41 research outputs found
1H NMR spectroscopy study of structural water in rehydrated biocomposite of Spongilla lacustris freshwater demosponge origin
Biocomposites of sponge origin attract scientific attention due to their renewability as well as special properties. Dried skeletons of fresh water demosponge Spongilla lacustris represent unique kind of naturally occurring silica-chitin-based biocomposites with long history of their applications in dermatocosmetics. However, there is still a lack of knowledge on their physico-chemical properties in model systems. The aim of this work was to model drug systems based on S. lacustris powdered biocomposite, water and a hydrophobic medium, which served as an analog of an oil base. Both thermogravimetric analysis and 1H NMR spectroscopy study of structural water in rehydrated biocomposite lead to obtaining of interesting experimental data useful for preparation of biocosmetic products. © 2020, The Author(s).Deutsche Forschungsgemeinschaft, DFG: HE 394-3PPN/BEK/2018/1/00071Deutsche Forschungsgemeinschaft, DFGSächsisches Staatsministerium für Wissenschaft und Kunst, SMWK: 02010311This work was financially supported by German Research Foundation (DFG) Grant HE 394-3, SMWK Project 02010311 (Germany). M.W. is thankful for financial support from Polish National Agency for Academic Exchange (PPN/BEK/2018/1/00071) and support from Ministry of Science and Higher Education (Poland) as financial subsidy to PUT
ЗАСТОСУВАННЯ БІЛКОВИХ ПРЕПАРАТІВ ТВАРИННОГО ПОХОДЖЕННЯ В ТЕХНОЛОГІЇЇ ШИНОК
It is theoretically founded and experimentally confirmed possibility of development and use in composition the meat products of protein-fatty emulsion (PFE) with high functional and technological properties and balanced amino acidic and fatty acidic composition, that is conditioned by the use of secondary protein included meat raw material.
The necessity of the use is scientifically well-proven in composition PFE of animal proteins pork triming AproGel is a 1 %, protein on the basis of blood Vepro 95 HV – 1%, protein stabilizer from a pork skin – 6 % and determinated law of stability`s change of functional and technological properties of emulsion is set from nature and content of proteins preparations and fatty composition.
It is founded adjusting possibility of functional and technological properties of PSE pork, that is reasonable by the use of PFE in an amount 15 % with the purpose of making from her ham wares in the shell with advanced biological value with stably high structural-mechanial and organolepic properties.
Теоретически обосновано и экспериментально подтверждена возможность разработки и использования в составе мясных продуктов белково-жировой эмульсии (БЖЭ) с высокими функционально- технологическими свойствами и сбалансированным аминокислотным и жирнокислотным составом, что обуславливается использованием вторичного мясного белоксодержащего сырья.Научно доказана необходимость использования в составе БЖЭ животных белков свиного тримминга AproGel – 1 %, белка на основе крови Vepro 95 HV – 1%, белкового стабилизатора из свиной шкурки – 6 % и установлена закономерность изменения стабильности функционально- технологических свойств эмульсии от природы и содержимого белковых препаратов и жировой композиции.Обоснована возможность регулирования функционально- технологических характеристик свинины PSE путем использования БЖЭ в количестве 15 % с целью изготовления из нее ветчинных изделий в оболочке повышенной биологической ценности со стабильно высокими структурно-механическими и органолептическими показателями. Теоретично обґрунтовано і експериментально підтверджено можливість розроблення та використання у складі м’ясних продуктів білково-жирової емульсії (БЖЕ) з високими функціонально-технологічними властивостями та збалансованим амінокислотним і жирнокислотним складом, що обумовлюється використанням вторинної м’ясної білковмісної сировини.
Науково доведено необхідність використання в складі БЖЕ тваринних білків свинячого тримінгу AproGel - 1 %, білка на основі крові Vepro 95 HV – 1%, білкового стабілізатора зі свинячої шкурки -6 % та встановлено закономірність зміни стабільності функціонально-технологічних властивостей емульсії від природи і вмісту білкових препаратів та жирової композиції.
Обґрунтовано можливість регулювання функціонально-технологічних характеристик свинини PSE шляхом використання БЖЕ в кількості 15 % з метою виготовлення з неї шинкових виробів в оболонці підвищеної біологічної цінності зі стабільно високими структурно-механічними та органолептичними показниками.
