a1802f1bdf5e78e
Author: Kai
Date: Thu Mar 30 18:01:54 2017 +0200
added additional axioms to #481
commit 8374d49ac47d3910e193b7be75fb3dc45f255516
Author: Kai
Date: Thu Mar 30 17:09:22 2017 +0200
fixed axioms breaking build in #481
commit 855136b02cbb21c8f61a7a7233d7433ac6e47109
Author: Kai
Date: Thu Mar 30 16:36:05 2017 +0200
added axioms for classes added in #481 and added powdery snow
commit cf835a3d6ed1444a8e9e55132bbfd83f986ac28e
Author: Kai
Date: Thu Mar 30 13:07:36 2017 +0200
fixed issues related to build failure for #481
commit 749ce2a4db8314f1af87dcf553fd89825148d5a5
Author: Kai
Date: Wed Mar 29 18:22:55 2017 +0200
fixed issues for project cryophile 2nd pull request #481
commit b280935eab396e12a795c1c0b6072625080787e5
Author: Pier Luigi Buttigieg
Date: Wed Mar 29 17:54:13 2017 +0200
Fixed subset wiki link
commit 55c5fff62194f303c5d923f09019d1ce98dcc56e
Author: Kai
Date: Tue Mar 28 20:15:19 2017 +0200
addressing #475 added: aeolian transport process, & soot
commit 14099a98718f847517065635df84affdbb94baf1
Author: Kai
Date: Tue Mar 28 19:07:06 2017 +0200
addressing #474 & #475 added: blue ice, compaction process, material accumulation process, material transport process, ice gain, glacial transport process, updated alpine glacier, added: cirque glaciers, cirque basin, glacial erosion process, geographic basin, glacial ice loss, material decumulation process, glacial ice loss, and englacial stream.
commit 299650d5ff6521a67d4a646548997ebe5d5fea0e
Author: Kai
Date: Tue Mar 28 15:26:41 2017 +0200
revamped definition for glacier, added glacial ice as subclass of ice mass, erosionally enriched glacial ice, & glacial erosion process.
commit 135a712c1c793c860507e06c36aab52624645169
Author: Kai
Date: Tue Mar 28 12:46:25 2017 +0200
added niviation
commit b8b6c594bcc96f01361c63191ae83c7f97b51d79
Author: Kai
Date: Tue Mar 28 11:45:42 2017 +0200
updated definitions for neve and fir
Recommended from our members
Ontology-Enriched Specifications Enabling Findable, Accessible, Interoperable, and Reusable Marine Metagenomic Datasets in Cyberinfrastructure Systems.
Marine microbial ecology requires the systematic comparison of biogeochemical and sequence data to analyze environmental influences on the distribution and variability of microbial communities. With ever-increasing quantities of metagenomic data, there is a growing need to make datasets Findable, Accessible, Interoperable, and Reusable (FAIR) across diverse ecosystems. FAIR data is essential to developing analytical frameworks that integrate microbiological, genomic, ecological, oceanographic, and computational methods. Although community standards defining the minimal metadata required to accompany sequence data exist, they havent been consistently used across projects, precluding interoperability. Moreover, these data are not machine-actionable or discoverable by cyberinfrastructure systems. By making omic and physicochemical datasets FAIR to machine systems, we can enable sequence data discovery and reuse based on machine-readable descriptions of environments or physicochemical gradients. In this work, we developed a novel technical specification for dataset encapsulation for the FAIR reuse of marine metagenomic and physicochemical datasets within cyberinfrastructure systems. This includes using Frictionless Data Packages enriched with terminology from environmental and life-science ontologies to annotate measured variables, their units, and the measurement devices