Mesenchymal stromal/stem cells and their exosomes for restoration of spermatogenesis in non-obstructive azoospermia: a systemic review

Stem cells have been introduced as new promising therapeutic agents in treatment of degenerative diseases because of having high differentiation potential while maintaining the ability to self-replicate and retaining features of their source cells. Among different type of cell therapies, mesenchymal stromal/stem cell (MSC) therapy is being increasingly developed as a new way to treat structural defects that need to be repaired and regenerated. Non-obstructive azoospermia (NOA) is a reproductive disease in men that causes infertility in 10% of infertile men. Based on in vitro studies, MSCs from different tissue sources have been differentiated into germ cells or gamete progenitor cells by simple methods in both male and female. On the other hand, the therapeutic effects of MSCs have been evaluated for the treatment of NOA animal models created by chemical or surgical compounds. The results of these studies confirmed successful allotransplantation or xenotransplantation of MSCs in the seminiferous tubules. As well, it has been reported that exosomes secreted by MSCs are able to induce the process of spermatogenesis in the testes of infertile animal models. Despite numerous advances in the treatment of reproductive diseases in men and women with the help of MSCs or their exosomes, no clinical trial has been terminated on the treatment of NOA. This systematic review attempts to investigate the possibility of MSC therapy for NOA in men

Literary And Educational Conversation, Dedicated Babur

This article analyzes the literary conversation of the well-known literary critic Ibrahim Hakkulov on the Uzbek classical literature, in particular, Z.M. Bobur . &nbsp

Peculiarities of the Child\u27s Body and Pediatric Surgery

The article describes the concept of pediatric surgery, its features, the distinguishing features of a child\u27s body from an adult\u27s, and also describes operations according to the urgency of their implementation. Based on the written article, a conclusion is made on the basis of the facts studied

Pedagogical Creativity as A Factor of the Professional Development of the Teacher-Teacher

The article examines the issues of the formation of individuality in a teacher, contributing to the upbringing of a child's creative personality. The more diverse personalities there are among teachers, the more likely they are to teach children who have many different and at the same time useful individual qualities

The Main Tendencies of Changes in the Territorial Composition of the Industry

He industrial complex plays a unique role in the integrated socio-economic development of regions. This is due to the fact that this area concentrates great opportunities and factors for the effective use of resource potential. Therefore, in the state regional economic policy, special attention is paid to the industrialization of regions. Industrialization processes occur in the countrys regions at different speeds and scales, depending on the conditions of the organizational and institutional, technical and technological, investment, financial, and natural resource potential

THE ROLE AND IMPORTANCE OF STRATEGIC PLANNING IN MARKETING

Marketing strategy is the marketing of a firm’s target market is a master program that represents the activities of the company and includes the process of achieving its goals through the development and implementation of a long-term marketing mix (marketing mix). Separate product, pricing, distribution, sales and communication policies are defined for each segment of the market. The marketing strategy determines which product (service) the firm should enter, which market, and when. The following marketing strategies have been tested and successfully used by companies in the world market practice

PREPARATION AND STRUCTURAL STUDYING OF THE TETRACLORIDOZINCATE (II) COMPLEX WITH METHYLENE BLUE - A POTENTIAL ANTIVIRAL AND ANTIMICROBIAL AGENT

Tetrachloridozincate(II) complex [MB]+2[ZnCl4]2- (where [MB]+ – methylthioninium cation; methylene blue cation) was synthesized as a result of the mechanochemical reaction of ZnCl2×2H2O hexahydrate with [MB]Cl×5H2O in the molar ratio 1:2. The asymmetric unit of the studied compound consists of a [ZnCl4]2- anion and two [MB]+ cations. Coordination polyhedron of the central atom is regular tetrahedron square planar. The planar [MB]+ cations are stacked in an antiparallel mode with sulfur atoms disposed alternatively on opposite sides, and exhibiting π-π stacking at the average interplanar distances of 3.482 Å and 3.478 Å