Role of Dashamoola Shatphala Ghrita in the management of Vataja Kasa w.s.r. to Tropical Pulmonary Eosinophilia - A Clinical Study

Kasa is a very common disease of Pranavaha Srotas. When Adhoga Gati of Vata is obstructed by Dusta Doshas, it attains the Urdhva Gati and takes Sthanasamshraya in Urah Pradesha and producing to Kasa. Vataja Kasa is one among the types of Kasa, where Shuska Kasa is prominent symptom. Vataja Kasa is taken as special reference to Tropical Pulmonary Eosinophilia because of similarities of signs and symptoms. India being one of the tropical country, the prevalence of Vataja Kasa vis-à-vis Tropical Pulmonary Eosinophilia is remarkably high. The syndrome is particularly endemic in India, Sri Lanka, South East Asia and Africa and has been reported from filarial epidemic areas worldwide. In this present study an attempt is made to evaluate the efficacy of Dashamoola Shatphala Ghrita in Vataja Kasa vis-à-vis Tropical Pulmonary Eosinophilia. A minimum of 30 subjects who fulfilled the diagnostic & inclusion criteria was subjected to the intervention. The overall results in the study revealed statistically highly significant result

मत्स्य उत्पाद उधोग

कृपया पूरा लेख पढे

Evaluations of Thinning Algorithms for Preprocessing of Handwritten Characters

Thinning algorithms have played an important role in preprocessing phase which decides the success of recognition in the OCR system. This paper report on the performance of 11 thinning algorithms from the perspective of character recognition where different aspects of the performance of each algorithm like computing time, deviation from perfect 8-connectedness, and number of possible noise spurs present in the skeletons are considered

DEVELOPMENT OF A DEVICE TO MEASURE THE BLADE TIP CLEARANCE OF AN AXIAL COMPRESSOR

Axial compressors, used in gas turbines, jet engines and also small scale power plants, are rotating, airfoil based compressors in which the working fluid flows parallel to the axis of rotation. There has been continuous struggle to maximize the efficiency of these compressors. One of the many ways to achieve the same is to minimize the tip clearance i.e. to reduce the distance between the blade tip and the housing. Experiments need to be conducted to measure the changes in the tip clearance while the  compressor is operating. Conventional devices to measure this tip clearance have proven to be costly if a small scale application is under consideration. Our aim in this project is to develop a device which will measure the blade tip clearance of an axial flow compressor economically. The literature review, development of the device, its working and results will be discussed in this paper

Overexpression of activin-A and -B in malignant mesothelioma - Attenuated Smad3 signaling responses and ERK activation promote cell migration and invasive growth

Peer reviewe

N 6 -Formyllysine as a Biomarker of Formaldehyde Exposure: Formation and Loss of N 6 -Formyllysine in Nasal Epithelium in Long-Term, Low-Dose Inhalation Studies in Rats

Exposure to both endogenous and exogenous formaldehyde has been established to be carcinogenic, likely by virtue of forming nucleic acid and proteins adducts such as N6-formyllysine. To better assess N6-formyllysine as a biomarker of formaldehyde exposure, we studied accumulation of N6-formyllysine adducts in tissues of rats exposed by inhalation to 2 ppm [13C2H2]-formaldehyde for 7, 14, 21, and 28 days (6 h/day) and investigated adduct loss over a 7-day postexposure period using liquid chromatography-coupled tandem mass spectrometry. Our results showed formation of exogenous adducts in nasal epithelium and to some extent in trachea but not in distant tissues of lung, bone marrow, or white blood cells, with a 2-fold increase over endogenous N6-formyllysine over a 3-week exposure period. Postexposure analyses indicated a biexponential decay of N6-formyllysine in proteins extracted from different cellular compartments, with half-lives of ∼25 and ∼182 h for the fast and slow phases, respectively, in cytoplasmic proteins. These results parallel the behavior of DNA adducts and DNA-protein cross-links, with protein adducts cleared faster than DNA-protein cross-links, and point to the potential utility of N6-formyllysine protein adducts as biomarkers of formaldehyde

Measurement of Oxygenated Polycyclic Aromatic Hydrocarbons Associated with a Size-Segregated Urban Aerosol