used. This approach was implemented in Planet Microbe, a cyberinfrastructure platform and marine metagenomic web-portal. Here, we discuss the data properties built into the specification to make global ocean datasets FAIR within the Planet Microbe portal. We additionally discuss the selection of, and contributions to marine-science ontologies used within the specification. Finally, we use the system to discover data by which to answer various biological questions about environments, physicochemical gradients, and microbial communities in meta-analyses. This work represents a future direction in marine metagenomic research by proposing a specification for FAIR dataset encapsulation that, if adopted within cyberinfrastructure systems, would automate the discovery, exchange, and re-use of data needed to answer broader reaching questions than originally intended
EnvironmentOntology/envo: Protected planet
Eponyms for this release
IUCN protected landscape/seascape
IUCN strict nature reserve
IUCN protected area with sustainable use of natural resources
Description
This backdated release captures progress across several development threads. Major themes include:
The expression of IUCN protected area classification for use in SDGIO and other resources handling socio-ecological protection
Expression of more CMECs classes to enhance marine semantics
Addition of terms to support GFBio data brokerage to PANGAEA and ENA/EBI
Further development of environmental zone semantics, with waste disposal use cases
Further refinement of process hierarchies for generalisabilityF
Extension of atmospheric semantics across cloud and aerosol formation processes
Initialisation of dust patterns linked to natural and anthropogenic sources
Exploration of radiation semantics (processes, dispositions, material entities)
Import of FOODON classes required by the envoMEO subse now linked to the MEO vocabulary in MicrobeDB.jp
A large number of terms from other ontologies were imported to allow denser axiomatisation. However, many of these are likely to be pruned back in subsequent releases to improve stability. As shown in the commit log, we have also trimmed away imports which 1) are not heavily woven in to ENVO semantics and 2) are causing errors due to autophagic imports of stale ontologies.
New Terms
acidic soil
acidic volcanic ash
active ecosystem management process
advective transport process
aerosol formation event
aerosol formation process
agricultural process
agronomic process
algal material
alluvial deposit
alluvial sediment
alluvium
alpine tundra ecosystem
aluminium dust
anchor ice
animal aquaculture process
animal husbandry
anthropised terrestrial environmental zone
aquatic estuarine layer
aquatic natural environment
arable land
arable or pasturable land
arable
area designated for human defecation
area designated for waste storage
area of developed space
area of low atmospheric pressure
area protected according to IUCN guidelines
asphalt road
atmospheric aerosol formation event
atmospheric secondary aerosol formation process
atmospheric wind direction
atmospheric wind speed
atmospheric zone
barium dust
Bondon cheese environment
brackish water body
brown sea ice
brush fire
bush area
bush fire
canopy
cirrus cloud
climate system
cnidarian-associated environment
coastal shrimp pond
commercial building
concrete road
conservation-focused active ecosystem management process
constructed pavement
convective storm
cosmic ray shielding disposition
crater zone
