Laboratory and telescope use of the NICMOS2 128 x 128 HgCdTe array

The second generation of Hubble Space Telescope (HST) instruments will include a near-infrared instrument. This choice has driven the development of near-infrared arrays to larger sizes and lower read noises. Rockwell International has delivered an array for use in the Near Infrared Camera and Multi-Object Spectrometer (NICMOS) instrument; this array has been dubbed NICMOS2. NICMOS2 is a 128x128 array of HgCdTe diodes In-bonded to a switched MOSFET readout. The readout was specifically designed for astronomical use with the HST requirement of low read noise a prime goal. These arrays use detector material which is similar to that used by Rockwell in previous arrays (e.g., HgCdTe produced on a sapphire substrate), but the NICMOS2 devices differ substantially from other 128x128 arrays produced by Rockwell in having a read noise of only 30 electrons when read out using appropriate correlated sampling. NICMOS2 has now been characterized in the laboratory, and it has been used on groundbased telescopes

Prediction of a deletion copy number variant by a dense SNP panel

<p>Abstract</p> <p>Background</p> <p>A newly recognized type of genetic variation, Copy Number Variation (CNV), is detected in mammalian genomes, e.g. the cattle genome. This form of variation can potentially cause phenotypic variation. Our objective was to determine whether dense SNP (single nucleotide polymorphisms) panels can capture the genetic variation due to a simple bi-allelic CNV, with the prospect of including the effect of such structural variations into genomic predictions.</p> <p>Methods</p> <p>A deletion type CNV on bovine chromosome 6 was predicted from its neighboring SNP with a multiple regression model. Our dataset consisted of CNV genotypes of 1,682 cows, along with 100 surrounding SNP genotypes. A prediction model was fitted considering 10 to 100 surrounding SNP and the accuracy obtained directly from the model was confirmed by cross-validation.</p> <p>Results and conclusions</p> <p>The accuracy of prediction increased with an increasing number of SNP in the model and the predicted accuracies were similar to those obtained by cross-validation. A substantial increase in accuracy was observed when the number of SNP increased from 10 to 50 but thereafter the increase was smaller, reaching the highest accuracy (0.94) with 100 surrounding SNP. Thus, we conclude that the genotype of a deletion type CNV and its putative QTL effect can be predicted with a maximum accuracy of 0.94 from surrounding SNP. This high prediction accuracy suggests that genetic variation due to simple deletion CNV is well captured by dense SNP panels. Since genomic selection relies on the availability of a dense marker panel with markers in close linkage disequilibrium to the QTL in order to predict their genetic values, we also discuss opportunities for genomic selection to predict the effects of CNV by dense SNP panels, when CNV cause variation in quantitative traits.</p

The Compressive Strength of High-Performance Concrete and Ultrahigh-Performance

The compressive strength of silica fume concretes was investigated at low water-cementitious materials ratios with a naphthalene sulphonate superplasticizer. The results show that partial cement replacement up to 20% produce, higher compressive strengths than control concretes, nevertheless the strength gain is less than 15%. In this paper we propose a model to evaluate the compressive strength of silica fume concrete at any time. The model is related to the water-cementitious materials and silica-cement ratios. Taking into account the author's and other researchers’ experimental data, the accuracy of the proposed model is better than 5%

Predicting sexual problems in women: The relevance of sexual excitation and sexual inhibition

This is the post-print version of the article. The official published version can be obtained from the link below.Data from a non-clinical sample of 540 heterosexual women were used to examine the relationships between scores on the Sexual Excitation/Sexual Inhibition Inventory for Women (SESII-W) and ratings of current sexual problems, lifetime arousal difficulty, lifetime orgasm difficulty, and lifetime problems with low sexual interest. Multiple regression analyses also included several demographic/background variables as predictors: age, full-time employment, completed college, children in household, married, health ratings, importance of sex, and whether the woman was in a sexual relationship. The strongest statistical predictors of both current and lifetime sexual problems were the SESII-W inhibition factors Arousal Contingency and Concerns about Sexual Function. Demographic factors did not feature largely in any of the models predicting sexual problems even when statistically significant relationships were found. If future research supports the predictive utility of the SESII-W in identifying women who are more likely to experience sexual difficulties, these scales may be used as prognostic factors in treatment studies.This study was funded, in part, by a grant from the Lilly Centre for Women's Health

Next-Generation Environment-Aware Cellular Networks: Modern Green Techniques and Implementation Challenges

Over the last decade, mobile communications have been witnessing a noteworthy increase of data traffic demand that is causing an enormous energy consumption in cellular networks. The reduction of their fossil fuel consumption in addition to the huge energy bills paid by mobile operators is considered as the most important challenges for the next-generation cellular networks. Although most of the proposed studies were focusing on individual physical layer power optimizations, there is a growing necessity to meet the green objective of fifth-generation cellular networks while respecting the user's quality of service. This paper investigates four important techniques that could be exploited separately or together in order to enable wireless operators achieve

Taking Healthy Steps: rationale, design and baseline characteristics of a randomized trial of a pedometer-based internet-mediated walking program in veterans with chronic obstructive pulmonary disease