 
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Breast cancer family history and allele-specific DNA methylation in the Legacy Girls Study
Family history, a well-established risk factor for breast cancer, can have both genetic and environmental contributions. Shared environment in families as well as epigenetic changes that also may be influenced by shared genetics and environment may also explain familial clustering of cancers. Epigenetic regulation, such as DNA methylation, can change the activity of a DNA segment without a change in the sequence; environmental exposures experienced across the life course can induce such changes. However, genetic-epigenetic interactions, detected as methylation quantitative trait loci (mQTLs; a.k.a. meQTLs) and haplotype-dependent allele-specific methylation (hap-ASM), can also contribute to inter-individual differences in DNA methylation patterns. To identify differentially methylated regions (DMRs) associated with breast cancer susceptibility, we examined differences in white blood cell DNA methylation in 29 candidate genes in 426 girls (ages 6-13 years) from the LEGACY Girls Study, 239 with and 187 without a breast cancer family history (BCFH). We measured methylation by targeted massively parallel bisulfite sequencing (bis-seq) and observed BCFH DMRs in two genes: ESR1 (Δ4.9%, P = 0.003) and SEC16B (Δ3.6%, P = 0.026), each of which has been previously implicated in breast cancer susceptibility and pubertal development. These DMRs showed high inter-individual variability in methylation, suggesting the presence of mQTLs/hap-ASM. Using single nucleotide polymorphisms data in the bis-seq amplicon, we found strong hap-ASM in SEC16B (with allele specific-differences ranging from 42% to 74%). These findings suggest that differential methylation in genes relevant to breast cancer susceptibility may be present early in life, and that inherited genetic factors underlie some of these epigenetic differences
"Pi of the Sky" - all-sky, real-time search for fast optical transients
An apparatus to search for optical flashes in the sky is described. It has
been optimized for gamma ray bursts (GRB) optical counterparts. It consists of
2x16 cameras covering all the sky. The sky is monitored continuously and the
data are analysed on-line. It has self-triggering capability and can react to
external triggers with negative delay. The prototype with two cameras has been
installed at Las Campanas (Chile) and is operational from July 2004. The paper
presents general idea and describes the apparatus in detail. Performance of the
prototype is briefly reviewed and perspectives for the future are outlined
Platelet Carbonic Anhydrase II, a Forgotten Enzyme, May Be Responsible for Aspirin Resistance
Background. Thromboembolic events constitute a major health problem, despite the steadily expanding arsenal of antiplatelet drugs. Hence, there is still a need to optimize the antiplatelet therapy. Objectives. The aim of our study was to verify a hypothesis that there are no differences in platelet proteome between two groups of healthy people representing different acetylsalicylic acid (aspirin) responses as assessed by the liquid chromatography/mass spectrometry (LC/MS) technique. Patients/Methods. A total of 61 healthy volunteers were recruited for the study. Physical examination and blood collection were followed by platelet-rich plasma aggregation assays and platelet separation for proteomic LC/MS analysis. Arachidonic acid- (AA-) induced aggregation (in the presence of aspirin) allowed to divide study participants into two groups aspirin-resistant (AR) and aspirin-sensitive (AS) ones. Subsequently, platelet proteome was compared in groups using the LC/MS analysis. Results. The LC/MS analysis of platelet proteome between groups revealed that out of all identified proteins, the only discriminatory protein, affecting aspirin responsiveness, is platelet carbonic anhydrase II (CA II). Conclusions. CA II is a platelet function modulator and should be taken into consideration as a cardiovascular event risk factor or therapeutic target
Device for compressibility and thermal expansion study up to 3 GPa
We present the realization of a project of a device utilizing a standard high-pressure chamber adapted to compressibility and thermal expansion measurements of solids at hydrostatic pressures up to 3 GPa. The device has been tested on the triglycine sulphate crystal (TGS)
Influence of Hydrostatic Pressure on the Zero-Field Splitting in NiSnCl·6HO
The dependence of the crystal-field splitting parameter D in NiSnCl·6HO on hydrostatic pressure was determined by the electron paramagnetic resonance method, for the pressures up to 500 MPa. The derivative (∂D/∂p) as well as the temperatures and pressures at which the D-parameter reaches zero, were determined. The molecular mechanism responsible for the temperature and pressure changes of the D-parameter is similar to that one observed in the isomorphic NiSiF·6HO
Influence of Hydrostatic Pressure on the Zero-Field Splitting in NiSnCl 6
The dependence of the crystal-field splitting parameter D in NiSnCl·6HO on hydrostatic pressure was determined by the electron paramagnetic resonance method, for the pressures up to 500 MPa. The derivative (∂D/∂p) as well as the temperatures and pressures at which the D-parameter reaches zero, were determined. The molecular mechanism responsible for the temperature and pressure changes of the D-parameter is similar to that one observed in the isomorphic NiSiF·6HO
Review. High pressure techniques used in the paramagnetic resonances
The aim of this review-paper is to overview high pressure techniques used in the magnetic resonances in laboratories. In this review, we would like to show the techniques that lead yielding high pressure applicable in the paramagnetic resonances. We would like to draw your attention to the separation of the effects resulting from the pressure and effects from the temperature, thereby separate the volume phonon contribution. Our main intention is to show the impact of high pressure on the structure of matter, in particular on its fundamental level