crop canopy
cropland ecosystem
crustacean farming process
cyclone
defence against flooding
desert
diurnal marine tidal flow process
diurnal marine tidal flow zone
driveway
ecosystem decay
ecosystem fragment
ecosystem fragmentation process
environment associated with an aquatic invertebrate
environmental zone of processual equilibrium
erosion
estuarine coastal lower water column
estuarine coastal pycnocline
estuarine coastal surface layer
estuarine coastal upper water column
estuarine open water lower water column
estuarine open water pycnocline
estuarine open water surface layer
estuarine open water upper water column
estuarine tidal riverine coastal lower water column
estuarine tidal riverine coastal pycnocline
estuarine tidal riverine coastal surface layer
estuarine tidal riverine coastal upper water column
estuarine tidal riverine open water lower water column
estuarine tidal riverine open water pycnocline
estuarine tidal riverine open water surface layer
estuarine tidal riverine open water upper water column
extra-tropical cyclone
finfish farming process
floating ice mass
forest canopy
forest ecosystem
fresh water body
freshwater macrophyte farming process
freshwater seep riverine anchor ice
gamma-ray stellar radiation
geodiversity
glacial equlibrium line
glacial ice accumulation zone
grassland ecosystem
habitat fragmentation process
Hill sphere
holothurian digestive tract contents
holothurian digestive tract
humic kerogen
hydroclimate
ice accumulation zone
ice decumulation zone
impermeable surface layer
induced magnetosphere
industrial fire
infrared stellar radiation
intrinsic magnetosphere
ionising stellar radiation
IUCN habitat/species management area
IUCN natural monument or feature
IUCN protected area with sustainable use of natural resources
IUCN protected landscape/seascape
IUCN strict nature reserve
IUCN wilderness area
kaolin dust
kerogen
labile kerogen
Lagrangian point
land fire
liquid air-water interface layer
liquid layer
liquid surface layer
lithification
lumber production process
magnetosphere
marine environmental zone
marine tidal flow process
marine tidal flow zone
marine tidal flow
material accumulation zone
material decumulation zone
material isosurface
microwave stellar radiation
mollusc farming process
newCloud
newCloud
nitrogen cycling
office building
office
Paramo
pasturable land
pasture fire
paved parking lot
phosphorous cycling
planktonic kerogen
plant aquaculture process
primary aerosol formation process
radiation shielding disposition
radio wave stellar radiation
ranch
recalcitrant kerogen
residual kerogen
rhizoplane
riverine anchor ice
rural stormwater
sacred site
saline shrimp pond water
saline water body
sapropelic kerogen
seaweed farming process
secondary aerosol formation process
sediment surface
semi-diurnal marine tidal flow process
semi-diurnal marine tidal flow zone
sidewalk
silica dust
slate dust
solid layer
solid surface layer
stellar radiation
stormwater
sulfrous kerogen
sulfur cycling
swamp area
talc dust
tended pasturable land
terrestrial environmental zone
terrestrial natural environment
thermal pollution of an aquatic system
thermal pollution
tidal flow process
tidal mangrove shrubland
transport of child feces to a designated site
transport of household waste to a designated storage site
transport of waste to a designated storage site
tropical marginal sea biome
tropical storm
tundra ecosystem
ultraviolet stellar radiation
urban stormwater
visible spectrum stellar radiation