Abstract Background Low levels of physical activity are common in patients with chronic obstructive pulmonary disease (COPD), and a sedentary lifestyle is associated with poor outcomes including increased mortality, frequent hospitalizations, and poor health-related quality of life. Internet-mediated physical activity interventions may increase physical activity and improve health outcomes in persons with COPD. Methods/Design This manuscript describes the design and rationale of a randomized controlled trial that tests the effectiveness of Taking Healthy Steps, an Internet-mediated walking program for Veterans with COPD. Taking Healthy Steps includes an uploading pedometer, a website, and an online community. Eligible and consented patients wear a pedometer to obtain one week of baseline data and then are randomized on a 2:1 ratio to Taking Healthy Steps or to a wait list control. The intervention arm receives iterative step-count feedback; individualized step-count goals, motivational and informational messages, and access to an online community. Wait list controls are notified that they are enrolled, but that their intervention will start in one year; however, they keep the pedometer and have access to a static webpage. Discussion Participants include 239 Veterans (mean age 66.7 years, 93.7% male) with 155 randomized to Taking Healthy Steps and 84 to the wait list control arm; rural-living (45.2%); ever-smokers (93.3%); and current smokers (25.1%). Baseline mean St. George’s Respiratory Questionnaire Total Score was 46.0; 30.5% reported severe dyspnea; and the average number of comorbid conditions was 4.9. Mean baseline daily step counts was 3497 (+/- 2220). Veterans with COPD can be recruited to participate in an online walking program. We successfully recruited a cohort of older Veterans with a significant level of disability including Veterans who live in rural areas using a remote national recruitment strategy. Trial registration Clinical Trials.gov NCT01102777http://deepblue.lib.umich.edu/bitstream/2027.42/109506/1/12890_2014_Article_479.pd

Three major steps toward the conservation of freshwater and riparian biodiversity

J.M. and J.H. thank Stiftelsen Längmanska kulturfonden for funding travel to the conference. As.L. and K.R. thank the Estonian Research Council (grant 1121) for financial support, and A.M. acknowledges the Leverhulme Trust (RPG-2019-402). H.H. was supported by the European Union Horizon 2020 Research and Innovation Programme under the Marie Sklodowska-Curie Actions (grant agreement 860800): RIBES (river flow regulation, fish behaviour, and status), and V.A. acknowledges the support from the Leibniz Competition project Freshwater Megafauna Futures. E.J. received support through the National Laboratory for Health Security (RRF-2.3.1-21-2022-00006), Centre for Ecological Research, Budapest, Hungary, and thanks Z. Molnár for support.Freshwater ecosystems and their bordering wetlands and riparian zones are vital for human society and biological diversity. Yet, they are among the most degraded ecosystems, where sharp declines in biodiversity are driven by human activities, such as hydropower development, agriculture, forestry, and fisheries. Because freshwater ecosystems are characterized by strongly reciprocal linkages with surrounding landscapes, human activities that encroach on or degrade riparian zones ultimately lead to declines in freshwater–riparian ecosystem functioning. We synthesized results of a symposium on freshwater, riparian, and wetland processes and interactions and analyzed some of the major problems associated with improving freshwater and riparian research and management. Three distinct barriers are the lack of involvement of local people in conservation research and management, absence of adequate measurement of biodiversity in freshwater and riparian ecosystems, and separate legislation and policy on riparian and freshwater management. Based on our findings, we argue that freshwater and riparian research and conservation efforts should be integrated more explicitly. Best practices for overcoming the 3 major barriers to improved conservation include more and sustainable use of traditional and other forms of local ecological knowledge, choosing appropriate metrics for ecological research and monitoring of restoration efforts, and mirroring the close links between riparian and freshwater ecosystems in legislation and policy. Integrating these 3 angles in conservation science and practice will provide substantial benefits in addressing the freshwater biodiversity crisis.Peer reviewe

The curvature tensor of (\ka,\mu,\nu)-contact metric manifolds

We study the Riemann curvature tensor of (\kappa,\mu,\nu)-contact metric manifolds, which we prove to be completely determined in dimension 3, and we observe how it is affected by D_a-homothetic deformations. This prompts the definition and study of generalized (\kappa,\mu,\nu)-space forms and of the necessary and sufficient conditions for them to be conformally flat

The effects of postmenopausal hormone therapy on social activity, partner relationship, and sexual life – experience from the EPHT trial

<p>Abstract</p> <p>Background</p> <p>With the exception of sexual functioning and weight, social and behavioural effects of postmenopausal hormone therapy (HT) have not been reported from trials. This paper reports such results from the EPHT-trial in Estonia.</p> <p>Methods</p> <p>A randomized trial, with a blind and non-blind sub-trial in Estonia. From 1999–2001, 1778 women were recruited. The mean follow-up was 3.6 years. Women's experiences were asked in the first and final study year by mailed questionnaires (74 and 81% response rates). Comparisons of the groups were made by cross-tabulation and logistic regression, adjusting for age.</p> <p>Results</p> <p>There were no differences between the HT and non-HT groups in regard to being employed, the extent of social involvement or marital status or opinions on aging. There was no difference in the frequency of free-time exercise, or overweight. Some of the indicators suggested less sexual inactivity, but the differences were small.</p> <p>Conclusion</p> <p>In a trial setting, postmenopausal hormone therapy did not influence work or social involvement or health behaviour.</p> <p>Trial registration</p> <p>ISRCTN35338757</p