267 research outputs found
Baryon chiral perturbation theory transferred to hole-doped antiferromagnets on the honeycomb lattice
A systematic low-energy effective field theory for hole-doped
antiferromagnets on the honeycomb lattice is constructed. The formalism is then
used to investigate spiral phases in the staggered magnetization as well as the
formation of two-hole bound states.Comment: Talk delivered by C.P. Hofmann at the XIII Mexican Workshop on
Particles and Fields, October 19-26, 2011, Leon, Guanajuato, Mexico; 15
pages, 7 figure
Staphylococcal enterotoxin B (SEB) activates TCR- and CD28-mediated inflammatory signals in the absence of MHC class II molecules
The inflammatory activity of staphylococcal enterotoxin B (SEB) relies on its capacity to trigger polyclonal T‐cell activation by binding both T‐cell receptor (TCR) and costimulatory
receptor CD28 on T cells and MHC class II and B7 molecules on antigen presenting cells (APC). Previous studies highlighted that SEB may bind TCR and CD28 molecules independently
of MHC class II, yet the relative contribution of these interactions to the pro‐inflammatory function of SEB remained unclear. Here, we show that binding to MHC class II is dispensable
for the inflammatory activity of SEB, whereas binding to TCR, CD28 and B7 molecules is pivotal, in both human primary T cells and Jurkat T cell lines. In particular, our finding is that
binding of SEB to B7 molecules suffices to trigger both TCR‐ and CD28‐mediated inflammatory signalling. We also provide evidence that, by strengthening the interaction between
CD28 and B7, SEB favours the recruitment of the TCR into the immunological synapse, thus inducing lethal inflammatory signallin
Schroedingers equation with gauge coupling derived from a continuity equation
We consider a statistical ensemble of particles of mass m, which can be
described by a probability density \rho and a probability current \vec{j} of
the form \rho \nabla S/m. The continuity equation for \rho and \vec{j} implies
a first differential equation for the basic variables \rho and S. We further
assume that this system may be described by a linear differential equation for
a complex state variable \chi. Using this assumptions and the simplest possible
Ansatz \chi(\rho,S) Schroedingers equation for a particle of mass m in an
external potential V(q,t) is deduced. All calculations are performed for a
single spatial dimension (variable q) Using a second Ansatz \chi(\rho,S,q,t)
which allows for an explict q,t-dependence of \chi, one obtains a generalized
Schroedinger equation with an unusual external influence described by a
time-dependent Planck constant. All other modifications of Schroeodingers
equation obtained within this Ansatz may be eliminated by means of a gauge
transformation. Thus, this second Ansatz may be considered as a generalized
gauging procedure. Finally, making a third Ansatz, which allows for an
non-unique external q,t-dependence of \chi, one obtains Schroedingers equation
with electromagnetic potentials \vec{A}, \phi in the familiar gauge coupling
form. A possible source of the non-uniqueness is pointed out.Comment: 25 pages, no figure
Limitations on the superposition principle: superselection rules in non-relativistic quantum mechanics
The superposition principle is a very basic ingredient of quantum theory.
What may come as a surprise to many students, and even to many practitioners of
the quantum craft, is tha superposition has limitations imposed by certain
requirements of the theory. The discussion of such limitations arising from the
so-called superselection rules is the main purpose of this paper. Some of their
principal consequences are also discussed. The univalence, mass and particle
number superselection rules of non-relativistic quantum mechanics are also
derived using rather simple methods.Comment: 22 pages, no figure
Inclusive pion and eta production in p+Nb collisions at 3.5 GeV beam energy
Data on inclusive pion and eta production measured with the dielectron
spectrometer HADES in the reaction p+93Nb at a kinetic beam energy of 3.5 GeV
are presented. Our results, obtained with the photon conversion method,
supplement the rather sparse information on neutral meson production in
proton-nucleus reactions existing for this bombarding energy regime. The
reconstructed e+e-e+e- transverse-momentum and rapidity distributions are
confronted with transport model calculations, which account fairly well for
both pi0 and eta production.Comment: 12 pages, 9 figures, submitted to Physical Review
Searching a Dark Photon with HADES
We present a search for the e+e- decay of a hypothetical dark photon, also
names U vector boson, in inclusive dielectron spectra measured by HADES in the
p (3.5 GeV) + p, Nb reactions, as well as the Ar (1.756 GeV/u) + KCl reaction.
An upper limit on the kinetic mixing parameter squared epsilon^{2} at 90% CL
has been obtained for the mass range M(U) = 0.02 - 0.55 GeV/c2 and is compared
with the present world data set. For masses 0.03 - 0.1 GeV/c^2, the limit has
been lowered with respect to previous results, allowing now to exclude a large
part of the parameter region favoured by the muon g-2 anomaly. Furthermore, an
improved upper limit on the branching ratio of 2.3 * 10^{-6} has been set on
the helicity-suppressed direct decay of the eta meson, eta-> e+e-, at 90% CL
Binding of Superantigen Toxins into the CD28 Homodimer Interface Is Essential for Induction of Cytokine Genes That Mediate Lethal Shock
Bacterial superantigen toxins bind directly to the dimer interface of CD28, the principal co-stimulatory receptor, to induce a lethal cytokine storm, and peptides that prevent this binding can suppress superantigen lethality
A genome-wide resource for the analysis of protein localisation in Drosophila
The Drosophila genome contains >13000 protein-coding genes, the majority of which remain poorly investigated. Important reasons include the lack of antibodies or reporter constructs to visualise these proteins. Here, we present a genome-wide fosmid library of 10000 GFP-tagged clones, comprising tagged genes and most of their regulatory information. For 880 tagged proteins, we created transgenic lines, and for a total of 207 lines, we assessed protein expression and localisation in ovaries, embryos, pupae or adults by stainings and live imaging approaches. Importantly, we visualised many proteins at endogenous expression levels and found a large fraction of them localising to subcellular compartments. By applying genetic complementation tests, we estimate that about two-thirds of the tagged proteins are functional. Moreover, these tagged proteins enable interaction proteomics from developing pupae and adult flies. Taken together, this resource will boost systematic analysis of protein expression and localisation in various cellular and developmental contexts
- …