vog
volcanic crater glacier
volcanic crater zone
volume of hydrological precipitation
warm core cyclone
waste disposal process
water accumulation process
water ice layer
water surface
water-based planetary surface
wetland ecosystem
woodland canopy
woodland ecosystem
x-ray stellar radiation
New imported classes
PURL
label
http://purl.obolibrary.org/obo/AGRO_00000002
tillage process
http://purl.obolibrary.org/obo/CHEBI_140503
kaolin
http://purl.obolibrary.org/obo/CHEBI_9171
skatole
http://purl.obolibrary.org/obo/CHEBI_58454
kynurenate
http://purl.obolibrary.org/obo/CHEBI_53388
poly(hydroxybutyrate)
http://purl.obolibrary.org/obo/CHEBI_47032
1,4-dioxane
http://purl.obolibrary.org/obo/CHEBI_39285
chloropicrin
http://purl.obolibrary.org/obo/CHEBI_35404
chromate
http://purl.obolibrary.org/obo/CHEBI_33666
polycyclic hydrocarbon
http://purl.obolibrary.org/obo/CHEBI_30762
salicylate
http://purl.obolibrary.org/obo/CHEBI_29125
arsenate
http://purl.obolibrary.org/obo/CHEBI_27798
nitrobenzene
http://purl.obolibrary.org/obo/CHEBI_27856
acetamide
http://purl.obolibrary.org/obo/CHEBI_27563
arsenic
http://purl.obolibrary.org/obo/CHEBI_27338
xylene
http://purl.obolibrary.org/obo/CHEBI_26986
threonine
http://purl.obolibrary.org/obo/CHEBI_26490
quinate
http://purl.obolibrary.org/obo/CHEBI_18139
trimethylamine
http://purl.obolibrary.org/obo/CHEBI_17347
testosterone
http://purl.obolibrary.org/obo/CHEBI_16482
naphthalene
http://purl.obolibrary.org/obo/CHEBI_16454
pantothenate
http://purl.obolibrary.org/obo/CHEBI_16236
ethanol
http://purl.obolibrary.org/obo/CHEBI_16199
urea
http://purl.obolibrary.org/obo/CHEBI_15611
sarcosine
http://purl.obolibrary.org/obo/CHEBI_37133
barium molecular entity
http://purl.obolibrary.org/obo/CHEBI_37134
elemental barium
http://purl.obolibrary.org/obo/CHEBI_72813
exopolysaccharide
http://purl.obolibrary.org/obo/CHEBI_16336
hyaluronic acid
http://purl.obolibrary.org/obo/CHEBI_62968
crystalline cellulose
http://purl.obolibrary.org/obo/CHEBI_16261
chitosan
http://purl.obolibrary.org/obo/CHEBI_17548
alginic acid
http://purl.obolibrary.org/obo/CHEBI_62967
amorphous cellulose
http://purl.obolibrary.org/obo/CHEBI_17029
chitin
http://purl.obolibrary.org/obo/CHEBI_8006
Peptidoglycan
http://purl.obolibrary.org/obo/CHEBI_46684
actinolite asbestos
http://purl.obolibrary.org/obo/CHEBI_46678
amosite asbestos
http://purl.obolibrary.org/obo/CHEBI_46682
anthophyllite asbestos
http://purl.obolibrary.org/obo/CHEBI_46666
crocidolite asbestos
http://purl.obolibrary.org/obo/CHEBI_46676
tremolite asbestos
http://purl.obolibrary.org/obo/CHEBI_46664
chrysotile
http://purl.obolibrary.org/obo/CHEBI_46661)
asbestos
http://purl.obolibrary.org/obo/CHEBI_32178
talc
http://purl.obolibrary.org/obo/CHEBI_32594
barium
http://purl.obolibrary.org/obo/CHEBI_30212
photon
http://purl.obolibrary.org/obo/CHEBI_30222
neutron
http://purl.obolibrary.org/obo/CHEBI_24636
proton
http://purl.obolibrary.org/obo/CHEBI_30216
alpha-particle
http://purl.obolibrary.org/obo/CHEBI_36352
neutrino
http://purl.obolibrary.org/obo/CHEBI_10545
electron
http://purl.obolibrary.org/obo/CHEBI_30225
positron
http://purl.obolibrary.org/obo/CHEBI_24870
ion
http://purl.obolibrary.org/obo/CHEBI_26130
pigment
http://purl.obolibrary.org/obo/CHEBI_46662
mineral
http://purl.obolibrary.org/obo/CHEBI_82661
diatomaceous earth
http://purl.obolibrary.org/obo/CHEBI_50816
iron oxide
http://purl.obolibrary.org/obo/CHEBI_30187
aluminium oxide
http://purl.obolibrary.org/obo/CHEBI_49936
