Bacillus subtilis as potential producer for polyhydroxyalkanoates

Polyhydroxyalkanoates (PHAs) are biodegradable polymers produced by microbes to overcome environmental stress. Commercial production of PHAs is limited by the high cost of production compared to conventional plastics. Another hindrance is the brittle nature and low strength of polyhydroxybutyrate (PHB), the most widely studied PHA. The needs are to produce PHAs, which have better elastomeric properties suitable for biomedical applications, preferably from inexpensive renewable sources to reduce cost. Certain unique properties of Bacillus subtilis such as lack of the toxic lipo-polysaccharides, expression of self-lysing genes on completion of PHA biosynthetic process – for easy and timely recovery, usage of biowastes as feed enable it to compete as potential candidate for commercial production of PHA

REVIEW ON MALNUTRITION HEALTH HAZARDS IN PEDIATRIC POPULATION AND ITS AYURVEDA MANAGEMENT

Objectives: The study was designed with the objectives: To study the role of Brimhana therapy in Karshya and to review the clinical research works on Karshya (malnutrition) in the Institute for Post Graduate Teaching and Research in Ayurveda (IPGT and RA), Jamnagar, and reach a final conclusion.Methods: This study was done by compiling the classical Ayurvedic literature, pediatric magazines, and research journals as well as PubMed and MedLine database for the search of the relevant literature. The review has been done from previous years of clinical research work in IPGT and RA, Jamnagar.Discussion: Brumhana and Vrushya Yoga have resulted in obtaining the phenomena of ideal anabolism. Brumhana Yoga has Kapikachhu, Shweta musli, and Shatavari are Brumhana and Vrushya both properties in it, that's why it shows a better result. Basti is better in Vatahara Guna and fruitful in microcirculation that is why it produces a better result.Conclusion: In the present study, it has been concluded that Brumhana is the line of treatment in Karshya (malnutrition) and gives a fruitful result. Ayurvedic medication and procedures are very efficacious to overcome this malnutrition named, a great burden on society. Assimilation has also a very big role for the absorption of Brumhana Yoga, and for this, regulation of Agni is very important. Basti procedure is more efficacious than drug administration. Overall Ayurveda is very efficacious in Karshya

Murine adenoviruses: tools for studying adenovirus pathogenesis in a natural host

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/153088/1/feb213699.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/153088/2/feb213699_am.pd

Contributory factors in Juvenile Diabetes manifestation from Ayurvedic View - A Cohort Survey

Over the period of time, human race has evolved and till date the development is going on. There is continuous civilization and change in life style of human being. Due to these changes in life style, human being is constantly struggling against the changing environmental conditions to maintain optimum health and vigor throughout the life. These changes have lead to increase in the disease burden in the society. Juvenile Diabetes is also such condition which is going to increase day by day in children. Children are the most vulnerable community in society. Juvenile diabetes (Insulin Dependent Diabetes Mellitus – IDDM/ Type 1 DM / T1DM) is the most common endocrine/metabolic disorder of childhood and adolescence. The high prevalence data of Juvenile Diabetes is also alarming. Globally, the incidence of Type 1 DM is increasing in children and youth by about 3% per annum. It is characterized by deficient insulin production and requires daily parenteral administration of insulin, otherwise may prove fatal. The cause of type 1 diabetes is not known and it is not preventable with current knowledge. So a survey of 50 diagnosed juvenile diabetes patients in Jamnagar city of Gujarat state was conducted. With this survey study an effort has been done t

Repeatability of swept-source optical coherence tomography retinal and choroidal thickness measurements in neovascular age-related macular degeneration

