Effect of seed treatments on seed germination and seedling parameters in the F2 generation of mundu chilli (Capsicum annum L.)

Germination in chilli seeds is poor and the duration taken for the germination is long. In order to overcome their problems in germination, the seeds were to be subjected to seed treatments, So that the germination would be effective. The experiment was conducted at the Department of Vegetable Science HC & RI, Tami Nadu Agricultural University (TNAU), Periyakulam to study the effect of seed treatment views on the seedling character of mundu chilli. The experiment was laid in FCRD design with three replications. In this study, four F2 crosses viz., PKM CA 20 X PKM CA 08 (C1), PKM CA 32 X PKM CA 33 (C2), PKM CA 32 X PKM CA 20 (C3), PKM CA 38 X PKM CA 33 (C4) and seven treatments namely, Control (T0), Seed treatment with KNO3 0.5% (T1), Seed treatment GA3 50 ppm (T2), Seed treatment with NAA 100 ppm (T3), Hot water seed treatment at 60° C for 15 minutes (T4), Seed treatment with cow urine (T5), Seed treatment with Trichoderma viride (T6). Among all F2 crosses, PKM CA 38 X PKM CA 33 (C4) was most responsive to seed treatments in terms of the percent of seed germination and vigor index, followed by progeny PKM CA 32 X PKM CA 33 (C2) for root length and PKM CA 32 X PKM CA 20 (C3) for shoot length. The statistical analysis of the data showed the superiority of all the seed treatments over the control. The GA₃ treatment resulted in the maximum percentage of seed germination, root length, shoot length and vigor index followed by KNO3.    GA3 breaks the dormancy in the seeds and induces seed germination rapidly. Thus GA3 finds its way as the seed treatment agent in chilli.

1-Chloro­acetyl-2,6-bis­(2-chloro­phen­yl)-3,5-dimethyl­piperidin-4-one oxime

In the title compound, C21H21Cl3N2O2, the piperidine ring adopts a distorted boat conformation. One of the chloro­phenyl rings is almost perpendicular to the best plane through piperidine ring, making a dihedral angle of 88.7 (1)°, whereas the other ring is twisted by 71.8 (1)°. The crystal packing is stabilized by inter­molecular C—H⋯O, C—H⋯Cl and O—H⋯O inter­actions

Teachers in an Interdisciplinary Learning Community: Engaging, Integrating, and Strengthening K-12 Education

This study examines the inputs (processes and strategies) and outputs (perceptions, skill development, classroom transfer, disciplinary integration, social networking, and community development) of a yearlong, interdisciplinary teacher learning and development experience. Eleven secondary math and science teachers partnered with an interdisciplinary team of university engineering mentors in a yearlong engineering education and project implementation program. It consisted of a 6-week on-site resident professional development and collaboration experience, with an ongoing support and follow-up including digital systems. Mixed-method, multisource data indicate that teachers engaged with motivations combining personal, intrinsic interest and classroom integration goals. They formed and sustained an active community of learning and practice that supported their success, on-site and through classroom integration, thereby promoting innovations. Teachers reported positive perceptions throughout the program and demonstrated significant, productive trajectories of change-over-time. Teachers learned and transferred task-specific engineering and scientific skills, as well as more general inquiry-based pedagogical strategies to their secondary classrooms.Yeshttps://us.sagepub.com/en-us/nam/manuscript-submission-guideline

Non Inflammatory Boronate Based Glucose-Responsive Insulin Delivery Systems

Boronic acids, known to bind diols, were screened to identify non-inflammatory cross-linkers for the preparation of glucose sensitive and insulin releasing agglomerates of liposomes (Agglomerated Vesicle Technology-AVT). This was done in order to select a suitable replacement for the previously used cross-linker, ConcanavalinA (ConA), a lectin known to have both toxic and inflammatory effects in vivo. Lead-compounds were selected from screens that involved testing for inflammatory potential, cytotoxicity and glucose-binding. These were then conjugated to insulin-encapsulating nanoparticles and agglomerated via sugar-boronate ester linkages to form AVTs. In vitro, the particles demonstrated triggered release of insulin upon exposure to physiologically relevant concentrations of glucose (10 mmoles/L–40 mmoles/L). The agglomerates were also shown to be responsive to multiple spikes in glucose levels over several hours, releasing insulin at a rate defined by the concentration of the glucose trigger

Why Functional Pre-Erythrocytic and Bloodstage Malaria Vaccines Fail: A Meta-Analysis of Fully Protective Immunizations and Novel Immunological Model

Background: Clinically protective malaria vaccines consistently fail to protect adults and children in endemic settings, and at best only partially protect infants. Methodology/Principal Findings: We identify and evaluate 1916 immunization studies between 1965-February 2010, and exclude partially or nonprotective results to find 177 completely protective immunization experiments. Detailed reexamination reveals an unexpectedly mundane basis for selective vaccine failure: live malaria parasites in the skin inhibit vaccine function. We next show published molecular and cellular data support a testable, novel model where parasite-host interactions in the skin induce malaria-specific regulatory T cells, and subvert early antigen-specific immunity to parasite-specific immunotolerance. This ensures infection and tolerance to reinfection. Exposure to Plasmodium-infected mosquito bites therefore systematically triggers immunosuppression of endemic vaccine-elicited responses. The extensive vaccine trial data solidly substantiate this model experimentally. Conclusions/Significance: We conclude skinstage-initiated immunosuppression, unassociated with bloodstage parasites, systematically blocks vaccine function in the field. Our model exposes novel molecular and procedural strategies to significantly and quickly increase protective efficacy in both pipeline and currently ineffective malaria vaccines, and forces fundamental reassessment of central precepts determining vaccine development. This has major implications fo

3-[(4-Oxo-4H-thiochromen-3-yl)methyl]-4H-thiochromen-4-one

The title molecule, C19H12S2O2, lies on a twofold rotation axis. The thiochromonone unit is essentially planar, with a maximum deviation of 0.0491 (14) Å. The dihedral angle between the thiochromenone ring systems is 64.48 (4)°. In the crystal, there are weak π–π stacking interactions, with a centroid–centroid distance of 3.7147 (9) Å

Unusual Cause of Swelling in the Upper Limb: Kimura Disease

Kimura disease is a rare chronic inflammatory disease of unknown etiology. The disease typically presents in young Asian males with single or multiple slowly progressing painless subcutaneous lumps in the head and neck region; regional lymphadenopathy is commonly accompanied. The disease is associated with peripheral blood eosinophilia and elevated serum immunoglobulin E levels. This gives an important clinical clue to the diagnosis and implies a possible immune-mediated pathophysiology. Although the disease commonly affects the head and neck region, it may also affect the extremities, axilla, groin, and abdomen. Upper limb involvement in Kimura’s disease is rare and few cases have been reported in the literature. We describe the case of a man who presented with a history of progressive upper limb swelling. He was diagnosed with Kimura’s disease based on concordant clinical, laboratory, radiological, and histopathological grounds. Although rare in the upper limb, the possibility of Kimura’s disease has to be considered in young males presenting with painless swelling in the medial epitrochlear region with compatible imaging appearance, particularly if associated with lymph node enlargement and increased blood eosinophils. Characteristic imaging findings of Kimura’s disease of the upper limb include specific location along the neuro-lymphovascular structures, the absence of necrosis or calcification, mutliple flow voids representing vascular structures, a varying amount of edema of subcutaneous fat plane overlying the lesion; displacement of adjacent muscles; and neurovascular structures without signs of direct invasion. Clinicians should be aware of this distinct entity in order to avoid misdiagnosis and to tailor appropriate management