uranium(0)
http://purl.obolibrary.org/obo/CHEBI_30050
gold(0)
http://purl.obolibrary.org/obo/CHEBI_82664
iron(0)
http://purl.obolibrary.org/obo/CHEBI_33400
platinum(0)
http://purl.obolibrary.org/obo/CHEBI_30052
copper(0)
http://purl.obolibrary.org/obo/CHEBI_35170
vanadium(0)
http://purl.obolibrary.org/obo/CHEBI_27889
lead(0)
http://purl.obolibrary.org/obo/CHEBI_49976
zinc dichloride
http://purl.obolibrary.org/obo/CHEBI_63248
oxidant
http://purl.obolibrary.org/obo/CHEBI_3311
calcium carbonate
http://purl.obolibrary.org/obo/CHEBI_80043
Nodularin
http://purl.obolibrary.org/obo/CHEBI_2706
Anatoxin a
http://purl.obolibrary.org/obo/CHEBI_48041
microcystin
http://purl.obolibrary.org/obo/CHEBI_27780
detergent
http://purl.obolibrary.org/obo/CHEBI_27594
carbon
http://purl.obolibrary.org/obo/CHEBI_33415
elemental carbon
http://purl.obolibrary.org/obo/CHEBI_86471
pyrite
http://purl.obolibrary.org/obo/CHEBI_18422
sulfur dioxide
http://purl.obolibrary.org/obo/CHEBI_16136
hydrogen sulfide
http://purl.obolibrary.org/obo/CHEBI_29919
hydrosulfide
http://purl.obolibrary.org/obo/CHEBI_61250
brevetoxin A
http://purl.obolibrary.org/obo/CHEBI_80770
Brevetoxin B
http://purl.obolibrary.org/obo/CHEBI_61275
ciguatoxin
http://purl.obolibrary.org/obo/CHEBI_25442
fungal toxins
http://purl.obolibrary.org/obo/CHEBI_27026
toxin
http://purl.obolibrary.org/obo/CHEBI_34970
saxitoxin
http://purl.obolibrary.org/obo/CHEBI_50594
carbon nanotubes
http://purl.obolibrary.org/obo/CHEBI_26710
sodium chloride
http://purl.obolibrary.org/obo/CHEBI_16908
NADH
http://purl.obolibrary.org/obo/CHEBI_16474
NADPH
http://purl.obolibrary.org/obo/CHEBI_15422
ATP
http://purl.obolibrary.org/obo/CHEBI_15022
electron donor
http://purl.obolibrary.org/obo/CHEBI_17654
electron acceptor
http://purl.obolibrary.org/obo/CHEBI_15379
dioxygen
http://purl.obolibrary.org/obo/CHEBI_78298
environmental contaminant
http://purl.obolibrary.org/obo/CHEBI_18276
dihydrogen
http://purl.obolibrary.org/obo/CHEBI_49987
monoatomic krypton
http://purl.obolibrary.org/obo/CHEBI_33687
diatomic helium
http://purl.obolibrary.org/obo/CHEBI_49994
monoatomic neon
http://purl.obolibrary.org/obo/CHEBI_49992
argon(•1+)
http://purl.obolibrary.org/obo/CHEBI_17997
dinitrogen
http://purl.obolibrary.org/obo/CHEBI_15377
water
http://purl.obolibrary.org/obo/CHEBI_16042
halide anion
http://purl.obolibrary.org/obo/CHEBI_16134
ammonia
http://purl.obolibrary.org/obo/CHEBI_16183
methane
http://purl.obolibrary.org/obo/CHEBI_16189
sulfate
http://purl.obolibrary.org/obo/CHEBI_16234
hydroxide
http://purl.obolibrary.org/obo/CHEBI_16301
nitrite
http://purl.obolibrary.org/obo/CHEBI_16526
carbon dioxide
http://purl.obolibrary.org/obo/CHEBI_16646
carbohydrate
http://purl.obolibrary.org/obo/CHEBI_16900
chlorophyllide a
http://purl.obolibrary.org/obo/CHEBI_17045
dinitrogen oxide
http://purl.obolibrary.org/obo/CHEBI_17051
fluoride
http://purl.obolibrary.org/obo/CHEBI_17245
carbon monoxide
http://purl.obolibrary.org/obo/CHEBI_17544
hydrogencarbonate
http://purl.obolibrary.org/obo/CHEBI_17632
nitrate
http://purl.obolibrary.org/obo/CHEBI_17883
hydrogen chloride
http://purl.obolibrary.org/obo/CHEBI_17996
chloride
http://purl.obolibrary.org/obo/CHEBI_18230
chlorophyll a
http://purl.obolibrary.org/obo/CHEBI_18246
(1?4)-?-D-glucan
http://purl.obolibrary.org/obo/CHEBI_18248
iron atom
http://purl.obolibrary.org/obo/CHEBI_18291
manganese atom
http://purl.obolibrary.org/obo/CHEBI_18310
alkane
http://purl.obolibrary.org/obo/CHEBI_18367
phosphate(3?)