BACKGROUND: The aim was to determine the intrasession repeatability of swept-source optical coherence tomography (SS-OCT)-derived retinal and choroidal thickness measurements in eyes with neovascular age-related macular degeneration (nAMD). METHODS: A prospective study consisting of patients with active nAMD enrolled in the Distance of Choroid Study at Moorfields Eye Hospital, London. Patients underwent three 12×9 mm macular raster scans using the deep range imaging (DRI) OCT-1 SS-OCT (Topcon) device in a single imaging session. Retinal and choroidal thicknesses were calculated for the ETDRS macular subfields. Repeatability was calculated according to methods described by Bland and Altman. RESULTS: 39 eyes of 39 patients with nAMD were included with a mean (±SD) age of 73.9 (±7.2) years. The mean (±SD) retinal thickness of the central macular subfield was 225.7 μm (±12.4 μm). The repeatability this subfield, expressed as a percentage of the mean central macular subfield thickness, was 23.2%. The percentage repeatability of the other macular subfields ranged from 13.2% to 28.7%. The intrasession coefficient of repeatability of choroidal thickness of the central macular subfield was 57.2 μm with a mean choroidal thickness (±SD) of 181 μm (±15.8 μm). CONCLUSIONS: This study suggests that a change >23.2% of retinal thickness and 57.2 μm choroidal thickness in the central macular subfield is required to distinguish true clinical change from measurement variability when using the DRI OCT-1 device to manage patients with nAMD

The effect of surveillance and appreciative inquiry on puerperal infections : a longitudinal cohort study in India

Peer reviewedPublisher PD

A realistic pattern of fermion masses from a five-dimensional SO(10) model

We provide a unified description of fermion masses and mixing angles in the framework of a supersymmetric grand unified SO(10) model with anarchic Yukawa couplings of order unity. The space-time is five dimensional and the extra flat spatial dimension is compactified on the orbifold $S^1/(Z_2 \times Z_2')$, leading to Pati-Salam gauge symmetry on the boundary where Yukawa interactions are localised. The gauge symmetry breaking is completed by means of a rather economic scalar sector, avoiding the doublet-triplet splitting problem. The matter fields live in the bulk and their massless modes get exponential profiles, which naturally explain the mass hierarchy of the different fermion generations. Quarks and leptons properties are naturally reproduced by a mechanism, first proposed by Kitano and Li, that lifts the SO(10) degeneracy of bulk masses in terms of a single parameter. The model provides a realistic pattern of fermion masses and mixing angles for large values of $\tan\beta$. It favours normally ordered neutrino mass spectrum with the lightest neutrino mass below 0.01 eV and no preference for leptonic CP violating phases. The right handed neutrino mass spectrum is very hierarchical and does not allow for thermal leptogenesis. We analyse several variants of the basic framework and find that the results concerning the fermion spectrum are remarkably stable.Comment: 30 pages, 7 figures, 4 table

Tuning the Reactivity of Nanoenergetic Gas Generators Based on Bismuth and Iodine oxidizers

There is a growing interest on novel energetic materials called Nanoenergetic Gas- Generators (NGGs) which are potential alternatives to traditional energetic materials including pyrotechnics, propellants, primers and solid rocket fuels. NGGs are formulations that utilize metal powders as a fuel and oxides or hydroxides as oxidizers that can rapidly release large amount of heat and gaseous products to generate shock waves. The heat and pressure discharge, impact sensitivity, long term stability and other critical properties depend on the particle size and shape, as well as assembling procedure and intermixing degree between the components. The extremely high energy density and the ability to tune the dynamic properties of the energetic system makes NGGs ideal candidates to dilute or replace traditional energetic materials for emerging applications. In terms of energy density, performance and controllability of dynamic properties, the energetic materials based on bismuth and iodine compounds are exceptional among the NGGs. The thermodynamic calculations and experimental study confirm that NGGs based on iodine and bismuth compounds mixed with aluminum nanoparticles are the most powerful formulations to date and can be used potentially in microthrusters technology with high thrust-to-weight ratio with controlled combustion and exhaust velocity for space applications. The resulting nano thermites generated significant value of pressure discharge up to 14.8 kPa m3/g. They can also be integrated with carbon nanotubes to form laminar composite yarns with high power actuation of up to 4700 W/kg, or be used in other emerging applications such as biocidal agents to effectively destroy harmful bacteria in seconds, with 22 mg/m2 minimal content over infected area