Size-segregated atmospheric particles were collected in Boston, MA, using a micro-orifice impactor. The samples were analyzed for oxygenated polycyclic aromatic hydrocarbons (OPAH) using gas chromatography/mass spectrometry. Seven PAH ketones (1-acenaphthenone, 9-fluorenone, 11H-benzo[a]fluoren-11-one, 7H-benzo[c]fluoren-7-one, 11H-benzo[b]fluoren-11-one, benzanthrone, and 6H-benzo[cd]pyrene-6-one), four PAH diones (1,4-naphthoquinone, phenanthrenequinone, 5,12-naphthacenequinone, and benzo[a]pyrene-6,12-dione), and one PAH dicarboxylic acid anhydride (naphthalic anhydride) were identified. Seven additional compounds with mass spectra typical of OPAH were tentatively identified. OPAH were generally distributed among aerosol size fractions based on molecular weight. Compounds with molecular weights between 168 and 208 were ap proximately evenly distributed between the fine (aerodynamic diameter, D_p, 2 μm) particles. OPAH with molecular weights of 248 and greater were associated primarily with the fine aerosol fraction. Most OPAH were distributed with particle size in a broad, unimodal hump similar to the the distributions observed for PAH in the same samples. These results suggest that OPAH are initially associated with fine particles after formation by either combustion or gas phase photooxidation and then partition to larger particles by vaporization and sorption. Two OPAH were distributed in bimodal distributions with peaks at D_p ≈ 2 μm and D_p ≈ 2 μm. These bimodal distributions may be indicative of sorption behavior different from PAH and other OPAH

Measurement of Oxygenated Polycyclic Aromatic Hydrocarbons Associated with a Size-Segregated Urban Aerosol

Size-segregated atmospheric particles were collected in Boston, MA, using a micro-orifice impactor. The samples were analyzed for oxygenated polycyclic aromatic hydrocarbons (OPAH) using gas chromatography/mass spectrometry. Seven PAH ketones (1-acenaphthenone, 9-fluorenone, 11H-benzo[a]fluoren-11-one, 7H-benzo[c]fluoren-7-one, 11H-benzo[b]fluoren-11-one, benzanthrone, and 6H-benzo[cd]pyrene-6-one), four PAH diones (1,4-naphthoquinone, phenanthrenequinone, 5,12-naphthacenequinone, and benzo[a]pyrene-6,12-dione), and one PAH dicarboxylic acid anhydride (naphthalic anhydride) were identified. Seven additional compounds with mass spectra typical of OPAH were tentatively identified. OPAH were generally distributed among aerosol size fractions based on molecular weight. Compounds with molecular weights between 168 and 208 were ap proximately evenly distributed between the fine (aerodynamic diameter, D_p, 2 μm) particles. OPAH with molecular weights of 248 and greater were associated primarily with the fine aerosol fraction. Most OPAH were distributed with particle size in a broad, unimodal hump similar to the the distributions observed for PAH in the same samples. These results suggest that OPAH are initially associated with fine particles after formation by either combustion or gas phase photooxidation and then partition to larger particles by vaporization and sorption. Two OPAH were distributed in bimodal distributions with peaks at D_p ≈ 2 μm and D_p ≈ 2 μm. These bimodal distributions may be indicative of sorption behavior different from PAH and other OPAH

Dosimetry of N 6 -Formyllysine Adducts Following [ 13 C 2 H 2 ]-Formaldehyde Exposures in Rats

With formaldehyde as the major source of endogenous N6-formyllysine protein adducts, we quantified endogenous and exogenous N6-formyllysine in the nasal epithelium of rats exposed by inhalation to 0.7, 2, 5.8, and 9.1 ppm [13C2H2]-formaldehyde using liquid chromatography-coupled tandem mass spectrometry. Exogenous N6-formyllysine was detected in the nasal epithelium, with concentration-dependent formation in total as well as fractionated (cytoplasmic, membrane, nuclear) proteins, but was not detected in the lung, liver, or bone marrow. Endogenous adducts dominated at all exposure conditions, with a 6 h 9.1 ppm formaldehyde exposure resulting in one-third of the total load of N6-formyllysine being derived from exogenous sources. The results parallel previous studies of formaldehyde-induced DNA adducts