http://purl.obolibrary.org/obo/CHEBI_22313
alkaline earth metal atom
http://purl.obolibrary.org/obo/CHEBI_22314
alkali metal atom
http://purl.obolibrary.org/obo/CHEBI_22563
anion
http://purl.obolibrary.org/obo/CHEBI_22918
branched-chain amino acid
http://purl.obolibrary.org/obo/CHEBI_22977
cadmium atom
http://purl.obolibrary.org/obo/CHEBI_22984
calcium atom
http://purl.obolibrary.org/obo/CHEBI_23014
carbon oxide
http://purl.obolibrary.org/obo/CHEBI_23116
chlorine atom
http://purl.obolibrary.org/obo/CHEBI_23367
molecular entity
http://purl.obolibrary.org/obo/CHEBI_24061
fluorine atom
http://purl.obolibrary.org/obo/CHEBI_24473
halogen
http://purl.obolibrary.org/obo/CHEBI_24870
ion
http://purl.obolibrary.org/obo/CHEBI_25016
lead atom
http://purl.obolibrary.org/obo/CHEBI_25017
leucine
http://purl.obolibrary.org/obo/CHEBI_25107
magnesium atom
http://purl.obolibrary.org/obo/CHEBI_25111
magnesium porphyrin
http://purl.obolibrary.org/obo/CHEBI_25212
metabolite
http://purl.obolibrary.org/obo/CHEBI_25355
mitochondrial respiratory-chain inhibitor
http://purl.obolibrary.org/obo/CHEBI_25362
elemental molecule
http://purl.obolibrary.org/obo/CHEBI_25435
mutagen
http://purl.obolibrary.org/obo/CHEBI_25512
neurotransmitter
http://purl.obolibrary.org/obo/CHEBI_25555
nitrogen atom
http://purl.obolibrary.org/obo/CHEBI_25567
nitrous acid
http://purl.obolibrary.org/obo/CHEBI_25585
nonmetal atom
http://purl.obolibrary.org/obo/CHEBI_25805
oxygen atom
http://purl.obolibrary.org/obo/CHEBI_25812
ozone
http://purl.obolibrary.org/obo/CHEBI_26216
potassium atom
http://purl.obolibrary.org/obo/CHEBI_26523
reactive oxygen species
http://purl.obolibrary.org/obo/CHEBI_26708
sodium atom
http://purl.obolibrary.org/obo/CHEBI_26822
sulfide
http://purl.obolibrary.org/obo/CHEBI_26833
sulfur atom
http://purl.obolibrary.org/obo/CHEBI_26835
sulfur molecular entity
http://purl.obolibrary.org/obo/CHEBI_27027
micronutrient !!! Preliminary !!!
