Vibrations of Axialflow Blower (1.Theoretical and Experimental Study about Fundamental Frequency)

The vibrations of blower being produced by the mutual action between machinery and fluid， sometimes the blades of blower vibrate remarkably and are taken the stress over the allowable limit. It may be reached to the fatigue， the crack or the bloken down by the continuous running. The many papers were reported on the centrifugal blowers， but the papers were not reported too much on the axial blowers. In this paper we achieved the study about the static and dynamic natural frequencies and the theoretical results were good agree with the experimental results for the natural frequencie

Calreticulin and integrin alpha dissociation induces anti-inflammatory programming in animal models of inflammatory bowel disease

Inflammatory bowel disease (IBD), including ulcerative colitis and Crohn’s disease, is a chronic intestinal inflammatory condition initiated by integrins-mediated leukocyte adhesion to the activated colonic microvascular endothelium. Calreticulin (CRT), a calcium-binding chaperone, is known as a partner in the activation of integrin α subunits (ITGAs). The relationship between their interaction and the pathogenesis of IBD is largely unknown. Here we show that a small molecule, orally active ER-464195-01, inhibits the CRT binding to ITGAs, which suppresses the adhesiveness of both T cells and neutrophils. Transcriptome analysis on colon samples from dextran sodium sulfate-induced colitis mice reveals that the increased expression of pro-inflammatory genes is downregulated by ER-464195-01. Its prophylactic and therapeutic administration to IBD mouse models ameliorates the severity of their diseases. We propose that leukocytes infiltration via the binding of CRT to ITGAs is necessary for the onset and development of the colitis and the inhibition of this interaction may be a novel therapeutic strategy for the treatment of IBD

Vibration Analysis of Ventilating Fan

The hydromatic machines， which are represented by blowers， ventilating fans， pumps etc.，usually consist of moters and blades. They sometimes ‘cause large amplitude of vibration， and then yield much dynamic stress on the roots of blades excited rotating unbalance forces， generated by sticked dirts on the blades， for example. Most undesirable case of operation for these machines is to the resonance phenomena between the natural frequencies of system and exciting forces. Therefore it is necessary to provide for the calculated natural frequencies of them， so we tried to calculate them assumed the system consist of a mass and springs of supporting structure using the flexibility matrix method. The results obtained from the calculation agree well with the measurements and then guidelines for design of these machines are required