http://purl.obolibrary.org/obo/CHEBI_27153
monoatomic trication
http://purl.obolibrary.org/obo/CHEBI_27363
zinc atom
http://purl.obolibrary.org/obo/CHEBI_27560
boron atom
http://purl.obolibrary.org/obo/CHEBI_27573
silicon atom
http://purl.obolibrary.org/obo/CHEBI_27594
carbon atom
http://purl.obolibrary.org/obo/CHEBI_28073
chromium atom
http://purl.obolibrary.org/obo/CHEBI_28112
nickel atom
http://purl.obolibrary.org/obo/CHEBI_28659
phosphorus atom
http://purl.obolibrary.org/obo/CHEBI_28694
copper atom
http://purl.obolibrary.org/obo/CHEBI_28793
beta-D-glucan
http://purl.obolibrary.org/obo/CHEBI_28938
ammonium
http://purl.obolibrary.org/obo/CHEBI_28966
chlorophyll
http://purl.obolibrary.org/obo/CHEBI_28976
carbonic acid
http://purl.obolibrary.org/obo/CHEBI_29228
hydrogen fluoride
http://purl.obolibrary.org/obo/CHEBI_29233
deuteron
http://purl.obolibrary.org/obo/CHEBI_29237
deuterium atom
http://purl.obolibrary.org/obo/CHEBI_29337
azanide
http://purl.obolibrary.org/obo/CHEBI_29412
oxonium
http://purl.obolibrary.org/obo/CHEBI_29438
methanide
http://purl.obolibrary.org/obo/CHEBI_30356
isobutyl group
http://purl.obolibrary.org/obo/CHEBI_30496
sulfur hexafluoride
http://purl.obolibrary.org/obo/CHEBI_30513
antimony atom
http://purl.obolibrary.org/obo/CHEBI_30514
caesium atom
http://purl.obolibrary.org/obo/CHEBI_30563
silicon dioxide
http://purl.obolibrary.org/obo/CHEBI_31001
montanic acid
http://purl.obolibrary.org/obo/CHEBI_31002
montanate
http://purl.obolibrary.org/obo/CHEBI_32627
leucinate
http://purl.obolibrary.org/obo/CHEBI_32628
leucinium
http://purl.obolibrary.org/obo/CHEBI_33232
application !!! is a CHEBI_role ; sort of weird !!!
http://purl.obolibrary.org/obo/CHEBI_33265
triatomic oxygen !!! preliminary !!!
http://purl.obolibrary.org/obo/CHEBI_33284
nutrient
http://purl.obolibrary.org/obo/CHEBI_33286
agrochemical
http://purl.obolibrary.org/obo/CHEBI_33287
fertilizer
http://purl.obolibrary.org/obo/CHEBI_33300
pnictogen
http://purl.obolibrary.org/obo/CHEBI_33302
pnictogen molecular entity
http://purl.obolibrary.org/obo/CHEBI_33303
chalcogen
http://purl.obolibrary.org/obo/CHEBI_33306
carbon group element atom
http://purl.obolibrary.org/obo/CHEBI_33317
boron group element atom
http://purl.obolibrary.org/obo/CHEBI_33324
strontium atom
http://purl.obolibrary.org/obo/CHEBI_33327
silicon oxide
http://purl.obolibrary.org/obo/CHEBI_33340
zinc group element atom
http://purl.obolibrary.org/obo/CHEBI_33350
chromium group element atom
http://purl.obolibrary.org/obo/CHEBI_33352
manganese group element atom
http://purl.obolibrary.org/obo/CHEBI_33356
iron group element atom
http://purl.obolibrary.org/obo/CHEBI_33362
nickel group element atom
http://purl.obolibrary.org/obo/CHEBI_33366
copper group element atom
http://purl.obolibrary.org/obo/CHEBI_33432
monoatomic chlorine
http://purl.obolibrary.org/obo/CHEBI_33455
nitrogen oxoacid
http://purl.obolibrary.org/obo/CHEBI_33458
nitrogen oxoanion
http://purl.obolibrary.org/obo/CHEBI_33482
sulfur oxoanion
http://purl.obolibrary.org/obo/CHEBI_33521
metal atom
http://purl.obolibrary.org/obo/CHEBI_33575
carboxylic acid
http://purl.obolibrary.org/obo/CHEBI_33627
monoatomic aluminium
http://purl.obolibrary.org/obo/CHEBI_33693
oxygen hydride
http://purl.obolibrary.org/obo/CHEBI_33704
alpha-amino acid
http://purl.obolibrary.org/obo/CHEBI_33709
amino acid
http://purl.obolibrary.org/obo/CHEBI_33893
reagent
http://purl.obolibrary.org/obo/CHEBI_33937
macronutrient !!! preliminary !!!
http://purl.obolibrary.org/obo/CHEBI_35106
nitrogen hydride
http://purl.obolibrary.org/obo/CHEBI_35107
azane
http://purl.obolibrary.org/obo/CHEBI_35196
nitrogen oxide
http://purl.obolibrary.org/obo/CHEBI_35204
tracer
http://purl.obolibrary.org/obo/CHEBI_35209
label
http://purl.obolibrary.org/obo/CHEBI_35230
fossil fuel
http://purl.obolibrary.org/obo/CHEBI_35274
ammonium ion
http://purl.obolibrary.org/obo/CHEBI_35480
analgesic
http://purl.obolibrary.org/obo/CHEBI_35604
carbon oxoanion
http://purl.obolibrary.org/obo/CHEBI_35620
vasodilator agent
http://purl.obolibrary.org/obo/CHEBI_35780
phosphate ion
http://purl.obolibrary.org/obo/CHEBI_36895
monoatomic fluorine
http://purl.obolibrary.org/obo/CHEBI_36916
cation
http://purl.obolibrary.org/obo/CHEBI_36934
nitrogen-15 atom
http://purl.obolibrary.org/obo/CHEBI_37022
amino-acid anion
http://purl.obolibrary.org/obo/CHEBI_37176
mononuclear parent hydride
http://purl.obolibrary.org/obo/CHEBI_38252
phorbines !!! preliminary !!!
http://purl.obolibrary.org/obo/CHEBI_38867
anaesthetic
http://purl.obolibrary.org/obo/CHEBI_38869
general anaesthetic
http://purl.obolibrary.org/obo/CHEBI_38870
inhalation anaesthetic
http://purl.obolibrary.org/obo/CHEBI_41609
carbonate
http://purl.obolibrary.org/obo/CHEBI_43474
hydrogenphosphate
http://purl.obolibrary.org/obo/CHEBI_45696
hydrogensulfate
http://purl.obolibrary.org/obo/CHEBI_46787
solvent
http://purl.obolibrary.org/obo/CHEBI_48107
nitric acid
http://purl.obolibrary.org/obo/CHEBI_48154
sulfur oxide
http://purl.obolibrary.org/obo/CHEBI_48218
antiseptic drug
http://purl.obolibrary.org/obo/CHEBI_48219
disinfectant
http://purl.obolibrary.org/obo/CHEBI_48356
protic solvent
http://purl.obolibrary.org/obo/CHEBI_48360
amphiprotic solvent !!! preliminary !!!
http://purl.obolibrary.org/obo/CHEBI_48706
antagonist
http://purl.obolibrary.org/obo/CHEBI_49470
aluminium(3+)
http://purl.obolibrary.org/obo/CHEBI_49637
hydrogen atom
http://purl.obolibrary.org/obo/CHEBI_50047
organic amino compound
http://purl.obolibrary.org/obo/CHEBI_50094
sulfur coordination entity
http://purl.obolibrary.org/obo/CHEBI_50183
P450 inhibitor
http://purl.obolibrary.org/obo/CHEBI_50313
onium cation
http://purl.obolibrary.org/obo/CHEBI_50406
probe
http://purl.obolibrary.org/obo/CHEBI_50904
allergen
http://purl.obolibrary.org/obo/CHEBI_50910
neurotoxin
http://purl.obolibrary.org/obo/CHEBI_51143
nitrogen molecular entity
http://purl.obolibrary.org/obo/CHEBI_52214
ligand
http://purl.obolibrary.org/obo/CHEBI_52625
inorganic hydroxy compound
http://purl.obolibrary.org/obo/CHEBI_53000
epitope
http://purl.obolibrary.org/obo/CHEBI_58072
carbon monoxide(1+)
http://purl.obolibrary.org/obo/CHEBI_58416
chlorophyll a(1-)
http://purl.obolibrary.org/obo/CHEBI_58950
very long-chain fatty acid anion
http://purl.obolibrary.org/obo/CHEBI_58954
straight-chain saturated fatty acid anion
http://purl.obolibrary.org/obo/CHEBI_59163
biomarker
- …